Category Archives: Lose Weight Fast

Its no exaggeration to say that plant-based baker Reece Hignell is almost half the size he used to be. The 28-year-old has lost a whopping 35kgs since he first took on the MasterChef kitchen back in 2018 - which, by the way, is quite the feat considering his trade literally involves eating cake.

The biggest inspiration for my transformation wasmy experience onMasterChef, he said in a recent interview with NowToLove. I was unhappy that I had put on weight whilst filming, but it wasn't until I saw myself on TV did I realise how unhealthy I had become.

RELATED:The 10 Best Exercises For Burning Belly Fat

The high-stress stakes of shooting coupled with constant grazing left Reece feeling uncomfortable and insecure in his skin. Today, I am a very different person, he continued. I am incredibly comfortable, not just in my appearance, but my personality, too.

While is transformation can largely be put down to his vegan diet, he also tracks his calorie intake via the help of an app on his phone.

Working in food all day I am faced with constant temptations, he said. The best way for me to manage this was to reflect on what I eat and transition to a fully plant-based diet.

Plus, hes taken up running and sticks to a regular exercise regime.

It was a slow process with a lot of discovery, but all worth it in the end, he said. I now realise what I put into my body is a lifestyle decision. If I am not on top of my health and fitness, I am more prone to health complications down the track.

Keep up the good work, Reece.

RELATED:4 Ways To Curb Your Sugar Cravings

Read the original post:
MasterChef's Reece's 35kg Weight Loss Is Seriously Impressive - Men's Health

GREGG Wallace has shown off the incredible results of his healthy eating and exercise regime thats seen him lose four stone.

The Masterchef host is launching his own wellbeing and weight loss subscription plan called Greggs ShowMe.Fit.

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The 55-year-old, who hit his goal weight in early April, took to Instagram to share two photos of his before and after transformation, captioning the snap: "4 stone later. I want to help people be fitter n happier."

Gregg is launching his fitness and diet website Gregg Show.Me.Fit on 25th June, which will offer subscribers exercise tips and healthy recipes for 7 a month.

It will feature his own personal trainer Danny Rai BSc, MSc who has put together a range of exercises that you can do at home to burn fat or to work on specific areas of your body.

The website also features wife Anna Wallace, who will be creating all the healthy home cooked recipes, all of take just 30 minutes to prepare and cook. Anna and Gregg met on Twitter in 2013 when she reached out to ask for advice on a rhubarb and duck recipe.

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The TV personality overhauled his lifestyle back in 2017 and has gradually transformed his physical image ever since.

During lockdown, he revealed to his followers that he was now below his target of 12 stone and was looking and feeling better than ever.

His followers were astonished with the images and rushed to tell the dad-of-two how impressed they were with his weight loss.

One wrote: "Brilliant work Greg!! That takes some hardcore willpower and motivation especially because you are surrounded by food in your job. A real inspiration, so proud of you "

"You look amazing, bloody well done! I need to find your mojo!," added another.

A third gushed: "Awesome achievement can't wait to sign up xx"

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Despite being in lockdown Gregg has been keeping up his regime and has kept his followers updated on what he's been doing to and the exercises that have been keeping him busy.

He said: There's no gyms, that doesn't matter, my PT Danny has sent me a five day programme.

Gregg, who was once 16 stone, previously discussed his decision to change his lifestyle, telling The Sun: "I made a conscious decision to cut down on fried and high sugar foods, as well as booze which helped me lose weight.

When I was at my biggest I was having a daily fry up, fish and chips once per week, takeaway a couple more times and drinking beer nearly every day. At first, I felt like I was missing out. But my body got used to what I was giving it and yours will too.

Gregg is currently holed up in the Kent countryside with his wife Anna and their son Sid, 11 months,

His in-laws Massimo and Rina are also in the house, as is his daughter Libby, 24, who he shares with ex wife Denise.

Got a story? email digishowbiz@the-sun.co.uk or call us direct on 02077824220.

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Gregg Wallace shares impressive weight loss before and after pictures as he launches wellbeing website - The Sun

Unexpected star Hailey Tomlinson recently showed off her slim physique in bikini pictures. Hailey and her daughter Kinsley Blevins spent some mommy-daughter time on the beach. Hailey and the father of her child, Matthew Blevins are no longer together. So, she has been doing the best she can to raise Kinsley as a single mother. And she has seemingly been doing a great job. Continue reading to find out more about her trip to the beach.

Earlier this month, Hailey Tomlinson spent some time soaking up the sun with her one-year-old daughter. She and Kinsley Blevins went to the beach. However, it doesnt seem like it was a family trip. Since Matthew Blevins wasnt there to see his daughter play in the sand. But, Hailey did have a few friends join her on their getaway. She also shared a few pictures from the trip online.

The Unexpected reality star and her daughter seemingly had a great time at the beach together. Kinsley Blevins seems to love the beach. Since she was always smiling in every picture. Hailey Tomlinson also seemed to have enjoyed herself. She was able to have a little mommy and daughter time. And spend such precious moments together.

Hailey Tomlinson did not hide her slimmed-down physique while on the beach. Losing weight after giving birth isnt always easy. But, she seems to have been able to bounce back quickly. She shared a picture of herself wearing a red bikini on the beach. And she looked amazing. Not everyone can feel comfortable in any type of bathing suit after having a baby.

Unexpected fans didnt hesitate to point out how great Hailey Tomlinson looked in her photos. Many fans left comments on the bikini picture. One fan said, you look amazing. Another fan said that they couldnt even tell youve had a baby. A fan also said that she looks incredible after carrying your beautiful baby. A bunch of fans also couldnt help but mention how cute her bikini is.

Hailey Tomlinson has also recently been able to mend her relationship with Hailey Tilford. The two had a fallout when Matthew Blevins broke up with Hailey #1 and then started dating Hailey #2. Kinsleys parents were then not on good terms after they split up. Matthew then found himself becoming a father to his second child. However, Matthew and Levi Tilfords mom eventually split up before their son was born.

Unexpecteds Hailey Tomlinson and Hailey Tilford have now found themselves mothers to half-siblings. They recently had their babies meet each other for the first time. Both young moms shared pictures from the meet up online. They have said that they would like their children to have a close siblings relationship. Unfortunately, the half-siblings have different relationships with their father, Matthew Blevins.

Soap Dirt keeps readers up to date on all the latest Unexpected updates, news and more.

Link:
'Unexpected': Hailey Tomlinson Shows off Weight Loss in Bikini Pictures - Soap Dirt

A popular social media influencer who is having her stepson's baby, went through a dramatic transformation before dumping her husband.

Marina Balmasheva says she was an unhappy woman when she weighed 20 stone before turning her life around to become a "thin b**ch".

She has shared a video of herself at her heaviest when she was just 29 and stepmum to five young adopted children.

The 35-year-old shared her dramatic weight loss with her 411,000 followers while she was married to her now ex-husband Alexey Shavyrin.

Marina from Russia shocked many of her fans when she announced she had left her husband and was now in a romantic relationship with his son, who she had raised since he was seven years old.

For the latest on the coronavirus pandemic, click here

Speaking about her two-year weight loss journey, she said: "All I was interested for the last couple of years was food, I got fat and wanted to die of such a life."

Marina shares her weight loss tips on a paid for website, where people have to sign up for her advice.

While still married she wrote posts thanking her husband for his patience as she went through her dieting and said she "roared with laughter" watching a video of herself when she was at her heaviest aged just 29.

Posting on one of her social media pages she said she always gets asked her secret to losing weight.

Marina replies: "Just close your mouth and set aside the bun and butter.

"Two years of effort and work is not easy.

"Now I will be a thin b**ch and you either look after yourself, and the look of your man, or console yourself that 'he loves me like that'."

Marina says she dumped her husband before a relationship blossomed with her stepson Vladimir Vova Shavyrin when he returned home on a break from university when he was 19.

He helped his stepmother in the kitchen, looking after the adopted children, and doing shopping.

Revealing the relationship earlier this year, she posted a picture of herself aged 22 with Voya when he was aged just seven.

The 2007 photo produced a critical backlash online and she was accused of immorality.

The pair last week announced they were having a baby, as Marina was four weeks pregnant.

I'm done hiding, she said.

But I want you to know it. Everything is possible in this world.

She added she knows they are at a very early stage of the pregnancy, but have so much to look forward.

She said she can't wait to see their child on an ultrasound for the first time in the coming weeks.

Marina said she and Voya would marry next month but we won't have a lavish celebration.

Vladimirs mother - another ex-wife of Alexeys - would help them care for the baby, she added.

See more here:
Influencer's dramatic weight loss before dumping husband to have stepson's baby - Mirror Online

TheWeight Loss Programs marketreport focuses on Major Leading Industry Players, providing info likeWeight Loss Programs market competitive situation, product scope, market overview, opportunities, driving force, and market risks.Profile the top manufacturers of Weight Loss Programs, with sales, revenue, and globalmarket share of Weight Loss Programsare analyzed emphatically bylandscape contrastand speak to info. Upstream raw materials and instrumentation and downstream demand analysis are additionally administrated. The Weight Loss Programs marketbusiness development trends and selling channelssquare measure analyzed. From a global perspective, It also represents the overall industry size by analyzingqualitative insights and historical data.

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This Weight Loss Programs market report provides a comprehensive analysis ofIndustry overview,cost structure analysis, technical data, and competitive analysis, topmost players analysis,development trend analysis, overall market overview, regional market analysis, consumer analysis, and marketing type analysis.

The Key Manufacturers covered in this Report:-:

Atkins Nutritionals, Kellogg, Nutrisystem, Weight Watchers, Herbalife, Technogym, Jenny Craig, Slimming World, Rosemary Conley

The report starts with amarket overviewand provides market definitions and analysis ofdrivers, constraints, and key trends. The following sections include analysis of trade activities, end users, types of transactions, and the Global Weight Loss Programs Market by region. This section assesses the global market based on a variety of factors coveringcurrent scenarios and future prospects.The report also providesregional datafor local and international companies.

Global Weight Loss Programs Market: Segment Analysis

This section of the report includes segmentation such asapplication, product type, and end-user. These segmentations aid in determining parts of the market that will progress more than others. The segmentation analysis provides information about the key elements that are thriving the specific segments better than others. It helps readers to understand strategies to make sound investments.

Global Weight Loss Programs Market: Regional Analysis

This part of the report includes detailed information of the market in different regions. Each region offers a different scope to the market as each region has different government policies and other factors. The regions included in the report areNorth America, Europe, Asia Pacific, and the Middle East and Africa.

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Highlights of TOC:

Executive Summary:The report starts with an easy-to-read, easy-to-understand summary of the entire market research study to help readers to gain a quick understanding of the global Weight Loss Programs market.

Company Profiles:This section provides key details about the business and market growth of leading players of the global Weight Loss Programs market.

Market Dynamics:The report offers a comprehensive analysis of key growth drivers, restraints, trends, and opportunities of the global Weight Loss Programs market.

Market Forecasts:Here, the report offers accurate market size forecasts for the global Weight Loss Programs industry, its segments and sub-segments, and all regions considered for the study.

Recommendations:Market recommendations provided in the report are very specific and research-backed. They have been created to help players move in the right direction during their journey to achieve success in the global Weight Loss Programs market.

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Weight Loss Programs Market 2020 Global Industry Size, Business Opportunities, Future Trends and Global Analysis by Forecast to 2027 - Cole of Duty

You can commit to your weight loss and also eat healthy (Shutterstock)

Here are some foods that can help you lose your weight while still maintaining health:

ALSO READ: Six common foods that will promote your hair growth

Cruciferous

This family consists of cabbage, broccoli, brussel sprouts and cauliflower. They are high in fibre and are very filling. When you eat these you're less likely to be eating more than you should.

They can be cancer-fighting and this makes these foods a go to option. They also have low to no exposure to cholesterol intake.Cruciferous have low to no exposure to cholesterol intake (Shutterstock)

Whole eggs

You may be thinking that eggs belong to another list, opposite from this one. However, they are actually great for weight loss regimes.

There are also studies done showing that eggs for breakfast increases weight loss on a calorie restricted diet, in comparison to eating donuts in the morning.

Leafy greens

ALSO READ: Six common reasons you have too much gas

If you're really eying a trim look, then these greens are the food for you. Greatly packed with fibre, you'll realize that they offer nutrients without getting you more kilos.

Kales, spinach, and collards, all but help to burn the fat and give you that trimmed up body.Greatly packed with fibre, greens offer nutrients without getting you more kilos (Shutterstock)

Boiled potatoes

This filling meal will get you avoiding any other food offers you get. They contain potassium, and starch.

These nutrients are great for the body and the potato intake will make you avoid adding onto your plate during the day.

A day kick started by eating boiled potatoes will be a full stomach day indeed.

Beans and legumes

ALSO READ: Five foods men should eat for a longer, healthier life

Here's an option that goes well with a vegetarian diet. They include the lentils, black beans, kidney beans and peas.

They tend to offer low calories, hence a preferable option for weigh loss. Their increase in protein gives them the quality of advocating for weight loss.

For More of This Stories Subscribe to the Standard Epaper to get a copy of Eve Woman in the Standard

Salmon

This is a fatty fish that is way so tasty when prepared. You can confidently add this to your daily weight loss diet, being sure to use better preparation rather than frying.

Grilling this will make the protein filled meaty to still be moist and juicy enough.

Weight loss should not be a journey that you're afraid of starting. Remind yourself that you can do it and commit to eating healthier.

Do not miss out on the latest news. Join the Eve Digital Telegram channel HERE.

The views and opinions expressed here are those of the author and do not necessarily reflect the official policy or position of Evewoman.co.ke

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Six food choices that will help you lose weight and stay healthy - The Standard

This material is intended for global medical media only, excl US.

For journalistic assessment and preparation before publication.

- A separate real-world study showed that people with type 2 diabetes on two oral antidiabetic drugs who intensified with a glucagon-like peptide-1 receptor agonist (GLP-1 RA) were significantly more likely to reach their blood sugar goals and lose weight compared to adding a further oral antidiabetic drug(s) or insulin.1

BAGSVRD, Denmark, June 15, 2020 /PRNewswire/-- Novo Nordisk today announced results from two real-world studies: EXPERT, which confirms the efficacy Ozempic (onceweekly semaglutide) demonstrated in the SUSTAIN clinical trial programme, and PATHWAY, which supports recommendations in clinical guidelines by showing that initiation of a GLP-1 receptor agonist (GLP-1 RA) helps people with type 2 diabetes reach their blood sugar goals (measured by HbA1c) while also losing weight. These studies, which analysed data from US databases, were presented during the American Diabetes Association 80th Scientific Sessions.1,2

The EXPERT study showed that a switch to Ozempic from another GLP-1 RA in people with type 2 diabetes was associated with statistically significant reductions in blood sugar and weight, independent of the previous GLP-1 RA used. After 6 months, the study showed HbA1c reductions of 2.2% for people with HbA1c levels above 9% at baseline and HbA1c reductions of 1.1% for those with HbA1c levels above 7% at baseline. These reductions were sustained after 12 months. Average weight loss of 2.2 kg was observed at 6 months, but was more pronounced with 3.5 kg at 12 months, for all participants.2

A second real-world study, PATHWAY, pointed to the increased effectiveness of the GLP-1 RA class compared with other oral antidiabetic drugs or insulin in people with type 2 diabetes on two oral antidiabetic drugs requiring treatment intensification. Ozempic was not one of the GLP-1 RA treatments given at intensification because the study data were collated before Ozempic was fully established on the US market.

The PATHWAY study showed thatintensifying treatment with a GLP-1 RA resulted in a statistically significant increased likelihood of achieving HbA1c below 7% and weight reduction from baseline compared with adding a further oral antidiabetic(s). These blood glucose and weight reductions were more pronounced compared with insulin intensification, where those taking a GLP-1 RA were almost twice as likely to achieve HbA1c below 7% and approximately three times more likely to lose weight.1

"GLP-1 receptor agonists have been shown to safely lower blood glucose levels and help lower weight, therefore they are recommended by all diabetes treatment guidelines as either second- or third-line treatment options in most people with type 2 diabetes," said study investigator Dr. Ildiko Lingvay, who consults for Novo Nordisk and is a Professor of Internal Medicine, and Population and Data Sciences at UT Southwestern Medical Center. "These data provide information from the real-world use of GLP-1 receptor agonists and further support the recommendations in the clinical guidelines by showing that initiation of a GLP-1 receptor agonist helps more people with type 2 diabetes reach their blood sugar goals while also helping them lose weight."

"More than half of people with type 2 diabetes do not reach their blood sugar target, yet we know that consistently poor blood sugar control can lead to serious complications," said Mads Krogsgaard Thomsen, executive vice president and chief science officer of Novo Nordisk. "Real-world data is therefore essential to help physicians select optimal treatment for their patients to meet their blood sugar goals, and it is reassuring to see from the EXPERT study that the efficacy Ozempic demonstrated in the SUSTAIN Phase 3 clinical trial programme is reflected in routine clinical practice."

Whilst real-world evidence generates valuable insights about the effectiveness of a medicine in a real-life setting, there are also limitations. Real-world studies may be subject to bias and confounding factors, aspects that are controlled for in randomised controlled trials (RCTs). For example, electronic data may be inconsistently collected, with missing data elements that can result in reduced statistical validity. Similarly, adverse events are rarely captured in databases that act as data sources for real-world studies. Therefore real-world evidence should be considered alongside the results of RCTs and the findings evaluated with appropriate caution. As seen in clinical trials, the most common side effects of Ozempic include nausea, vomiting, diarrhoea, stomach (abdominal) pain, and constipation.

For additional media materials, including video footage of the EXPERT and PATHWAY study investigators providing further context on the data, please visit: http://www.epresspack.net/novonordiskADA2020/RWEGLP1Class

About EXPERT

The GLP-1-Experienced Patients Switching to Once-Weekly Semaglutide in a Real-World Setting (EXPERT) study used prescription data from Explorys (IBM Watson Health) US medical records database (data cut-off 12/5/19). Adults with type 2 diabetes with 1 prescription for semaglutide (index/switch date), a prescription for any other GLP-1 RA (baseline) in the previous year, and separate HbA1c/weight measurements at 6 and/or 12 months post-index and in the 90-day pre-index period were identified from the database. Participants with valid HbA1c (n=365) and weight (n=480) data were included in the study and had similar baseline characteristics.2

About PATHWAY

The PATHWAY study compared treatment intensification options for glycaemic control in people with type 2 diabetes on two oral antidiabetic drugs (OADs). The PATHWAY study used linked electronic medical records and claims data from IBM MarketScan Explorys Claims-EMR (index period: 3/1/1310/31/18). The study comprised two groups: the HbA1c cohort (n= 4,792) and the weight and composite endpoint analysis cohort (n = 3,927). Participants with 1 claim for 2 different OADs in the 180 days pre-index, 1 claim for another OAD/GLP-1 RA/insulin (index date), 1 HbA1c and/or weightmeasurement 180 days post-index, and 1 HbA1c and/or weight measurement close to index date (baseline) were included in the study. Cohorts for GLP-1 RAs vs OADs and vs insulin were propensity score matched pairwise by baseline variables and exact matched by HbA1c category, resulting in well balanced cohorts across all baseline characteristics.1

About SUSTAIN clinical trial programme

The SUSTAIN clinical development programme for Ozempiccurrently comprises 10 Phase 3 global clinical trials, including a cardiovascular outcomes trial, which included people with type 2 diabetes and high cardiovascular risk. The programme involves more than 10,000 adults with type 2 diabetes in total.3-12

About Ozempic

Ozempic(once-weekly semaglutide) is an analogue of the naturally occurring hormone glucagon-like peptide-1 (GLP-1). It is administered in a once-weekly injection of 0.5 mg or 1 mg and indicated as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes as well as to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease.13 Ozempicwas first approved by the US FDA in 2017 and is now launched in 25 countries.

About Novo Nordisk

Novo Nordisk is a leading global healthcare company, founded in 1923 and headquartered in Denmark. Our purpose is to drive change to defeat diabetes and other serious chronic diseases such as obesity and rare blood and endocrine disorders. We do so by pioneering scientific breakthroughs, expanding access to our medicines and working to prevent and ultimately cure disease. Novo Nordisk employs about 43,100 people in 80 countries and markets its products in around 170 countries. For more information, visit novonordisk.com,Facebook, Twitter, LinkedIn, YouTube.

References

Further information

SOURCE Novo Nordisk

See original here:
Switching to Ozempic(R) from another GLP-1 RA significantly reduced blood sugar and weight in people - PharmiWeb.com

Zumba Training: Sucheta Pal, Zumba Master Trainer has shared some lesser-known and other important details about this popular workout.

We all know how fun and popular Zumba workout is. But aside from this major perk and social benefits of a group workout, one can improve quality of life as there are several health benefits of it right from weight loss to better immune system, better blood pressure among others. Those who burn excess calories have toned body and sculpted muscles but looking for an easy and effective workout then look no further. For the unversed, Zumba workout features movements inspired by varied styles of Latin American dance.

It is a full-body-workout which means it involves the movement of the entire body right from your arms to your feet. To know more about this particular workout, we asked Sucheta Pal, Master Trainer (Zumba Education Specialist ZES), Zumba, Miami to reveal how Zumba can help to build immunity considering how important it is right now more than ever. She also shared about India's largest living room fitness masterclass (featured none other than Zumba creator Beto Perez) which was held recently. Read on to know more.

1. Can you share how Zumba aids in immunity?

The first and foremost benefit of Zumba which is like a "happy workout" is that it slows down the release of stress hormones which is the number one reason for illness. The increase in blood circulation and body temperature during and after exercise tremendously helps fight infections better. The best part is that regular exercise like Zumba has an anti-inflammatory influence which is key to fighting off viruses.

2. How can Zumba help weight watchers?

Many of our participants across the world have recorded a calorie burn of over 500 and sometimes even reaching 800 calories per session which typically lasts 60 mins. We have had amazing stories of Zumba fans in India who have seen substantial weight loss within 3 months of regularly attending classes whether live or virtual.

4. What are the types of Zumba that people are not aware of?

Zumba is one of the top group fitness brands in the world. Its also now a household name in India with every gym and studio offering a class whether it's in Mumbai or in Madurai. But some of the other formats of Zumba are now slowly catching on. One major hit is the Zumba Kids program which has specially designed music and kid-friendly choreography created to get the little rockstars moving and grooving. Another format is Aqua Zumba which takes this fitness party like the class to the pool in summers. We also have the Zumba Gold program for the active old adults and Zumba Toning for those who wish to incorporate some dumbells into their Zumba workout. Only licensed Zumba instructors in these formats conduct these specialized formats and will be listed on zumba.com for anyone to find and attend.

4. What are the vital things to know/follow before you start a virtual or offline Zumba class?

It is very important that we treat a virtual class similar to how we would a live class. Have ample space to move safely at your home, have a bottle of water for hydration, wear comfortable workout clothes and the right shoes to ensure ease of movement and safety. With a virtual class, one thing to add would be to test out the online platform via which your licensed Zumba instructor will be teaching the class whether its zumba.dance or Zoom and attach a speaker and have a good internet connection to create the right experience for yourself.

5. Can you share about the record-breaking living room fitness masterclass?

We created history in India with this class. Not only through the huge number of participants but with 17 Zumba Education Specialists leading the class from their homes in every corner of the country. We are proud to spotlight the importance of fitness instructors in this country, especially during these difficult times.

ALSO READ: Zumba creator Beto Perez OPENS UP on weight loss, lesser-known benefits and myths of this workout

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From Weight Loss to Better Immunity: Here's why you should add Zumba to your fitness routine - PINKVILLA

This material is intended for global medical media only, excl US.

For journalistic assessment and preparation before publication.

- A separate real-world study showed that people with type 2 diabetes on two oral antidiabetic drugs who intensified with a glucagon-like peptide-1 receptor agonist (GLP-1 RA) were significantly more likely to reach their blood sugar goals and lose weight compared to adding a further oral antidiabetic drug(s) or insulin.1

BAGSVRD, Denmark, June 13, 2020 /PRNewswire/-- Novo Nordisk today announced results from two real-world studies: EXPERT, which confirms the efficacy Ozempic (onceweekly semaglutide) demonstrated in the SUSTAIN clinical trial programme, and PATHWAY, which supports recommendations in clinical guidelines by showing that initiation of a GLP-1 receptor agonist (GLP-1 RA) helps people with type 2 diabetes reach their blood sugar goals (measured by HbA1c) while also losing weight. These studies, which analysed data from US databases, were presented during the American Diabetes Association 80th Scientific Sessions.1,2

The EXPERT study showed that a switch to Ozempic from another GLP-1 RA in people with type 2 diabetes was associated with statistically significant reductions in blood sugar and weight, independent of the previous GLP-1 RA used. After 6 months, the study showed HbA1c reductions of 2.2% for people with HbA1c levels above 9% at baseline and HbA1c reductions of 1.1% for those with HbA1c levels above 7% at baseline. These reductions were sustained after 12 months. Average weight loss of 2.2 kg was observed at 6 months, but was more pronounced with 3.5 kg at 12 months, for all participants.2

A second real-world study, PATHWAY, pointed to the increased effectiveness of the GLP-1 RA class compared with other oral antidiabetic drugs or insulin in people with type 2 diabetes on two oral antidiabetic drugs requiring treatment intensification. Ozempic was not one of the GLP-1 RA treatments given at intensification because the study data were collated before Ozempic was fully established on the US market.

The PATHWAY study showed thatintensifying treatment with a GLP-1 RA resulted in a statistically significant increased likelihood of achieving HbA1c below 7% and weight reduction from baseline compared with adding a further oral antidiabetic(s). These blood glucose and weight reductions were more pronounced compared with insulin intensification, where those taking a GLP-1 RA were almost twice as likely to achieve HbA1c below 7% and approximately three times more likely to lose weight.1

"GLP-1 receptor agonists have been shown to safely lower blood glucose levels and help lower weight, therefore they are recommended by all diabetes treatment guidelines as either second- or third-line treatment options in most people with type 2 diabetes," said study investigator Dr. Ildiko Lingvay, who consults for Novo Nordisk and is a Professor of Internal Medicine, and Population and Data Sciences at UT Southwestern Medical Center. "These data provide information from the real-world use of GLP-1 receptor agonists and further support the recommendations in the clinical guidelines by showing that initiation of a GLP-1 receptor agonist helps more people with type 2 diabetes reach their blood sugar goals while also helping them lose weight."

"More than half of people with type 2 diabetes do not reach their blood sugar target, yet we know that consistently poor blood sugar control can lead to serious complications," said Mads Krogsgaard Thomsen, executive vice president and chief science officer of Novo Nordisk. "Real-world data is therefore essential to help physicians select optimal treatment for their patients to meet their blood sugar goals, and it is reassuring to see from the EXPERT study that the efficacy Ozempic demonstrated in the SUSTAIN Phase 3 clinical trial programme is reflected in routine clinical practice."

Whilst real-world evidence generates valuable insights about the effectiveness of a medicine in a real-life setting, there are also limitations. Real-world studies may be subject to bias and confounding factors, aspects that are controlled for in randomised controlled trials (RCTs). For example, electronic data may be inconsistently collected, with missing data elements that can result in reduced statistical validity. Similarly, adverse events are rarely captured in databases that act as data sources for real-world studies. Therefore real-world evidence should be considered alongside the results of RCTs and the findings evaluated with appropriate caution. As seen in clinical trials, the most common side effects of Ozempic include nausea, vomiting, diarrhoea, stomach (abdominal) pain, and constipation.

For additional media materials, including video footage of the EXPERT and PATHWAY study investigators providing further context on the data, please visit: http://www.epresspack.net/novonordiskADA2020/RWEGLP1Class

About EXPERT

The GLP-1-Experienced Patients Switching to Once-Weekly Semaglutide in a Real-World Setting (EXPERT) study used prescription data from Explorys (IBM Watson Health) US medical records database (data cut-off 12/5/19). Adults with type 2 diabetes with 1 prescription for semaglutide (index/switch date), a prescription for any other GLP-1 RA (baseline) in the previous year, and separate HbA1c/weight measurements at 6 and/or 12 months post-index and in the 90-day pre-index period were identified from the database. Participants with valid HbA1c (n=365) and weight (n=480) data were included in the study and had similar baseline characteristics.2

About PATHWAY

The PATHWAY study compared treatment intensification options for glycaemic control in people with type 2 diabetes on two oral antidiabetic drugs (OADs). The PATHWAY study used linked electronic medical records and claims data from IBM MarketScan Explorys Claims-EMR (index period: 3/1/1310/31/18). The study comprised two groups: the HbA1c cohort (n= 4,792) and the weight and composite endpoint analysis cohort (n = 3,927). Participants with 1 claim for 2 different OADs in the 180 days pre-index, 1 claim for another OAD/GLP-1 RA/insulin (index date), 1 HbA1c and/or weightmeasurement 180 days post-index, and 1 HbA1c and/or weight measurement close to index date (baseline) were included in the study. Cohorts for GLP-1 RAs vs OADs and vs insulin were propensity score matched pairwise by baseline variables and exact matched by HbA1c category, resulting in well balanced cohorts across all baseline characteristics.1

About SUSTAIN clinical trial programme

The SUSTAIN clinical development programme for Ozempiccurrently comprises 10 Phase 3 global clinical trials, including a cardiovascular outcomes trial, which included people with type 2 diabetes and high cardiovascular risk. The programme involves more than 10,000 adults with type 2 diabetes in total.3-12

About Ozempic

Ozempic(once-weekly semaglutide) is an analogue of the naturally occurring hormone glucagon-like peptide-1 (GLP-1). It is administered in a once-weekly injection of 0.5 mg or 1 mg and indicated as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes as well as to reduce the risk of major adverse cardiovascular events in adults with type 2 diabetes and established cardiovascular disease.13 Ozempicwas first approved by the US FDA in 2017 and is now launched in 25 countries.

About Novo Nordisk

Novo Nordisk is a leading global healthcare company, founded in 1923 and headquartered in Denmark. Our purpose is to drive change to defeat diabetes and other serious chronic diseases such as obesity and rare blood and endocrine disorders. We do so by pioneering scientific breakthroughs, expanding access to our medicines and working to prevent and ultimately cure disease. Novo Nordisk employs about 43,100 people in 80 countries and markets its products in around 170 countries. For more information, visit novonordisk.com,Facebook, Twitter, LinkedIn, YouTube.

References

Further information

https://www.novonordisk.com

SOURCE Novo Nordisk

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Switching to Ozempic from another GLP-1 RA significantly reduced blood sugar and weight in people with type 2 diabetes in routine clinical practice -...

In this sensitive, timely and, literally, vital piece, Dr. Oz outlines the doable and practical ways that all of us, especially the most vulnerable among us, can realistically tackle the conditions that undermine good health and make people less able to fight such terrible diseases as Covid-19.

Guest post by Dr. Mehmet Oz.

Vulnerable populations have been hard hit by Covid-19.

We are taught early on in medical school that when an avalanche of complex patient data sounds like hoofbeats, we should expect horses more than zebras. As the nation has focused on a daily firehose of Covid-19 information, doctors have been searching for the subtle predictors of why some groups are spared and others suffer disproportionately. We now have evidence explaining why African Americans have over twice the complication rate with Covid-19 as white populations. Over the past weeks, this documentation has revealed the higher prevalence of such chronic health conditions as obesity, hypertension, diabetes and lung diseaseailments that are much more common in underserved communities due to complex factors, including chronic stress and jobs that make social distancing nearly impossible.It also exposes how African Americans are disproportionately suffering.

. For example, Northwell Health, the large New York hospital system, shared the fact that 88% of their hospitalized patients have two or more co-morbid conditions. CDC data and experiences from other countries reflect similar findings.

Not surprisingly, when the Presidents new guidelines for Opening up America Again'' were announced, I noticed that if the guidelines were followed 60% of our fellow citizens wouldnt be going anywhere for quite a while. Through the first two phases, shelter in place remains the rule for the vulnerable population who have co-morbid conditions. Many would advise restricting this groups activity until we have a vaccine.

Its feared that highlighting this reality would embarrass people who are already struggling. But after helping people address their chronic conditions for my entire career, Im confident that this empowering wake-up call would be heeded by many Americans who feel their lives and livelihood are no longer under their control. More important, influencing these risk factors through lifestyle changes would accrue benefits far beyond this pandemic.

So how do we make it easy for people to do the right thing? We start with knowledge.If the body is fighting internal battles to protect its health against poor lifestyle choices, our immune-system defenses are distracted from external threats like the Covid-19 virus. Chronic ailments also damage the thin lining of our arteries, which causes scarring and plaques to build up. Viral infections may increase blood clotting, cause an overreaction by the immune system (so-called cytokine storm), and plaque rupture leading to heart attacks.

But we can reverse these risks, starting with simple steps to move us from being Vulnerable to Vital as we engage in life.

High blood pressureabove 140/90is reported by many doctors to be both the biggest driver of aging and the most common risk factor among those hospitalized by Covid-19. Walking is an ideal first step for people to take as the country is reopening, but vulnerable populations should socially distance. For them something to remember is high-intensity interval training (HIIT), which can help reducethe stiffness of artery walls, leading to alowerrestingblood pressure. HIIT allows us to exercise at our max for short periods and at lower intensity in between.Try doing intense squats, jumping jacks or planks for one minute and then rest for another minute. Gently build up to 4 minutes of activity followed by 3 minutes off until you reach 20 minutes total. Or even better, visit IHRSA.org and enter your zip code to find a gym near you that can safely kickstart you with some home online programs.

Losing inches off your waistline will also reduce blood pressure and prevent fat cells from creating inflammation, which inhibits the bodys ability to fight infections and even lowers the effectiveness of some vaccines. Roughly half of hospitalized young patients are obese because of inflammation, which starts in belly fat. This is why the tape measure is the best tool in determining if we are inflamed. Forget Quarantine Fifteen (the catch phrase for weight gain during the Covid-19 lockdown) on the scale; instead, get out a tape measure: Mens waists should be less than 37 inches, womens less than 35 inches.

To shave off a few inches, start by cutting back on simple sugars and lean into ancient whole grains like quinoa or farro. Immune-supporting herbs and spices upgrade the diet while reducing salt, so start addingginger,garlicand turmeric into meals. Snacks like nuts and hummus help quench our cravings. Desserts are metabolic suicide and should go the way of the handshake during Covid-19.If you still want to mindlessly eat calories to feed your feelings, opt for high-volume foods with little calories to lessen the damage. My favorites are air-popped popcorn, watermelon, frozen grapesand, of course, kale.

Pre-diabetes afflicts a third of the U.S.population, though many people are unaware they fit the category. It is addressed by the weight-loss tips offered above. If you want a comprehensive jumpstart, my television show, The Dr. Oz Show, has developed and tested a very popular System 20 plan designed for 2020 that will help you lose 20 pounds (if you need to lose weight) while cutting down the risks of chronic illness by up to 20%. Intermittent fasting is critical to its success, so we ask that you delay breakfast until late morning and eat dinner in early evening so your body can recover from having to digest food all night long.The program is free. Print out the one-sheet for your fridge, so you can start cutting back on processed foods.

Finally, lung disease hinders our ability to power through pneumonia, which often accompanies Covid-19 in hospitalized patients. Vaping and smoking damage the lungs defense mechanisms, so let me share the advice that I offer my heart-surgery patients: At least for the several weeks around your procedure, help me to help you by stopping smoking/vaping. Covid-19 is as dangerous as heart surgery for some people, so please accept the same advice. Hopefully, once you break the habit, youll never go back to inhaling again.

Even a few weeks of having a healthy lifestyle should yield measurable improvements, but youll feel better almost immediately. And instead of passively watching the world spin wildly around you, youll be able to can take charge of your most precious assetyour bodyand say goodbye to your sheltering-in-place days.

Mehmet Oz, M.D., Attending Physician, New York Presbyterian/Columbia, host of The Dr. Oz Show

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Dr. Oz: A Message To The Vulnerable - Forbes