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Posted: June 9, 2012 at 11:11 pm
* Better glucose control than Januvia or glimepiride
* Significant weight loss seen with J&J's canagliflozin
* Far less hypoglycemia than glimepiride with canagliflozin
* Canagliflozin has been submitted to FDA for approval decision
June 9 (Reuters) - An experimental treatment for type 2 diabetes developed by Johnson & Johnson (TLO: JNJ-U.TI - news) demonstrated greater reduction in blood sugar than Merck (Xetra: A0YD8Q - news) & Co's Januvia and an older common treatment, glimepiride, according to data from a pair of late stage clinical trials.
The J&J drug, canagliflozin, also led to significantly greater weight loss than both of the other drugs and far fewer incidents of hypoglycemia, or potentially dangerous drops in blood sugar levels, than glimepiride, a member of the sulfonylurea class of medicines.
Weight loss is an especially attractive effect as obesity is a leading cause of type 2 diabetes and some older medicines cause weight gain.
Canagliflozin, belongs to a new class of diabetes treatments called SGLT2 inhibitors that work by blocking reabsorption of glucose by the kidney and increases glucose excretion in the urine to lower blood sugar.
The data from the two 52-week studies, presented on Saturday at the American Diabetes Association (ADA (Paris: FR0000053076 - news) ) meeting in Philadelphia, are part of a massive approval application J&J submitted to the U.S. Food and Drug Administration last week that comprised nine separate Phase III trials involving more than 10,000 patients. If approved it would be the giant healthcare conglomerate's first diabetes medicine.
"There are clearly some unmet needs in diabetes to get glucose control. Hypoglycemia is a big limitation and right now we don't have effective weight loss therapy, so this class of drugs clearly provides clinical benefits," said Dr. William Cefalu, the primary researcher on the glimepiride study.
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J&J diabetes drug tops older therapies in studies
Posted: June 9, 2012 at 11:11 pm
Maria Sharapova Weight Loss 2012 Maria Sharapova Diet Programs - Isn't amazing how all of the celebrities you see have a celebrity diet plan for weight loss to maintain their weight. Some of them are shapely and healthy looking, and look good on camera. Others look like they haven't eaten in weeks, like they just got back from the famine in Ethiopia for a few weeks. Like they had been starving themselves to lose weight, and that is probably what they have been doing. You see it in all the tabloids, this person lost 100 pounds again, this one gained 100 pounds, and then lost 150 pounds. Some are not as dramatic; this one lost 40 pounds and is a television spokesperson, because the previous celebrity diet spokesperson gained the weight back. The fact is they may be starving themselves to lose weight, fasting like they are going through a famine.
Celebrities make dieting look so easy, don't they? One month they're on the cover of US Weekly for gaining too much weight and the next they're headlining the "sexiest beach bods" story. It is true that seriously overweight people can lose large amounts of fat in a quick amount of time, because of the large fat content in their cells. But those that are only a few pounds overweight, losing 40 pounds in a month, is not only starvation, it is malnutrition and can have serious side effects. Our body weight can fluctuate day to day and the best diets take the weight off gradually, the way it came on.
Researches indicate that individuals who indulge in a weight loss program by taking prepared meals end up losing an additional 31% weight as against those who cook their own meals. With help, losing weight is made easier and at times much faster as against doing it on your own.Diet delivery is gaining popularity in a big way as it is fairly affordable by even the common man, roughly around $20 a day with an increasing variety to choose from. A few of which include: Zone-compliant meal, low carbs plan, veggie meals, and gourmet too.
"Click Here to Watch Weird VIDEO About The 5 Foods that KILL Abdominal Fat!"
With the rapidly increasing epidemic of obesity and increasing BMI levels, there is an array of products and diet plan to aid in combating obesity. Celebrity slim diet, the basic idea is to educate people and not to depict food as an enemy. Like a lot of famous diets in Hollywood, if your body thinks you are starving, it is going to hold on to every calorie you take in to keep you from starving to death instead of burning them for energy. When you follow a properly balanced weight loss diet, your metabolism will hardly notice the decrease in calories and continue to burn fat it doesn't need to store. This is a more long-term weight loss strategy.
Celebrities do not have secrets about dieting. They are normal people like the rest of us but, unlike most of us, they have people working for them such as diet advisors and personal trainers. Celebrity diets involve a level of commitment and dedication which we struggle with. The best celebrity diets involve eating sensibly and limiting our calorie intake. Having these factors in mind will allow you to have safe and easy weight loss that will provide you with short term and long term consistent results.
Original post:
Maria Sharapova Weight Loss 2012 Maria Sharapova Diet Programs
Posted: June 9, 2012 at 11:11 pm
Danny Welbeck Weight Loss 2012 Danny Welbeck Diet Programs - Isn't amazing how all of the celebrities you see have a celebrity diet plan for weight loss to maintain their weight. Some of them are shapely and healthy looking, and look good on camera. Others look like they haven't eaten in weeks, like they just got back from the famine in Ethiopia for a few weeks. Like they had been starving themselves to lose weight, and that is probably what they have been doing. You see it in all the tabloids, this person lost 100 pounds again, this one gained 100 pounds, and then lost 150 pounds. Some are not as dramatic; this one lost 40 pounds and is a television spokesperson, because the previous celebrity diet spokesperson gained the weight back. The fact is they may be starving themselves to lose weight, fasting like they are going through a famine.
Celebrities make dieting look so easy, don't they? One month they're on the cover of US Weekly for gaining too much weight and the next they're headlining the "sexiest beach bods" story. It is true that seriously overweight people can lose large amounts of fat in a quick amount of time, because of the large fat content in their cells. But those that are only a few pounds overweight, losing 40 pounds in a month, is not only starvation, it is malnutrition and can have serious side effects. Our body weight can fluctuate day to day and the best diets take the weight off gradually, the way it came on.
Researches indicate that individuals who indulge in a weight loss program by taking prepared meals end up losing an additional 31% weight as against those who cook their own meals. With help, losing weight is made easier and at times much faster as against doing it on your own.Diet delivery is gaining popularity in a big way as it is fairly affordable by even the common man, roughly around $20 a day with an increasing variety to choose from. A few of which include: Zone-compliant meal, low carbs plan, veggie meals, and gourmet too.
"Click Here to Watch Weird VIDEO About The 5 Foods that KILL Abdominal Fat!"
With the rapidly increasing epidemic of obesity and increasing BMI levels, there is an array of products and diet plan to aid in combating obesity. Celebrity slim diet, the basic idea is to educate people and not to depict food as an enemy. Like a lot of famous diets in Hollywood, if your body thinks you are starving, it is going to hold on to every calorie you take in to keep you from starving to death instead of burning them for energy. When you follow a properly balanced weight loss diet, your metabolism will hardly notice the decrease in calories and continue to burn fat it doesn't need to store. This is a more long-term weight loss strategy.
Celebrities do not have secrets about dieting. They are normal people like the rest of us but, unlike most of us, they have people working for them such as diet advisors and personal trainers. Celebrity diets involve a level of commitment and dedication which we struggle with. The best celebrity diets involve eating sensibly and limiting our calorie intake. Having these factors in mind will allow you to have safe and easy weight loss that will provide you with short term and long term consistent results.
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Danny Welbeck Weight Loss 2012 Danny Welbeck Diet Programs
Posted: June 9, 2012 at 11:11 pm
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Posted: June 9, 2012 at 6:13 am
07-06-2012 06:00 - Time-Limited FREE Ebook Revealing The Exact Trick I Learned To Lose 13 Pounds In 30 Days! ... And you can use the same exact technique that I've used to start losing weight and becoming the slim, attractive person you know you can become. Topics covered: - How I was able to lose 13 pounds in 30 days - How to avoid the "false" promises that weight-loss programs try and pitch to you - How to start losing weight today - The exact secrets that weight-loss "experts" fail to tell you How To Lose Weight Fast: Losing 13 Pounds in 30 Days
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How To Lose Weight Fast: Losing 13 Pounds In 30 Days - Video
Posted: June 8, 2012 at 4:10 am
Where other shows feature teams of experts, here the focus is just two people. The trainer, Chris Powell, and his client. Chris Powell vaulted to fame when he helped out David Smith, who at the time was 630 pounds. He lost 401 pounds over 26 months to end up at 229 pounds. After the rounds of media, Chris was soon offered his own TV show to do the same with other morbidly obese people.
As a sad side note, David Smith has since gained 300 of those pounds back. So it was not a permanent weight loss.
So, on to his current projects. In each case Chris sets out a year goal, helps the person get started, and then stays in contact with them while they do the rest on their own.
The episode we watched featured Tony Mims, a 49 year old man who weighed 398 pounds. He was planning to get married and wanted to start his new life with a healthier body.
Tony certainly had a lot to shoulder. He had left his two alcoholic parents at age 14. One of his children has cerebral palsy and passed away during the year of effort. He broke up with his girlfriend, too, which left him homeless. He was unemployed.
I watched this with my boyfriend. We've both seen Biggest Loser for many years as well as numerous other documentaries on weight loss. So we are quite familiar with the style of show.
Our first impression was that Chris was not as comfortable as other hosts with the supportive language. There were several times that we cringed at the way he phrased something. He would say "don't listen to your body" which goes against much of what we believe in. We would say you should always listen to your body - and then objectively evaluate its message.
Also, I was not enthusiastic about the idea that Chris would pummel him for 90 days then abandon him. Chris didn't even know where the guy was half the time. Tony absolutely gets a lot of credit for plowing through the project on his own - but I'm not comfortable with that idea. I think ongoing support is important.
It also felt that the show turned into a soap opera, not about the weight loss, but about traumas and troubles. We got barely a minute about how to eat healthy foods which mostly seemed a promotion for the resort center. There was a glimpse of Chris telling Tony to run on the treadmill. But really that was it.
As an example, Tony's fiance clearly had some weight issues of her own. And Chris knew it was important to include her - but he never did. Instead, she ended up feeling alienated. It wasn't fair to expect Tony to know how to include her - he was in serious trouble himself. He was just keeping his own head out of the water. So Tony's fiance was imperfect of her handling of the stress, certainly - but the end result is that Tony left her and promptly started seeing someone else. Judging by comments at the funeral there wasn't much time between the two. If I was the fiance I'd be pretty disappointed watching this episode, how they are fairly snarky about her and she has no way to respond or present her side.
Posted: June 8, 2012 at 4:10 am
Waist Size Signals Increased Risk of Diabetes
Measuring your waist circumference could help gauge your risk for developing type 2 diabetes. Doctors have long used body mass index, a measurement of body fat based on height and weight, to determine patients' diabetes risk, but adding waist circumference makes those predictions more accurate, according to a study published Tuesday in the journal PLoS Medicine. While BMI doesn't make any distinction between different kinds of fat, waist circumference identifies visceral fat in the abdomen, which has the strongest link to diabetes. It's not affected by fat in the arms, thighs, or any other part of the body. The study authors found that, among women, diabetes risk was more closely associated with waist size than with BMI, HealthDay reports. The findings suggest that, if doctors paid more attention to waist size, they could refer high-risk patients to weight-loss and diabetes-prevention programs.
Safe Weight-Loss Tips for Wedding Season
Over the years, brides-to-be have taken drastic measures to lose weight ahead of the Big Day: drinking a concoction of lemon juice, water, syrup, and cayenne pepper, wiring their mouths shut, and taking a pregnancy hormone while following the 500-calorie hCG diet.
But a feeding tube?
Yes, indeed. News media were abuzz recently with stories of brides resorting to the K-E Diet, in which a feeding tube funnels a slow drip of 800 calories of protein, water, and fatno carbs from the nose, down the esophagus, and into a person's stomach each day for 10 days. The draw: Patients can lose up to 20 pounds, says Oliver Di Pietro, a Florida-based internal medicine physician who charges $1,500 for the plan. One bride, his patient, reportedly had the tube removed after eight days because she had already lost the weight she wanted.
Medical and nutrition professionals immediately responded. "Rapid weight loss increases the risk of heart arrhythmias, dehydration, and electrolyte disturbances," says Ethan Lazarus, a family doctor in Denver who specializes in obesity medicine. Shedding pounds this quickly, he says, makes it likely that you will lose more lean body mass and water than fat. This can slow metabolism and result in an instant regain of weight once you go off the diet. "You may gain more than you lost," says Lazarus. Other effects include shrunken fingers and feet and a drooping facewhich can result in a loose wedding ring, flopping shoes, and a blushing bride with a dull expression, he says. And while the risk of inserting a feeding tube is small, Lazarus notes the possibility of lacerations in the sinuses (the tube goes down through the nose) and the esophagus, and some brides may experience vomiting and nausea. [Read more: Safe Weight-Loss Tips for Wedding Season]
Trouble Trying to Conceive? This May Be Why
Girl meets boy. Girl marries boy. Girl and boy have a baby. For many folks, this is how they envision their life will beor at least some sort of semblance of these milestone eventsbut for a large number of people, this has become an unattainable reality. According to the Centers for Disease Control and Prevention, about 7.3 million women between the ages of 15 and 44 suffer from infertility, which is defined as the inability to get pregnant after six to 12 months of trying. And while a woman's increasing age is the most familiar reason for this conditionmore and more women are waiting to have childrenresearchers are discovering that there are new and once-unconsidered factors at play. And men are not exempt from this pregnancy problem, as one-third of infertility issues stem from the male partner. Here are some of the latest findings and what doctors say you can do in response to them.
1. Move in moderation and watch your weight. We all know that movement does the body good, but recent research suggests that too much of a good thing can be a hindrance. A study published in March in Fertility and Sterility revealed that normal-weight womanthose with a body mass index (BMI) under 25who engaged in vigorous exercise like running, swimming, and aerobics for five or more hours a week were 42 percent less likely to get pregnant than women who did not exercise at all. "Very vigorous exercise can affect ovulation, and thereby disrupt menstrual cycles," says Jessica Scotchie, a reproductive endocrinologist practicing in Chattanooga, Tenn. "The pituitary gland interprets the strenuous exercise as meaning that this is not an optimal time to further stress the body with reproduction, and thus shuts down the signaling to the ovary to promote ovulation." Researchers also add that extreme exercise could affect implantation, a fertilized egg's ability to attach to the inside of the uterus. [Read more: Trouble Trying to Conceive? This May Be Why]
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Health Buzz: Waist Size Predicts Diabetes Risk
Posted: June 8, 2012 at 4:10 am
Jeff Levinson, 23, was in Florida celebrating his graduation from Mizzou last year when, "I felt this discomfort in my chest. It wasn't chest pains, but it made me think, I want to live longer than this."
Levinson stood 6 feet and weighed 350 pounds. He returned from his trip and his mom told him about a weight loss coach she'd heard about from a friend.
The coach, Charles D'Angelo, specializes in fast but healthful weight loss. He recently published a book: "Think and Grow Thin."
D'Angelo said Levinson was attracted to his program "because I started at 360 pounds."
There was some empathy there, Levinson agreed.
"I started gaining at 14 years old," Levinson said. "My parents were going through a divorce, and I took it hard."
He started stress eating, mostly junk food, for eight years pizza, fried foods, chicken fingers, toasted ravioli, fries, onion rings.
"I didn't eat vegetables or fruit," he said. "I couldn't walk up stairs without getting winded." He was 300 pounds when he graduated from high school.
Levinson jumped on the rigid eating plan in August of last year, and the pounds dropped quickly. The plan also included exercise up to an hour a day, he said.
"Now I eat vegetables with every meal," he said. "I love eating that stuff. I'm still getting used to fruit."
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Weight loss coach inspires participant
Posted: June 8, 2012 at 4:10 am
Jun 7, 2012 8:09am
Tony Mims always smiled, but hed had a tough life. The son of alcoholic parents, he left home when he was 14 and worked in the fast-food industry.
Over time, Mims weight ballooned.
Im tired of having limitations of what I have to do, he said. And I sweat like crazy. Id give one of my kidneys to have a smaller body.
Mims was tasting wedding cakes with his fiance when Chris Powell, the trainer on Extreme Makeover: Weight Loss Edition, showed up and pledged to help him change his body and his life.
At the weigh-in, Mims, then 49 years old, got harsh news. After years and years of overeating, he weighed 398 pounds. He had to be weighed on a truck scale.
As part of Mims weight-loss program, he would learn how to cook healthy meals. Powell got him exercising.
It wasnt easy. Added to the pressure, Mims son, Marcus, fell ill. His son suffered from cerebral palsy, and the hospitalization helped put things into perspective for Mims.
Im here fighting for my life and hes in the hospital fighting for his , Mims said tearfully.
Powell moved in with Mims and his fiance, and helped them remake their home. For a while, things went well, at 90 days into his program, Mims weighed 294 pounds.
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Tony Mims Loses 198 Pounds on 'Extreme Makeover: Weight Loss Edition'
Posted: June 6, 2012 at 10:17 pm
NEW YORK, June 6, 2012 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue:
Global Weight Control Products Industry
This report analyzes the worldwide markets for Weight Control Products in US$ Million by the following Product Segments: Low-Fat & Fat-Free Dairy Products, Carbonated & Other Liquids, Light Foods, Prepared Intakes, Herbal Supplements, and Dressings. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Rest of World. Annual estimates and forecasts are provided for the period 2009 through 2017. Also, a six-year historic analysis is provided for these markets. The report profiles 135 companies including many key and niche players such as Abbott Laboratories, EAS Corp., Abbott Nutrition, The Coca-Cola Company, Genisoy Food Company, Inc., HJ Heinz, Idea Sphere Inc., Twinlab Corp., Kraft Foods, Inc., Mead Johnson Nutritionals, Nestle SA, PepsiCo, Inc., Rexall Sundown Inc., The Groupe Danone, Unilever, Slim-Fast Foods Co., and Schiff Nutrition International, Inc. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based upon search engine sources in the public domain.
I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS Study Reliability and Reporting Limitations I-1Disclaimers I-2Data Interpretation & Reporting Level I-3Quantitative Techniques & Analytics I-3Product Definitions and Scope of Study I-3Low-Fat & Fat-Free Dairy Products I-4Carbonated and Other Liquids I-4Light Foods I-4Prepared Intakes I-4Herbal Supplements I-5Dressings I-5II. EXECUTIVE SUMMARY
1. MARKET DYNAMICS II-1
A Quick Market Primer II-1
Obesity Grows to Alarming Levels: A Statistical Review II-2
Table 1: Obesity Rates in Major Countries Worldwide (2008):
Percentage of Total Population in the US, Mexico, Europe,
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Global Weight Control Products Industry
