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Caraway is a unique spice long used in cooking and herbal medicine (1).

Although frequently mistaken for a seed, this small, brown pod is really the dried fruit of the caraway plant (Carum carvi L.) (2).

Its slightly bitter, earthy flavor is reminiscent of licorice, coriander, anise, and fennel. It can be used whole or ground in both sweet and savory dishes, such as breads, pastries, curries, and stews. Its sometimes infused into spirits and liqueurs as well.

When used medicinally, caraway can be made into a tea or taken as a supplement. You can also apply its essential oils to your skin (2).

In fact, emerging research suggests that the aromatic compounds responsible for its distinct taste may also provide health benefits, such as improved digestion (1).

This article explores caraways nutrients, benefits, and uses.

Caraway boasts a wide variety of essential nutrients, several of which are lacking in Western diets. These include iron, zinc, calcium, and fiber (3).

Just 1 tablespoon (6.7 grams) of caraway provides (4):

Whats more, caraway boasts a rich supply of health-promoting antioxidants, including limonene and carvone (5).

Caraway is loaded with fiber and several important minerals, including iron, magnesium, copper, and calcium. Its also a rich source of antioxidants.

Caraway has been used in traditional and folk medicine for centuries. Interestingly, preliminary research supports several of these benefits.

Several caraway compounds demonstrate strong antioxidant and anti-inflammatory properties (2).

While inflammation is a natural bodily response, chronic inflammation can lead to various ailments, such as inflammatory bowel disease (IBD). Its symptoms may include ulcers, cramping, gas, diarrhea, bowel urgency, and irritation of digestive tissue.

In a study in mice with IBD, both caraway extract and essential oil reduced inflammation in colon tissue as effectively as common steroid-based drugs (6).

Despite these promising results, human research is needed.

Caraway has historically been utilized to treat several digestive conditions, including indigestion and stomach ulcers.

A handful of small human studies show that caraway oil relaxes your digestive tracts smooth muscle tissue, thus relieving indigestion symptoms like gas, cramping, and bloating (7, 8, 9).

Although the precise mechanism is unknown, its antimicrobial capacity may be responsible (1, 2).

One test-tube study revealed that caraway essential oil blocked the growth of harmful gut bacteria while leaving beneficial bacteria untouched. These good bacteria produce nutrients, reduce inflammation, improve digestion, and support your immune health (10, 11).

Another test-tube study found that caraway extract fought H. pylori, a bacterium known to cause stomach ulcers and digestive inflammation (12).

All the same, more studies are necessary.

Caraway may support weight loss and body composition.

In a 90-day study in 70 women, those who took 1 ounce (30 ml) of a 10% caraway oil solution daily experienced significantly greater reductions in weight, body mass index (BMI), and body fat percentage than those who received a placebo (13).

They also saw significant declines in total calorie and carb intake, compared with the placebo group.

Scientists speculate that these effects may be due to positive changes in gut bacteria that affect hormone regulation, fat metabolism, and appetite.

Keep in mind that research is ongoing.

Early research suggests that caraway may promote weight loss and help treat various inflammatory conditions and digestive disorders.

Caraway is cultivated around the world and relatively inexpensive. Its readily available in most grocery stores, as well as online.

Caraway is best known as an ingredient in rye and soda bread, but it can likewise be used in other baked goods, such as muffins, cookies, croutons, dinner rolls, and French toast.

It adds a peppery, warm bite to fruit-based desserts and sweets like pies, tarts, jams, jellies, and custards.

It can also be used in savory foods, such as dry rubs, curries, casseroles, soups, stews, and sauces. Whats more, you can try it as a seasoning for roasted vegetables or add it to pickled or fermented foods like sauerkraut.

Alternatively, steep caraway in hot water to make a soothing tea.

Caraway comes in various forms, including the whole fruit (or seed), capsules, essential oils, and extracts.

Most types are ingested, but oil formulations diluted to 2% can be safely applied to unbroken skin (2).

No clear dosage recommendation has been established, but some research suggests that 1/2 teaspoon to 1 tablespoon (16.7 grams) of whole caraway divided into 3 daily doses is likely safe and effective (2).

Most healthy people tolerate caraway well, and few side effects have been reported. However, due to insufficient safety research, it shouldnt be consumed by children or women who are pregnant or breastfeeding (2).

Plus, anyone with liver or gallbladder dysfunction should avoid caraway, as some evidence suggests that it can inhibit gallbladder emptying (2).

If youre unsure whether caraway is safe for you, consult your healthcare provider.

Caraway can be added to countless sweet and savory dishes, as well as taken as a supplement.

Caraway is a multifaceted spice with numerous culinary and medicinal applications.

Although widely considered a seed, it comes from the fruit of the caraway plant and boasts several minerals and plant compounds. In fact, it may aid weight loss, relieve inflammation, and promote digestive health.

This versatile ingredient can be used whole or ground to flavor desserts, sauces, breads, and baked goods.

Although its generally very safe, children, pregnant and breastfeeding women, and people with liver or gallbladder disease should not use caraway. Talk to a medical practitioner if you have any reservations about adding it to your routine.

View post:
Caraway: Nutrients, Benefits, and Uses - Healthline

Intermittent fasting is officially more than a diet trend. The eating regimen has exploded in popularity, largely because of what it doesn't require: counting calories, tracking macros, labeling foods as "good" or "bad."

When it comes to intermittent fasting for women, there are some specific risks to consider.

Credit: Hero Images/Hero Images/GettyImages

This type of fasting which restricts eating to certain hours of the day or certain days of the week has also received praise from the scientific community because of budding research on its benefits, including effective weight loss and lowered disease risk, per Harvard Health Publishing.

But when it comes to intermittent fasting for women, there are also some risks to consider.

Indeed, some groups of women should avoid practicing IF or at least consult a health professional first. And all women may benefit from easing into a fasting pattern and following a protocol that reduces the risk of negative side effects.

Here, we'll lay out everything you need to know about intermittent fasting for women.

Did you know that keeping a food diary is one of the most effective ways to manage your weight? Download the MyPlate app to easily track calories, stay focused and achieve your goals!

Most women can safely partake in intermittent fasting, Pamela Nisevich Bede, RD, dietitian and author of Sweat. Eat. Repeat., tells LIVESTRONG.com.

"Women find weight-loss success on intermittent fasting for a plethora of reasons, [including] a forced reduced-calorie intake, a low-energy state that prompts ketosis and a thoughtful connection with food in which individuals become more mindful of intake," Bede says.

IF also opens the door to a wealth of potential health benefits for women specifically, according to a review published in the April-June 2016 issue of the Journal of Mid-Life Health, which connected periodic fasting to:

However, it's important to keep in mind that the research looking at intermittent fasting for women specifically is extremely limited, Amy Rothberg, MD, an endocrinologist and associate professor at Michigan Medicine, tells LIVESTRONG.com. Most of the currently available information on IF and female physiology comes from rodent studies, she says.

"There is better evidence from studies of time-restricted feeding, [which means] limiting the window of eating during the day, which lengthens the period of fasting at night" Dr. Rothberg says, "and also studies that align eating with our circadian clock."

One such study, published March 2015 in Cell, notes that time-specific food intake has profound effects on our physiology, and especially our hormones and metabolism. When we disrupt the natural cycle of eating during daylight hours, the study author notes, that can throw our other bodily processes out of whack, increasing our risk of disease.

So far, Dr. Rothberg notes, studies have primarily focused on how IF affects body weight, metabolism (meaning markers like insulin and blood lipids) and mortality. Limited evidence suggests some hormonal changes, but such changes are almost always associated with overall caloric restriction, so they don't seem to be unique to IF.

However, young women should be aware that, "When food supply is insufficient to meet metabolic demands, puberty is delayed and ovulation and the normal menstrual cycle is suppressed," Dr. Rothberg says.

In other words, women run the risk of developing amenorrhea (loss of their menstrual period for at least three consecutive months) if calorie intake becomes too low, according to a June 2017 review in Seminars in Reproductive Medicine. That's because a lack of calories can cause changes to the hormones estrogen and progesterone, which regulate the menstrual cycle. It can also potentially cause a loss of bone density and do potential harm to a developing fetus if a woman was to get pregnant, Dr. Rothberg says.

If your calorie intake remains adequate, though, intermittent fasting alone should not put you at risk for amenorrhea or these other conditions it's all about overall calorie and nutrient intake.

Other non-hormonal changes that women may experience due to fasting or calorie restriction include cramping, fatigue, headaches, fainting spells and if severe nausea and vomiting, says Dr. Rothberg. These symptoms typically occur due to shifts in electrolyte balance.

"The studies that exist on intermittent fasting suggest that both sexes respond to fasting and have similar rates of weight loss. That being said, both men and women succeed and struggle with it."

"There is not much research currently to show how intermittent fasting affects men and women differently," Natalie Allen, RD, dietitian and instructor of biomedical sciences at Missouri State University, tells LIVESTRONG.com. "As a relatively new diet trend, we are still gathering credible information on intermittent fasting."

Bede argues that the difference isn't sex-specific, but genome-specific. That is, everyone responds differently to fasting regardless of sex because our genes differ.

"The studies that exist on intermittent fasting suggest that both sexes respond to fasting and both have similar rates of weight loss," says Bede. "Anecdotally, I know many more women who experiment with intermittent fasting than men. That being said, both men and women succeed and struggle with it."

Across both sexes, it's important to note that fasting is not necessarily easy, says Bede. "We humans are hardwired to seek food for survival, and these innate signals are put in place to drive us to refuel."

So if you experiment with intermittent fasting and continuously feel poorly, seek advice from your health care provider and reconsider your approach intermittent fasting is certainly not the only way to achieve the health or wellness benefits you seek, says Bede.

Intermittent fasting isn't for everyone.

Credit: erdikocak/E+/GettyImages

If you're interested in intermittent fasting, the best way to start is to ease into it, Dr. Rothberg says. " I would suggest that most ease into intermittent fasting gradually to make sure that it's something they think they can adopt and to which they can also adapt," she says.

So, if you'd like to try fasting for 16 hours each day, for example, start by fasting for 10 hours, then assuming you feel well slowly bumping up your fasting time every few days until you hit 16.

If you try IF and notice any of the following effects, stop and talk to a doctor or dietitian:

There simply isn't enough data looking at the effects of intermittent fasting on women specifically, Dr. Rothberg notes, so women need to look out for symptoms that indicate that fasting or their overall calorie or nutrient intake is messing with their physiology, particularly their hormones. The scenarios above are rare-but-serious effects that can occur when your body doesn't adjust to a fasting protocol.

Despite the potential benefits of intermittent fasting, some women should steer clear of this eating pattern. For some, IF can cause more harm than good. According to Bede and Allen, those groups include:

Women with a history of eating disorders or disordered eating, because intermittent fasting can perpetuate dysfunctional eating habits, such as a binge/purge cycle, restrictive eating and emotionally charging food.

Women who are pregnant or breastfeeding should not try intermittent fasting without first discussing with a doctor, because there is not enough data to support the idea that fasting while pregnant is healthy for mom or baby.

"Very low-calorie diets, lack of balance of both macro and micronutrients and fasting can result in abnormal fetal growth and lifelong consequences for the offspring, including a higher risk of being overweight and obese," says Dr. Rothberg.

If you are trying to conceive, talk to your doctor first to make sure that intermittent fasting won't affect your likelihood of getting pregnant.

Female athletes who perform high volumes of training or are preparing for competition shouldn't start intermittent fasting without talking with a sports dietitian, coach, trainer or doctor, as they may be at risk for amenorrhea or female athlete triad disorder.

Women with diabetes shouldn't try IF without clearance from a doctor because there isn't enough data available to support fasting with diabetes.

Women with certain autoimmune conditions or genetic disorders should consult with a doctor or dietitian before trying intermittent fasting to ensure that their condition is not a contraindication for fasting.

Women who are otherwise already at risk for nutrient deficiencies shouldn't attempt intermittent fasting without working with a registered dietitian or physician who can ensure adequate nutrient intake.

There are many different versions of IF, which range from fasting for 12 hours each day to completing a 24-hour fast once or twice per week. There's also the Warrior Diet, which calls for 20 hours of daily fasting, and alternate-day fasting, during which you restrict calories to 500 per day every other day, then eat normally the other days.

"An individual needs to think about her routine, eating patterns, workout plans and weight-loss goals as she chooses which plan to follow," Allen says.

Bede recommends the 16:8 protocol for women, especially for those who are new to intermittent fasting, because it's the most researched of the IF protocols. The 16:8 protocol involves eating all of your food during an eight-hour window (10 a.m. to 6 p.m., for example) and fasting for the other 16 hours. It's often considered the easiest IF protocol because most people are sleeping for seven to nine of their fasting hours.

"It also appears to be the most reasonable and achievable" says Bede. "This approach is as simple as shutting down the kitchen after an early dinner, which prevents mindless snacking and grazing while watching late-night TV and also forces one to recognize hunger signals before diving into lunch."

Additionally, the 16:8 protocol allows for fasted training or "training low" for those who exercise early in the morning, says Bede. Exercising at the tail end of a fast allows your body to work off of its fat stores and burn additional calories. Bede cautions, however, that you should utilize fasted training only occasionally and never before a competition or race, as you'd put yourself at risk for low glycogen and low blood sugar. Low glycogen means your muscles are running low on energy stores, which can affect your physical performance, while low blood sugar (hypoglycemia) can result in dizziness, shakiness, rapid heartbeat and fainting.

Dr. Rothberg notes that there's not really enough evidence to promote one intermittent fasting protocol over another, but based on the info available, the 16:8 protocol makes sense. "I think the best evidence, again limited, is for time-restricted feeding," she says. "That is, eating during the day for eight hours and fasting in the evening and overnight for 16 hours, and eating the larger meals of the day in the beginning of the day."

More here:
Intermittent Fasting for Women: What Are the Health Risks? - LIVESTRONG.COM

A former bulging Bulldog from Walsall, who used to scoff Mr Whippy and McFlurry ice creams, has scooped a top slimming award after shedding a quarter of her bodyweight.

Eight-year-old Missi ballooned to a whopping 6st 13lb after devouring tubs of ice-cream and mammoth-sized portions more than 75 per cent over her ideal weight.

Her 24-year-old owner, Gemma Slattery, said that Missi would love nothing more than a Mr Whippy from the ice-cream van and even got them for FREE after striking up a friendship.

But after PDSA vets warned that the pooches health was at serious risk from her excess inches, her concerned owner cut out ice creams and her sumo-sized portions and increased her exercise. Missi can be seen waddling along above.

Every year vet charity PDSA helps the UKs fattest pets battle the bulge in Pet Fit Club a six-month diet and exercise challenge, specially tailored and overseen by its vets and nurses.

And now Missis calorie-filled ice-creams are a thing of the past and six months on, the strict diet and exercise programme has changed her life.

The loveable dog has lost so much weight around six inches off her waist that she was crowned second in the national competition.

Gemma said: Missi is a completely different dog now. Shes like a puppy again and has so much energy. She has a new-found love for her toys and will spend hours playing with them, its amazing to see.

Weve changed our routine and we go on long daily walks without fail, which she absolutely loves. She no longer waddles along, its a gallop!

One of the biggest changes Ive seen in her is her ability to climb the stairs. She couldnt do this before and meant we had to wash her in the paddling pool outside. But now climbing the stairs is easy for her, and she loves a bath in the tub!

She used to constantly bite her paws due to the pain her excess weight caused, but shes stopped doing this since losing weight. She also suffered from joint problems and I know that the weight-loss has helped reduce the pain and inflammation. To know shes healthier now is the best thing of all.

Pet Fit Club hasnt only impacted Missis life, but has changed Gemmas outlook too. Shes cut out junk food and increased her exercise and has lost a stone over the last six months.

Weve been on a weight-loss journey together and Im excited that this is only just the start for us, adds Gemma.

Gemma added: I cant recommend Pet Fit Club enough. They have been there every step of the way and Im so pleased that Missi can now lead a more healthy, happy and active life now.

My friends and neighbours cant believe how much weight shes lost. Pet Fit Club is the best thing we could have done for her and were going to carry on with the diet until she reaches her perfect weight.

Despite her impressive weight loss, Missi still has more weight to lose to reach her ideal weight 25kg (3st 13lb).

Missis programme has been supervised by PDSA vet nurse, Kay Brough, at Wolverhampton PDSA Pet Hospital.

Kay Brough said: The change I have seen in Missi has been remarkable. She looks like a completely different dog to the one that first came here six months ago. Every month weve seen the big changes in her as the weight has come off.

Her owner Gemma has been very dedicated, she has stuck to the diet and it has paid off in a big way.

Any owners who are worried about their pets weight should seek advice from their vet, who can work with them to get them on the right diet and safely increase their pets exercise levels.

PDSA Vet Nurse Nina Downing, who is on the Pet Fit Club judging panel, added: It has been hugely rewarding to see Missi and the other pets weight decrease over the last six months. Their success is testament to the hard work of their owners and our PDSA veterinary teams.

Pet obesity is a growing issue that affects millions of UK pets. We believe up to 50%* of dogs and cats in the UK are overweight or obese, which can lead to serious long term health problems and a shortened life expectancy.

Originally posted here:
McDonald's McFlurry Bulldog from Walsall scoops top prize in slimming contest - Birmingham Live

While many anglers sing the praises of Floridas warmer fishing months, seasoned anglers know that winter can offer great fishing opportunities for some of the states most sought-after fish species. As the temperatures drop, youll spot many anglers, including veteran kayak angler Stephen Stubbs, following spotted seatrout to fresher water, where the fish congregate in large schools.

While this can make spotted seatrout an easy target, this species is also especially vulnerable to fatigue and exposure, so as the winter bite turns on, its important to use proper gear and fish handling techniques. This ensures the best chance of survival for released fish. Read on for some tips to help you handle the fishing as the weather cools down and the action heats up.

Prepping for the dayA successful day of fishing begins with preparation. Be aware of the area you will be fishing and local fish you might catch. Know the regulations for your target species and make sure you have all the proper gear. Determining ahead of time which fish you are going to keep versus which fish you will release is an easy step to take and something that Stubbs practices regularly.

My friends and I tend to harvest only slot trout under 19 inches to keep the more productive egg-layers (20 inches and over) in the water to continue the sustainability of this wonderful species, Stubbs said.

Knowing which fish he plans to release helps to get those fish back in the water quickly, increasing survival and benefitting the fish population.

Some great gear to have in your stash is:

Barbless circle hooks Are 90% more likely to hook a fish in the mouth. Hooking a fish in the mouth reduces internal harm and decreases dehooking time, getting the fish back in the water faster and increasing its chance of survival.

Dehooking tool Allows anglers to quickly release their catch while minimizing injuries and handling time.

Correct weight tackle Using tackle heavy enough to land a fish quickly is important so fish are less exhausted and more able to avoid predators upon release.

Knotless, rubber-coated net These support the weight of the fish while removing a minimal amount of slime, which protects the fish from infection.

Make sure to reel the fish in as quickly as possible. According to Stubbs, the key to landing a nice trout, especially a big one, is to manage the drag tension. Horsing a trout into the boat can usually result in additional tearing of the area they are hooked, especially around the mouth. It can also cause you to lose the fish. Work them in as they tire and keep tension on the line to prevent a hook release. Playing the fish too much can result in an exhausted fish that cannot avoid predators once released.

Landing the fishStubbs reminds anglers to always use a net for landing medium-to-large trout and dip/wet any measuring board with water before laying the fish on the board. That helps reduce the loss of slime and scales. Once youve got your catch to the boat, use these additional tips to ensure that fish are landed quickly and safely for the best outcome for both the angler and the fish.

Avoid removing large fish from water. If you must remove them, support their weight horizontally to prevent damage to their internal organs.

Take pictures of your catch while it is in the water. This puts less stress on the fish and the fish will look bigger.

If a net is needed to land or control a fish, always use a knotless, rubber-coated landing net.

Fish handlingUsing the correct methods to handle your fish once youve landed them is important to ensure that released fish are in prime condition when returned to the water.

Return the fish to the water as quickly as possible. One of the major factors in the survival of a released fish is how much time it spends out of the water. The more fish that survive upon release today, the more fish there will be available to catch tomorrow.

Wet your hands before handling a fish to prevent damaging its protective slime coating. Dont use gloves or towels, as this will remove the protective slime.

Never hold a fish by the gill cover or eyes.

Hold fish horizontally to support their internal organs.

Gripping devices can be effective for controlling and handling fish, especially ones with sharp teeth. Grip behind the lower lip and support the weight of the fish in a horizontal position.

Removing the hookRemoving a hook can be tricky. Use these tips to get the hook out and protect your trout (and other catches).

If possible, keep the fish in the water while removing the hook.

If the fish has swallowed the hook, cut the line as close to the hook as possible. Attempting to remove the hook can do more harm than good. Use non-stainless-steel hooks since they eventually dissolve or pass naturally.

Using a dehooking tool will allow you to remove hooks safely and quickly without touching the fish, giving it a better chance to survive.

Taking steps to return fish to the water properly can be a significant factor in their survival. With a little extra effort, you can give your fish a fighting chance at survival to reproduce and fight another day.

Place the fish in the water and allow it to swim away on its own; do not toss the fish back.

Revive fish that do not swim away immediately or appear lethargic.

Place fish in the water head first it is easiest to hold one hand on the bottom lip or tail and one hand under the belly of the fish.

Move the fish forward in the water this allows the water to be flow through the mouth and over the gills. The fish must face the direction of water flow.

Use a figure-8 motion to move the fish forward constantly, ensuring water continues to flow over the gills. Never jerk fish back and forth, since this action prevents water from properly flowing through the gills.

For fish caught in deep water with signs of barotrauma, use a descending device to return fish to depth or vent the fish by inserting a sharpened, hollow tube at a 45-degree angle, one inch behind the base of the pectoral fin.

Practice C-P-R: Catch-Photo-Release. Quickly land your fish, have a friend snap a quick photo during the action and return fish to the water expediently. Then submit your photos on com to earn prizes for your fishing achievements!

Ensure fish survive to help populations thriveThe steps you take on the water today can help positively impact the future of your Florida fish populations. Dropping temperatures dont have to mean a drop in the survival of the fish you release. To learn more about proper catch-and-release techniques, visit MyFWC.com/FishHandling.

Excerpt from:
With temperatures dropping, can you handle the fish? - Dothan Eagle

MAPLE GROVE, Minn., Dec. 6, 2019 /PRNewswire/ --Upsher-Smith Laboratories, LLC (Upsher-Smith) today announced that it will be attending the 2019 Annual Meeting of the American Epilepsy Society (AES) December 6-10, 2019 in Baltimore, MD. Meeting attendees are encouraged to visit booth #526 to learn more about Upsher-Smith's epilepsy products including Vigadrone (vigabatrin) for Oral Solution 500 mg, a fully substitutable, AA-rated generic version of Sabril (vigabatrin) powder for oral solution* and Qudexy XR (topiramate) extended-release capsules. Representatives will also be on hand to discuss Upsher-Smith's Access Pathways Program, a program designed to reduce the barriers associated with prescribing vigabatrin by providing brand-quality support to physicians, patients, and caregivers.

Vigadrone is indicated for the treatment of:

Please see Important Safety Information for Vigadrone, including Boxed Warning for Risk of Permanent Vision Loss at the end of this communication."Treating infantile spasms requires early intervention, and at Upsher-Smith, ensuring that physicians are able to quickly and seamlessly start their patients on vigabatrin is a priority," said Rusty Field, President and CEO of Upsher-Smith. "That is why we launched Vigadrone, a fully substitutable generic, with brand-quality support. We look forward to discussing how our Access Pathways Program provides physicians, patients and caregivers with a dedicated, experienced team to overcome the obstacles that sometimes come along with prescribing vigabatrin."

Access Pathways is fully committed to providing the support patients and caregivers need, regardless of when they need it. The program includes:

To learn more about Access Pathways, visit vigadrone.com. Access Pathways Program Support can be reached at 1-866-923-1954 Monday-Friday from 8:00 a.m. 8:00 p.m. EST or on weekends and after hours.

Vigabatrin REMS ProgramThe U.S. FDA has approved a single shared system Risk Evaluation and Mitigation Strategy (REMS) for all vigabatrin products called the Vigabatrin REMS Program. It is required by the FDA to ensure informed risk-benefit decisions before initiating treatment and to ensure appropriate use of vigabatrin while patients are treated.

Healthcare providers must be certified in the Vigabatrin REMS Program to prescribe Vigadrone and patients must be enrolled in the Vigabatrin REMS Program to receive Vigadrone. All certified prescribers and enrolled patients in the SABRIL REMS Program have been transitioned to the Vigabatrin REMS Program and do not need to recertify or re-enroll.

WHAT IMPORTANT SAFETY INFORMATION SHOULD I KNOW ABOUT VIGADRONE?

WARNING: PERMANENT VISION LOSS

See Medication Guide and full Prescribing Information for complete information.

All people who take VIGADRONE:

VIGADRONE can cause serious side effects such as low red blood cell counts (anemia), sleepiness and tiredness, nerve problems, weight gain, and swelling. BecauseVIGADRONE causes sleepiness and tiredness, do not drive, operate machinery, or perform any hazardous task, unless it is decided that these things can be done safely. VIGADRONE may make certain types of seizures worse. Tell your healthcare provider right away if seizures get worse.

Before starting VIGADRONE,tell your doctor about all of your (or your child's) medical conditions, including mental illnesses, and all the medicines you (or your child) take.

If you are breastfeeding or plan to breastfeed, VIGADRONE can pass into breast milk and may harm your baby.

If you are pregnant or plan to become pregnant, it is not known if VIGADRONE will harm your unborn baby. You and your healthcare provider will have to decide if you should take VIGADRONE while you are pregnant.

The most common side effects of VIGADRONE in adults include:problems walking or feeling uncoordinated, feeling dizzy, shaking (tremor), joint pain, memory problems and not thinking clearly, and eye problems like blurry vision, double vision, and eye movements that cannot be controlled.

The most common side effects of VIGADRONE in children 10 to 16 years of ageinclude weight gain, upper respiratory tract infection, tiredness, and aggression. Also expect side effects like those seen in adults.

The most common side effects of VIGADRONE in babies include:sleepinesssome babies may have a harder time suckling and feeding or may be irritable, swelling in the bronchial tubes (bronchitis), ear infection, and irritability.

Tell your healthcare provider if you or your child have any side effect that bothers you or that does not go away.

This is the most important information to know about VIGADRONE, but not all of the possible side effects of VIGADRONE. For more information, ask your healthcare provider or pharmacist, or please visit vigadrone.com/PI for VIGADRONE Medication Guide,full Prescribing Informationincluding Boxed Warning for risk of permanent vision loss, andInstructions for Use. You can also visit upsher-smith.com or call 1-888-650-3789.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visitwww.fda.gov/medwatch, or call1-800-332-1088.

Important Patient Safety Information for Qudexy XR (topiramate) Extended-Release Capsules

WHAT IS QUDEXY XR?

Qudexy XR (topiramate) Extended-Release Capsules is a prescription medicine used:

WHAT IMPORTANT SAFETY INFORMATION SHOULD I KNOW?

Qudexy XR can cause serious side effects, including:

Call your healthcare provider right away if you have any of the above symptoms.

Like other antiepileptic drugs, Qudexy XR may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Before taking Qudexy XR, tell your healthcare provider if you have or have had depression, mood problems, or suicidal thoughts or behavior. Call a healthcare provider right awayif you have: thoughts about suicide or dying; attempt to commit suicide; have new or worsening depression or anxiety; feel agitated or restless; experience panic attacks, have trouble sleeping (insomnia); have new or worsening irritability; feel or act aggressive, angry, or violent; act on dangerous impulses; experience an extreme increase in activity and talking (mania); or other unusual changes in your behavior or mood.

Qudexy XR can harm your unborn baby.All women of childbearing age should talk to their healthcare provider about possible alternative treatments. If you take Qudexy XR during pregnancy, your baby has a higher risk for birth defects called cleft lip and cleft palate. These defects can begin early in pregnancy, even before you know you are pregnant. Also, if you take Qudexy XR during pregnancy, your baby may be smaller than expected at birth; the long-term effects of this are not known. If the decision is made to use Qudexy XR, you should use effective birth control (contraception).Tell your healthcare provider right away if you become, or plan to become pregnant while taking Qudexy XR.

The most common side effects of Qudexy XR include:tingling of the arms and legs (paresthesia), not feeling hungry, weight loss, nervousness, nausea, speech problems, tiredness, dizziness, sleepiness/drowsiness, a change in the way foods taste, upper respiratory tract infection, decreased feeling or sensitivity especially in the skin, slow reactions, difficulty with memory, fever, abnormal vision, diarrhea, and pain in the abdomen. These are not all the possible side effects of Qudexy XR. For more information, ask your healthcare provider or pharmacist.

Before taking Qudexy XR, tell your healthcare provider about all of your medical conditions, including if you: have had depression, mood problems, or suicidal thoughts or behavior; have kidney problems, kidney stones, or are getting kidney dialysis; have a history of metabolic acidosis (too much acid in the blood); have liver problems; have weak, brittle or soft bones (osteomalacia, osteoporosis, osteopenia, or decreased bone density); have lung or breathing problems; have eye problems, especially glaucoma; have diarrhea; have a growth problem; are on a diet high in fat and low in carbohydrates, which is called a ketogenic diet; are having surgery; are pregnant or planning to become pregnant; or if you are breastfeeding. The medicine in Qudexy XR (topiramate) passes into your breast milk. It is not known if the medicine, topiramate, that passes into breast milk can harm your baby. Talk with your healthcare provider about the best way to feed your baby if you take Qudexy XR.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take metformin (e.g., Glucophage); valproic acid (e.g., Depakene or Depakote); any medicines that impair or decrease your thinking, concentration, or muscle coordination; birth control pills (Qudexy XR may make birth control pills less effective); medicines used to prevent seizures; or any other carbonic anhydrase inhibitors (e.g., zonisamide or acetazolamide).

Do not stop Qudexy XR without first talking to a healthcare provider.If you have epilepsy and you stop taking Qudexy XR suddenly, you may have seizures that do not stop. Your healthcare provider will tell you how to stop taking Qudexy XR slowly.

Do not drink alcohol while taking Qudexy XR.Qudexy XR and alcohol can cause side effects such as sleepiness and dizziness.

Do not drive a car, swim, climb, or operate heavy machinery until you know how Qudexy XR affects you.Qudexy XR can slow your thinking and motor skills, and may affect vision. Even when taking Qudexy XR, some patients with epilepsy will continue to have unpredictable seizures.

This is the most important information to know about Qudexy XR but is not comprehensive. For more information, talk to your healthcare provider and read the Medication Guide for Qudexy XR. You can also visit http://www.upsher-smith.com or call 1-888-650-3789.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch or call 1-800-FDA-1088.

About Upsher-SmithUpsher-Smith Laboratories, LLC is a trusted U.S. pharmaceutical company that strives to improve the health and lives of patients through an unwavering commitment to high-quality products and sustainable growth. Since 1919, it has brought generics and brands to a wide array of customers backed by an attentive level of service, strong industry relationships, and dedication to uninterrupted supply.

As Upsher-Smith celebrates its 100-year anniversary, the company enters a new ambitious era that has been accelerated by its 2017 acquisition by Sawai Pharmaceutical Co., Ltd. Upsher-Smith and Sawai plan to leverage each other for growth worldwide and embark on an exciting new chapter as they seek to deliver the best value for their stakeholders, and most importantly, Do More Good for the patients they serve. For more information, visit http://www.upsher-smith.com.

*Sabril is a registered trademark of Lundbeck.Prior authorization support can be provided only for indicated disease states.**Medicare, Medicaid and other state and federal health care program patients are not eligible.

Vigadrone, Qudexy, Access Pathways and Do More Good are trademarks of Upsher-Smith Laboratories, LLC.

PM-000681

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SOURCE Upsher-Smith Laboratories, LLC

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Upsher-Smith To Attend 2019 Annual Meeting Of The American Epilepsy Society - P&T Community

Heavyweight line in the sand: Ruiz Joshua 2 preview - Communities Digital News

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Heavyweight line in the sand: Ruiz Joshua 2... - Communities Digital News

Credit: Associated Press

Above: A closeup of a beam scale in New York, April 3, 2018.

The holiday season is all about family and food, which might have you concerned about your waistline. Scientists at the Salk Institute in La Jolla have uncovered a science-backed strategy that could help some people keep the pounds off.

And this strategy has to do with biological clocks, says Salk chronobiologist Emily Manoogian.

The biological clock system is amazing. Its this internal system you have within your body. Pretty every cell in your body has a molecular clock and its going to control each function within each individual cell," Manoogian said.

Examples include times when people naturally wake up in the morning or start to feel cold and shiver around the same time every night.

Manoogian says these clocks get cues on when to reset, so they can work better.

"So light and food are actually two of the biggest cues to tell our bodies the time of day. So when we are talking about light it tends to have the biggest influence on our activity sleep cycles. But food is gonna more directly regulate your metabolism, heart function, pretty much any organ within your abdomen," Manoogian said.

People tend to eat for 15 hours a day, Manoogian said. That means seemingly harmless activities, like getting a midnight snack, could be telling the body work when functions, like digestive systems and metabolism, should be resetting to work properly the next day.

So, Salk scientists decided to conduct a trial with 19 people, who had metabolic or cardiovascular conditions, to eat within a 10-hour time frame for 12 weeks. The strategy is known as time-restricted eating.

"We have found that combining time-restricted eating with medications can give metabolic syndrome patients the ability to better manage their disease," said Satchin Panda, co-corresponding author and professor in Salk's Regulatory Biology Laboratory.

"Unlike counting calories, time-restricted eating is a simple dietary intervention to incorporate, and we found that participants were able to keep the eating schedule," Panda said in a press release.

Participants experienced improved sleep and a three to four percent reduction in body weight, body mass index, abdominal fat and waist circumference. Many also experienced reduced blood pressure and cholesterol.

Salk scientists will be conducting a much larger trial with more than 100 participants to test out the strategy further. But, Manoogian said, its a free and simple diet intervention people can try on their own.

KPBS' daily news podcast covering local politics, education, health, environment, the border and more. New episodes are ready weekday mornings so you can listen on your morning commute.

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Original post:
Time-Restricted Eating Could Lead To Weight Loss, Scientists Find - KPBS

Statistics on weight gain in the U.S. can give the impression that it is happening everywhere, to everyone, and in every season of the year. The best science on the subject, however, reveals that weight gain primarily occurs in a smaller and predictable set of circumstances. Surprisingly, these circumstances frequently defy conventional beliefs about how and when weight gain occurs. For example, working adults yearn for weekends, purportedly for greater recreation, yet research shows that we become less active and gain more weight on weekends versus weekdays (1). Similarly, schools often receive criticism for their role in childhood obesity usually directed towards school lunch quality and lack of PE classes yet longitudinal data indicate that the strongest predictor of a child developing obesity during their school years is being overweight before entering kindergarten (2) and that fitness declines and weight increases are more common during the summer months instead of the school year. Despite decades of research, these kinds of mistaken beliefs about weight gain remain remarkably popular and resistant to correction (3).

Perhaps the weight gain circumstance where conventional beliefs are most accurate is the widely held view that holiday weight gain is common in the U.S. The best prospective research affirms that adults gain more weight during the November-January holiday interval relative to the rest of year (4). However, even this rare instance of weight gain opinions aligning with science comes with conditions. What is the condition? That the average weight gain is .48 kilograms (converting to 1.06 pounds if your calculator isnt handy). This seemingly trivial pound of weight gain, however, is generally maintained the rest of the year, slowly accumulating over time for the average adult.

Source: Pixaay: TeroVesalainen

Rarely discussed in all the above research is the consistency of weight gain occurring in a one-sided pattern. Specifically, in most of the circumstances where weight gain reliably occurs, it primarily occurs among those already struggling with their weight. Adults with overweight and obesity are the least active and most weight gain-prone on weekends; Children who are overweight entering school are at highest risk of unhealthy weight gain across both their school years and during the summer months; and, finally, adults with excess weight are those most prone to gain weight during the holidays. This pattern can seem unfair and even cruel; thankfully, it also comes with explanations that can be useful to us. Firstly, weight gain science is a persuasive reminder that it is easier to prevent excess weight gain than to lose excess weight afterwards. The human body possesses an assortment of mechanisms designed to resist weight loss that we are best off avoiding when the option is available. Secondly, there is considerable variability in holiday weight gain patterns among the normal weight and overweight that are largely explained by different behavior patterns. It is both encouraging and instructive to consider holiday weight gain to be the result of modifiable behaviors than some sort of predetermined metabolic destiny.

Although tips about preventing holiday weight gain dominate the internet this time of year, the sad truth is that little of this advice has any empirical support. Mostly, these tips consist of well-intended but unsubstantiated opinions from experts, being about as useful as a Dr. Oz supplement recommendation. Many holiday tips are simply repackaged generic advice about weight loss that do not consider the unique challenges of the holiday season or possess any evidence to suggest whether or how they apply during this time of year. Some tips, finally, are more sinister, acting as disguised sales pitches intended to help you shed excess weight from your wallet or purse. A person determined to get the best results should settle for neither of these sources of information. For those committed to improving or at least maintaining their weight and fitness during the holiday season and wary of this minefield of advice from the media and internet What are the highest quality scientific recommendations?

1). Increase physical activity levels ABOVE normal. In the same seminal study from the New England Journal of Medicine that shed light on holiday weight gain patterns, the authors observed a linear relationship between physical activity patterns during the holidays and their weight changes during the same period. Predictably, those who became less active during the holiday season gained the most weight (about 50% more than average). More surprising was that maintaining a normal activity level also did not prevent weight gain. Those who kept up their regular activity levels gained only slight less weight on average than the overall group. The only group in which weight loss occurred during the holiday period were those reporting being much more active than usual. Unfortunately, the authors didnt quantify the meaning of much more, leaving us to fill in the blank ourselves. As a health scientist, I translate much more to 50%+ more activity than normal; for example, aiming for 7,500 steps/day instead of 5,000 for the moderately active, and 15,000 steps/day instead of 10,000 for the more active.

2) Weigh yourself AT LEAST 2-3 times per week. In independent treatment studies published in 2018 and 2019, regular weighing was shown to effectively prevent holiday weight gain (5). This makes sense for several reasons. Typically, people avoid the scale even more than usual during the holidays and ignorance is bliss does not apply when it comes to preventing holiday weight gain. Instead, research suggests we adopt a knowledge is power mentality. Doing the opposite of the norm by weighing ourselves anywhere from daily to at least 2-3 times/week provides us with feedback about weight gain/weight loss trends while they are small and easily correctable. The 2019 study authors took this a step further than others by combining daily weighing with a graphical display of the results to provide people with an even more potent form of feedback.

3) Use HOLIDAY-SPECIFIC tips and information. In contrast to the generic weight loss advice proliferated by the media this time of year, authors of a 2018 clinical trial from the journal, BMJ (6), showed that holiday-tailored advice and information (e.g., providing calorie information for common holiday foods and drinks, and minutes of walking/running required to burn those calories) prevented holiday weight gain compared to a control group provided with standard healthy lifestyle information.

The next time you see a headline titled twenty tips to prevent holiday weight gain, and you almost certainly will, consider that few or even none of these tips have any proven merit. Instead, we can more confidently set and achieve our holiday weight goals by adopting specific strategies shown to work in quality research.

Read more from the original source:
The Science of Holiday Weight Loss And Weight Maintenance - Psychology Today

After beginning aweight loss journeyat 90 pounds, Wolfgang the beagle is all the #healthgoals we need this holiday season.

Erin McManus began fostering the overweight dog and didn't want to give the adorable guy up, so she decided to adopt him and help him lose the weight.

Wolfgang's goal weight? 25 pounds.

He's losing about a pound a week, McManus told InsideEdition.com. Knowing that it was going to be a journey with him was a big reason why we did adopt them. He's just such a nice dog. Hard to say no to that face.

To stay on the weight loss train and shed pounds, Wolfgang is now on a 600-calorie diet.

I make his own food. It's lean turkey as the base, lots of vegetables, and some supplements, McManus said.

He swims in the pool now, goes on walks, and even exercises on a water treadmill weekly.

He takes his toy with them. He always has a toy, McManus said. "We don't know why he likes to work out with a toy, but I guess most people like working out with a friend, so I think he thinks the toys are his workout buddies.

While McManus said she doesnt know much about Wolfgangs previous life, she said he has a minor thyroid problem that he is now on medication for.

McManus created an Instagramaccount for Wolfgang, which has already racked up 37,000 followers. So Wolfgang has all the support he needs. The dog mom said she definitely wasnt expecting all of the attention.

I was expecting maybe my mom would follow on Instagram, and maybe one or two other people. But you know, I mean, his personality I think, shines through, McManus said. Everyone likes feeling encouraged. And a morbidly obese dog trying to get fit, I think has encouraged a lot of people. I know he encourages us.

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This Once 90-Pound Beagle Is Nailing His Weight Loss Journey - Inside Edition

MONCTON, NB, Dec. 5, 2019 /PRNewswire/ - Using artificial intelligence, FITIV PULSE can intelligently predict a user's rate of weight loss and provide curated activity and nutrition advice to help them reach their goals. This new feature is called FITIV Insights - making it easier than ever to interpret health and fitness data by displaying data trends and providing expert advice to help users create actionable fitness goals and receive objective measures of their progress.

Founder Sylvio LeBlanc's early life was fraught with years of gaining and losing the same 20 pounds, over and over, without consistent and sustainable progress. "I developed FITIV for myself, primarily. I'm the kind of person that needs to know that what I'm doing is working. Seeing those numbers really kept me motivated and tracking my calories was the key to my success." Now, Sylvio is happy to unveil a feature that will help more people take control of their health. "The sky's the limit," says LeBlanc, "...with all of the data users are already tracking we have an opportunity to really make health and fitness information accessible."

The first edition of FITIV Insights will be available on the App Store on December 5, 2019 and will include the aforementioned weight management insight as well as an activity insight: demonstrating, at a glance, whether a user is hitting daily activity goals.

Future insights will provide information on whether users' heart health is improving and how their fitness performance is changing over time. "You don't need to be a professional to interpret your health data anymore." LeBlanc says. "...whether you're worried that you're overtraining or are wondering if you're getting the right kind of exercise, FITIV Pulse can now provide that analysis for you".

About FITIV Pulse:FITIV Pulse is a health and fitness tracking application for iOS and Android that uses heart rate tracking to give users one of the fitness industry's best tools: heart rate zone training. With an in-app community, a customizable fitness and nutrition dashboard, and a huge number of workout tracking options, FITIV Pulse truly is an all-in-one solution. Leveraging wearable technology FITIV keeps users informed in real-time, helping them level up their workouts and train according to their fitness goals.

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FITIV Pulse: Using Artificial Intelligence to Take the Guesswork Out of Weight Loss - PRNewswire