Category Archives: Lose Weight Fast

The prevalence of obesity was 39.8% and affected about 93.3 million of US adults in 2015~2016, according to data from U.S. Centers for Disease Control and Prevention (CDC).Gelesis is a Boston-based biotech startup developing therapeutics to safely treat obese, overweight, and diabetic patients.

Over the weekend, the company announcedit hassecured $84.6 million in new funding to support the U.S. launch of Plenity in the second half of 2020.This latest round of equity funding, which totals $63.4 million, was led by private equity firm Vitruvian Partners and included other investors. Gelesis has raised nearly $100 million this year to support the U.S. launch of its flagship product Plenity.

Gelesis was co-founded in 2006 byYishai Zohar andPureTech Health, a clinical-stage biotechnology company dedicated to discovering, developing and commercializing highly differentiated medicines for devastating diseases. Its lead product, Gelesis100, is an orally- administered smart pill which is constructed of materials that are General Recognized as Safe (GRAS) by the Food and Drug Administration (FDA).Each Gelesis100 capsule contains thousands of hydrogel particles approximately the size of a grain of salt that expand to 100 times their dry weight. The pill is designed to act mechanically in the stomach and small intestine to increase satiety and decrease hunger, resulting in reduced caloric intake and weight loss.

We are delighted to begin this partnership with Vitruvian, whose mission of driving rapid growth and change across industries is very much aligned with our approach to launching this first-of-its-kind product that could potentially make a difference in the lives of people struggling with excess weight, said Yishai Zohar, founder and chief executive officer of Gelesis. With this new capital, we are well-positioned to enhance our strategic launch initiatives and leverage our early commercial experience as we prepare for large scale commercial availability of Plenity in the U.S.

Based upon the Gelesis proprietary manufacturing facility location, the company was also awarded a grant of $12.9 (11.7) million from the European Regional Development Fund (ERDF), regulated by the Puglia Region of Italy. This builds on the $10.6 (9.4) million grant announced in April 2019 and brings the total non-dilutive funds secured this year to $23.5 million. The company also further enhanced its financial flexibility by entering into a long-term, low interest $8.3 million loan agreement.

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Biotech startup Gelesis raises over $84 million to support the U.S. launch of Plenity, a drug for treatment of obesity and other gastrointestinal...

By Jay L. Zagorsky, Boston University

Gift giving is a big deal this time of year.

To find the perfect gift, Americans will spend about 15 hours shopping. Women will do about twice as much as men. And theyll shell out about US$1 trillion on gifts.

While retailers relish the holiday shopping season as a time when consumers open their purses or wallets, for many consumers especially those who do not like shopping these days are filled with dread. They mark moments when shoppers clog malls, websites become overloaded and delivery trucks block streets. The entire process generates untold amounts of stress and anxiety.

Jay Zagorsky, Boston University

One source of stress is just how much to spend on gifts. Spending too much can put you in financial distress. Spending too little may make you look cheap.

How do you decide whats the right amount to spend on gifts?

As an economist, I study holidays and gift giving because a large fraction of retail shopping is driven by seasonal events like Black Friday, Cyber Monday and Super Saturday also and more appropriately known as Panic Saturday which is the last Saturday before Christmas.

Dead weight loss

Gift giving is stressful because nobody wants to buy what they think is a perfect gift only to discover it is a dud.

The long lines of people returning items after the holidays seem evidence enough for that.

This has led some economists to argue theres a dead weight loss to Christmas presents that destroys as much as a third of their actual value. A 2018 study estimated Americans spend $13 billion a year on unwanted gifts.

Other economists, however, have resisted this Scrooge-like view of gift giving and point to evidence that a present can actually have more value to the recipient than the price the giver paid. In other words, a gift, even when technically unwanted, could have more value simply because someone else bought it for you.

Setting a budget

So if youre dead set on buying some gifts, how much should you budget for it?

Since gifting is a social act, it makes sense to consider how much other people typically spend.

There are a number of surveys run each year that ask people during the fall to estimate what they plan on spending for holiday gifts. The National Retail Federations annual survey of holiday spending estimates the typical American will spend $659 on gifts for family, friends and co-workers in 2019. On the high end, Gallup puts the average at $942, with more than a third of respondents expecting to spend over $1,000 on gifts.

But these figures arent that helpful for an individual since $659 means something different to someone making $40,000 a year versus $200,000.

Thats where the Consumer Expenditure Survey comes in. Its a large survey run by the Bureau of Labor Statistics that tracks the spending habits of 12,000 to 15,000 families each year. The government uses the survey to determine the cost of living and inflation rates for the typical family.

The survey follows gift giving very precisely. It has categories for common holiday presents like electronics, books and clothes, as well as gifts that typically arent associated with the season such as housing and transportation.

After removing these non-holiday gifts, the typical U.S. family spends about 1% of its annual take-home pay on gifts. So whatever you earn, you could multiply it by 1% to get a figure that is in the ballpark of what the average American spends but wont break the bank.

Making the holidays memorable

While calculating a gift budget is one way to take the stress out of how much to spend on gifts, my family has another: Only give gifts to children.

Adults get wrapped boxes filled with paper. After the real gifts are opened and the young children are safely moved out of the way, we crumple up the paper and throw it at each other in our annual paper fight.

That keeps the cost down while making the kids feel special. It also ensures the kids dont feel left out when their friends talk about the gifts they received. Other families follow their own methods for controlling expenses, such as secret Santa gifts or by focusing attention more on togetherness than on the stuff received.

Whether you have a paper fight or follow another family tradition, my main message is that it doesnt take very much money to make the winter holidays memorable.

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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How to Pick the 'Right' Amount to Spend - WCAI

Anaplasmosis is a disease caused by bacteria affecting red blood cells in ruminants including cattle. While livestock of all ages can be infected with the illness, it is rarely fatal to the young, but quite serious in adult animals. It can cause abortion, weakness, rapid weight loss, and even death. Anaplasmosis is contracted by either biting horse flies or ticks as well as via dehorning, needles, as well as surgical or tattoo instruments if the equipment is not properly cleaned after each use. The disease is on the rise and found throughout Kansas including Barton and Ellis counties. Education and proper practices are key to keeping your cattle healthy.

On Dec. 18, the Cottonwood Extension District will host an Anaplasmosis and safe vaccine handling program in both Ellis and Barton counties. Dr. Gregg Hanzlicek, DVM from KSU College of Veterinary Medicine will discuss what you need to know about Anaplasmosis and how to prevent it in your herd. I will also talk about vaccines and how to safely handle and administer to your livestock.

In Great Bend the program is set at the American Ag Credit building at 5634 10th St. from 8:30-10 a.m. Following in Hays the program will be presented from noon to 2 p.m. at the Ellis Co. Extension office at 601 Main St. Please RSVP to me at 620-793-1910 for either program to insure enough program materials are available. Snacks and a noon meal will be provided by the Kansas State Veterinary Diagnostics Laboratory.

If you have any questions, or would like more information, you can contact me by calling 620-793-1910, by email at aboor@ksu.edu or just drop by the office located at 1800 12th St. in Great Bend.

Alicia Boor is the Agriculture and Natural Resources agent with K-State Research and Extension Cottonwood District. Contact her by email at aboor@ksu.edu or call 620-793-1910.

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Anaplasmosis and vaccines in livestock - Great Bend Tribune

Do you know the way to San Jose? It doesn't matter if you're in a self-driving car. As they previewed earlier this year, Bosch and Mercedes-Benz have commenced trials for an automated ride-hailing service in the Silicon Valley city of San Jose. To start with, autonomous S-Class Mercedes-Benz vehicles (with safety drivers at the wheel) will shuttle "a select group of users" between North San Jose and downtown.

The busy San Carlos/Stevens Creek corridor between west San Jose and downtown should be good test for the self-driving tech used by Mercedes and Bosch. Rather than just playing with prototypes, the companies want to create a production-ready SAE Level 4/5 self-driving system that can be built into different makes and models. To do that, they're using a combination of AI, a million-square foot proving ground in Stuttgart and the real world San Jose ride-hailing tests.

San Jose is expected to grow by 40 percent over the next two years, so the city wants to see the impact of autonomous cars. "We want to know more about how automated vehicles can help improve safety and reduce congestion, as well as make mobility more available, sustainable, and inclusive," said San Jose project director Dolan Beckel in a statement. "If automated driving is to become everyday reality, the technology has to work reliably and safely."

Mercedes-Benz and Bosch for an app-based ridesharing servic

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Mercedes and Bosch commence self-driving trials in San Jose - Yahoo News Australia

An interesting new clinical study is suggesting restricting food intake to a 10-hour window each day may be a simple yet beneficial way to help treat metabolic syndromes such as diabetes or heart disease. The 12-week pilot study revealed the eating intervention, in conjunction with prescribed medicines, improved patients health outcomes.

One of the more fascinating dietary fashions to arise in recent times is known as time-restricted eating (TRE). Instead of interspersing whole days of fasting across a week or month, this eating strategy looks to limit your caloric intake to short windows of time in a given 24-hour period. Generally, TRE methods suggest only eating between four and eight hours a day, meaning a fasting stretch of 16 to 20 hours.

One of the theories underpinning these dietary strategies is that restricting eating to a limited time window better synchronizes a persons caloric intake with their circadian rhythms. Epidemiological studies have found a majority of people spread their food intake over at least 15 hours a day. As little as 10 percent of people compress all their meals into a 12-hour-or-less stretch each day. While some research is building to suggest health benefits to only eating in four- to eight-hour windows, this new study set out to find out whether a 10-hour eating window could be just as beneficial.

"There has been a lot of discussion about intermittent fasting and what time window people should eat within to get the benefits of this kind of diet," explains Satchidananda Panda, co-corresponding author on the new study. "Based on what we've observed in mice, a 10-hour time window seems to convey these benefits. At the same time, it's not so restrictive that people can't follow it long-term."

To test the eating strategy on human subjects a team of researchers from the Salk Institute and the University of California, San Diego, conducted a small pilot study. They recruited 19 subjects, most classified as obese and receiving pharmacological treatment for a diagnosed metabolic condition. All subjects self-reported prior eating patterns spanning at least 14 hours a day.

The intervention tested was incredibly simple. Subjects were directed to continue regular diets and exercise but simply compress any caloric intake to a 10-hour window each day, essentially letting their bodies fast for 14 hours across every 24-hour cycle.

For such a small and simple intervention the results were somewhat impressive, with an average three to four percent reduction in body weight and body mass index seen across the entire cohort after three months. Alongside self-reported improvements to general energy levels and sleep quality, the cohort displayed reductions in cholesterol levels and blood pressure at the end of the 12-week trial.

"We told people that they could choose when they ate their meals, as long as they remained within the 10-hour window," says Panda. "We found that universally, they chose to eat breakfast later, about two hours after waking, and to eat dinner earlier, about three hours before going to bed."

The researchers behind the new study are well-aware of the numerous limitations behind such a small trial. Most notably the trial did not include a control group which makes it certainly difficult to clearly correlate the final result with the studied eating intervention. Duane Mellor, from Aston University, points out the lack of control isnt the only problem with this particular study.

In the case of this study there are lots of limitations, not just the lack of a control group a key one being that the act of recording food intake has been shown in other studies to reduce calorie intake and help with weight loss, says Mellor, who did not work on this new study. Also, although lots of tests were done on the participants, it seems unclear how they justify the conclusion that improvements were seen independent of weight change as there simply was not a big enough number of people to make this assessment.

So, were the beneficial effects seen in this study directly related to the TRE strategy? Or were the health improvements more a reflection of the diet indirectly lowering overall caloric intake and making the cohort more aware of their eating patterns?

Its possible to over speculate that time-restricted eating is a magic bullet to health whereas it may be that its just through calorie restriction, suggests Jenna Macciochi, an immunologist from the University of Sussex. On the flip side, for people who are struggling with fad diets it may be a useful tool and help compliance.

Macciochi, who did not work on this new research, does point out the most encouraging part of the new study is that it highlights how easy this particular dietary modification can be implemented and sustained. The compliance rate for the trial was very high, with a significant number of the participants reporting continuing the dietary strategy, in some form, for up to a year. This suggests, unlike some other intermittent fasting or TRE diets, a 10-hour daily eating window is relatively easy to integrate into a persons life, and can be maintained for extended periods of time without too much trouble.

So, moving forward the next step for the researchers is to better verify the metabolic benefits of this eating plan in larger cohorts. A clinical trial is already underway in a much larger group with the hopes of understanding the physiological effects of what could essentially be called a 14:10 eating plan.

The new study was published in the journal Cell Metabolism.

Sources: Salk Institute, Cell Press

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Trial suggests fasting 14 hours a day helps diabetes and weight loss - New Atlas

The snake diet is an extreme fasting plan that is currently gaining popularity among people who are trying to lose weight. Its has been debated against by several health professionals. Heres everything you need to know about the dangerous new weight loss diet:

The controversial diet was designed by a trainer named Cole Robinson (who doesnt have any qualifications or backgrounds in the field of medicine, biology, or nutrition) who lives the way a snake does. It is designed to mimic the way wild animals like snakes eat. The overall plan is to eat only one large meal and then fast for the remaining of the day, or even for a few days altogether. And throughout the fasting times, you are allowed to drink only the snake juice which is made using water, sea salt, sulfate salts, baking soda, and potassium chloride. The creator of this diet who made this drink opines that it will help replenish the electrolytes in the body.

The advantages of the snake diet according to its creator are:

And heres what experts opine:

Alternate day fasting may lead to successful weight loss. Photo: Image by PublicDomainPictures from Pixabay

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This Dangerous New Weight Loss Diet Encourages You To Fast For Most Of The Day - International Business Times

THEY are often deemed the enemy when it comes to weight loss - with many believing they ruin an otherwise good diet.

However, it seems as though carbs actually have an unnecessary rep - as one expert has finally debunked this myth.

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In particular, personal trainer Terry Fairclough has emphasised that carbohydrates can actually speed up weight loss and help the body to function to the best of it's ability.

The nutritional therapist, from Your Body Programme, said: "These foods are essential for good health as they are full of important nutrients, antioxidants, enzymes, polyphenols and fibre which is all the more reason to make sure we arent cutting these foods out of our diets.

"Yes, its true that eating the wrong type of carbs, in the wrong amounts, at the wrong time of day can contribute to fat gain, but so can eating the wrong type of protein and fat.

"Understanding how carbs actually work and how important they are is a huge help in learning how to lose or maintain weight sensibly."

Here, speaking to Healthista, Terry talks us through the importance of carbs and which ones you should be sticking to for your body type.

When we eat a meal or snack, the carbohydrates from that food are broken down into glucose which then circulates the body through our blood.

This glucose thats transported around our body provides us with an immediate source of energy, which we use for activity or exercise.

If we are sedentary, or have a job that involves a lot of sitting at a desk, then the glucose is pushed into our muscles and liver and stored as glycogen for later use.

If your glycogen stores are already full after you have eaten carbs, and you go on to consume more carbs or you ate too many to begin with, you are more likely to store those extra carbs as fat

Once these muscle and liver stores are full of glycogen, any excess glucose from the carbohydrates we have eaten that is still travelling through our bloodstream, will be stored as fat.

So basically, if your glycogen stores are already full after you have eaten carbs, and you go on to consume more carbs or you ate too many to begin with, you are more likely to store those extra carbs as fat.

The next consideration is how big your glycogen stores are and how quickly you use them up, and this is different for everyone depending on their body type.

There are three different body types, endomorphs, mesomorphs and ectomorphs.

The best way to tell what body type you are is quite simply by looking in the mirror, but its important to be objective when evaluating yourself.

Take a close look at your physique and at your bodys frame.

Are you long and lean and lose weight easily? Maybe youre an ectomorph.

Broad and stocky and tend to put weight on easily? You could be an endomorph.

Do you have proportional shoulders and hips and look naturally athletic? Perhaps you are a mesomorph.

Endomorphs require quick release carbs for energy such as white pasta, bread and rice in order to have enough energy to complete those fast explosive exercises

Endomorph body types tend to have bigger glycogen stores, as they have what is known as fast twitch muscle fibres.

For this they require quick release carbs for energy such as white pasta, bread and rice in order to have enough energy to complete those fast explosive exercises.

Endomorphs also tend to have a slower metabolism, so if you have a more sedentary lifestyle as an endomorph, your glycogen stores will take longer to be used up.

If this is the case then your need for carbohydrates will be lower than other peoples.

Conversely, ectomorph body types have smaller glycogen stores and use them up far quicker as they have predominantly slow twitch muscle fibres.

Those who have slow twitch muscle fibres, are best suited for endurance type exercise such as running or cycling.

This utilises the stored glucose in our bodies and can also burn a high percentage of fat also.

I have recently seen Instagram posts showing a potato being the same before and after 6pm, while this is true, how we use our body before and after 6pm is generally not the same.

The majority of us are far more mentally and physically active during the day than we are in the evening. The food we consume is digested and enters the blood stream, we then use this to power whatever it is we are doing during the day.

If we are sitting at home after a long day at work we simply do not need as much energy as we needed during the day, so any extra fuel that isnt being used or stored as glycogen in muscle will inevitably be stored as fat.

First of all, avoiding carbs is not the answer, using them wisely is.

Eating the correct type of carbohydrate and the right amount at the right time for your body type, lifestyle and goal is the key.

That may sound confusing but it neednt be and, once you get to grips with it, your carbohydrate need and intake will become second nature to you.

I have seen people get short term results when cutting out carbohydrates - the reason for this isnt always fat loss though.

Six tips to avoid putting on a STONE over Christmas

1. Stick to the portion plate

Every time you sit down to a meal try and make it 1/4 plate protein, plate complex carbohydrates, plate of vegetables and 1-2 tablespoons of healthy fats.

2. Stay active

Dont compromise on your usual exercise in the lead up to Christmas either because exercising get those endorphins going which help you to make healthy food choices.

3. Meal prep

Making sure you are prepared with some healthy meals/ snacks or just ingredients may involve some time and organisation but it is well worth the effort.

4. Keep snacks on hand

Snacking regularly throughout the day can actually aidweight lossand stop you from making unhealthy choices.

5. Keep an eye on your alcohol intake

Drink water in between alcoholic drinks and choose drinks that are served with mineral/soda water.

6. Eat before finger food events

Either eat a full nutritious meal before you go and politely decline the finger food, or at least eat half of a meal so that you can get plenty of veggies in and then just enjoy two to three items at the event.

For every molecule of carbohydrate there are two to three molecules of water attached, so weight (not fat) is lost from the removed carb stores and the water it was attached to.

Secondly, by removing our bodies preferred energy store carbohydrates it has to rely on the remaining options, fat and protein.

Yes, we will increase fat burning, but we will also break down protein from muscle which is biologically active, and remember the more muscle you have the more calories you burn, so you really dont want to be losing muscle where you can help it.

Over a longer period of time the loss of protein will slow your metabolism, making it harder to lose fat. The body sees fat as its life preserving fuel.

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If we suddenly and dramatically alter our diet, the body will go into panic mode and do what it can to hold on to the fat.

Although we do not advocate eating low carbohydrate diets, certain body types (endomorphs and meso-endomorphs) who tend to be less tolerant to large amounts of carbohydrates, should eat a smaller percentage, without eating too few.

The bottom line is, the more sedentary a person is, the fewer carbohydrates they will need.

Continued here:
Weight loss: The best carbs to eat to shed pounds based on your body type - The Sun

Speed-o'-Sound Sonic is One-Punch Man's resident anti-hero/pseudo-villain/Saitama rival. The ninja is first introduced as Zeniru's bodyguard but quickly becomes relevant to the story as a whole. Like most of the characters in the series, Sonic derives pleasure from fighting powerful opponents.

RELATED: One-Punch Man: 10 Stunning Cosplays That Look Just Like The Characters

Unfortunately, being the protagonist's rival means he'll never be more than second-best and that frustration drives Sonic's entire arc. He has become a fan favorite, but casual viewers might not be aware of how intriguing the troublemaker actually is. Here are 10 weird facts you never knew about One-Punch Man's Speed-o'-Sound Sonic.

Speed-o'-Sound Sonic is always prepared for battle, whether he's armed or not, but nine times out of ten you'll find him wandering around with his token ninjat. He's also known for carrying kunai and special shurikens that either explode on impact or provide a smokescreen for cover.

Most ninjas are so formidable that no one ever stops to ask this one very valid question: Where do they get all those weapons from? The answer is more reasonable than you'd expect, at least in Sonic's case. He buys them from a weapons shop. Simple as that.

Sonic's distinct look could partly be attributed to his hair or outfit, but the purple marks under his eyesare typicallyconsidered his mostdistinguishable feature. However, these aren't unique ninja marks with some obscure or special meaning. They were actually inspired by sports American football, to be exact.

In that same vein, the marks also serve as a reference to Eyeshield 21. The American football series is illustrated by Yusuke Murata, who isthe artist behindthe redrawn One Punch Man manga.

Sonic's culinary skills were displayed in the One Punch Man anime during a humorous sequence where he cooked a monster cell. The scene is also present in the manga, though the meal arguably looks better in color.

RELATED: One Punch Man: 5 Best Villains in the Series (& 5 Worst)

This doesn't necessarily make Sonic a top chef, but itmust require some level oftalent to make a monster cell look edible. On top of that, he paired the plate with a glass of red wine, which is known to complement most meats. The man knew what he was doing.

This fun fact correlates with Sonic's aforementioned culinary skills because, in his attempt to become a monster, the ninja actually gave himself stomach problems. Monster cells are meant to be consumed raw, so cooking them negates their effects (and sends you to the toilet, apparently).

Sonic's diarrhea was so intense that he ended up losing about 2 kilograms approximately four and a half pounds in the process. He presumed that the weight loss was the result of his "monster transformation". The reality is that the cell did absolutely nothing besides help him trim a few pounds.

Speed-o'-Sound Sonic and loyal Saitama disciple Genos have already crossed paths in the storyline. The two sparred for quite a while before being interrupted bythe main character. It appeared that the cyborg had been defeated, but series creator ONE insists otherwise.

ONE has stated that a fight between Genos and Sonic would ultimately end in a draw and not a victory for the ninja, as the season two showdown insinuated. We'd like to file a petition for a rematch, please.

An extra chapter within volume four of the One Punch Man manga titled "Prison" gave some insight into Sonic's life behind bars. Spoiler alert: It was a chaotic mess. To be fair, the detention facility he was confined in was home to some of the most savage criminals around.

RELATED: 10 Anime To Watch If You Like One Punch Man

Sonic told the other prisoners that he would kill them all and proceeded to fight them one-on-one. This displeased the prison's boss and everyone did their best to correct their behavior... besides Sonic, of course.

The Deep Sea King was a fearsomebeing that gave almost every hero that confronted him a nasty beatdown. Sonic held his own for a respectable amount of time, but he couldn'tgain the upper hand on the creature. Nonetheless, ONE has confirmed that Sonic could've emerged victorious from this encounter... with a few stipulations.

For starters, Sonic was fresh out of prison when he faced the monster, so he didn't have any of his usual weapons on hand. He would need them for his hypothetical win. Secondly, Deep Sea King would have to be in his dry, pre-rain form to be conquered by the ninja.

"The Ninja Who Is Too Complicated" is the third OVA of theOne Punch Man series and many fans might have missed the extra episode. We're introduced to an adorable baby boar named Ino who becomes Sonic's right-hand piglet for a while.

The boar becomes fond of Sonic after the ninjasaves him from a massive snake. The duo trains together and the relationship is documented in a sweet training montage. After Sonic leaves, Ino stays with an acquaintance named Frank.

Saitama's appearance is underwhelmingly average for such an overpowered character. It's a running joke within the series, but what you might not know is thatGenos and Sonic were specifically designed to look much cooler than him.

RELATED: One Punch Man: 10 Hilarious Saitama Memes As Powerful As He Is

ONE intended to use physical appearance to add a gap between Genos/Sonic and Saitama. However,Yusuke Murata's incredible drawings multiplied that gap in an unforeseen manner. Thus, the ninja and the cyborg ended up looking miles more impressive than the most powerful human in the series.

As illustrated in the aforementioned OVA, "The Ninja Who Is Too Complicated", Sonic is so scarred by his loss to Saitama that he literally has nightmares about him. In the extra episode,Sonic trains to become stronger and aims to rid himself of said nightmares by defeating the protagonist.

As expected, he has yet to experience the victory he so eagerly desires. Perhaps he should focus on besting Genos first, especially since ONE claims that they're equal in terms of strength.

NEXT: 10 Common Anime Tropes You See Everywhere

NextDragon Ball: 10 Hilarious Piccolo and Gohan Memes Only True Fans Will Understand

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One-Punch Man: 10 Weird Facts You Never Knew About Speed-o'-Sound Sonic - CBR - Comic Book Resources

The devastated mum of a teenager who died a day after being diagnosed with cancer said she had been failed by the doctors who should have diagnosed the problem earlier.

Aspiring footballer Tanisha Baverstock, 13, had fallen sick with persistent cough and weight loss for a few weeks before she was referred to hospital in Salisbury District Hospital, Wiltshire, earlier this year.

They went home with some antibiotics, expecting a return appointment a month later.

But at 11am the following day, hospital staff phoned Kelly to say they had found something worrying on the scan.

A radiologist recognised signs of a tumour and put out 'Code Red' - meaning urgent action was needed - on the hospital's internal recording system.

Kelly took Tanisha to Bristol Royal Hospital for Children later that day and at 11pm was told her daughter had lumphoma - a blood cancer which is treatable if quickly identified.

But Tanisha, who had been given trials by the Arsenal girls' squad, died the next day on January 31.

Mum Kelly, 39, from Swindon, said: "You don't recover from the loss of a child, especially when she has been so badly failed by her doctors.

"One day she is sent home with antibiotics. The next I get a phone call saying she has cancer.

"It was spotted immediately yet nothing happened.

"These were wasted hours which could have given Tanisha a chance."

An NHS Serious Incident Inquiry report into the case concluded: "If the patient had been seen at BRCH some days earlier it is likely that there would still have been some risk to her but this may have been substantially less.

"Assuming treatment could have been given, her lymphoma could have been successfully managed."

Salisbury NHS Foundation Trust said an extensive investigation had been conducted but as an inquest was pending it would be inappropriate to comment.

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Mum of teen who died a day after being diagnosed with cancer says doctors 'failed' her - Mirror Online

It also means that you could use a serious dose of inspo from ladies who have stuck out their journey long enough to see real success. Because let's face it: Losing weight is hard, and it's even harder for women than men, thanks to metabolic and hormonal differences, research shows.

Most of the weight-loss warriors here tried multiple avenues, from going vegan to intermittent fasting to at-home Pilates workouts, before finding the methods and eating regimes that worked with their lifestyles. And part of their success was being realistic about what was achievable in the long run. Take it from one wise woman: "I promised in the beginning that I wouldnt want to eat or do anything while losing weight that I wouldnt want to eat or do once I hit [my] goal, even if that meant it took a little bit longer," says @ashleys_officially_lost_it.

Finding a workout routine you love can also help keep you on track throughout the ups and downs. As one woman, @kaitlynesse, says, "Truly all of my weight loss came from working out to feel better and not to look a certain way. I just found this passion for it weightlifting I never had before," she says, noting that lifting helped her fight through a bout of depression after a breakup.

One more nugget of advice? Don't underestimate the small stuff, since any effort is better than no effort. "Even when you think those 30 minutes of walking wont add up to anything, trust meit will," @branjay24 says. You have to keep telling yourself, "'Yes, you are worth it!'" she adds.

Together, these powerful women lost more than 2,500 poundsand gained so much strength along the waywhich youll see in these dramatic before-and-afters. Take them in as needed to stay focused, inspired, and invested in your journey toward achieving your own health goals. If they can do it, so can you.

@stellaisstriving lost 243 poundsmore than 42 percent of her starting body weightby overhauling her eating habits with the keto diet and focusing on fat loss (not just losing pounds).

@_jens_journey_ started out doing keto but didn't feel that it worked for her, so she stuck with intermittent fasting, a sugar-free diet, and keeping her carbs down. She dropped more than 100 poundsthen gained back about 15 of those pounds to feel her healthiest, she previously told Women's Health .

It was WW that got @sweet_pea_leigh to a place of kicking her food addiction , which had been causing her to keep gaining weight as well as numerous body aches and pains. She's lost over 150 pounds.

The Couch to 5K app was hugely transformative for @lizzy_rockzsoon after hopping on the app, she started triathlon training and subsequently ran four marathons. Meal prepping with lots of protein and few carbs was huge for her, too, in her journey to lose about 150 pounds.

@rachellsharp93 went down a little more than 100 pounds, starting with her own version of alternate-day fasting , consuming small amounts of food in between days, and then segueing into another type of intermittent fasting.

Down about 220 pounds, @losing_for_health started out doing keto, then continued to count her macros with a free online calculator.

Originally through gastric bypass surgery , @kathleeng1112 shed 179 pounds, but she kept it up by eating tons of protein and few carbs. She stays active with Pilates, yoga, and at-home workouts.

@gessisfitnessjourney hit her goal of losing 124 pounds first by trying going vegan, then vegetarian, and low-carb, but she ultimately succeeded by tracking everythingcalories, stepson her Fitbit .

It was a combination of keto and intermittent fasting that helped @gritandgrace__ lose more than 50 pounds and her status as prediabetic. Once she cut out sugar, her PCOS symptoms were more manageable, too.

@hannah_day28's big turnaround came from BeachBody toning workouts . She also began practicing clean eating and portion control. She still eats buffalo chicken, but in a zucchini boat rather than fried.

She started out with VSG surgery , but @cam_bree_uhhh kept off 148 pounds by eating a vegan diet. She now belongs to two different gyms to stick with her love of weight lifting and doing circuits.

@carlywontquit lost 108 pounds with a strict policy of no added sugar , even in her coffee. She's also a cardio fanatic and can't get enough of Zumba or Total Body Pump.

Realizing the power of a nutritious home-cooked meal turned @_iwokeupinbeastmode;s nutrition around, helping her to lose a total of 130 pounds. She started out tracking every macro, but after hitting her goal, she stopped counting calories and focused on just eating clean instead.

@laurenlosing did VSG surgery in 2013 as a tool to change her lifestyle. She kept going with eating a high-protein diet, counting macros, and weight lifting.

A new-found love of lifting heavy was a major transforming factor for @kaitlynesse. She lost 80 pounds in about a year, focusing on squats and deadlifts, which she says made her feel strong and powerful. She also put on about 10 pounds of solid muscle in the process.

Keto and kickboxing were the power duo for @thestairlady. She went down 100 pounds in a year without giving up her favorite food, pizza.

@healthylivinislife's weight-loss journey started with VSG surgery. She continued to drop 120 pounds through the keto diet, and then a general low-carb eating plan. She also supplemented with a hot-yoga routine to help with her anxiety and started running and amping up her core workouts, too.

Struggling with symptoms of both PCOS and IBS, @get_moefit first cut carbs and started going beast mode in the gym, and then worked with a nutritionist to do an elimination diet. She cut out some cruciferous veggies that bothered her, as well as beef and pork (but kept other types of lean meat) to reduce GI issues and lose 80 pounds.

Starting with gastric-sleeve surgery, @gi_sciortino shed 120 pounds and kept it off with intense strength-training and HIIT workouts.

Counting calories with the My Fitness Pal app was a factor for @hayleysweightlossjourneyx to lose 70 pounds. "It was the simple science of tracking calories in vs. out, mixed with self-discipline and self belief," she says.

@journeytoslimsyddie dropped 140 pounds between VSG surgery, three to five weekly hard-core workouts in the gym, and eating mindfully (with a low-carb and high-protein diet).

It all started with a fun, competitive "biggest loser" challenge at work for @branjay24. She lost 105 pounds by cutting out carbs and sweets and exercised six times a week. Another major factor for her? Taking care of her mental health throughout.

@wokeuplikedez dropped 150 pounds after having gastric-bypass surgery, and then continued the momentum with a high-protein diet. She kept consuming fewer calories and working out more consistently than she had in the past, too.

In the beginning, @ashleys_officially_lost_it tried losing weight simply by counting calories, but she needed more accountability and support, she says. She jumped on the WW (formerly Weight Watchers) bandwagon and later became an ambassador in the midst of her 120-pound weight loss, which she's maintained for almost two years. Her transformation was mostly accomplished via healthier food swapsshe loves to make cleaner versions of favorite fast-food dishes, like a chipotle chicken avocado sandwich from Panera.

Down 80 pounds from clean eating and at-home workouts, @beast_girl_22 toned up using BeachBody Body Beast. She also made a major change in her eating routine: switching from eating three healthy meals a day to eating smaller healthy meals every two to three hours, with lots of water.

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25 Incredible Weight-Loss Transformations You Just HAVE To See - Pulse Nigeria