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Posted: April 20, 2020 at 9:51 pm
Written by Roger Philby, CEO of The Chemistry Group
Over the past couple of weeks, households across the UK received a letter from the Government outlining important COVID-19 health advice, including rules on leaving the house and social distancing. Yet I can say with confidence that such a letter will fail to elicit any form of meaningful change in the publics behaviour towards minimising the spread of the virus.
A letter in the post will not change behaviour because knowledge is not behaviour. If it were, we wouldnt speed, smoke or fail to keep a 2m social distance from each other when we know that these things are bad for us and everyone around us.
In my time at The Chemistry Group, we have helped many companies create effective organisational change, and in the process have identified some key principles that will be useful for people undergoing the fairly major, enforced changes that are our current reality. These principles will not only help now but will also be vital for those determined to emerge from the current crisis stronger and more successful than before.
Firstly, let me rewind to why and how we developed these principles.
Chemistry has just finished a big piece of insight work for an FTSE 100 multinational organisation. The client was worried that with a huge change of context (post-financial crash) salespeople were struggling with new ways of working
Anticipating this the client had put their 150 managers through rigorous and extensive management training. Chemistrys data clearly showed that most of the managers had the Intellect, Personality, Motivation and Experience to succeed, they just werent. The problem was that the organisation had conflated knowledge with behaviour.
This organisation needed to focus on three behaviours to turn around its revenue gap, only three:
When the client challenged us to help them implement these behaviours, we started gathering information, looking for data-driven insights. What was out there in the world of training/learning & development could help initiate scale behavioural change?
It turns out weight loss is a perfect analogy for what is wrong with training in organisations. Like all of us that have struggled to lose weight, these sales managers knew what to do, they just didnt do it. I know I need to exercise and run a calorie deficit, I even know what to eat and what exercises to doI just dont do it? Why not? Because I dont have time, because I have other pressing things to do, because, because, because. How many times have you run those kinds of thoughts through your head at home and at work? If you are anything like me, too many to count.
Within three weeks we had studied Weight Watchers and Alcoholics Anonymous and within six weeks we had a behavioural change methodology that scaled across an organisation of 1,000+ people. We have illustrated three of them below:
Do one thing at a time, get great at it, be consistent, then do the next thing. In the above example, we worked on one behaviour for 3 months and only when we hit a level of consistency did we introduce the next behaviour.
Finally, focus on managers of people. For our client, just 150 managers caused a wave of behavioural change that turned around an organisations fortunes. 7% behind their target in February, the organisation ended up beating it by 14%, achieving the market-leading position for the first time in 8 years and receiving industry-wide accolades.
Make the behavioural change in groups, at Chemistry we call them Pods. There is a reason all WW classes and AA meetings are groups of people. Behavioural change is hard, you need support from people who are all going through the same change.
Not only does instituting the change in a group encourage support it also adds motivation. Whether people lack rigorous self-discipline or have a competitive streak that means they perform best against others, a group dynamic can motivate people to adopt the behaviours they know they should more quickly, and more effectively.
Behavioural change has to be led by one of the cohort going through the change, not an expert. The person leading the WW class was often not the kind of fitness influencer we see plastered all over social media, thats the point. Managers are far more likely to listen to one of their peers who has achieved the change they are trying to make and accept candid feedback from this person.
Having a peer in the behavioural change process is also likely to result in more effective and accurate feedback, as they will have a more in-depth and immediate experience of the context and process, rather than just a finished idea of what the end result should look like.
See the rest here:
Behavioural Change: Why a letter in the post won't work - Business Leader
Posted: April 20, 2020 at 9:51 pm
What If They dont take The Obvious Receiver?
Every Packer Fan is praying for Rodgers to have another weapon in the passing game. The 2020 draft class might be so deep in wide receiver that the Packers could wait to find LaFleurs new tool. So if the Packers skip on a wide receiver in the first round, who should they target?
Feb 28, 2020; Indianapolis, Indiana, USA; Wisconsin Badgers running back Jonathan Taylor (RB27) participates in a workout drill during the 2020 NFL Combine at Lucas Oil Stadium. Brian Spurlock-USA TODAY Sports
College: University of Wisconsin
Year: Junior
Over Taylors three years in Madison, he ran for over 6,000 yards and averaged almost seven yards per carry. He is one of the fastest running backs in this draft class, clocking a 4.4 40-yard dash time. Taylor is a durable and quick back that can add some juice for the Green Bay backfield coming in when Aaron Jones needs a rest.
Taylor would fit in the passing part of Green Bays offense on all downs eventually. Even though he only had a little over 400 receiving yards in college, he started to show his true receiving skills in his final year as a Badger. Coach LaFleur will be able to recognize how elusive he is when he gets into the open field and how hard it is to bring him down when the ball is in his hands. I can see the Packers splitting him out as a slot receiver and have him run mesh routes on critical downs. He can also be valuable running smash routes, curls, and screens out of the backfield. Jonathan Taylor could thrive in this offense because Lafleur always keeps his running backs active and Rodgers is always best finding a running back on a checkdown letting them make a play in the open field.
Aaron Jones rookie contract will expire after this years season, as well as Jamaal Williams. Jones will most likely be re-signed after this years season proving to be the franchise back. The only question that makes this decision hard is veterans, Kenny Clark, Corey Linsley, and Kevin Kings contracts will expire too.
The Packers could go a different route and re-sign Pro Bowler Kenny Clark and veteran Center Corey Linsley, while also giving the same opportunity to Kevin King(5 INT last season). This would mean that they would have to let Jones walk. Jones will become an expensive target for teams, and if Green Bay doesnt want to go the expensive route, they have to start looking for the future and heavily consider taking a shot at Jonathan Taylor. Even if Aaron Jones does re-sign long term, Taylor could be a great aspect to the offense opening up new challenges for opposing defenses.
Wisconsin Alumni already making him a fan favorite
Able to make a play when the play is already busted (Comparison= Saquon Barkley)
A bruiser in traffic and slippery in the open field
Has talent as a receiver and could make a living in the empty set or in the checkdowngame
Can become a number one RB if Aaron Jones does not re-sign
Feb 29, 2020; Indianapolis, Indiana, USA; Louisiana State Tigers linebacker Patrick Queen (LB32) runs the 40 yard dash during the 2020 NFL Combine at Lucas Oil Stadium. Brian Spurlock-USA TODAY Sports
College: LSU
Year: Junior
The inside linebacker out of Baton Rouge recorded 85 tackles with 12 of them being for a loss of yards. He also added three sacks to the Tigers historical run and an interception off of Tua Tagovailoa (Alabama QB) in the game of the year. The Packers have never had an inside linebacker that would stick around and Queen could finally fill that gap in Pettines defense.
Defensive MVP of The National Championship, Patrick Queen was able to lead his defense by calling every play. What really opens the Packers eyes is his aggressiveness when there is a ball carrier in sight. Also, Queen plays with a different type of swagger that would fit the Packers defense. His biggest impact on the Tigers defense was how well he covered the tight end in deep routes and mesh routes. He was also able to cover running backs in checkdown situations and blew up most screens in sight. Ex Packers Linebacker Blake Martinez struggled to cover tight ends on seam routes and had trouble picking up receivers over the middle. What would make Queen so special is he would be able to pick up on passing situations easily and has the intelligence to call the defense as a rookie. Also, with offensive lines and quarterbacks already focusing on how to contain the Smith brothers, this will give Queen a chance to make big plays in the backfield. The Packers past linebackers have always struggled against tight ends and picking up receivers on broken plays, so making the addition of Queen to Pettines defense will only make them more exciting to watch this season.
Recently the Packers were able to sign former Browns Linebacker Christian Kirksey, filling Blake Martinezs spot temporarily. Kirksey is a veteran who brings a lot of knowledge to the Packers defense. Kirksey is also known to be injury prone, playing only nine games for Cleveland last year. If the Packers draft Queen, he will be able to rotate with Kirksey and be able to gain knowledge from the veteran. Eventually Queen would prove himself and push out Christian Kirksey becoming a leader for the Packers young defense.
Intense hard hitting Linebacker
Able to cover receiving Running Backs and Tight Ends
Recognizes the screen well Plays with the Packers type of Swagger
Has experience being the Play caller already
Will have chances to make big plays with opposing teams fearing the Packers front.
Charlie Neibergall/Associated Press
College: Boise State
Year: Junior
The junior tackle out of Boise is an athletic big man that played every game since 2017 and also ran a 4.93 at the NFL Combine. He is able to move quickly to the block and does the best in pass protection. He does well in the run game when sealing off blocks that open up holes that can provide a spark to the Jones/Williams backfield.
Erza Cleveland is a quick guy who produced a lot of open holes for the run game at Boise State. He has quick feet making him able to seal off fast linebackers and defensive ends. In the run protection he is best on stretch plays because of his quickness and his ability to reach for a block. Cleveland also is able to play both left and right tackles which fits with the Packers history of producing versatile linemen. It seems that Cleveland might be a work in progress forthe first year or so because he would need to put some weight and muscle tone on giving him a stockier build giving him an advantage at being able to protect the inside run. Cleveland may be a bridge at first, but has the athletic ability to soon fill for the loss of Bryan Bulaga.
Recently, the Packers lost long time veteran, Bryan Bulaga, to the Chargers. Bulaga was able to protect Rodgers when All-Pro defensive ends would line up on the other side. He was able to shut down defensive ends Von Miller and Bradley Chubb, who were quick players that easily got after the quarterback. Rick Wagner of the Detroit Lions will be replacing Bulaga and will have to fill a big role. Cleveland would be able to prove himself in the preseason by beating out Wagner and becoming that quick lineman that can keep up with all these fast moving defensive ends and outside linebackers. He will also be successful because the Packers like to run toss/stretch plays where it will be easy for him to get out of his stance and go make a block up the field. The same thing applies for when they run screens with Davante Adams and Aaron Jones.
Agile
Quick feet and able to seal blocks to make holes for the running back
Will thrive in Outside zone runs and screens passes Quick enough to keep up with fast defensive linemen
Will have to put more weight on to be able to have a wide base in the Inside Runprotection
Can be a starter to fill Bulagas role
Related
See the article here:
3 Out of the Box First Round Choices To Improve The Packers - Total Packers
Posted: April 20, 2020 at 9:51 pm
NEWTON, Mass., April 20, 2020 (GLOBE NEWSWIRE) -- Karyopharm Therapeutics Inc. (KPTI) today announced dosing of the first patient in a randomized Phase 2 clinical study evaluating low dose oral selinexor in hospitalized patients with severe COVID-19. This global study is expected to enroll approximately 230 patients at clinical sites in the U.S., Europe, and Israel. Selinexor is an oral selective inhibitor of nuclear export (SINE) compound which blocks the cellular protein XPO1 which is involved in both the replication of SARS-CoV-2, the virus that causes COVID-19, and in the inflammatory response to the virus.
The randomized, multi-center, placebo-controlled Phase 2 study (XPORT-CoV-1001/NCT04349098) of low dose selinexor is designed to assess the activity and safety of 20mg of selinexor given orally three times a week for two weeks. Patients tolerating therapy well and experiencing clinical benefit may be eligible to continue treatment for an additional two weeks at the discretion of the treating physician. The primary endpoint of the study is time to clinical improvement based on improvement in the Ordinal Scale, consistent with the COVID-19 trial recommendations by the World Health Organization and the U.S. Food and Drug Administration (FDA). Additional secondary endpoints in the study include the overall death rate at day 28 as well as the rate of, and time to, mechanical ventilation.
In less than two weeks since announcing our intention to study selinexor in patients with severe COVID-19, we have quickly mobilized our team to activate clinical trial sites across the globe and are proud to announce the dosing of the first patient in our randomized study, said Sharon Shacham, PhD, MBA, President and Chief Scientific Officer of Karyopharm. This important milestone marks the first study of an XPO1 inhibitor in patients with severe viral infections. We remain highly encouraged by the potential anti-viral and anti-inflammatory activity of XPO1 inhibition with selinexor and look forward to working with the medical community of regulators, treating physicians and patients on advancing this important study as quickly as possible.
SINE compounds have been identified as having the potential to interfere with key host protein interactions with influenza, RSV and other viruses including SARS-CoV-2.1 Furthermore, XPO1 (also called CRM1) was identified as one of the host proteins with the highest number of functional connections with SARS-CoV proteins.2 Finally, SINE compounds, including selinexor, have demonstrated potent anti-inflammatory activity through the inhibition of Nuclear Factor kB (NF-kB), leading to reductions in cytokines such as IL6, IL1, IFNg and others in a variety of models, which may be particularly beneficial to hospitalized patients with COVID-19 and other severe viral infections.
In my laboratory, we have now used two different approaches to investigate selinexors ability to inhibit the viral propagation of the SARS-CoV-2 virus in Vero cells, which are monkey cells commonly used in modeling human viral infections. In our first experiment, with the assistance of Jackelyn Murray in my lab, we demonstrated that selinexor inhibited the production of new virus by 90% at a low concentration (100 nM) from cells that were already infected with SARS-CoV2. This is very exciting as low oral doses of selinexor are expected to deliver levels over 300 nM. In the second experiment, we showed that even lower levels of selinexor, only 10nM, could reduce the ability of the virus to infect new cells by about 99%. I am highly encouraged by these results and thrilled to see how quickly Karyopharm is able to test these scientific findings in patients so dramatically impacted by the current COVID-19 pandemic, said Ralph Tripp, PhD, a Georgia Research Alliance Eminent Scholar and Professor in the Department of Infectious Diseases in the College of Veterinary Medicine at the University of Georgia.
Selinexor, marketed as XPOVIO, is currently approved at higher doses by the FDA as a treatment for patients with relapsed or refractory multiple myeloma. Selinexor is currently the only XPO1 inhibitor approved for commercial use by the FDA and has been extensively tested in clinical trials across numerous cancer indications worldwide since 2012. Karyopharm has sufficient supply of selinexor for current and expected commercial patients with multiple myeloma, for ongoing clinical trials in patients with various cancers, as well as for this study in patients with COVID-19.
About XPOVIO (selinexor)
XPOVIO is a first-in-class, oral Selective Inhibitor of Nuclear Export (SINE) compound. XPOVIO functions by selectively binding to and inhibiting the nuclear export protein exportin 1 (XPO1, also called CRM1). XPOVIO blocks the nuclear export of tumor suppressor, growth regulatory and anti-inflammatory proteins, leading to accumulation of these proteins in the nucleus and enhancing their anti-cancer activity in the cell. The forced nuclear retention of these proteins can counteract a multitude of the oncogenic pathways that, unchecked, allow cancer cells with severe DNA damage to continue to grow and divide in an unrestrained fashion. Karyopharm received accelerated U.S. Food and Drug Administration (FDA) approval of XPOVIO in July 2019 in combination with dexamethasone for the treatment of adult patients with relapsed refractory multiple myeloma (RRMM) who have received at least four prior therapies and whose disease is refractory to at least two proteasome inhibitors, at least two immunomodulatory agents, and an anti-CD38 monoclonal antibody. Karyopharm has also submitted a Marketing Authorization Application (MAA) to the European Medicines Agency (EMA) with a request for conditional approval of selinexor. A supplemental New Drug Application was recently accepted by the FDA seeking accelerated approval for selinexor as a new treatment for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), and selinexor has received Fast Track and Orphan designation and Priority Review from the FDA with a scheduled PDUFA date of June 23, 2020 for this patient population. Selinexor is also being evaluated in several other mid-and later-phase clinical trials across multiple cancer indications, including in multiple myeloma in a pivotal, randomized Phase 3 study in combination with Velcade (bortezomib) and low-dose dexamethasone (BOSTON), for which Karyopharm announced positive top-line results in March 2020. Additional, ongoing trials for selinexor include as a potential backbone therapy in combination with approved myeloma therapies (STOMP), in liposarcoma (SEAL) and in endometrial cancer (SIENDO), among others. Additional Phase 1, Phase 2 and Phase 3 studies are ongoing or currently planned, including multiple studies in combination with approved therapies in a variety of tumor types to further inform Karyopharms clinical development priorities for selinexor. Additional clinical trial information for selinexor is available at http://www.clinicaltrials.gov.
For more information about Karyopharms products or clinical trials, please contact the Medical Information department at:
Tel: +1 (888) 209-9326Email: medicalinformation@karyopharm.com
IMPORTANT SAFETY INFORMATION
Thrombocytopenia
XPOVIO can cause thrombocytopenia, leading to potentially fatal hemorrhage. Thrombocytopenia was reported as an adverse reaction in 74% of patients, and severe (Grade 3-4) thrombocytopenia occurred in 61% of patients treated with XPOVIO. The median time to onset of the first event was 22 days. Bleeding occurred in 23% of patients with thrombocytopenia, clinically significant bleeding occurred in 5% of patients with thrombocytopenia and fatal hemorrhage occurred in <1% of patients.
Monitor platelet counts at baseline, during treatment, and as clinically indicated. Monitor more frequently during the first two months of treatment. Institute platelet transfusion and/or other treatments as clinically indicated. Monitor patients for signs and symptoms of bleeding and evaluate promptly. Interrupt and/or reduce dose, or permanently discontinue based on severity of adverse reaction.
Neutropenia
XPOVIO can cause neutropenia, potentially increasing the risk of infection. Neutropenia was reported as an adverse reaction in 34% of patients, and severe (Grade 3-4) neutropenia occurred in 21% of patients treated with XPOVIO. The median time to onset of the first event was 25 days. Febrile neutropenia was reported in 3% of patients.
Obtain neutrophil counts at baseline, during treatment, and as clinically indicated. Monitor more frequently during the first two months of treatment. Monitor patients for signs and symptoms of concomitant infection and evaluate promptly. Consider supportive measures including antimicrobials for signs of infection and use of growth factors (e.g., G-CSF). Interrupt and/or reduce dose, or permanently discontinue based on severity of adverse reaction.
Gastrointestinal Toxicity
Gastrointestinal toxicities occurred in patients treated with XPOVIO.
Nausea/Vomiting
Nausea was reported as an adverse reaction in 72% of patients, and Grade 3 nausea occurred in 9% of patients treated with XPOVIO. The median time to onset of the first nausea event was 3 days.
Vomiting was reported in 41% of patients, and Grade 3 vomiting occurred in 4% of patients treated with XPOVIO. The median time to onset of the first vomiting event was 5 days.
Provide prophylactic 5-HT3 antagonists and/or other anti-nausea agents, prior to and during treatment with XPOVIO. Manage nausea/vomiting by dose interruption, reduction, and/or discontinuation. Administer intravenous fluids and replace electrolytes to prevent dehydration in patients at risk. Use additional anti-nausea medications as clinically indicated.
Diarrhea
Diarrhea was reported as an adverse reaction in 44% of patients, and Grade 3 diarrhea occurred in 6% of patients treated with XPOVIO. The median time to onset of diarrhea was 15 days.Manage diarrhea by dose modifications and/or standard anti-diarrheal agents; administer intravenous fluids to prevent dehydration in patients at risk.
Anorexia/Weight Loss
Anorexia was reported as an adverse reaction in 53% of patients, and Grade 3 anorexia occurred in 5% of patients treated with XPOVIO. The median time to onset of anorexia was 8 days.
Weight loss was reported as an adverse reaction in 47% of patients, and Grade 3 weight loss occurred in 1% of patients treated with XPOVIO. The median time to onset of weight loss was 15 days.
Monitor patient weight at baseline, during treatment, and as clinically indicated. Monitor more frequently during the first two months of treatment. Manage anorexia and weight loss with dose modifications, appetite stimulants, and nutritional support.
Hyponatremia
XPOVIO can cause hyponatremia; 39% of patients treated with XPOVIO experienced hyponatremia, 22% of patients experienced Grade 3 or 4 hyponatremia. The median time to onset of the first event was 8 days.
Monitor sodium level at baseline, during treatment, and as clinically indicated. Monitor more frequently during the first two months of treatment. Correct sodium levels for concurrent hyperglycemia (serum glucose >150 mg/dL) and high serum paraprotein levels. Treat hyponatremia per clinical guidelines (intravenous saline and/or salt tablets), including dietary review. Interrupt and/or reduce dose, or permanently discontinue based on severity of adverse reaction.
Infections
In patients receiving XPOVIO, 52% of patients experienced any grade of infection. Upper respiratory tract infection of any grade occurred in 21%, pneumonia in 13%, and sepsis in 6% of patients. Grade 3 infections were reported in 25% of patients, and deaths resulting from an infection occurred in 4% of patients. The most commonly reported Grade 3 infections were pneumonia in 9% of patients, followed by sepsis in 6%. The median time to onset was 54 days for pneumonia and 42 days for sepsis. Most infections were not associated with neutropenia and were caused by non-opportunistic organisms.
Neurological Toxicity
Neurological toxicities occurred in patients treated with XPOVIO.
Neurological adverse reactions including dizziness, syncope, depressed level of consciousness, and mental status changes (including delirium and confusional state) occurred in 30% of patients, and severe events (Grade 3-4) occurred in 9% of patients treated with XPOVIO. Median time to the first event was 15 days.
Optimize hydration status, hemoglobin level, and concomitant medications to avoid exacerbating dizziness or mental status changes.
Embryo-Fetal Toxicity
Based on data from animal studies and its mechanism of action, XPOVIO can cause fetal harm when administered to a pregnant woman. Selinexor administration to pregnant animals during organogenesis resulted in structural abnormalities and alterations to growth at exposures below those occurring clinically at the recommended dose.
Advise pregnant women of the potential risk to a fetus. Advise females of reproductive potential and males with a female partner of reproductive potential to use effective contraception during treatment with XPOVIO and for 1 week after the last dose.
ADVERSE REACTIONSThe most common adverse reactions (incidence 20%) are thrombocytopenia, fatigue, nausea, anemia, decreased appetite, decreased weight, diarrhea, vomiting, hyponatremia, neutropenia, leukopenia, constipation, dyspnea, and upper respiratory tract infection.
The treatment discontinuation rate due to adverse reactions was 27%; 53% of patients had a reduction in the XPOVIO dose, and 65.3% had the dose of XPOVIO interrupted. The most frequent adverse reactions requiring permanent discontinuation in 4% or greater of patients who received XPOVIO included fatigue, nausea, and thrombocytopenia. The rate of fatal adverse reactions was 8.9%.
Please see XPOVIO Full Prescribing Information available atwww.XPOVIO.com.
References
1 Gordon, D. et al. A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug Repurposing. bioRxiv. 2020. 03.22.002386. https://doi.org/10.1101/2020.03.22.002386
2 Zhou, Y. et al. Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2. Cell Discovery. 2020. 6:14. https://doi.org/10.1038/s41421-020-0153-3
About Karyopharm Therapeutics
Karyopharm Therapeutics Inc. (KPTI) is an oncology-focused pharmaceutical company dedicated to the discovery, development, and commercialization of novel first-in-class drugs directed against nuclear export and related targets for the treatment of cancer and other major diseases. Karyopharm's Selective Inhibitor of Nuclear Export (SINE) compounds function by binding with and inhibiting the nuclear export protein XPO1 (or CRM1). Karyopharms lead compound, XPOVIO (selinexor), received accelerated approval from the U.S. Food and Drug Administration (FDA) in July 2019 in combination with dexamethasone as a treatment for patients with heavily pretreated multiple myeloma. A Marketing Authorization Application for selinexor is also currently under review by the European Medicines Agency. A supplemental New Drug Application was recently accepted by the FDA seeking accelerated approval for selinexor as a new treatment for adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). In addition to single-agent and combination activity against a variety of human cancers, SINE compounds have also shown biological activity in models of neurodegeneration, inflammation, autoimmune disease, certain viruses and wound-healing. Karyopharm has several investigational programs in clinical or preclinical development. For more information, please visit http://www.karyopharm.com.
Forward-Looking Statements
This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Such forward-looking statements include those regarding Karyopharms expectations and plans relating to selinexor as a potential treatment for hospitalized patients with severe COVID-19; the design and execution of a global randomized clinical trial to study this potential application of selinexor, including the dosing regimen; the potential anti-viral and anti-inflammatory properties of selinexor; submissions to, and the review and potential approval of selinexor in this indication by, regulatory authorities, including the anticipated availability of data to support such submissions, timing of such submissions and actions by regulatory authorities and the potential availability of accelerated approval pathways; the sufficiency of selinexor supply for commercial demand and clinical trial use; and the therapeutic potential of and potential clinical development plans for Karyopharms drug candidates, including the impact of a selinexor clinical trial on the timing or prioritization of other key company milestones, such as its expected submission of a supplemental new drug application in the second quarter of 2020 for XPOVIO in combination with once-weekly Velcade and low dose dexamethasone. Such statements are subject to numerous important factors, risks and uncertainties, many of which are beyond Karyopharm's control, that may cause actual events or results to differ materially from Karyopharm's current expectations. For example, there can be no guarantee that Karyopharm will successfully complete necessary clinical development phases of selinexor in this indication; that data from a clinical trial of selinexor would support its use in treatment of hospitalized patients with severe COVID-19; that regulators will approve the use of selinexor in hospitalized patients with severe COVID-19, or that such approval will be made on an accelerated timeline. Further, there can be no guarantee that any positive developments in the development or commercialization of Karyopharms drug candidate portfolio will result in stock price appreciation. Managements expectations and, therefore, any forward-looking statements in this press release could also be affected by risks and uncertainties relating to a number of other factors, including the following: the risk that the COVID-19 pandemic could disrupt Karyopharms business more severely than it currently anticipates, including by reducing sales of XPOVIO, interrupting or delaying research and development efforts, impacting the ability to procure sufficient supply for the development and commercialization of selinexor or other product candidates, delaying ongoing or planned clinical trials, impeding the execution of business plans, planned regulatory milestones and timelines, or inconveniencing patients; the adoption of selinexor for treatment of COVID-19 in the commercial marketplace, the timing and costs involved in commercializing selinexor for such indication or any of Karyopharms drug candidates that receive regulatory approval; the ability to retain regulatory approval of selinexor for such indication or any of Karyopharms drug candidates that receive regulatory approval; Karyopharm's results of clinical trials and preclinical studies, including subsequent analysis of existing data and new data received from ongoing and future studies; the content and timing of decisions made by the U.S. Food and Drug Administration and other regulatory authorities, investigational review boards at clinical trial sites and publication review bodies, including with respect to the need for additional clinical studies; the ability of Karyopharm or its third party collaborators or successors in interest to fully perform their respective obligations under the applicable agreement and the potential future financial implications of such agreement; Karyopharm's ability to obtain and maintain requisite regulatory approvals and to enroll patients in its clinical trials; unplanned cash requirements and expenditures; development of drug candidates by Karyopharms competitors for indications in which Karyopharm is currently developing its drug candidates; and Karyopharms ability to obtain, maintain and enforce patent and other intellectual property protection for any drug candidates it is developing. These and other risks are described under the caption "Risk Factors" in Karyopharms Annual Report on Form 10-K for the year ended December 31, 2019, which was filed with the Securities and Exchange Commission (SEC) on February 26, 2020, and in other filings that Karyopharm may make with the SEC in the future. Any forward-looking statements contained in this press release speak only as of the date hereof, and, except as required by law, Karyopharm expressly disclaims any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise.
Velcade is a registered trademark of Takeda Pharmaceutical Company Limited.
Contacts:
Investors: Karyopharm Therapeutics Inc. Ian Karp, Vice President, Investor and Public Relations857-297-2241 | ikarp@karyopharm.com
Media:
FTI ConsultingSimona Kormanikova or Robert Stanislaro212-850-5600 |Simona.Kormanikova@fticonsulting.com or robert.stanislaro@fticonsulting.com
Posted: April 20, 2020 at 9:51 pm
Thor has easily become many people's favorite Avenger, even if he didn't originally start out that way.Thor has changed a lot as a character over the course of the MCU and has gone through significant developments, especially in his last three film appearances alone.
RELATED:Thor's 10 Best Fights In The MCU
Some of the changes have been minor and others major. One thing is for certain, he is a much different character than when he first appeared in Thor back in 2011.
Thor has gone through a lot of physical changes in the MCU and one of the most interesting being the loss of his eye. During his battle against Helain Thor: Ragnarok, Thor has his right eye slashed out. At the end ofthe movie,he's sporting an eyepatch making him lookvery similar to his father, Odin. The following year, during Avenger: Infinity War, he receives a replacement eye from Rocket with the only noticeable difference between the two being that his new eye is hazel as opposed to his natural iris color of blue.
One of the saddest and most beautiful moments in the MCU was Frigga's funeral in Thor: The Dark Worldafter she waskilled while attempting to protect Jane Foster. When he lost his mother, Thor was devastated but unfortunately, she was only the first of the many friends and family thathe would lose. Odin faded away in Ragnarok, The Warriors 3 were killed almost instantly by Hela upon her arrival,Thorwas forced to kill his sister in order to save his people,Loki was killed at the hand of Thanos during the opening scene ofInfinity War and to make matters worse during the same scene, he also loses Heimdall. With all the loss he has experienced, it's surprising that he has somehow managed to continue to fight.
Another devastating moment for Thor was when his hammer,Mjolnir, was destroyed by Hela in Ragnarok. Although he learned the lesson that he didn't need a hammer since his power was already apart of him, it is always better to have a weapon of some sort.
RELATED:MCU: 10 People Thor Should Have Been With Other Than Jane Foster
After realizing that he would need a new weapon in order to even stand a chance at defeating Thanos in Infinity War, He,Rocket, and Groot travel to have the ax called "Stormbreaker" forged,leading to the epic scene which sees the God of Thunder take on the full force of a dying star in order to form the metal and thewooden handle being provided by Groot.
Something Ragnarok did better than the other Thor movies was give him a strong arc. Throughout the film hestruggles with his abilities after losing Mjolnir.Aftera touching scene in which Odin comes to him in a vision and asks if he'sthe "God of Hammers",he realizesthat his strength didn't come from hisweapon but from inside him. The display of his true strength comes during the epic fight on the rainbow bridge in which he completely demolishes Hela's army of the dead without anytoolaiding him.
When the Avengers decided in Endgame that they were going to need to put the team back together in order to properly pull off the time heist to retrieve the Infinity Stones from the past, Rocket and Hulk were tasked with traveling to New Asgard to retrieve him. However, they quickly notice that he's gained a significant amount of weight over the 5-year gap likely due to all the beer he had been drinking. Thor's weight gain, despite being the source of some of the film's comedy, was used as a physical representation of the character's depression and guilt that came after feeling the effects of Thanos' snap.
The first and second Thor movies put part of the focus on the relationship between Thor and Jane, so it was surprising that the character was completely absent in Ragnarok, with Thor saying that they've broken up off-screen.It even became a joke during a scene in Endgame in which Thor is discussing during the events of Thor: The Dark World and extracting the Aether from Jane. Jane has been confirmed to return in Thor: Love and Thunder as the Mighty Thor, sothere is a chance we will see the relationship rekindled.
Although the first two Thor movies had their share of comedic moments, lots of the comedy from the first film coming from him being a fish-out-of-water on Earth, trying to adapt and understand human customs and the second had the majority of the comedic beats coming from characters like Darcy and Selvig. After seeing the lackluster fan reception to thosefilms, Marvel decided to take him in a new direction.
RELATED:10 Thor Mannerisms From The Comics Chris Hemsworth Nails
Thanks to Taika Waititi's more improvisational comedic style, the character wasway morehumorous in Ragnarok,making it more similar in tone to Guardians of the Galaxywhich is likely why he blended soseamlessly with those characters in Avengers: Infinity War.
In Ragnarok, Thor realized that the only way to save Asgard from Hela was to destroy it, which meant saying goodbye to the realm forever. In the end, Thor learnsthat the physical location wasn't what was important but rather the people that made it up. The film ends with the citizens boarding a ship in order to escape the destruction and heading off in the direction of Earth.
In Endgame, Thor has established New Asgard on Earth inTnsberg, Norway. Despite the move being unplanned, the new location for the Asgardian's home wasn't chosen at random. Often regarded as the oldest town in Norway,Tnsberg has played a role in the MCU before with it being the location where the Frost Giants arrived centuries agoand is also where Odin spent his final moments before his death.
At the end ofEndgame, after a heartfelt goodbye in which heappointsValkyrie to the mantle on King of New Asgard, Thorboards the Benatar with the rest of the Guardians of the Galaxy. Ever since audiences saw himinteract with theteam in Infinity War, they have been asking for more and the ending of the Endgame, especially Thor referring to them as the Asgardians of the Galaxy, seemingly confirms thatwill be in Phase 4 of the MCU. While it is unclear how long Thor will be a member for, some of Guardians have even been confirmed to show up in his 4th solo movie, Thor: Love and Thunder.
Thor's longgolden hair had become a staple of the character, so it was surprising when, like many things inRagnarok, he was forced to give it up. Before his gladiatorial match on Sakaar, he wasordered by the Grandmaster to have his hair cut in a hilariousscenefeaturing one of Stan Lee's funniest cameos as Thor's barber with a metal hand made of varying blades. While the end result ended up looking pretty good, Thor later allowed his hair to get long again during theBlip, so it is unclear if he would return to the look going forward.
NEXT:MCU: 10 Worst Decisions Thor Has Made
Next10 Obscure (But Awesome) Sci-Fi Movies You can Stream Today On Amazon Prime
Wesley Bell is a writer based out of Silver Spring, MD. He has a passion for film, art, music and all other forms of artistic expression. When he is not spending his time writing, he enjoys watching tv and movies.
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MCU: 10 Ways Thor Changed Throughout The Movies | ScreenRant - Screen Rant
Posted: April 20, 2020 at 9:47 pm
In these trying times it can help to have a target to work towards, and lots of people have embraced home workouts during the COVID-19 lockdown, with the aim of getting fitter or losing weight.
However, we reckon a more precise target is better than those general goals, and heres a doozy learn how to do a handstand.
The School of Calisthenics has launched the #handstanduptocorona challenge to encourage people to do just that and, to help, is offering 50% off a virtual membership, which includes a comprehensive handstand training programme. The challenge is free to enter, and youre encouraged to use the challenge of achieving it to raise money for the NHS. The School of Calisthenics is doing its bit as well, donating 10% of its proceeds from virtual classroom sales throughout April to the Nottingham Hospitals Charity Help Our Hospital Heroes emergency appeal and the Robin Hood Fund.
To give you a flavour of whats involved we asked Tim Stevenson, co-founder and director of School of Calisthenics, for a workout that will help build the strength required for handstands.
Where there are different sets and time values to choose from, start with the smallest and gradually increase the volume over time.
Sets 1 Time 1-2min each hand Rest As required
If youre new to handstand training then it is important to ensure your wrists are prepared and conditioned, says Stevenson. This begins with mobilising the joint, which also helps to improve your ability to balance by helping to create alignment throughout the rest of your body when youre upside down.
Kneel and place one hand on the floor with your fingers facing forwards. Gently lean forwards, keeping the heel of your hand on the floor, and feel the stretch down your forearms. Start to move around in this position by rocking forwards and backwards, side to side and rotating the elbow. You will feel the wrist being mobilised and this will improve your range of motion. You can repeat this by spinning your hand around so your fingers face towards you to get a slightly different angle and mobilisation position.
Sets 2-3 Time 10-20sec Rest 60sec
Lie on your back with your hands behind your head, says Stevenson. Lift your feet, hands and shoulders off the floor and make yourself into a shallow dish shape. Imagine youre locking your ribs down on top of your hips like youre ready to take a punch in the stomach. Hold this dish shape without allowing your lower back to arch off the ground. If this is difficult you can bring your arms and legs higher so you make a deeper dish shape.
Sets 2-3 Reps 3-4 Time 10-20sec Rest 1-2min
Our handstand training process is split into three chunks, meaning we break the movement down and learn it from the bottom up, then the top down, and then connect in the middle, says Stevenson. The first bottom-up progression is the frog stand, which helps you to build confidence balancing on your hands for the first time and teaches you some of the basics of grip and balance.
Start by placing your hands on the floor, around shoulder-distance apart. Grip the floor with your fingertips so there is a little space between the floor and your fingers. Imagine youre screwing your hands outwards even though your fingers stay facing forwards. This helps to create stability around the shoulder.
Sit into a deep squat position, then rise onto your tiptoes and rest your knees on your slightly bent elbows. Push the ground down hard and rock forwards so that you can take one foot off the floor. As you feel more confident, try to take the other one off too. Practise this position until you can find the balance point. You can make this easier by trying to stack your hips above your shoulders and hands.
Sets 2-3 Reps 3-4 each side (more if youre having fun) Rest 1-2min
It might have been many years since you did a cartwheel but were going to bring it back because its an important part of building confidence for the handstand, says Stevenson. Cartwheels are a fun way to get upside down and they offer some conditioning for the wrist and shoulders, but most importantly they teach you how to bail out of a handstand. If you lose your balance against the wall or in free space its useful to know how to get your feet back on the floor safely.
Stand side on with your feet shoulder-width apart. Put your hands in the air and keep your arms straight throughout the movement. Initiate the cartwheel by simultaneously moving your hand down towards the floor and pushing off from your feet, letting your legs swing over your head. As you move over the centre point put your other hand on the floor as well and let your momentum take your feet all the way over to the other side."
Sets 2-3 Reps 3-4 Time 5-10sec Rest 1-2min
To learn to do a handstand your brain needs time to practise the fine motor control required to help you balance, says Stevenson. The wall kick-up allows you to do this in a way that progresses the difficulty until you can handstand next to the wall without touching it.
Place your hands on the floor about 20-30cm from a sturdy wall. In a split stance position like youre in the blocks at the start of a sprint, push upwards with the front leg and flick the back leg over your head. Progressively push and flick harder, allowing your head and shoulders to rotate between your biceps. The objective is to get your back leg to hit the wall and then bring your front leg to meet it so youre in a handstand position using the wall for support.
Its important to practise your alignment once in the handstand position. Keep your feet together and push your feet towards the ceiling to make yourself as straight, strong and long as possible. As you get confident you can try to take one foot off the wall, and then both feet and hold a handstand.
Sets 2-3 Reps 1-2 Rest 1-2min
The wall walk is a great handstand strength and stability builder, says Stevenson. It conditions your shoulders and wrists and improves the stability of your movement chain, all of which are important attributes for the handstand.
Start in a press-up position with your feet next to a wall. Lift your feet and place them on the wall and start walking your hands backwards and your feet up so you progressively start moving into a handstand. You can walk as far as you feel confident going, before walking your hands forwards again and back into the press-up position.
Sets 2-3 Time 5-10 minutes of practice Rest As required
This is the final piece of the puzzle and is a progression to try once you can kick up to a wall handstand without your feet touching the wall, says Stevenson.
Place your hands on the floor in front of you and assume the same split stance position you did with the wall kick-up. Push with your front leg and flick your back leg up over your head. Use the back leg like a pendulum so youre trying to position it above your head while the front leg stays at around 90. This helps to limit the amount of momentum going overhead which often causes people to topple over. Kick up and work on trying to find the balance position.
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Start Building Up To Do A Handstand With This Workout - Coach
Posted: April 20, 2020 at 9:47 pm
Trying to lose weight does not mean that a person has to give up all the snacks.Certain snacks, such as almonds and hummus, can help a person achieve their weight loss goals.Contrary to popular belief, when a person tries to lose weight, they dont have to avoid eating or just eat at mealtime.
Some studies suggest that people are more likely to maintain their weight loss if they have a healthy eating pattern.
According to the American Heart Association (AHA), skippingfoods to lose weightgenerally works against you because it causes a person to overeat.
However, when a person satisfies their hunger with healthy snacks, they are much less likely to want to eat unhealthy foods or exceed their calorie limit.
Eating healthy snacks can help a person lose weight.
Some foods are better for weight loss than others.
In general, foods rich in fiber or protein tend to fill more.This means that the person will feel satiated more quickly and will be able to eat less at each snack or meal.
Other considerations are finding foods that are low in calories but high in volume or density.The more space a food occupies in the stomach, the fuller the person can feel.Again, this helps a person eat less with each snack.
People may also want to consider foods that help with metabolism and energy.Greater energy can help a person burn more calories, and better metabolism can help a person process the food they eat more efficiently.
People looking to lose weight should avoid foods that contain large amounts of:
Unprocessed foods are good options because many processed snacks contain high levels of sugar, salt, or both.Eating snacks between meals can help you lose weight.Eating snacks with healthy options can help prevent someone from overeating, as well as provide vitamins, fiber, and protein.
The following are some of the best weight loss snacks.
Hummus is a traditional Mediterranean dish prepared with chickpea puree.Due to its increasing popularity, there are often several flavor options for premade hummus sauces available in stores.People can also make hummus at home.
According to a 2016 study, hummus offers many potential benefits.Hummus provides a good source of protein and fiber, which can help a person feel fuller faster.
When people eat hummus with vegetables, they are getting the benefits of hummus, as well as any other additional nutrients from vegetables.
Celery is a low calorie vegetable.According to the United States Department of Agriculture (USDA), two large stalks of celery count as 1 cup of vegetables out of the 2.5 cups needed per day for a 2,000-calorie diet.
Celery is primarily water, which can help a person feel full.Dipping celery in nut butter, such as peanut or almond butter, can also provide the benefits of healthy fats and protein.
Apples and peanut butter are a good diet snack.
People can be creative with their fruit and nut butter combinations if they want.According to the USDA, a medium apple provides 20 percent of a persons dietary fiber, and 1 of the 2 recommended cups of fruit each day.
Dipping a slice of apple in peanut or other nut butter also adds protein and good fat to a persons snack.
Low-fat cheese is a source of protein and calcium.
Low-fat cheese products offer many nutrients and less fat than regular cheese.
Some of the benefits include:
Low-fat cheese also contains fewer calories than whole cheese.
What can be eaten with a low carb diet?Here are some tips for a low carb diet.
Walnuts can be a very healthy and filling snack.
Walnuts provide good protein and fat.However, those looking to limit their salt intake should check the label to make sure there is no added salt.Also, a person should avoid flavored cooked nuts, as flavors often contain sugar or salt.
People should look for raw or dry roasted nuts.Walnuts are relatively high in calories, so a person should only eat a small amount per snack.
Eggs are an excellent source of protein.However, in previous years, many people thought that eggs were unhealthy due to concerns about cholesterol.
However, more recent research suggests that eggs do not raise cholesterol levels and contain many essential nutrients.
Greek yogurt is high in protein and calcium and low in fat and calories.A person can safely add fresh fruit or nuts to Greek yogurt to improve its flavor and add nutritional value.
The best Greek yogurt for weight loss is the simple variety.Greek flavored yogurts often contain extra sugar, which is not good for weight loss.
Edamame is a legume that a person can eat as a snack.Like other legumes, edamame is a source of fiber and protein.
It is also high in potassium, iron, and magnesium.When people eat it between meals, edamame can help a person feel more satisfied while providing some essential nutrients.
Popcorn is a popular snack in the U.S.Often you get a bad reputation because of the extra amount of sugar, fat, or salt that people put on you.
Air-popped popcorn does not contain these additional ingredients. Simple popcorn is a low-calorie whole grain that offers plenty of filling fiber.
A person may find it helpful to prepare healthy snacks beforehand.
The most effective way to add healthy snacks to your diet is to keep a stock of them in an easily accessible location.
For example, a person could prepare a week of snacks at the beginning of the week.Once prepared, the person can divide the sandwich into individual portions.
For example, a person can prepare hummus in a large batch at the beginning of the week by mashing chickpeas with olive oil, tahini, and seasonings in a food processor.
After preparation, they can put the hummus in small containers and accompany each container with a bag of carrot sticks.
Those who dont have time to make their own sandwiches can search for sandwich-sized portions sold at grocery stores.Many products come prepackaged in snack sizes.
People looking for pre-made and proportioned snacks should know that they are often more expensive.They will also have to be on the lookout for added sugars, salt, and fat.
Eating healthy snacks can play an important role in helping a person lose and control their weight.
People should look for snacks that are low in sugar, fat, and salt.They should also look for snacks rich in nutrients like fiber and protein.
Beans, nuts, and raw vegetables and fruits are often good choices that will help a person feel fuller and provide the necessary nutrients.
Nichole Kerr is a reporter for SYP Studios. Sarah has previously worked for Wired, MacWorld, PCWorld, and VentureBeat covering countless stories concerning all things related to tech and science. Nichole studied at Anthem Institute in Las Vegas.
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Why does your cat poop in the house? - SYP Studios
Posted: April 20, 2020 at 9:47 pm
Seventeen days in hospital.
Eight of them on a ventilator.
The helpless shock of your body learning how to breathe again.
"The best way I can describe it is imagine someone holding a cushion against your mouth and nose.
"Very occasionally it slips, giving you just enough breath to keep going."
Paranoia, post-traumatic stress disorder and 'horrifying, untrue' hallucinations, some violent.
Patients dying six feet away.
A Covid-19 survivor who fought and won has shared in graphic, personal detail exactly what it's like to battle the virus by revealing a daily diary of his experience he wrote to aid his recovery after returning home.
Peter Julian is 54.
He said he wanted to share his story with the Manchester Evening News not to shock or scare.
"I want people to understand what this is," he said.
Peter doesn't smoke, had no pre-existing health conditions and said he's only had three days off work sick in the last decade.
He admits to a little 'middle-age spread', but exercises every day at home and cycles 30 miles a week.
But Covid-19, he said, respects no one and no circumstance.
The day the UK went into lockdown, father-of-three Peter, a business consultant, woke up at home in Sale, Trafford, with a few aches and pains.
Seven days later, he couldn't breathe to even speak and was rushed to an intensive care unit at Wythenshawe Hospital.
What followed over more than a fortnight is detailed in his entries.
Peter told of 'rows of people two feet apart all going through the same terror'.
Post-traumatic stress disorder, he said, was common for any patient leaving intensive care.
But Peter arrived back home to his family on Saturday.
In a moving gesture, neighbours left their houses to cheer and applaud as the car pulled onto the driveway. Messages chalked on pavements and signs in windows proclaimed 'welcome home Pete'.
"Having narrowly survived Covid- 19, I wanted just to write up my own personal experience," he said.
"I would like you to share as much of this as you want to, to as many people as you want.
"My main message is that the Covid 24-hour rolling news, and even the government and NHS websites, are at best very generalised news and could mislead you.
"You may conclude you are at no risk or at high risk. Neither is likely to be true.
"I would be lying to you if I didn't say there were a number of times when I just wanted to give it up and join my dad.
"That thought was inviting and almost comforting. However, I knew I had a legion on my side who I wasn't going to let down.
"Our NHS are truly the heroes.
"They kept me and thousands of others alive, whilst putting up with enormous trauma in exchange for somewhere between 9.23- 10.20 an hour in day, and 13 at nights.
"Their culture is just to stoically get on with things. Whilst brilliant and inspiring, this can work against them.
"This is going to be around for a year at least.
"Just in the time I was in hospital, the medics were rapidly learning the correct drugs cocktail to increase likelihood of life.
"The longer they get, the more of us will survive."
Monday, March 23 : Had some aches and pains. Given the news, I went onto the NHS Covid-19 checker. Based on the list, I had no symptoms and therefore guessed at worst it was some other seasonal flu.
Tuesday, March 24 : I planted out some potatoes and carrots in a plot. Felt absolutely fine.
Wednesday, March 25 : Woke up with aches. Given I still had no symptoms, I assumed it was either seasonal flu, me maybe over-doing the digging, or a combination of the two.
Friday, March 27 : It was a lovely sunny day. I never sleep in the day, but fell asleep in the garden. So, if nothing else, I later went on to have best tan in the intensive care unit.
Weekend of March 28/29 : Started feeling breathless.
Re-checked my symptoms. With exception of breathlessness, I had no others. Stayed in bed again assuming flu.
Monday, March 30 : Increasingly concerned, so I called paramedics. They came and took my vitals. No swab kits - so they said I may have Covid-19 based on some symptoms.
My profile, coupled with the observations, made them conclude I was in the two weeks/in bed/bit of paracetamol category.
They said I had none of the symptoms, re-confirming what I thought I knew and, in any case, I did not meet meet the criteria in terms of risk, age, etc.
Again, re-confirming what I thought I knew.
Wednesday, April 1 : Breathlessness increased.
Decided that if it continued into the following morning, I was calling 999 regardless.
Thursday, April 2 : My wife, Carol, called an ambulance as I could not speak due to breathlessness. Had some paracetamol prior to them arriving. My temp was 39.1C versus top range of 37.5.
My blood oxygen was really low. Rushed into intensive care. I was put on a ventilator as my body could not survive unaided. They brought me off at 9am on the 7th, five days later, thinking they had won.
By 9.45pm the same day, they had put me back on as my body was unable to exist without it. Even intensive care was shocked.
What's interesting is that from a patient view, whilst medically this is the worst part, personally it was fine. I was out of it, so unaware of anything.
I could have been on it one day or 10 years, alive or dead. I wouldn't have known.
Friday, April 10 : After nine days on the ventilator, I was brought off. This is the first instalment of difficult times.
So, whilst medically the good news is your body can now breathe, with help of massive oxygen levels, the experience is terrifying.
The best way I can describe it is imagine someone holding a cushion against your mouth and nose. Very occasionally, it slips giving you just enough breath to keep going.
Also a combination of the drugs and Covid-19 bacteria means everyone is hallucinating.
Finally remember we are all on lockdown, so no visitors Just rows of people two feet apart all going through the same terror.
Every day someone dies in front of you or has CPR. Ribs and sternums breaking all around you.
Saturday, April 11 : Yippee! Moved off intensive care onto a Covid-19 specific general ward. The breathing and hallucinations continued for everyone - however this is really the start of what I can remember.
A note of caution. In your own mind, the hallucinations are absolutely real, so from here on in, whatever I say may or may not be true. Where I have fact-checked, I will mark it as true.
Otherwise, it could be either.
Another key point is everyone is suffering from a form of PTSD associated with Covid. It is a well-established fact that anyone who has been in intensive care for any reason reacts to the outcome.
Paranoia and active hallucination are part of this. How it is expressed will vary by individual. Some people just make bad decisions, some have pleasant, benign hallucinations and others have terrifying active ones, where people are coming to torture and kill you.
The cause of the hallucinations is the trauma. But it can also be the ongoing fight with bacteria, medication not yet being quite balanced for you, or something as simple as a water infection or constipation.
The benign ones I had are as follows.
I went on a cruise around the South China sea, spent a night at Lagos airport, spent a night at an aquarium. Had X-mas lights on the bed and a firework display every night.
It is something that has touched all our lives.
From cradle to grave, the National Health Service is a part of British life.
Today, more than ever, we should cherish those who dedicate themselves to our care as they work tirelessly to care for people in the face of the coronavirus pandemic.
So lets show them some love, and create a living map of gratitude from every corner of Britain.
Click HERE to drop a heart on the map, and show you appreciate the efforts undertaken daily in the NHS.
I also told all the staff Millie [Peter's daughter] and Carol were in Finland. Obviously, I couldn't tell them about Millie dating Romeo Beckham, as I had signed the confidentiality clause.
I would have bet you five years' wages this was all true.
But wherever I went in the world, weirdly the staff seemed the same and spoke with Manc accents. Who knew?
The horrifying untrue ones that I had were that people were coming to kill me. There was also a wolf in the ward, a giant and men with machetes all coming to do me immediate harm.
All I knew was that I was going to attack first and not be on the back foot.
My only problem was I was still on oxygen, could not walk at all, could not talk, was on a drip for fluids and food an on a catheter, making my fighting skills lower than their previous 'wet paper bag' prime.
Wednesday, April 15 : Literally first steps and first day I can talk. Maybe managed four steps?
The horrific hallucinations get worse.
I know what I need to do. Yep, pro-actively kill any man, other than my fellow patients, that I come across before they kill me. Ladies. You will be pleased to know you were all off the death list.
Thursday, April 16. 8.45am : Go to physically attack as many men as possible, armed with plastic cutlery despite not able to walk. Security are called. I explain to the three, strong, experienced guys aged in their 30s that I am going to kill all of them.
Safe to say I was safely restrained in about 30 seconds.
My pal wakes up. He said that whilst my implementation was poor, no one could take away my ambition!
In reality, I felt dreadful.
The 'all hands to the pump' approach in the NHS meant some nurses knew what they were seeing was PTSD and some just thought they had a raging madman on their hands.
Carol rang about 9am-ish to ask what type of night I have had. Suffice to say, the answer wasn't really the one she wanted.
I felt terrible. I know what these staff are going through and felt awful that I had added to their workload and worries. The guilt was crushing.
My son Tom is a junior doctor working in Covid-19 in Sheffield. He had just finished a 12-hour night shift.
He rang in to check my night.
Again, was not the answer he wanted, but he did a great job in talking me down and suggesting that maybe rather than killing all medics, I might find they were there to help me.
Friday, April 17 : Play around with meds, fluids etc and move ward.
First night of non-horrific hallucinations. Also, on solid food.
Saturday, April 18 : Released home - hoorah!
I reckon about four to nine months to deal with the physical effects- loads of body muscle gone and about 1st 8lb in weight. Then there is losing the trauma.
I reckon I saw someone die or have CPR daily and within six feet of me. That's going to take time to process.
They reckon for everyday in an ICU, it will be around a week of recovery afterwards.
Peter spoke out to praise the 'sheer compassion and professionalism' of all the NHS staff, included those who have already served their time but have bravely gone back to the frontline during the pandemic.
He said having a belief system helped get him through.
"I also thought I had lots to live for - my family," he said.
"Lots of people sit there, getting institutionalised and waiting for decisions to be given to them. I maintained my own responsibility for my own outcomes and challenged where needed.
"This was important as you need to remember the only people used to dealing with Covid symptoms are intensive care staff.
"Most other doctors and experienced staff hadn't properly understood the trauma.
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Learning to breathe again: Between life and death on the coronavirus ward - Manchester Evening News
Posted: April 19, 2020 at 4:46 pm
Some healthy foods rich in protein and fibre can make you feel full for a long time. They can also reduce your appetite, slowing down the digestion process. This process will eventually contribute to weight loss making you eat less.
Weight loss is the most concerning health problem amongst us. We are always conscious about weight gain for which we try to maintain a strict diet and workout regularly. After all this, we may often gain some extra kilos and get tensed about it because shedding that extra fat is way tougher than gaining them. Other than that, we tend to try different remedies for weight loss. But we can lose and control our weight just with our food as well. Eating should not be stopped at all for it.
One simple and easy way of weight management is less eating and that can be possible when we feel full. Some types of food can give you a feeling of satiety. Those filling foods can help you cut down on your sudden hunger pangs and your portion of foods. Feeling less hungry will eventually make you eat lesser which will contribute towards weight loss and control.
Foods for Satiety: 15 types of foods to get the feeling of satiety.
Boiled potato
This vegetable is a good source of vitamin C, potassium, fibre and protein. They have also high water content and carbohydrate. And boiled potatoes are more filling than any other high-carb foods. Because they have the proteinase inhibitor protein in them which may also suppress appetite.
Oatmeal
Oats are a great option for breakfast. They are rich in fibre and can provide you with a high satiety feeling. Its filling power comes from its high fibre content and the ability to soak water. This will also help you to have fewer calories at lunch.
Eggs
Eggs a great source of protein that has all kinds of essential nutrients. Eggs are also good for our eye health and it gives us a great feeling of satiety. Breakfast with eggs is a great idea as it's packed with all kinds of amino acids.
Fish
Fish is fully loaded with protein and omega-3 fatty acids, which is extremely essential for our health. And in terms of giving the feeling of fullness, fish is the most powerful one than any other protein-rich foods, especially for people who are overweight and obese. Research says, between fish and chicken, fish can give you the strongest feeling of satiety.
Meat
Meat, especially lean meat, is a good source for satiety after fish. They are highly rich in protein. In a research, it has been seen that people who consume meat at lunch have less dinner than those with high-carb lunch.
Greek Yoghurt
Its generally thicker than normal yogurt and contains higher protein as well. Greek yoghurt can make you feel full for a longer period. Its a great breakfast and afternoon snack option which will make you less hungry and eat less at dinner.
Veggies
Vegetables are always highly packed with all kinds of important nutrients- vitamins and minerals. They have a low amount of calories and a high amount of water and fibre. They are also filling foods to make you less hungry.
Soups
A research has shown that soups can be more filling than any other solid foods. And they also take a longer time to leave the stomach.
Cottage Cheese
Cottage cheese or Paneer is low in calories and fats and high in protein. Its protein content has a strong impact on fullness. A study showed that the filling effects of cottage cheese are similar to that of eggs.
Legumes
Legumes like lentils, beans, peas and peanuts have all kinds of important nutrients. They are rich in fibre and a great source of plant-based protein. Legumes have also great effects on the feeling of satiety.
Fruits
Fruits have low energy and high fibre content. They slow down the process of digestion which makes it potential for the fullness. Mostly, orange and apples are the strongest ones for the satiety feeling. But its important to have solid fruits rather than juices.
Nuts
Nuts, mainly almonds, and walnuts have a high energy density. Its rich in nutrients, fats and proteins and its also a great option for snacking. They also give us a high feeling of satiety.
Coconut Oil
Coconut oil comes with a unique combination of fatty acids which can be turned into ketone bodies in the liver. And ketone bodies are known to reduce our appetite.
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Weight Loss Tips: THESE healthy foods can give you the feeling of satiety and aid in shedding extra kilos - PINKVILLA
Posted: April 19, 2020 at 4:46 pm
You can ask anyone who is battling obesity or extra kilos, and they will all tell you the same thing. It is the difficulty of carrying your own weight that becomes troublesome and exhausting after a point of time. For 30-year-old Rohit Prakash, it was the very fact that he wasnt able to walk properly that served as a wake-up call for him. He decided that enough was enough and he needed to get back in shape.Name: Rohit PrakashOccupation: Service
Age: 30 yearsHeight: 5 feet 6 inches
City: Hyderabad
Highest weight recorded: 99 kgs
Weight lost: 20 kgs
Duration it took me to lose weight: 7 monthsThe turning point: Earlier, my whole life revolved around eating the delicacies of my choice and my work. However, soon this lifestyle landed me in a situation where I wasnt even able to walk properly on my own feet. It left me really troubled and I visited a doctor the very next day. The doctor simply told me that I needed to change my lifestyle if I wanted to get back on my feet.
Even though I tried making certain changes, it did not last long. Eventually, it was only my father's words that pushed me to make a fresh start. Seeing my plight, he had simply asked me to "be the change and write a new chapter."
From that day onwards, there was no looking back. Things actually began to look up for me as my friend introduced me to a fitness studio and motivated me to be the best version of myself. Trust me, things were not at all easy in the beginning and only I know how hard it has been to reach so far. It has been a long, taxing journey but certainly worth it.
My breakfast: 5 boiled egg whites with 2 slices of brown bread with peanut butter and 1 whole orange or any other whole fruit
My lunch: Carrot, beetroot and peanut salad with grilled chicken and sauted vegetablesMy dinner: Grilled fish with sauted vegetables or 200 grams of soya paneer with sauted vegetables
Pre-workout meal: Black coffee with 5-6 soaked almonds. I have it around 15 minutes before working out
Post-workout meal: My protein shake and it has to be taken within 15 minutes of working out
I indulge in: More or less, I do not believe in the concept of cheat days. So, whenever I crave for litti with ghee (a Bihari delicacy) and Thai curry with Jasmine rice, I do indulge in them.
My workout: I used to work out for 1.5 to 2 hours and it included cardio, muscle and weight training. I used to exercise for 6 days a week along with swimming twice a week.
Low-calorie recipes I swear by: I vouch on spiced chicken and spinach. All you need to do is boil some spinach and chicken, cook it with a dash of olive oil and top it off with few herbs and spices.
Fitness secrets I unveiled: Eating the right food is very essential to staying fit and healthy along with good sleep and drinking a lot of water. You should try to stick to the basics and you will definitely get good results.
How do I stay motivated? I have put a goal chart in my room and I look at that every day. It motivates me to chase my fitness dream. Also, whenever I feel low, I close my eyes and visualize all the good things that have happened in my life to date which motivated me to continue my weight loss dream. And even on days when I feel a little down and out, my trainer Naveen and my fitness partner Sudhir are always there to pull me back up.
How do you ensure you dont lose focus? I believe that I am still on my weight loss journey, irrespective of the weight I have lost. This ensures that I do not give up or lose my focus. I also surround myself with positive and inspiring people who help me stay focussed to the path of fitness.
Whats the most difficult part of being overweight? Undoubtedly, the worst aspect of being overweight is the fact that you are not able to carry your own weight. It is upsetting and saddening both, but it also starts bogging you down mentally. I had also reached a point where I was doubting my own potential because of my growing weight.
What shape do you see yourself 10 years down the line? I have realised that your shape actually does not matter when it comes to measuring how healthy you are. So, I actually want to be healthy, both physically and mentally in the coming 10 years.
Posted: April 19, 2020 at 4:46 pm
Analysis Report on Weight Loss and Obesity Management Market
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Some key points of Weight Loss and Obesity Management Market research report:
Strategic Developments: The custom analysis gives the key strategic developments of the market, comprising R&D, new product launch, growth rate, collaborations, partnerships, joint ventures, and regional growth of the leading competitors operating in the market on a global and regional scale.
Market Features: The report comprises market features, capacity, capacity utilization rate, revenue, price, gross, production, production rate, consumption, import, export, supply, demand, cost, market share, CAGR, and gross margin. In addition, the report offers a comprehensive study of the market dynamics and their latest trends, along with market segments and sub-segments.
Analytical Tools: The Global Weight Loss and Obesity Management Market report includes the accurately studied and assessed data of the key industry players and their scope in the market by means of a number of analytical tools. The analytical tools such as Porters five forces analysis, feasibility study, and many other market research tools have been used to analyze the growth of the key players operating in the market.
COVID-19 Impact on Weight Loss and Obesity Management Market
Adapting to the recent novel COVID-19 pandemic, the impact of the COVID-19 pandemic on the global Weight Loss and Obesity Management market is included in the present report. The influence of the novel coronavirus pandemic on the growth of the Weight Loss and Obesity Management market is analyzed and depicted in the report.
The global Weight Loss and Obesity Management market segment by manufacturers include
market segmentation.
Chapter 16 Middle East and Africa Weight Loss and Obesity Management Market Analysis 2013-2017 and Forecast 2018-2028
This chapter provides information about the growth of the weight loss and obesity management market in the major countries of the MEA region, such as GCC Countries, Turkey and South Africa, during the period 2018-2028.
Chapter 17 Emerging Countries Weight Loss and Obesity Management Market Analysis 2013-2017 and Forecast 2018-2028
Readers can find important factors that can significantly impact the growth of the weight loss and obesity management market in emerging countries like China, India, and Brazil during the forecast period based on the market segmentation.
Chapter 18 Competition Landscape
In this chapter, readers can find a comprehensive list of all the leading manufacturers in the weight loss and obesity management market, along with detailed information about each company, which includes the company overview, revenue shares, strategic overview, and recent company developments. Some of the players featured in the weight loss and obesity management market report are Novo Nordisk A/S, GlaxoSmithKline plc., F. Hoffmann-La Roche AG, Allergan Plc, Johnson & Johnson Services, Inc, Medtronic plc., Vivus Inc., Eisai Co., Ltd., ReShape Lifesciences, Inc, Obalon Therapeutics, Aspire Bariatrics, Allurion Technologies Inc., Nalpropion Pharmaceuticals, Inc., Beijing Noble Laser Technology Co., Ltd, and others.
Chapter 19 Assumptions and Acronyms
This chapter includes a list of acronyms and assumptions that provide a base to the information and statistics included in the report.
Chapter 20 Assumptions and Acronyms
This chapter helps readers understand the research methodology followed to obtain various conclusions and important qualitative information & quantitative information about the weight loss and obesity management market.
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Important queries addressed in the report:
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