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Statewide COVID-19 Total Jumped by 14 to 109 on Tuesday Morning – Kgab
Posted: April 1, 2020 at 4:43 am
The total number of reported positive cases of the novel coronavirus jumped to109 on Tuesday, up by 14 in just a few hours, according to the Wyoming Department of Health.
Natrona County has 12 presumptive positive cases, and the cases are in 15 of the state's 23 counties, according to an update earlier Tuesday that pegged the total at 95.
Of the 109 reported cases, 26 have recovered.
Casper-Natrona County Health Department officials are working to complete contact tracing on the newly reported cases.
The Department of Health reports the Woming Public Health Laboratory has completed 1,563 tests; the U.S. Centers for Disease Control and Prevention has completed one test; and commercial labs have completed 544 tests.
The newest patients are self-isolating, along with their immediate household members.
No deaths have been reported in Wyoming in connection to COVID-19.
These are the cases by county:
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How to Be Intentional About Consuming Coronavirus News – Greater Good Science Center at UC Berkeley
Posted: April 1, 2020 at 4:43 am
My inbox is flooded with news about the coronavirus outbreak. Every hour, Im hearing about how many people are infected and dying, how woefully unprepared we are for this pandemic, and how the economy is tanking. Its enough to make my head explode with panic and dread.
Of course, I want to stay informed, and its important to know what I can do to help prevent the spread of the infection. How can I do that without feeling overwhelmed? Is there a better way to consume the news?
It turns out that there is, according to media experts and researchers. Taking in a constant stream of alarming news increases your stress and anxietyand has long-term consequences for your physical health, too. The key is to balance your media diet with news stories that are more inspiring or offer solutions, and then share them with friends and family. Taking those steps will help instill a sense of hope and personal agency, in yourself and others.
Of course, we need to know whats going on with the coronavirus pandemic in order to make good decisions, like washing our hands regularly and social distancing. Those actions help us fight the spread of the disease. But, as a new paper published in Health Psychology suggests, constantly reading negative, sensationalist news stories can have long-term consequences for our well-being.
Alison Holman and her colleagues at UC Irvine have studied past epidemics and disasters to see how news reporting affects people. They found that those who read or saw more sensationalist, repetitive news stories experienced acute stress and other symptoms similar to post-traumatic stress disorder, with poorer health up to three years later.
These effects can be even harsher for people in communities that have already suffered disaster. In one study, Holman and her colleagues found that New Yorkers (who lived through 9/11) following sensationalist news stories about the Boston Marathon bombings had as much stress as people who actually lived in Boston where the bombings took place.
Media coverage tends toward sensationalism, showing repeated images designed to grab your attention, and repeated exposure to that is not good for our mental health, says Holman. This can become a distress cycle, where people have a lot of fears about what the future looks like, and it just gets worse and worse as people continue to pay too much attention to the media.
Holman also points out how a diet of bad news hurts our ability to make good decisionsespecially under circumstances where the future seems uncertain or ambiguous. In the current epidemic, she sees this playing out by people hoarding products like toilet paper or, more seriously, protective masks needed by health care workers. Overblown fears lead people to run to the doctor when they have even mild symptoms of infection, thereby clogging up health care facilities needed for more serious cases.
Luckily, there are ways to get factual information without gorging ourselves on negative news. Holman recommends going to The Centers for Disease Control and the World Health Organization websites for information about the virus that is less alarmist and also non-partisan. Reading the facts about the disease and what we can do to prevent its spreadmaybe once a day, suggests Holmanis infinitely better for us than scrolling through our newsfeeds on social media every hour.
Dont let yourself sit there in front of your computer and constantly look up and refresh your screen to see whats going on, says Holman. Things are changing fast, but we already know what we need to do.
Still, its hard to pull our attention away from fear-inducing news; our minds fight us. As John Tierney, coauthor of The Power of Bad, explains, our brains have a negativity bias thats designed to root out danger so that we can stay safe. We cant help but be hijacked by bad news stories, and news sources want to capitalize on that by publishing the most sensational stories designed to invoke fear.
As an example, he points to the many articles and websites monitoring death rates from COVID-19 and speculating on how bad it could get without having all of the factslike how many real cases there are in a community, including people exposed to the virus without showing symptoms. Following this barrage of misinformation might incite fear rather than rational responses to the pandemic, Tierney says.
Media researcher Karen McIntyre of Virginia Commonwealth University also warns us that negative news can lead us to be less kind and helpful toward others, right at the time we need to come together the most. While research suggests that experiencing positive emotions can make us better friends and neighbors, consuming a lot of negative news leads people to be less tolerant of others, engage in more antisocial behavior, trust people less, and criticize the media more, she says. All of these general, negative effects of negative news are just exacerbated during a time like this, when were seeing even more negative news.
Sensationalist news is pretty hard to avoid, thoughespecially if you are tuned into social media. Social media has its upsides, of course, allowing us to check in with people we cant see in person due to social isolation. But it can also be a firehose of bad news, where stories about the pandemicwhether accurate or notare shared over and over again, perpetuating fear, anger, and hopelessness.
As media expert Jeff Hancock of Stanford University warns, Getting your news from news outlets in social media is problematic, because were still having a hard time distinguishing between reputable sources online and non-reputable ones.
To avoid being taken for an emotional ride by these highly emotional, clickbait, misinformation-type stories, he suggests avoiding them altogether and reading only news stories written by reputable journalists or looking to science experts to provide accurate information about the pandemiclike this site from John Hopkins University.
We also need to be careful about how a constant diet of negative news might affect our rational response to the pandemic. Cognitive biases impact how we process news, too, according to McIntyre. For example, our brains confirmation bias drives us to seek out only information thats aligned with what we already believe and to discredit the rest; the anchoring bias means we rely heavily on the first piece of information we hear and ignore what comes after. Biases like these can prevent us from learning from the ever-changing news around the pandemic, hurting our chances to fight it effectively.
The optimism biasthinking bad things are less likely to happen to us than to other peopleis a problem, too, says McIntyre. If you think youre unlikely to get COVID-19, you may be less inclined to take the necessary precautions to prevent it from spreading. So, we need to be careful about how these biases make us pay attention to certain types of news and ignore others.
Being aware of these biases can help you prevent yourself from falling prey to them, she says.
What can we do instead? We can be more selective about our media consumption and use it to promote more kindness, connection, and inspiration.
If you are going to use social media, Hancock suggests using it to see how the people you care about are doing, how you can keep calm, or how to help others in needespecially your nearby neighbors and communities.
Media can show us what people are doing so that we might feel like its not just usnot just mestuck at home, he says. If I can see what other people are doing, it can make us feel like were all in the same boat, and I think that can be really powerful.
While fear leaves people feeling helpless and exhausted, seeing that were in it together helps ease the emotional burden we feel and encourages more agencythe sense that we can do something constructive to fight the pandemic. You can encourage more coming together, McIntyre suggests, by reading whats called solutions-based journalismstories that go into depth around a problem, but also let you know whats being done to solve the problem effectively.
When you see whats workingthat the news isnt all bad, and there are a lot of things that the world is doing well right nowthat helps ease the helplessness and hopelessness you may be feeling, she says. And it can lead to more altruism, too, because reading a news story about how somebody is doing something to help inspires you to want to do something to help, too.
Where can people go to get this kind of news? McIntyre suggests the Solutions Journalism Network, where you can find a large database of solution-focused news storiesincluding stories related to the virus. She also mentions that several newspapers, including the New York Times and the Guardian, have sections that focus on uplifting news stories, which can help us break up our diet of bad news.
Though most newspapers operate on the assumption that if it bleeds, it leads, it may surprise you to know that positive, in-depth reporting engages readers more than sensationalist stories, says McIntyre. Research shows that people share uplifting stories more, and they keep their eyes on the page longer when they read solution-based storiesall the more reason for news outlets to provide more positive and in-depth coverage and for all of us to share it.
Its important that we do try to read the news thoroughly and listen to all the facts, says McIntyre. Making sure that youre checking your sources, that youre going to reliable sources to get information, and that you get a mix of sources, incorporating some constructive news into your mixall of these things help.
Staying informed without alarming yourself is not just important for you, but for everyone. If we can all do our part to put ourselves on what Tierney calls a low bad news diet, no doubt we will get through this pandemic together better and help preserve our own mental health in the process.
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Coronavirus Update: Outbreak could kill up to 200,000 Americans, expert warns – The Globe and Mail
Posted: March 29, 2020 at 8:45 pm
Good evening here are the coronavirus updates you need to know tonight.
Have questions about the coronavirus? Email audience@globeandmail.com. The Globes paywall has been removed on coronavirus news stories.
"Let's get hope back": graffiti in Caracas, Venezuela. (If you use a protective face mask, please don't wear it the way this man is!)
Matias Delacroix/The Associated Press
The coronavirus outbreak could kill 100,000 to 200,000 Americans, the U.S. governments top infectious-disease expert warned on Sunday as smouldering hot spots in nursing homes and a growing list of stricken cities heightened the sense of dread across the country.
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Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, made the dire prediction of fatalities on CNN, adding that millions in the U.S. could become infected.
By mid-afternoon, the U.S. had over 135,000 infections and 2,300 deaths, according to the running tally kept by Johns Hopkins University.
6,243 cases in Canada reported; with 484 recoveries and 63 deaths.
From Ottawa:
716,101: cases confirmed around the world; with 149,071 recoveries and 33,854 deaths reported.
Question: What happens on day 15 of self-isolation?
Answer: If you have tested positive for coronavirus, after 14 days you must undergo testing to ensure you are now negative, and be cleared by public health. If you self-isolated because you were showing symptoms, or because you had travelled outside Canada before the legal order, you can resume normal living. Or, at least new normal living, where we are all expected to practise social distancing.
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The Globes health columnist Andr Picard answered other reader questions.
Need more answers? Email audience@globeandmail.com
What happened today?
Opinion: Ive fought epidemics around the world. Now its Canada that must prepare for the worst
S.R. Slobodian: Quality stocks to target, safety plays amid dividend cuts and is it time to buy? What you need to know in investing this week
Lia Grainger: Astrologers navigate the tricky waters of COVID-19
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Josh OKane: Fintech lenders say Ottawa should be using them to more effectively get relief funds to small businesses
Saira Peesker: Bars, nightclubs and cannabis growers dont qualify for BDC COVID-19 loans
Have you witnessed or performed acts of kindness in your neighbourhood? Share your stories, photos and videos and they might be included in the Globe and Mail. Email audience@globeandmail.com.
A montage of frame grabs of friends and relatives wishing a happy birthday to Cindy Stewart, who was stuck in Peru for her birthday. Courtesy of family
Courtesy of family
The birthday girl
Cindy Stewart had been expecting little more than a bag of Hawkins Cheezies for her birthday. For years, she and her husband, Charles, have opted to backpack the world during her big day, March 20. No matter their far-flung location, Charles would pull from his bag a beat-up card and that distinct red-and-white bag of Hawkins finest to celebrate. Its become our little ritual, she says.
On Mar. 20, while the couple remained stranded in Peru due to travel bans, the cheezies appeared. But a sense of unease remained. At around 7 p.m., an e-mail from Ms. Stewarts daughter, Megan, pinged. She knew her parents predicament and wanted to ease their anxiety. Mom, check your Facebook page," the e-mail read. Ms. Stewart followed the directions. There, she found a three-minute video featuring various friends and family from all over the world wishing her a happy 63rd birthday and swift return. Everyone who watched was overcome with emotion. At a time of extreme separation, Ms. Stewart had rarely felt so connected. It was honestly the best gift I could have imagined, she said. Global Affairs Canada got them home on Mar. 25.
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Here are some recommendations for what to read, watch and activities to do.
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Coronavirus: What to do if you start showing symptoms of COVID-19 – Newshub
Posted: March 29, 2020 at 8:45 pm
The WHO initially recommended people with COVID-19 avoid taking ibuprofen to relieve symptoms. But it retracted that advice days later, so it seems reasonable to also consider using anti-inflammatory drugs.
You can treat nasal congestion with decongestants and nasal saline. Effective treatments for a sore throat include honey, salt water gargles, and sore throat sprays or gargles.
Cough is a more difficult symptom to control, but you may be able to improve it with honey, steam inhalations and saline nose sprays. Cough suppressants have only minimal benefit in reducing a dry cough.
It's also important to support your immune system, particularly with rest and a healthy diet.
There's some evidence zinc lozenges may shorten the duration of some colds and flus, including COVID-19. But this evidence is conflicting and not of high quality.
Meanwhile, there's no convincing evidence beyond the placebo effect for a range of other common treatments, such a vitamin C and echinacea. But these are unlikely to cause harm.
It's important not to take medicines that haven't been approved for the treatment of colds and flus.
Anecdotal reports and a small case series of patients in China have suggested a role for the antimalarial drug chloroquine in treating COVID-19.
Further clinical trials of this drug are currently underway, but at this stage it's recommended as treatment only in COVID-19 cases complicated by viral or bacterial pneumonia, and under the guidance of medical professionals.
One HIV antiviral combination drug, lopinavir-ritonavir, seemed promising. But it failed to make a significant difference in 199 patients with COVID-19 in China.
So there are no effective curative treatments as yet, but clinical trials of different antiviral agents are continuing.
While lots of information about prevention and treatments for coronavirus is circulating online, a good rule of thumb is if it sounds too good to be true, it probably is.
If you're unsure about anything, look to reliable sources like the Australian government or the WHO, or consult a doctor.
Follow this link:
Coronavirus: What to do if you start showing symptoms of COVID-19 - Newshub
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There’s no need to panic and make drastic changes to your diet – The Home of Swimming | Swimming.org
Posted: March 29, 2020 at 8:44 pm
March 29, 2020
Swim England Performance nutritionist Jasmine Campbell has advised athletes not to panic or make drastic changes to their diet due to a reduced amount of training.
In the first of a series of videos, Jasmine says there is no need to cut down on the amount of food you eat simply because youre unable to train as regularly due to pools being closed.
She said: I want to talk to athletes about supporting their nutritional needs during this unprecedented time.
The first and probably most important thing to do is not to panic. You might not be doing as much training as normal but this does not mean that you should be reducing what youre eating by a lot especially if you are not an adult and youre still growing.
Jasmine also stresses the importance of protein in your diet as well as keeping your meals colourful.
Increase the amount of vegetables on your plate, she said. Support your muscles by consuming regular feeds of protein. It hopes some people feel more full than a snack or a meal.
Its still okay for you to eat snacks but do think about what would be better choices foods like yoghurts fresh fruit or nuts are a good idea
Recover with foods and fluids. Eat soon after your home training sessions and make sure you include some carbohydrates.
And make sure you have a routine that fits in with your nutrition.
Jasmine will be sending regular updates, including recipe videos giving you the perfect chance to expand your kitchen skills.
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Bill Turnbull reveals healthy diet and meditation are helping him battle cancer amid mood swings from hormone – The Sun
Posted: March 29, 2020 at 8:44 pm
BILL Turnbull has revealed how his new diet has made him feel more healthy as he battles cancer.
The news presenter was diagnosed with incurable prostate cancer in 2017, and also said hormone treatment has left him experiencing mood swings.
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Bill, 64, explained: "Most of the time, I am absolutely fine, I get hot flushes, they pass. But occasionally, I can feel my mood THREAT doorstep dipping.
"Now when we go down into a dip and I howl like a baby - well, like a grown man, which is much worse - I understand it is chemically induced and it will pass the next day. And it always does.
"At the moment, we are holding steady. I'm on a treatment called Radium 223. It was working very well for five months, now it is working sort of OK."
The telly favourite says lifestyle changes such as removing meat and dairy from his diet and taking up yoga and meditation have left him feeling healthier.
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And putting his career skills to good use, he conducted some research on plant-based diets.
The journalist told The Mirror: "I did a lot of research and it comes up time and time again that a wholefood, plant-based diet is good for you. It gets overwhelming, but it is great to be part of that cancer family.
"You get a lot of support from other people."
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FEELING BROODYStacey hints she could get pregnant again soon as she lusts over Joe Swash
baby can i hold youRonan Keating reveals wife Storm has given birth to their second child
'HELLO, LEGS OPEN!'Michelle Keegan almost flashes fans in Instagram chat with Olly Murs
NOT OUR GIRLDani Dyer cried during audition for Our Girl before Michelle Keegan won role
family completeJames and Ola Jordan finally share their baby daughter's name with fans
'where's storm?'Jac and Dan Osborne confuse fans with 'new puppies' in sweet family photo
Just last month, Bill temporarily returned to presenting duties as he reunited with Susanna Reid six years after they fronted BBC breakfast together.
However, the show, which took place on a Wednesday descended into chaos when he lost his earpiece in the ad break and Susanna mocked her co-presenter as she joked: "You know that they call Wednesday hump day. Bill is really having one of those Wednesdays."
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Easy recipes to boost your mood during coronavirus lockdown – The Sun
Posted: March 29, 2020 at 8:44 pm
A HEALTHY diet is about far more than losing weight, and as coronavirus forces millions of people to lock themselves away from the world, it could prove invaluable for our mental health too.
While good nutrition has long been linked to a healthier mindset, experts have now revealed the simple act of cooking can make us happier too - offering a much-needed distraction and group activity inside.
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"Cooking can benefit our mental health because it is a mindful activity - right the way from meal prep to making the actual dish," says Dr Elena Touroni, a consultant psychologist and co-founder of The Chelsea Psychology Clinic.
"Provided were not on autopilot, when were cooking were free from distraction and fully engaged in what were doing."
Dr Clare Bailey, wife of TV favourite Dr Michael Mosleys, tells Sun Online that a healthy diet can dramatically reduce stress levels and even help with sleeplessness.
"The link lies in our gut. Eighty per cent of our serotonin - our happy hormone - is produced in the gut, so the healthier the gut the more emotionally resilient we are," she explains.
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Essentially she says the more relaxed and happy you're feeling, the more likely you are to enjoy a deep sleep - and in turn improve your bodys ability to fight infection.
Mental health charities have reported a surge in calls to their helplines and many people are feeling panicked by the financial insecurity, loneliness and uncertainty brought on by coronavirus and lockdown.
That's why The Sun's You're Not Alone campaign has launched a series to raise awareness of the pandemic's effect on mental wellbeing.
"Baking is a great activity to keep the kids busy and put smiles on their faces - and it's good therapy for stressed-out grown-ups, too," says baker Sarah Rainey.
Here, chefs share their recipes and tips for cheap and easy meals - from one pot wonders to three-ingredient cakes:
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(Serves 8-10)
YOU NEED
METHOD:
Preheat the oven to 200C (fan 180C) and grease and line a standard 2lb loaf tin with a little butter and greaseproof paper.
Sift the flour into a mixing bowl, and add the sugar followed by the beer. Pour the beer in gradually so it doesnt froth too much.
Mix everything together using a wooden spoon and transfer the dough to the tin.
Dust the top with a little flour before putting it in the oven. Bake the loaf for 45-50 minutes. Youll know its done when the crust on top turns golden (and you can stick a skewer down the centre of the loaf to check the inside is cooked through).
Turn it out onto a wire rack to cool.
If you cant get your hands on a dark beer, pale ale will do just fine or you could even use a can of low-sugar lemonade for a slightly sweet-slightly salted loaf that goes well with cheese.
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(Serves 2)
YOU NEED:
METHOD:
Heat the olive oil in a large frying pan over a low-medium heat. Once warm, add the garlic, fry until starting to turn golden, then add the spices and cook for a further 30 seconds.
Tip in the plum tomatoes, Worcestershire sauce, sugar, vinegar and cannellini beans. Season, bring to the boil, then simmer on a medium-high heat for 1520 minutes until slightly thickened.
Toast your bread and serve piled high with the beans, topped with a fried egg, if you like.
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(Makes 1 portion - 4 lettuce tacos)
YOU NEED:
METHOD:
Coat the chicken thigh in a mixture of paprika, a pinch of salt and pepper and a drizzle of olive oil.
Pan-fry the chicken over a low-medium heat, skin-side down first, for 1012 minutes on each side until cooked through and caramelised on the outside.
Remove from the heat and set the chicken to one side.
Add the couscous to the pan (off the heat), along with the water, and stir for a few seconds to incorporate all the pan juices, then leave the couscous to rest for a few minutes and plump up.
Slice the chicken into thin strips, then assemble your tacos by spooning some of the peri peri-infused couscous onto each lettuce leaf, placing some chicken strips on top, then drizzling with the yogurt and sprinkling over some cracked black pepper.
Super Easy One Pound Meals by Miguel Barclays (8.95, Headline).
Nutritional tips for a good gut
There's no set rule when it comes to choosing what you eat each day, but Dr Bailey has shared a few simple diet tips to boost gut health and your ability to cope with stress:
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(Serves 2)
YOU NEED:
METHOD:
Preheat your oven to 180C/gas mark 6.
On a large baking tray, toss together the squash, chilli flakes, fennel and cumin seeds, cinnamon, garlic and oil, then season and roast for 20 minutes, or until the squash is starting to turn golden and soft but still holding its shape.
Toss the chickpeas through and roast in the oven for a further 10 minutes.
Meanwhile, boil the pasta in salted water according to pack instructions or until tender, reserve a mug of the cooking water, then drain.
Using a potato masher, roughly crush about half the butternut squash and chickpea mixture. Add the pasta, yogurt, parsley and enough of the reserved cooking water to the tray to coat the pasta in the sauce. Adjust the seasoning, top with the breadcrumb mixture and serve.
Take One Tin by Lola Milne (Kyle Books, 14.99). Photography by Lizzie Mayson.
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(Serves 4-6)
Preparation time: 15 minutes
Cooking time: (Pre-cook 10 minutes) Auto-low 8 hours, or high 4 hours
YOU NEED:
METHOD:
Preheat the slow cooker, if required.
Heat the oil in a large heavy-based pan over a medium heat, add the onion, and cook for 34 minutes until soft.
Season with salt and pepper, then stir through the garlic and celery and cook for a further 5 minutes or until the celery is soft.
Stir in the carrots, tarragon, and rosemary and cook for a minute before transferring everything to the slow cooker. Stir in the pured tomatoes and stock and cook on auto/low for 8 hours or on high for 4 hours.
Add the potatoes for the last 15 minutes of cooking.
When the potatoes are soft, add the beans and cook for 10 minutes, or until they are cooked but retain a bite.
Taste and season, remove the rosemary, and ladle into warmed large shallow bowls. Sprinkle over the Parmesan, if using, and serve with some crusty French bread.
The Slow Cook Book by Heather Whinney (DK, 16.99)
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(Makes 4)
YOU NEED:
METHOD:
Preheat the oven to 190C/Fan 170C. Grease 4 small ramekins with butter or flavourless oil.
Mix one tablespoon of icing sugar into the chocolate spread. Separate the eggs and whisk the yolks into the chocolate mixture. In another bowl, whisk the whites until they form stiff peaks. Slowly fold the whites into the chocolate mixture, a little at a time, taking care not to beat out the air.
Divide between the ramekins, filling each 2/3 full. Wipe excess batter off the rims so they rise. Bake on a tray in the centre of the oven, for 15-18 minutes until fluffy and risen. Dust the remaining icing sugar over the top and serve immediately topped, if you like, with ice cream or whipped cream.
Six Minute Showstoppers by Sarah Rainey is out on May 14th. Her first book, Three Ingredient Baking, (Michael Joseph, 12.99) is available now.
You're Not Alone
EVERY 90 minutes in the UK a life is lost to suicide.
It doesn't discriminate, touching the lives of people in every corner of society - from the homeless and unemployed to builders and doctors, reality stars and footballers.
It's the biggest killer of people under the age of 35, more deadly than cancer and car crashes.
And men are three times more likely to take their own life than women.
Yet it's rarely spoken of, a taboo that threatens to continue its deadly rampage unless we all stop and take notice, now.
That is whyThe Sun launched the You're Not Alone campaign.
The aim is that by sharing practical advice, raising awareness and breaking down the barriers people face when talking about their mental health, we can all do our bit to help save lives.
Let's all vow to ask for help when we need it, and listen out for others...You're Not Alone.
If you, or anyone you know, needs help dealing with mental health problems, the following organisations provide support:
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(Serves 10)
Preparation time: 25 minutes
Bakine time: 25 minutes
YOU NEED:
METHOD:
Heat the oven to 200C/180C fan/400F/Gas 6.
Blitz the biscuits in a food processor to fine crumbs. Remove 2 tablespoons of the crumbs and set aside. Add the melted butter to the crumbs in the food processor and blitz for a few seconds more until combined.
Transfer the buttery biscuit mixture to the prepared tin and use the back of a spoon to press it down firmly and evenly all the way to the edges of the tin to give an even base.
Place the egg yolks in a medium bowl. Using a balloon whisk, whisk in the condensed milk until fully incorporated. Then, slowly whisk in the lemon juice until combined. Pour the mixture on top of the biscuit base.
Place the egg whites in a clean, grease-free bowl and whisk with an electric hand whisk to stiff peaks.
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Esperion Announces Three Data Presentations of the NEXLETOL (bempedoic acid) Tablet and the NEXLIZET (bempedoic acid and ezetimibe) Tablet at the…
Posted: March 29, 2020 at 2:47 am
ANN ARBOR, Mich., March 28, 2020 (GLOBE NEWSWIRE) -- Esperion (NASDAQ:ESPR) today announced that two pooled analyses from four Phase 3 clinical trials of NEXLETOL and results from the Phase 2 (1002-058) study of NEXLIZET were presented at the American College of Cardiologys 69th Scientific Session Together with World Congress of Cardiology (ACC.20/WCC).
A poster titled Bempedoic Acid 180 mg + Ezetimibe 10 mg Fixed Combination Drug Product vs Ezetimibe Alone or Placebo in Patients with Type 2 Diabetes and Hypercholesterolemia was presented by Harold E Bays, MD, FOMA, FTOS, FACC, FACE, FNLA. The poster highlighted that in the Phase 2 (1002-058) study, NEXLIZET significantly lowered LDL-Cholesterol (LDL-C) by a mean 40% compared to placebo, reduced high-sensitivity C-reactive protein (hsCRP) by 25% compared to baseline and resulted in no worsening of glycemic control. The incidence of adverse events rates were generally comparable to placebo.
In addition, a poster, titled Factors Influencing Bempedoic AcidMediated Reductions in High-sensitivity C-reactive Protein: Analysis of Pooled Patient-level Data from 4 Phase 3 Clinical Trials was presented by Eric S. G. Stroes, MD, PhD. The poster highlighted that in the pooled Phase 3 studies, NEXLETOL significantly lowered hsCRP in patients with hypercholesterolemia regardless of the presence or intensity of background statin therapy. In patients whose hsCRP levels were >2 mg/L at baseline, the analysis showed NEXLETOL significantly reduced this marker of inflammation by 42% at 12 weeks.
The third poster, titled Bempedoic Acid Efficacy and Safety in Patients at High Risk for CVD Treated with or Without Ezetimibe: Pooled Analysis of 4 Phase 3 Clinical Trials was presented by Maciej Banach, MD, PhD, FAHA, FESC. The pooled analysis showed that in the Phase 3 studies, NEXLETOL provided significant additional LDL-C lowering as well as significantly lowered other lipid (total cholesterol, non-HDL-C Apo B, HDL-C) endpoints, regardless of the presence of background ezetimibe. Importantly, the safety profile of NEXLETOL was similar with or without background ezetimibe therapy.
We are pleased with the final results of the Phase 2 study that highlight NEXLIZET achieved an impressive 40 percent LDL-C lowering, a significant 25 percent reduction in hsCRP and did not worsen glycemic control in patients with Type 2 diabetes. The additional pooled analyses from the Phase 3 LDL-C lowering development program demonstrate NEXLETOL can be safely added to multiple LDL-C medicines, which is important to help more patients reach their LDL-C goals, said Tim Mayleben, president and chief executive officer of Esperion. These additional analyses further affirm the efficacy and safety of our medicines for the millions of patients needing to lower their bad cholesterol.
NEXLETOLTM(bempedoic acid) Tablet
NEXLETOL is a first-in-class ATP Citrate Lyase (ACL) inhibitor that lowers LDL-C by reducing cholesterol biosynthesis and up-regulating LDL receptors. Phase 3 studies detailed in the label were conducted in more than 3,000 patients, with over 2,000 patients treated with NEXLETOL, demonstrated an average 18 percent placebo corrected LDL-C lowering when used in patients on moderate or high-intensity statins. NEXLETOL was approved by the FDA in February 2020.
Indication and Limitation of Use
NEXLETOL is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C. The effect of NEXLETOL on cardiovascular morbidity and mortality has not been determined.
Important Safety Information
Warnings and Precautions:
Adverse Reactions:
Drug Interactions:
Use in Specific Populations
Patients or their physicians are encouraged to report negative side effects of prescription drugs to the FDA. Visitwww.fda.gov/medwatchor call 1-800-FDA-1088 or report side effects to Esperion at 833-377-7633 (833 ESPRMED).
Click here to see thefull prescribing informationfor NEXLETOLTM(bempedoic acid) tablet.
NEXLIZETTM(bempedoic acid and ezetimibe) Tablet
NEXLIZET contains bempedoic acid and ezetimibe and lowers elevated LDL-C through complementary mechanisms of action by inhibiting cholesterol synthesis in the liver and absorption in the intestine. Phase 3 data demonstrated NEXLIZET lowered LDL-C by a mean of 38 percent compared to placebo when added on to maximally tolerated statins. NEXLIZET was approved by the FDA in February 2020.
Indication and Limitation of UseNEXLIZET is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C. The effect of NEXLIZET on cardiovascular morbidity and mortality has not been determined.
Important Safety Information
Contraindications:
Warnings and Precautions:
Adverse Reactions:
Drug Interactions:
Use in Specific Populations
Click here to see thefull prescribing information for NEXLIZET (bempedoic acid and ezetimibe) tablet. Patients or their physicians are encouraged to report negative side effects of prescription drugs to the FDA. Visitwww.fda.gov/medwatchor call 1-800-FDA-1088 or report side effects to Esperion at 833-377-7633 (833 ESPRMED).
CLEARCardiovascularOutcomes Trial
The effect of NEXLETOL on cardiovascular morbidity and mortality has not been determined. Esperion initiated a global cardiovascular outcomes trial (CVOT) to assess the effects of bempedoic acid on the occurrence of major cardiovascular events in patients with, or at high risk for, cardiovascular disease (CVD) who are only able to tolerate less than the lowest approved daily starting dose of a statin and are considered "statin averse." The CVOT known as CLEAR Cardiovascular Outcomes Trial is an event-driven, global, randomized, double-blind, placebo-controlled study that completed enrollment in August 2019 of 14,032 patients with hypercholesterolemia and high CVD risk at over 1,400 sites in 32 countries.
Esperion Therapeutics
Through scientific and clinical excellence, and a deep understanding of cholesterol biology, the experienced Lipid Management Team at Esperion is committed to developing new LDL-C lowering medicines that will make a substantial impact on reducing global cardiovascular disease, the leading cause of death around the world. For more information, please visitwww.esperion.comand follow us on Twitter atwww.twitter.com/EsperionInc.
Esperion Therapeutics Commitment to Patients with Hyperlipidemia
High levels of LDL-C can lead to a build-up of fat and cholesterol in and on artery walls (known as atherosclerosis), potentially leading to cardiovascular events, including heart attack and stroke. In the U.S., 96 million people, or more than 37 percent of the adult population, have elevated LDL-C. There are approximately 18 million people in the U.S. living with elevated levels of LDL-C despite taking maximally tolerated lipid-modifying therapy including individuals considered statin averse leaving them at high risk for cardiovascular events1. In the United States, more than 50 percent of atherosclerotic cardiovascular disease (ASCVD) patients and heterozygous familial hypercholesterolemia (HeFH) patients who are not able to reach their guideline recommended LDL-C levels with statins alone need less than a 40 percent reduction to reach their LDL-C threshold goal2.
Esperion's mission as the Lipid Management Company is to deliver oral, once-daily medicines that complement existing oral drugs to provide the additional LDL-C lowering that these patients need.
Forward-Looking Statements
This press release contains forward-looking statements that are made pursuant to the safe harbor provisions of the federal securities laws, including statements regarding the regulatory approval pathway for bempedoic acid tablet and the bempedoic acid / ezetimibe fixed dose combination tablet, the therapeutic potential of, and the clinical development plan for bempedoic acid tablet and the bempedoic acid / ezetimibe fixed dose combination tablet, including Esperion's timing, designs, plans for announcement of results regarding its CLEAR Outcomes study and other ongoing clinical studies for bempedoic acid tablet and the bempedoic acid / ezetimibe combination fixed dose tablet, timing for the review and approval of the NDAs and the MAAs, and Esperion's expectations for the market for medicines to lower LDL-C, including the commercial launch and market adoption of bempedoic acid tablet and the bempedoic acid / ezetimibe fixed dose combination tablet, if approved. Any express or implied statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. Forward-looking statements involve risks and uncertainties that could cause Esperion's actual results to differ significantly from those projected, including, without limitation, delays or failures in Esperions studies, that positive results from a clinical study of bempedoic acid may not be sufficient for EMA approval or necessarily be predictive of the results of future or ongoing clinical studies, that notwithstanding the completion of Esperions Phase 3 clinical development program for LDL-C lowering, the FDA or EMA require additional development in connection with seeking regulatory approval, or approval of an expanded indication, that existing cash resources may be used more quickly than anticipated, and the risks detailed in Esperion's filings with the Securities and Exchange Commission. Esperion disclaims any obligation or undertaking to update or revise any forward-looking statements contained in this press release, other than to the extent required by law.
References(1)Esperion market research on file: research project interviewing 350 physicians. Esperion Therapeutics, Inc. Sept-Oct 2018.(2)Data on file: analysis of NHANES database. Esperion Therapeutics, Inc. 2018.
Investor Contact:Alex SchwartzEsperion734-249-3386aschwartz@esperion.com
Media Contact:Ben ChurchEsperion734-864-6774bchurch@esperion.com
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The Global Chef: Diet and the fight against disease in West Africa – Traverse City Record Eagle
Posted: March 29, 2020 at 2:46 am
In the years 2014 through 2016 West Africa witnessed the largest Ebola virus outbreak since the virus was first discovered in 1976. The outbreak began in a rural Guinea village with a small boy and then his family. In weeks, Ebola travelled from the village across land borders to Sierra Leone and Liberia and spread to urban areas.
Within months Ebola became a global pandemic. In those two years, more than 11,000 people died in West Africa alone. (EVD kills 50 percent to 90 percent.) Ebola is still not fully eradicated.
West Africans have had to deal long and painfully with this virulent disease. To combat Ebola, or any disease, requires the dedicated work of doctors, nurses, scientists, government and life-saving medications together with our work of strengthening our immune systems.
That always includes diet. It may be the difference between surviving and dying.
Fumiaki Imamura and his research team from the University of Cambridge conducted a study analyzing West African diets for foods such as fruit, vegetables, legumes, whole grains, and fish, as well as foods containing fiber and omega-3s. The study used self-reported diet surveys from 187 countries, home to 89% of the worlds adult population. They also looked at the intake of unhealthy foods like sugary drinks, saturated fats and processed meats. (Researchers did not look at quantity of food 24 percent of West Africans are starving.)
According to the study, published in 2015 The Lancet Global Health, Taken all together, Sub-Saharan Africa, particularly West Africa, ranked better than wealthier regions in North America and Europe, probably because of a diet comprised of lean meats, vegetables, legumes and staple starches, with less processed foods than countries that fared worse (such as the U.S. and Russia). The study concluded that (most) inhabitants of West Africa enjoy healthier diets than counterparts in the United States, the United Kingdom, Japan or Canada.
Looking at just diet quality is not perfect, we know, Imamura said. For better public health, we should all look at social and environmental factors.
The studys shocking conclusion is that our eating habits are getting worse. Worldwide consumption of healthy foods has increased, but in wealthy countries that is outstripped by the growing consumption of unhealthy foods.
Fear of African food has led many people to avoid it. Africa is abundant with native foods, but very few are known, perhaps because of a perception that they are somehow inferior.
According to the National Academy of Sciences, Africa has more indigenous grains (millet, amaranth, groundnuts and rice) and native food plants (more than 2,000) than any other continent. Other indigenous foods include desert dates, butterfruit, kei apple, custard apples, guinea bananas, star apples, spirulina, tamarind, mushrooms, Ethiopian mustard, Hausa potatoes, tiger nuts, African bitter eggplant, spinach-like leaves of rosella plant, varieties of yams and legumes, and many herbs and spices.
In the online journal Nature, author Rachel Cernansky writes that Raymond Vodouhe, a plant breeder and geneticist with Bioversity International in Cotonou, Benin, and his team have focused work in West Africa on domesticating wild vegetables. Hardy wild plants help African families get through periods of drought or crop failure. Wild plants are threatened by deforestation and land-clearing. Researchers are domesticating wild vegetables so farmers have reliable access to indigenous vegetables and can better endure lean times.
Watermelon, coffee, black-eyed peas, kidney beans, sesame and okra migrated with slaves to the Caribbean, Europe and the New World. Along with abundant seafood (West Africa sits on the Atlantic Ocean), many legumes, whole grains, roots, tubers and greens this is a cuisine worth exploring.
Cookbook author and culinary historian Jessica B. Harris thinks that chicken yassa is an important key that opens the door for some people to African food. With simple ingredients, it is non-threatening. Its brilliant flavor comes from first being marinated, then grilled, and finally, stewed. Harris notes that all three techniques contribute to this strange and wondrous dish. Some recipes call for olives, carrots, and Dijon mustard to be simmered with the chicken.
Yields about 10 cups, 6 to 8 servings
6 lbs. bone-in chicken breasts, legs and thighs
1-1/4 to 1-1/3 C. fresh lime juice
5 T. olive or peanut oil, divided
2 chicken bouillon cubes, mashed (Maggi is good)
8 to 9 C. halved and sliced 1/4-inch thick onions
1 Scotch Bonnet chili
Cooked rice
Remove skin and excess fat from chicken parts and discard to yield 5-1/4 to 5-1/2 pounds chicken.
Zest 3 limes. Pour lime juice and zest into large mixing bowl. Stir in 2 tablespoons oil and bouillon cubes until dissolved. Transfer onions and chicken to bowl and rub mixture into chicken parts. Cover bowl and marinate 1 hour at room temperature or 2 hours refrigerated. Turn chicken halfway during marination. Remove chicken and drain excess marinade back into bowl.
Place chicken onto parchment-covered sheet pan or in mixing bowl and season with salt. Set a strainer over another bowl and pour marinade through. (Allow onions to drain while chicken cooks.) Reserve both onions and marinade separately.
Preheat broiler or grill over high heat. Working in batches, grill or broil chicken pieces, turning once, until browned but not cooked through. Set chicken aside in a bowl.
Heat remaining 3 tablespoons oil in a heavy 8-quart pot over medium heat. Add reserved drained onions, cover, and cook until soft and browned, 25 to 30 minutes. Sugars from the lime juice will caramelize on the bottom of the pan; stir onions and scrape bottom of pan occasionally. Pour marinade and the chili into onions. Transfer grilled chicken and any collected juices to pot, and tuck chicken into onions. Bring to a boil, lower heat, and simmer, partially covered, until chicken is cooked through, 30 to 45 minutes. Turn chicken once or twice so it cooks evenly.
To Serve: With tongs, transfer chicken to a platter. Taste sauce and season with salt if necessary. Pour or spoon onion sauce over top of chicken. Serve with rice.
Adapted from Yolele! Recipes from the Heart of Senegal by Pierre Thiam.
Black-eyed peas dont need long soaking and cooking so theyre ideal for meals in the heat of Africa or summer.
Yields 8 cups, 6 to 8 servings
2 C. dry black-eyed peas
1 to 1-1/3 C. peeled and 1/4-inch cubed tomato
1-1/4 C. peeled, seeded and 1/4-inch cubed cucumber
1 C. cored, seeded and 1/4-inch cubed red or green bell pepper
2/3 to 1 C. trimmed and finely sliced green onions
1 C. coarsely chopped Italian parsley
1 Scotch Bonnet or Serrano chili, stemmed, seeded and diced, to taste
1/2 C. olive or peanut oil
1/3 C. fresh lime juice, to taste
Rinse black-eyed peas, and soak in cold water 1 hour. Drain. Pour peas into 4-quart saucepan with 1 quart cold water. Bring to a boil over high heat. Lower heat to a simmer and cover. Simmer until peas are tender but not splitting, about 30 minutes. Strain peas, season with salt, and set aside.
In a large mixing bowl, toss together tomato, cucumber, bell pepper, green onions, parsley, and chili. Fold in oil, lime juice, salt, and freshly ground black pepper to taste. Fold in cooked black-eyed peas. Cover salad and allow flavors to develop 1 hour. Taste and season with more lime juice, salt, or pepper.
To Serve: Pile salad into serving vessel and serve chilled or at room temperature.
Adapted from Yolele! Recipes From the Heart of Senegal by Pierre Thiam.
This salad brings to mind a French Salade Nicoise, the classic composed salad. Senegalese cooks often stuff prawn or shrimp salads into avocado halves and serve as appetizers.
Adapted from Discovering Global Cuisines by Nancy Krcek Allen
Yields 4 servings
1 C. black-eyed peas
1/4 C. peeled and finely diced onion
3 T. oil, divided
6 T. fresh lime juice
2 large eggs
1 medium red bell pepper or 2 ounces sliced canned pimento
16 large peeled and de-veined shrimp
4 C./4 ounces clean, torn lettuce or baby greens
5 oz. plum tomatoes
Garnish: Italian parsley leaves
Soak black-eyed peas 1 hour in cold water. Drain peas, pour into 2-quart saucepan, and cover with water. Bring to a boil, lower heat, and simmer peas until tender, about 30 minutes. Cool peas and drain to yield about 2-1/2 cups cooked peas.
Measure 2 cups drained peas and set the extra 1/2 cup aside for another use. Toss 2 cups drained peas with onion, 2 tablespoons oil, and 2 tablespoons fresh lime juice. Season with salt and pepper; set dressed peas aside.
Place eggs into 2-quart saucepan and cover with cold water. Bring to a boil, cover pan and remove pan from heat. Time eggs 12 minutes. Remove eggs from hot water, crack the ends, and place in bowl of cold water 10 minutes. Peel eggs and quarter lengthwise into 8 wedges. Set aside.
Roast bell pepper over flame or under broiler until evenly blackened. Set aside in bowl, covered, until cooled. Peel pepper and discard stem, skin, membranes, and all seeds. Slice into thin julienne to yield about 1/2 cup, and set aside.
Steam shrimp or prawns until just cooked through and opaque, 3 to 5 minutes. Remove from steamer and cool. Refrigerate until needed.
Dice peeled avocado halves into 3/8- to 1/2-inch cubes and toss with 4 tablespoons lime juice and 1 tablespoon oil. Season with salt and pepper. Set aside.
Line up 4 large salad plates or shallow bowls. Lay a fourth of the lettuce on each plate. On each plate: Pile 1/2-cup black-eyed peas in the center. Spoon a fourth of avocado mixture over peas and greens. Slice plum tomato into twelve 1/4-inch thick rounds. Arrange 3 slices of tomato, 2 quarters hard-cooked egg and 4 prawns around the sides. Arrange sliced bell peppers (there will be some left over) or pimento slices across the top of the salad.
To Serve: Garnish salad with parsley leaves. Serve with salt and pepper grinder on table. Advise diners to toss salad before eating.
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The Global Chef: Diet and the fight against disease in West Africa - Traverse City Record Eagle
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Suffering from thinning hair? Your diet could be the reason why – Telegraph.co.uk
Posted: March 29, 2020 at 2:46 am
Lets talk about hair loss. Yes, I know its not the sexiest beauty topic, but its nonetheless something many of us will have to deal with. It can be genetic, of course, which is classed as female pattern hair loss and is caused by an increase in male hormones in the body. Stress has an impact, too (it raises the testosterone levels in women), but what experts are increasingly seeing is diet-related hair loss.
Leading trichologist Anabel Kingsley has noted a rise in cases where women have lost hair after following a fad diet. Your hair is an essential tissue, she explains. If you dont have enough calories, carbohydrates or fats in your diet, your hair is the first thing to suffer. Your hair cells are the second-fastest dividing cells in your body and they need energy from carbohydrates to regenerate.
A lack of protein can also cause brittle hair, Kingsley tells me, but her biggest no-no? Juice fasting is awful for your hair. You can guarantee six to 12 weeks after a juice cleanse youll experience hair loss. Kingsley also suggests doing your homework before trying veganism, because it can have a detrimental effect on the hair. Always take a vitamin B12 supplement (its not found in plants), get plenty of iron from leafy greens and eat quinoa and chia seeds, which have complete proteins.
Everyone, vegan or not, should take a vitamin D capsule supplement to promote hair growth, too, says Kingsley. Every hair follicle has a vitamin D receptor, which influences the hair-growth cycle. Low vitamin D is linked to alopecia, so taking a supplement is an easy win to help with hair loss.
Thinning hair is trickier to style, too. In a recent survey of 2,000 women, Tresemm found that over half of us regularly have a bad hair day, whether its a lack of volume or hard-to-style cuts. I can relate. I met with the celebrity hairstylist Jenny Cho recently (she counts Scarlett Johansson and Charlize Theron among her regulars) and she shared her tips for managing thinning hair on a daily basis.
Dont brush your hair when its wet and tangled from the roots down, she advises. Start from the ends with a detangling brush and gently work your way up to the roots to prevent any breakage. Jenny also suggests using old-school mousse, such as Thickening Mousse by Bumble and bumble, to get more volume. (Before you say anything, mousse has come a long way from its crunchy 80s roots.) Use with abandon, ditch the juicediets and get some vitamin D.
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Suffering from thinning hair? Your diet could be the reason why - Telegraph.co.uk
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