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Category Archives: Testosterone
The Male Menopause Treatment market to Stay Inorganically upward between 2019 and 2029 – TechnoWeekly
Posted: October 21, 2020 at 5:54 pm
Male menopause refers to the hormonal imbalance or hormonal changes in the males due to which there is a reduction in the testosterone levels in the males. There are various symptoms of male menopause. Some of the symptoms include low energy, increasing body fat, decreasing bone density, erectile dysfunction, infertility, etc. There are many other changes associated with the testosterone level changes. Some of the major changes observed in males are a growth of the muscle mass, lowering of voice and changes related to sexual functioning. The male menopause can be treated by changing the lifestyle habits or it can be treated by taking testosterone replacement therapy. Healthy lifestyle habits such as taking a healthy diet. Having proper nap etc. can treat the male menopause treatment market.
Increasing research and developmental activities is one of the major factor driving the growth of male menopause treatment market. The rate of smoking is increasing, which can lead to hormonal imbalance, increasing the growth of the male menopause treatment market. Large intake of drugs and alcohol is another important factor, which can be responsible for the reduction of testosterone level and is expected to increase the growth of male menopause treatment market. Increasing adoption of poor lifestyle habits such as a high intake of junk food, lack of exercise, etc. can be responsible for increasing the growth of male menopause treatment market. Increasing stress due to daily hectic routine can also increase the growth of male menopause treatment market. Other factors, such as increasing healthcare awareness, technological advancements leading to better diagnostic rates, increasing disposable income, modernization of the Indian society, etc. can be responsible for the significant growth of male menopause treatment market.
There are various side effects of male menopause treatment drugs, which can hinder the growth of male menopause treatment market. Lack of awareness in some of the developing regions can restrain the growth of male menopause treatment market.
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The global Male Menopause Treatment market is segmented on basis of drug type, Source of administration, distribution channel and geographic region:
Based on the drug type, the Male Menopause Treatment has been divided into testosterone supplements and vitamin supplements. Testosterone supplements can be given in various forms and are expected to hold the largest revenue share in the male menopause treatment market. Testosterone replacement therapy is the most common therapy, used for the treatment of male menopause treatment market. Amongst all the testosterone supplements, DHEA and D-Aspartic acid are expected to hold the maximum revenue share in the male menopause treatment market. Based on the route of administration, the male menopause treatment market has been divided into oral administration and subcutaneous administration. Oral route of administration is expected to hold the maximum revenue share in the male menopause treatment market as it is the most common form of administration used by the male patients. Based on the distribution channel, the male menopause treatment has been divided into hospital pharmacies, retail pharmacies, drug stores, and online pharmacies. Drug stores and hospital pharmacies are expected to hold the maximum revenue share in the male menopause treatment market.
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On the basis of geography, the global Male Menopause Treatment market is studied and divided into a few key regions such as North America, Latin America, Europe, Asia, Middle East & Africa and Oceania. North America is expected to hold a large revenue share in global Male Menopause Treatment market because of the presence of a large number of research and developmental activities and availability of technological advancement in the field of healthcare. Europe is expected to hold the second largest market share because of the presence of the large population. The Asia Pacific can also show a large revenue share in the Male Menopause Treatment market because of the increasing healthcare awareness
There are many companies manufacturing Male Menopause Treatment drugs. Some of the big pharmaceutical companies involved in the manufacture of Male Menopause Treatment drugs are Thermofisher Scientific Inc., Abbott, Sun Pharmaceuticals Industries Ltd., Perrigo Company plc, Bayer AG and many other companies.
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The Male Menopause Treatment market to Stay Inorganically upward between 2019 and 2029 - TechnoWeekly
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24 Ways to Increase Penis Sensitivity: Tips, Techniques, and More – Healthline
Posted: October 15, 2020 at 10:57 pm
For many folks, sexual satisfaction is all about the feels, so if you or your penis-having partner are experiencing decreased sensitivity down there, it could really mess with your ability to get off.
There are a few things that can cause a decrease in penile sensation, from the way a person masturbates to lifestyle habits and hormone imbalances. The good news: There are ways to get back that lovin feeling.
To be clear, theres a big difference between less sensation and numbness.
Having less sensation which is what were focusing on in this article means you dont feel as much sensation in your peen as you did before.
A numb penis is a whole other ball of wax and refers to not being able to feel any normal sensation when your penis is touched.
Yep, how you pleasure yourself might be affecting your penile sensation.
The way you masturbate can lead to decreased sensitivity. Some people call this death grip syndrome.
The gist is that people who masturbate using a very specific technique or tight grip can become desensitized to other types of pleasure over time.
When this happens, coming or even getting any pleasure without the exact move or pressure becomes difficult.
If youre feeling all the feels just fine when you masturbate but find that partner sex is where the sensation is lacking, there are a couple potential reasons.
A thinner or smaller-than-average penis, or even too much lube (natural wetness or synthetic), can mean less friction and ultimately sensation during intercourse.
Just switching up your technique should do the trick and help you recondition your sensitivity.
If death grip is the issue, depending on how youre used to masturbating, this might mean loosening your grip, stroking at a slower pace, or both.
You could also mix things up with a sex toy made for penis play, like the Super Sucker UR3 Masturbator, which you can buy online, or TENGA Zero Flip Hole Masturbator, which is also available online. And dont forget the lube!
If intercourse is the issue, some positions make for a tighter fit and therefore more friction.
Heres a little secret: Tweaking any position so your partner can keep their legs tight together during sex should work.
Plus, if anal sex is what youre both into, the anus is by nature a tighter squeeze. Just be sure to use a lot of lube if you take it to the backside.
And speaking of a lot of lube: If an abundance of wetness is making sex feel a bit like a Slip N Slide, a quick wipe with some tissue should fix it.
Certain lifestyle habits can be to blame for your peens lessened sensitivity.
Do you bicycle a lot? Do you masturbate frequently? These things can cause the sensitivity in your peen to tank if you do them often.
When it comes to masturbation, how often you do it matters if youre doing it a lot, according to research that has linked hyperstimulation to decreased penile sensitivity.
As for bicycling, bicycle seats put pressure on the perineum the space between your balls and anus. It presses on blood vessels and nerves that provide feeling to the penis.
Sitting in a hard or uncomfortable chair for long periods can do the same.
Masturbation is healthy, but if the frequency of your handy treats is causing a problem, taking a break for a week or two can help get your penis feeling back to itself.
If you sit or bicycle for long periods, take regular breaks. Consider swapping out your bike seat or usual chair for something more comfortable.
Testosterone is the male sex hormone responsible for libido, not to mention a bunch of other functions.
If your testosterone (T) level drops, you might feel less responsive to sexual stimulation and have trouble getting aroused.
T levels decrease as you age. Damage to your danglers aka testicles can also affect T, as well as certain conditions, substances, and cancer treatment.
Your doctor can diagnose low T with a simple blood test and treat it using testosterone replacement therapy (TRT). Lifestyle changes, like regular exercise, maintaining a moderate weight, and getting more sleep can also help.
Certain medical conditions and medications can affect sensation in the penis.
Diabetes and multiple sclerosis (MS) are just a couple conditions that can damage nerves and affect sensation in different body parts, including the penis.
Medications used to treat Parkinsons disease can also reduce penile sensation as a side effect.
Ensuring that any underlying condition is well managed might help bring the feels back.
If medications the culprit, your doctor may be able to adjust your dose or change your medication.
Sexual pleasure isnt just about your D. Your brain plays a big role, too.
If youre dealing with anxiety, stress, depression, or any other mental health issue, getting in the mood can be near impossible. And even if you really want to get down to business, your penis may not be as receptive.
It really depends on whats going on mentally.
Taking some time to unwind before sexy time can help if youre feeling stressed or anxious.
A hot bath or shower can help your mind and muscles relax. The warm water also increases circulation, which can help increase sensitivity and make your skin more responsive to touch.
If youre regularly struggling with feelings of anxiety or depression, or having trouble coping with stress, reach out for help.
Talk to a friend or loved one, see a healthcare provider, or find a local mental health provider through the Anxiety and Depression Association of America (ADAA).
Not to be punny, but try to not beat yourself silly over this.
We get how frustrating it must be to not be able to enjoy the sensation you want or expect during sexual activity.
Here are some things to keep in mind if youre struggling.
Chances are your lessened penile sensation can be improved.
As weve already covered, changes in technique, getting in the right frame of mind, or some lifestyle tweaks may be all thats needed to get your penis feeling right again.
A healthcare provider can help with any underlying medical or mental health issues and recommend the right treatments.
Were not just talking about choking your chicken either! Stressing about this and putting pressure on yourself will only make things worse in the pleasure department.
Give yourself time to relax and get in the mood before play, and permission to stop and try another time if youre not feeling it.
Penis health and sexual health are just as important as other aspects of your health.
If theres something going on with your penis or your ability to enjoy sexual activity, a professional can help.
You cant control everything, but there are things you can do to help keep your penis healthy:
If its your partner whos struggling with lessened sensitivity down there, dont worry. Chances are theres a good reason for it, and its probably not what you think.
Here are some things to keep in mind if its getting to you.
Your first instinct may be to blame yourself if your partner isnt enjoying sex. Try to not do this.
Sounds harsh, but: Not your penis, not your problem.
As a loving partner, of course you want them to feel good. But unless youve damaged their penis by taking a hammer to it, their lessened penile sensitivity isnt your fault, so dont make it about you.
Seriously, its not your penis!
Not trying to dismiss your feelings or anything, but as frustrated as you may be that your partner isnt feeling it even when you pull out your best moves, its probably a lot more frustrating for them.
That said, if your partners lack of sensation results in a marathon shag sesh that causes chafing to your nether regions, of course you have the right to take a break or stop. Its your body, after all. Just be mindful of how you say it.
EVERYONE should be asking what their partner needs when it comes to sex and relationships. Its the key to making both great.
Do they need a little time to relax before action moves to the peen? Do they need more foreplay that focuses on other pleasure spots to help them get in the mood? Do they want to just stop altogether? Dont be afraid to ask.
If youve lost some of that lovin feeling down below, your lifestyle and pleasure routine solo or partnered may provide some clues. If not, your doctor or other healthcare provider can help.
In the meantime, be patient and kind with yourself, and consider some of your other pleasure zones for satisfaction.
Adrienne Santos-Longhurst is a Canada-based freelance writer and author who has written extensively on all things health and lifestyle for more than a decade. When shes not holed up in her writing shed researching an article or off interviewing health professionals, she can be found frolicking around her beach town with husband and dogs in tow or splashing about the lake trying to master the stand-up paddle board.
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24 Ways to Increase Penis Sensitivity: Tips, Techniques, and More - Healthline
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Earlier pubertal timing predicts higher psychosexuality in adulthood – PsyPost
Posted: October 13, 2020 at 6:54 pm
New research from Penn States Behavioral Endocrinology and Evolution Lab provides evidence that pubertal timing is associated with psychosexuality in men and women. The findings have been published in the journal Psychoneuroendocrinology.
We are interested in how sex hormones influence the development of the brain and behavior, said study authors Talia Shirazi and David Puts, a PhD candidate and associate professor, respectively.
There is growing evidence that sex hormones have permanent effects on the brain and on psychological traits during least two windows in development the first is during gestation and right after birth, and the second is during puberty. Studies in laboratory animals show that testosterone exposure earlier in the pubertal window has a larger effect on male sexual behaviors than hormone exposure later on, but little is known about whether this is also the case in humans.
For their study, the researchers examined 72 men and 32 women with isolated GnRH deficiency (IGD), a rare disorder in which individuals have absent or nonfunctional gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus. GnRH is a neurohormone that controls sexual maturation, the appearance of puberty, and fertility in adults.
Because individuals with IGD are unable to produce endogenous gonadal hormones, they require hormone replacement therapy (HRT) to initiate puberty and must remain on HRT across adulthood. By utilizing data on the timing of initiation of HRT, we are thus able to pinpoint the precise age at which pubertal hormone exposure began for this clinical group.
The study also included 231 healthy men and 648 healthy women, who provided estimates of when they first started experiencing pubertal changes.
The participants completed a measure of sociosexuality, which assessed attitudes, behaviors, and desires regarding casual sex, along with a general measure of sexual desire. Many participants also provided saliva samples, which were used to statistically control for variations in hormone concentrations.
The researchers found that earlier onset of puberty was associated with heightened psychosexuality.
Earlier puberty was associated with greater sexual interest in both sexes, but it was more strongly associated with interest in uncommitted sex in men and with general sexual desire in women. This pattern may reflect decreasing sensitivity of the brain to sex hormones across the pubertal time window, Shirazi and Puts told PsyPost.
Beyond having implications for our basic understanding of behavioral neuroendocrinology, our results have clinical implications. There are several cases in which doctors will medically block or induce puberty. In these cases, the top concern is usually the physical health of the adolescent. What our research suggests is that altering pubertal timing also has long-term psychological effects, the researchers explained.
The extent to which these psychological effects should be considered when creating treatment plans is up to clinicians, patients, and their families, but it is our hope that our research provides information for people to make better-informed decisions.
But, as with all research, the new findings come with some caveats.
Correlation doesnt mean causation, so we cannot be certain that earlier pubertal timing causes higher psychosexuality in adulthood. To better understand relationships between pubertal timing and adult phenotypes, we need longitudinal studies that recruit children before puberty and follow them throughout puberty and into adulthood, Shirazi and Puts explained.
If studies continue finding links between pubertal timing and adult phenotypes, an important next step will be to figure out the neurobiology underpinning these relationships. How do the neural regions and circuits responsive to hormones at puberty differ between individuals based on the timing of puberty, and can those neural differences predict differences in psychological traits? Theres a lot of exciting work to be done.
The study, Pubertal timing predicts adult psychosexuality: Evidence from typically developing adults and adults with isolated GnRH deficiency, was authored by Talia N. Shirazi, Heather Self, Khytam Dawood, Rodrigo Crdenas, Lisa L.M. Welling, Kevin A. Rosenfield, Triana L. Ortiz, Justin M. Carr, Ravikumar Balasubramanian, Angela Delaney, William Crowley, S. Marc Breedlove, and David A. Puts.
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Testosterone Replacement Therapy Market Report Covers New Aspects Impact on Share, Size, Types, Applications and Manufacturer Growth during 2020-2024…
Posted: October 13, 2020 at 6:54 pm
The Report Titled GlobalTestosterone Replacement Therapy Market has recently added by Global Marketers include 120+ pages of the research report with TOC built-in in its research database to get a stronger and valuable business outlook. Newest released the research study on Global Testosterone Replacement Therapy Market offers a comprehensive overview of the factors that influence the global business scope.
The report provides key statistics on the market status, size, share, growth factors of the Testosterone Replacement Therapy . Testosterone Replacement Therapy Market research report shows the most recent market insight, current position analysis with the forthcoming trend. The Covid-19 Impact on Testosterone Replacement Therapy market report is an ultimate solution for businesses if they want to stay ahead of the competition in todays fast-moving business environment.
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The following manufacturers are covered in this report:
AbbVieEndo InternationalEli lillyPfizerActavis (Allergan)BayerNovartisTevaMylanUpsher-SmithFerring PharmaceuticalsKyowa KirinAcerus Pharmaceuticals
The study enumerates the regional scope of the Global Testosterone Replacement Therapy market, categorized into the United States, China, Europe, Japan, and Southeast Asia & India.
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Global Testosterone Replacement Therapy Market by detectors Type:-
GelsInjectionsPatchesOther
Global Testosterone Replacement Therapy Market by application:-
HospitalsClinicsOthers
Key Benefits:-
1. The study provides an in detail analysis of the global Testosterone Replacement Therapy market with present and outlook trends to explain the imminent investment pockets in the market
2. Current and future trend are outlined to determine the overall prettiness and single out cost-effective trends to increase a stronger foothold in the market
3. Quantitative analysis of the present market and estimation through 2020-2025 are providing to showcase the
Testosterone Replacement Therapy of the market
4. Drivers and opportunities are evaluated to underline the top factors liable for market growth.
5. Porters Five Forces model and SWOT analysis of the industry illustrates the potency of the buyers &
suppliers participating in the market
6. The study includes the Testosterone Replacement Therapy market share of key players
Inquire Before Buying:
The key questions answered in the report:
Table of Contents:
* Global Testosterone Replacement Therapy Market Overview
* Economic Impact on Industry
* Production, Revenue (Value), Price Trend by Type
* Market Analysis by Application
* Cost Analysis
* Industrial Chain, Sourcing Strategy and Downstream Buyers
* Marketing Strategy Analysis, Distributors/Traders
* Market Effect Factors Analysis
* Global Testosterone Replacement Therapy Market Forecast
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Testosterone Replacement Therapy Market Report Covers New Aspects Impact on Share, Size, Types, Applications and Manufacturer Growth during 2020-2024...
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Global Testosterone Replacement Therapy Market Current Scenario (COVID-19) on Trends and Growth Parameters 2020 to 2025 – re:Jerusalem
Posted: October 8, 2020 at 5:56 am
Global Testosterone Replacement Therapy Market Report 2020, Forecast to 2025 is the latest skillful and deep analysis of the markets present situation and prospects. The report displays the market size, share, status, production, cost analysis, and market value with the forecast period 2020-2025. The report offers an insightful take on the historical data of the market and compared it with the current market situation. The report includes analysis of an assessment of current market trends and dynamics, which helps in mapping the trajectory of the global Testosterone Replacement Therapy market. It comprises information about the top key players, sales, revenue, future trends, research findings, and opportunities. The report studies the competitive landscape read of the business.
Our best experts have surveyed the market report with the reference of inventories and data given by the key players: AbbVie, Endo International, Eli lilly, Pfizer, Actavis (Allergan), Bayer, Novartis, Teva, Mylan, Upsher-Smith, Ferring Pharmaceuticals
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NOTE: Our analysts monitoring the situation across the globe explains that the market will generate remunerative prospects for producers post COVID-19 crisis. The report aims to provide an additional illustration of the latest scenario, economic slowdown, and COVID-19 impact on the overall industry.
Growth Prospects:
The report demonstrates insights associated with the overall present and future market scenario. This and the past performance enabled them to come out with an outlook for the period 2020 2025. The report includes revenue generated from the existing market players and based on all players. The total market size is also derived. The report comprises an in-depth study of the potential segments including product type, application, and end-user, and their contribution to the overall market size.
Market research supported product sort includes: Gels, Injections, Patches, Other
Market research supported application coverage: Hospitals, Clinics, Others
Regional and Country- Level Analysis:
Different geographical areas are studied comprehensively and an economical scenario has been offered to assist new entrants, leading market players, and investors to regulate emerging economies. The top producers and consumers focus on production, product capacity, value, consumption, growth opportunity, and market share in these key regions, covering: North America (United States, Canada and Mexico), Europe (Germany, France, UK, Russia and Italy), Asia-Pacific (China, Japan, Korea, India and Southeast Asia), South America (Brazil, Argentina, Colombia etc.), Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria and South Africa)
What Market Factors Are Explained In The Report?
To conclude up, as per the study of the global Testosterone Replacement Therapy market report client gets point by point and confirmed data about the business. The report covers the different significant focuses which are useful to comprehend the global market, such as significant drivers for development, different components which make a negative effect on showcase development, current market patterns, and then notice the market estimating for the coming a very long time till 2025.
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Testosterone Replacement Therapy Market Analysis: Leading Industry Players, Recent trends, Potential Growth, Share, Demand and Forecast To 2025 – News…
Posted: October 8, 2020 at 5:56 am
A comprehensive research study on Testosterone Replacement Therapy market available at MarketStudyReport.com provides insights into the market size and growth trends of this industry over the forecast timeline. The study evaluates key aspects of Testosterone Replacement Therapy market in terms of the demand landscape, driving factors and growth strategies adopted by market players.
The Testosterone Replacement Therapy market study is an in-depth analysis of this business sphere which entails pivotal insights pertaining to industry deliverables, notably industry trends, market size, market share, present valuation, and predicts proceeds by the end of the projection period. The synopsis of the industry also recognizes the Testosterone Replacement Therapy market growth rate during the forecast timeline, triggered by certain catalysts, an essence of which has been decrypted in this research study, in tandem with the leading challenges and prevailing growth opportunities.
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Key components underscored in the Testosterone Replacement Therapy market report:
Expounding the regional outlook of the Testosterone Replacement Therapy market:
Testosterone Replacement Therapy Market Bifurcation: USA, Europe, Japan, China, India, South East Asia.
Insights incorporated in the market study have been framed with respect to the industry indicators:
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An exhaustive guideline of the Testosterone Replacement Therapy market in terms of the product & application landscape:
Product landscape:
Product types: Gels, Injections, Patches and Other
Top observations included in the report:
Application landscape:
Application segmentation: Hospitals, Clinics and Others
Details highlighted in the report:
Other significant pointers encompassed in the report:
What does the competitive landscape of the Testosterone Replacement Therapy market imply?
Manufacturer base of the industry: AbbVie, Upsher-Smith, Endo International, Pfizer, Actavis (Allergan), Eli lilly, Teva, Bayer, Mylan, Novartis, Ferring Pharmaceuticals, Acerus Pharmaceuticals and Kyowa Kirin
Competitive overview outlined in the report includes:
Besides the abovementioned indicators, the Testosterone Replacement Therapy market study also provides vital information pertaining to the market concentration ratio, that would possibly aid proactive competitors in defining the business strategy to outcompete other eminent players partaking in the business sphere.
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Testosterone Replacement Therapy Market Analysis: Leading Industry Players, Recent trends, Potential Growth, Share, Demand and Forecast To 2025 - News...
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Testosterone Replacement Therapy Market Industry Development Trends & Competitive Analysis by Leading Industry Players – The Daily Chronicle
Posted: October 4, 2020 at 11:48 pm
The testosterone replacement therapy market is segmented on the lines of its product type and ingredient type. Based on product type the testosterone replacement therapy market is segmented into oral, implants, gums/ buccal adhesives, injections, patches and creams/ gels. The testosterone replacement therapy market is segmented on the lines of its ingredient type like testosterone, testosterone cypionate, testosterone enanthate, testosterone undecanoate and methyl testosterone. The testosterone replacement therapy marketis geographic segmentation covers various regions such as North America, Europe, Asia Pacific, Latin America, Middle East and Africa. Each geography market is further segmented to provide market revenue for select countries such as the U.S., Canada, U.K. Germany, China, Japan, India, Brazil, and GCC countries.
Browse Full Report: https://www.marketresearchengine.com/upcommingreport/testosterone-replacement-therapy-market
Testosterone is responsible for the improvement of male sexual characteristics and this hormone formed by the testicles. It is also important to maintain various functions such as sexual function, bone growth, adequate levels of red blood cells, and a sense of well being and muscle bulk. Insufficient production of testosterone causes erectile dysfunction. Erectile dysfunction occurs due to decreased testosterone production to overcome this testosterone replacement therapy is used to improve the problem. Testosterone replacement therapy occurs in various forms containing its own set of advantages and hazards such as subdemal pellets, transdemal patches and injections. Testosterone replacement therapy also helps to recover symptoms of low testosterone. Low testosterone is caused due to age growth it generally lowers down after the mid 30s and further decreases accordingly to the age factor.
The scope of the report includes a detailed study of global and regional markets of Testosterone Replacement Therapy Market. The reasons given for variations in the growth of the industry in certain regions.
Global Testosterone Replacement Therapy Market is expected to exceed more than US$ 1.0 billion by 2024 at CAGR of 4% in the given forecast period.
The major driving factors of testosterone replacement therapy market are as follows:
Rise in incidence of testosterone deficiency.Increase in geriatric populace with high risk of testosterone deficiency.Increasing awareness about testosterone substitute therapy.
The restraining factors of testosterone replacement therapy market are as follows:
High possibility of side effects associated to testosterone replacement therapy.Patent expiry of key drugs and entry of generics.
The report covers detailed competitive outlook including the market share and company profiles of the key participants operating in the global market. Key players profiled in the report include AbbVie, Inc., Allergan plc, Bayer AG, Endo Pharmaceuticals, Inc., Eli Lilly and Company, Kyowa Kirin International plc, Mylan N.V., Novartis AG, and Pfizer, Inc. Company profile includes assign such as company summary, financial summary, business strategy and planning, SWOT analysis and current developments.
The Testosterone Replacement Therapy Market has been segmented as below:
The Testosterone Replacement Therapy Market is Segmented on the lines of Product Type Analysis, Ingredient Type Analysis and Regional Analysis. By Product Type Analysis this market is segmented on the basis of Oral, Implants, Gums/Buccal Adhesives, Injections, Patches and Creams/Gels.
By Ingredient Type Analysis this market is segmented on the basis of Testosterone, Testosterone Cypionate, Testosterone Enanthate, Testosterone Undecanoate and Methyl Testosterone. By Regional Analysis this market is segmented on the basis of North America, Europe, Asia-Pacific, MEA and Rest of the World.
This report provides:
1) An overview of the global market for testosterone replacement therapy and related technologies.
2) Analyses of global market trends, with data from 2015, estimates for 2016 and 2017, and projections of compound annual growth rates (CAGRs) through 2024.
3) Identifications of new market opportunities and targeted promotional plans for testosterone replacement therapy.
4) Discussion of research and development, and the demand for new products and new applications.
5) Comprehensive company profiles of major players in the industry.
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Table of Contents
1 INTRODUCTION
2 Executive Summary
3 Global Testosterone Replacement Therapy Market Industry Analysis
4 North America Testosterone Replacement Therapy Market Analysis
5 Europe Testosterone Replacement Therapy Market Analysis
6 Asia Pacific Testosterone Replacement Therapy Market Analysis
7 Middle East and Africa (MEA) Testosterone Replacement Therapy Market Analysis
8 Latin America Testosterone Replacement Therapy Market Analysis
9 Global Testosterone Replacement Therapy Market, Country Snippets
9.1. Global Testosterone Replacement Therapy Market Revenue, by Country, (US$ Mn), 201420249.2. U.S. Testosterone Replacement Therapy Market Revenue, (US$ Mn), 201420249.3. Japan Testosterone Replacement Therapy Market Revenue, (US$ Mn), 201420249.4. Germany Testosterone Replacement Therapy Market Revenue, (US$ Mn), 201420249.5. U.K. Testosterone Replacement Therapy Market Revenue, (US$ Mn), 201420249.6. Canada Testosterone Replacement Therapy Market Revenue, (US$ Mn), 201420249.7. China Testosterone Replacement Therapy Market Revenue, (US$ Mn), 201420249.8. Brazil Testosterone Replacement Therapy Market Revenue, (US$ Mn), 201420249.9. Mexico Testosterone Replacement Therapy Market Revenue, (US$ Mn), 201420249.10. United Arab Emirates (UAE) Testosterone Replacement Therapy Market Revenue, (US$ Mn), 20142024
10 Company Profiles
10.1. AbbVie, Inc.
10.2. Allergan plc
10.3. Bayer AG
10.4. Endo Pharmaceuticals, Inc.
10.5. Eli Lilly and Company
10.6. Kyowa Kirin International plc
10.7. Mylan N.V.
10.8. Novartis AG
10.9. Pfizer, Inc.
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Testosterone Replacement Therapy Market Industry Development Trends & Competitive Analysis by Leading Industry Players - The Daily Chronicle
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Testosterone Replacement Therapy Market size was US$ 1665.5 million and it is expected to reach US$ 1238.2 million by the end of 2026, with a CAGR of…
Posted: October 4, 2020 at 11:48 pm
LOS ANGELES, United States: QY Research has recently published a research report titled, Global Testosterone Replacement Therapy Market Size, Manufacturers, Supply Chain, Sales Channel and Clients, 2020-2026. This report has been prepared by experienced and knowledgeable market analysts and researchers. It is a phenomenal compilation of important studies that explore the competitive landscape, segmentation, geographical expansion, and revenue, production, and consumption growth of the global Testosterone Replacement Therapy market. Players can use the accurate market facts and figures and statistical studies provided in the report to understand the current and future growth of the global Testosterone Replacement Therapy market.
The report includes CAGR, market shares, sales, gross margin, value, volume, and other vital market figures that give an exact picture of the growth of the global Testosterone Replacement Therapy market.
Competitive Landscape
Competitor analysis is one of the best sections of the report that compares the progress of leading players based on crucial parameters, including market share, new developments, global reach, local competition, price, and production. From the nature of competition to future changes in the vendor landscape, the report provides in-depth analysis of the competition in the global Testosterone Replacement Therapy market.
Key questions answered in the report:
TOC
1 Study Coverage1.1 Testosterone Replacement Therapy Product Introduction1.2 Market by Type1.2.1 Global Testosterone Replacement Therapy Market Size Growth Rate by Type1.2.2 Gels1.2.3 Injections1.2.4 Patches1.2.5 Other1.3 Market by Application1.3.1 Global Testosterone Replacement Therapy Market Size Growth Rate by Application1.3.2 Hospitals1.3.3 Clinics1.3.4 Others1.4 Study Objectives1.5 Years Considered 2 Executive Summary2.1 Global Testosterone Replacement Therapy Market Size Estimates and Forecasts2.1.1 Global Testosterone Replacement Therapy Revenue 2015-20262.1.2 Global Testosterone Replacement Therapy Sales 2015-20262.2 Testosterone Replacement Therapy Market Size by Region: 2020 Versus 20262.3 Testosterone Replacement Therapy Sales by Region (2015-2026)2.3.1 Global Testosterone Replacement Therapy Sales by Region: 2015-20202.3.2 Global Testosterone Replacement Therapy Sales Forecast by Region (2021-2026)2.3.3 Global Testosterone Replacement Therapy Sales Market Share by Region (2015-2026)2.4 Testosterone Replacement Therapy Market Estimates and Projections by Region (2021-2026)2.4.1 Global Testosterone Replacement Therapy Revenue by Region: 2015-20202.4.2 Global Testosterone Replacement Therapy Revenue Forecast by Region (2021-2026)2.4.3 Global Testosterone Replacement Therapy Revenue Market Share by Region (2015-2026) 3 Global Testosterone Replacement Therapy by Manufacturers3.1 Global Top Testosterone Replacement Therapy Manufacturers by Sales3.1.1 Global Testosterone Replacement Therapy Sales by Manufacturer (2015-2020)3.1.2 Global Testosterone Replacement Therapy Sales Market Share by Manufacturer (2015-2019)3.2 Global Top Testosterone Replacement Therapy Manufacturers by Revenue3.2.1 Global Testosterone Replacement Therapy Revenue by Manufacturer (2015-2020)3.2.2 Global Testosterone Replacement Therapy Revenue Share by Manufacturer (2015-2020)3.3 Global Testosterone Replacement Therapy Price by Manufacturer (2015-2020)3.4 Competitive Landscape3.4.1 Key Testosterone Replacement Therapy Manufacturers Covered: Ranking by Revenue3.4.2 Global Testosterone Replacement Therapy Market Concentration Ratio (CR5 and HHI) & (2015-2020)3.4.3 Global Testosterone Replacement Therapy Market Share by Company Type (Tier 1, Tier 2 and Tier 3)3.5 Global Testosterone Replacement Therapy Manufacturing Base Distribution, Product Type3.5.1 Testosterone Replacement Therapy Manufacturers Manufacturing Base Distribution, Headquarters3.5.2 Manufacturers Testosterone Replacement Therapy Product Type3.5.3 Date of International Manufacturers Enter into Testosterone Replacement Therapy Market3.6 Manufacturers Mergers & Acquisitions, Expansion Plans 4 Company Profiles4.1 AbbVie4.1.1 AbbVie Corporation Information4.1.2 AbbVie Description, Business Overview4.1.3 AbbVie Testosterone Replacement Therapy Products Offered4.1.4 AbbVie Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.1.5 AbbVie Testosterone Replacement Therapy Revenue by Product4.1.6 AbbVie Testosterone Replacement Therapy Revenue by Application4.1.7 AbbVie Testosterone Replacement Therapy Revenue by Geographic Area4.1.8 AbbVie Testosterone Replacement Therapy Revenue by Sales Channel4.1.9 AbbVie Recent Development4.2 Endo International4.2.1 Endo International Corporation Information4.2.2 Endo International Description, Business Overview4.2.3 Endo International Testosterone Replacement Therapy Products Offered4.2.4 Endo International Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.2.5 Endo International Testosterone Replacement Therapy Revenue by Product4.2.6 Endo International Testosterone Replacement Therapy Revenue by Application4.2.7 Endo International Testosterone Replacement Therapy Revenue by Geographic Area4.2.8 Endo International Testosterone Replacement Therapy Revenue by Sales Channel4.2.9 Endo International Recent Development4.3 Eli lilly4.3.1 Eli lilly Corporation Information4.3.2 Eli lilly Description, Business Overview4.3.3 Eli lilly Testosterone Replacement Therapy Products Offered4.3.4 Eli lilly Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.3.5 Eli lilly Testosterone Replacement Therapy Revenue by Product4.3.6 Eli lilly Testosterone Replacement Therapy Revenue by Application4.3.7 Eli lilly Testosterone Replacement Therapy Revenue by Geographic Area4.3.8 Eli lilly Testosterone Replacement Therapy Revenue by Sales Channel4.3.9 Eli lilly Recent Development4.4 Pfizer4.4.1 Pfizer Corporation Information4.4.2 Pfizer Description, Business Overview4.4.3 Pfizer Testosterone Replacement Therapy Products Offered4.4.4 Pfizer Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.4.5 Pfizer Testosterone Replacement Therapy Revenue by Product4.4.6 Pfizer Testosterone Replacement Therapy Revenue by Application4.4.7 Pfizer Testosterone Replacement Therapy Revenue by Geographic Area4.4.8 Pfizer Testosterone Replacement Therapy Revenue by Sales Channel4.4.9 Pfizer Recent Development4.5 Actavis (Allergan)4.5.1 Actavis (Allergan) Corporation Information4.5.2 Actavis (Allergan) Description, Business Overview4.5.3 Actavis (Allergan) Testosterone Replacement Therapy Products Offered4.5.4 Actavis (Allergan) Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.5.5 Actavis (Allergan) Testosterone Replacement Therapy Revenue by Product4.5.6 Actavis (Allergan) Testosterone Replacement Therapy Revenue by Application4.5.7 Actavis (Allergan) Testosterone Replacement Therapy Revenue by Geographic Area4.5.8 Actavis (Allergan) Testosterone Replacement Therapy Revenue by Sales Channel4.5.9 Actavis (Allergan) Recent Development4.6 Bayer4.6.1 Bayer Corporation Information4.6.2 Bayer Description, Business Overview4.6.3 Bayer Testosterone Replacement Therapy Products Offered4.6.4 Bayer Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.6.5 Bayer Testosterone Replacement Therapy Revenue by Product4.6.6 Bayer Testosterone Replacement Therapy Revenue by Application4.6.7 Bayer Testosterone Replacement Therapy Revenue by Geographic Area4.6.8 Bayer Recent Development4.7 Novartis4.7.1 Novartis Corporation Information4.7.2 Novartis Description, Business Overview4.7.3 Novartis Testosterone Replacement Therapy Products Offered4.7.4 Novartis Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.7.5 Novartis Testosterone Replacement Therapy Revenue by Product4.7.6 Novartis Testosterone Replacement Therapy Revenue by Application4.7.7 Novartis Testosterone Replacement Therapy Revenue by Geographic Area4.7.8 Novartis Recent Development4.8 Teva4.8.1 Teva Corporation Information4.8.2 Teva Description, Business Overview4.8.3 Teva Testosterone Replacement Therapy Products Offered4.8.4 Teva Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.8.5 Teva Testosterone Replacement Therapy Revenue by Product4.8.6 Teva Testosterone Replacement Therapy Revenue by Application4.8.7 Teva Testosterone Replacement Therapy Revenue by Geographic Area4.8.8 Teva Recent Development4.9 Mylan4.9.1 Mylan Corporation Information4.9.2 Mylan Description, Business Overview4.9.3 Mylan Testosterone Replacement Therapy Products Offered4.9.4 Mylan Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.9.5 Mylan Testosterone Replacement Therapy Revenue by Product4.9.6 Mylan Testosterone Replacement Therapy Revenue by Application4.9.7 Mylan Testosterone Replacement Therapy Revenue by Geographic Area4.9.8 Mylan Recent Development4.10 Upsher-Smith4.10.1 Upsher-Smith Corporation Information4.10.2 Upsher-Smith Description, Business Overview4.10.3 Upsher-Smith Testosterone Replacement Therapy Products Offered4.10.4 Upsher-Smith Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.10.5 Upsher-Smith Testosterone Replacement Therapy Revenue by Product4.10.6 Upsher-Smith Testosterone Replacement Therapy Revenue by Application4.10.7 Upsher-Smith Testosterone Replacement Therapy Revenue by Geographic Area4.10.8 Upsher-Smith Recent Development4.11 Ferring Pharmaceuticals4.11.1 Ferring Pharmaceuticals Corporation Information4.11.2 Ferring Pharmaceuticals Description, Business Overview4.11.3 Ferring Pharmaceuticals Testosterone Replacement Therapy Products Offered4.11.4 Ferring Pharmaceuticals Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.11.5 Ferring Pharmaceuticals Testosterone Replacement Therapy Revenue by Product4.11.6 Ferring Pharmaceuticals Testosterone Replacement Therapy Revenue by Application4.11.7 Ferring Pharmaceuticals Testosterone Replacement Therapy Revenue by Geographic Area4.11.8 Ferring Pharmaceuticals Recent Development4.12 Kyowa Kirin4.12.1 Kyowa Kirin Corporation Information4.12.2 Kyowa Kirin Description, Business Overview4.12.3 Kyowa Kirin Testosterone Replacement Therapy Products Offered4.12.4 Kyowa Kirin Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.12.5 Kyowa Kirin Testosterone Replacement Therapy Revenue by Product4.12.6 Kyowa Kirin Testosterone Replacement Therapy Revenue by Application4.12.7 Kyowa Kirin Testosterone Replacement Therapy Revenue by Geographic Area4.12.8 Kyowa Kirin Recent Development4.13 Acerus Pharmaceuticals4.13.1 Acerus Pharmaceuticals Corporation Information4.13.2 Acerus Pharmaceuticals Description, Business Overview4.13.3 Acerus Pharmaceuticals Testosterone Replacement Therapy Products Offered4.13.4 Acerus Pharmaceuticals Testosterone Replacement Therapy Sales, Revenue and Gross Margin (2015-2020)4.13.5 Acerus Pharmaceuticals Testosterone Replacement Therapy Revenue by Product4.13.6 Acerus Pharmaceuticals Testosterone Replacement Therapy Revenue by Application4.13.7 Acerus Pharmaceuticals Testosterone Replacement Therapy Revenue by Geographic Area4.13.8 Acerus Pharmaceuticals Recent Development 5 Breakdown Data by Type5.1 Global Testosterone Replacement Therapy Sales by Type (2015-2026)5.1.1 Global Testosterone Replacement Therapy Sales by Type (2015-2020)5.1.2 Global Testosterone Replacement Therapy Sales Forecast by Type (2021-2026)5.1.3 Global Testosterone Replacement Therapy Sales Market Share by Type (2015-2026)5.2 Global Testosterone Replacement Therapy Revenue Forecast by Type (2015-2026)5.2.1 Global Testosterone Replacement Therapy Revenue by Type (2015-2020)5.2.2 Global Testosterone Replacement Therapy Revenue Forecast by Type (2021-2026)5.2.3 Global Testosterone Replacement Therapy Revenue Market Share by Type (2015-2026)5.3 Testosterone Replacement Therapy Average Selling Price (ASP) by Type (2015-2026) 6 Breakdown Data by Application6.1 Global Testosterone Replacement Therapy Sales by Application (2015-2026)6.1.1 Global Testosterone Replacement Therapy Sales by Application (2015-2020)6.1.2 Global Testosterone Replacement Therapy Sales Forecast by Application (2021-2026)6.1.3 Global Testosterone Replacement Therapy Sales Market Share by Application (2015-2026)6.2 Global Testosterone Replacement Therapy Revenue Forecast by Application (2015-2026)6.2.1 Global Testosterone Replacement Therapy Revenue by Application (2015-2020)6.2.2 Global Testosterone Replacement Therapy Revenue Forecast by Application (2021-2026)6.2.3 Global Testosterone Replacement Therapy Revenue Market Share by Application (2015-2026)6.3 Testosterone Replacement Therapy Average Selling Price (ASP) by Application (2015-2026) 7 North America7.1 North America Testosterone Replacement Therapy Market Size YoY Growth 2015-20267.2 North America Testosterone Replacement Therapy Market Facts & Figures by Country7.2.1 North America Testosterone Replacement Therapy Sales by Country (2015-2026)7.2.2 North America Testosterone Replacement Therapy Revenue by Country (2015-2026)7.3 North America Testosterone Replacement Therapy Sales by Type7.4 North America Testosterone Replacement Therapy Sales by Application 8 Asia-Pacific8.1 Asia-Pacific Testosterone Replacement Therapy Market Size YoY Growth 2015-20268.2 Asia-Pacific Testosterone Replacement Therapy Market Facts & Figures by Region8.2.1 Asia-Pacific Testosterone Replacement Therapy Sales by Region (2015-2026)8.2.2 Asia-Pacific Testosterone Replacement Therapy Revenue by Region (2015-2026)8.3 Asia-Pacific Testosterone Replacement Therapy Sales by Type8.4 Asia-Pacific Testosterone Replacement Therapy Sales by Application 9 Europe9.1 Europe Testosterone Replacement Therapy Market Size YoY Growth 2015-20269.2 Europe Testosterone Replacement Therapy Market Facts & Figures by Country9.2.1 Europe Testosterone Replacement Therapy Sales by Country (2015-2026)9.2.2 Europe Testosterone Replacement Therapy Revenue by Country (2015-2026)9.3 Europe Testosterone Replacement Therapy Sales by Type9.4 Europe Testosterone Replacement Therapy Sales by Application 10 Latin America10.1 Latin America Testosterone Replacement Therapy Market Size YoY Growth 2015-202610.2 Latin America Testosterone Replacement Therapy Market Facts & Figures by Country10.2.1 Latin America Testosterone Replacement Therapy Sales by Country (2015-2026)10.2.2 Latin America Testosterone Replacement Therapy Revenue by Country (2015-2026)10.3 Latin America Testosterone Replacement Therapy Sales by Type10.4 Latin America Testosterone Replacement Therapy Sales by Application 11 Middle East and Africa11.1 Middle East and Africa Testosterone Replacement Therapy Market Size YoY Growth 2015-202611.2 Middle East and Africa Testosterone Replacement Therapy Market Facts & Figures by Country11.2.1 Middle East and Africa Testosterone Replacement Therapy Sales by Country (2015-2026)11.2.2 Middle East and Africa Testosterone Replacement Therapy Revenue by Country (2015-2026)11.3 Middle East and Africa Testosterone Replacement Therapy Sales by Type11.4 Middle East and Africa Testosterone Replacement Therapy Sales by Application 12 Supply Chain and Sales Channel Analysis12.1 Testosterone Replacement Therapy Supply Chain Analysis12.2 Testosterone Replacement Therapy Key Raw Materials and Upstream Suppliers12.3 Testosterone Replacement Therapy Clients Analysis12.4 Testosterone Replacement Therapy Sales Channel and Sales Model Analysis12.4.1 Testosterone Replacement Therapy Distribution Channel Analysis: Indirect Sales VS Direct Sales12.4.2 Testosterone Replacement Therapy Distribution Channel Analysis: Online Sales VS Offline Sales12.4.3 Testosterone Replacement Therapy Distributors 13 Market Dynamics13.1 Testosterone Replacement Therapy Market Drivers13.2 Testosterone Replacement Therapy Market Opportunities13.3 Testosterone Replacement Therapy Market Challenges13.4 Testosterone Replacement Therapy Market Restraints13.5 Porters Five Forces Analysis 14 Research Findings and Conclusion 15 Appendix15.1 Research Methodology15.1.1 Methodology/Research Approach15.1.2 Data Source15.2 Author Details15.3 Disclaimer
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Testosterone Replacement Therapy Market size was US$ 1665.5 million and it is expected to reach US$ 1238.2 million by the end of 2026, with a CAGR of...
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Testosterone Replacement Therapy Market Potential Growth, Size, Share, Demand and Analysis of Key Players Research Forecasts to 2027 – The Daily…
Posted: October 4, 2020 at 11:48 pm
Fort Collins, Colorado The Testosterone Replacement Therapy Market is growing at a rapid pace and contributes significantly to the global economy in terms of turnover, growth rate, sales, market share and size. The Testosterone Replacement Therapy Market Report is a comprehensive research paper that provides readers with valuable information to understand the basics of the Testosterone Replacement Therapy Report. The report describes business strategies, market needs, dominant market players and a futuristic view of the market.
The report has been updated to reflect the most recent economic scenario and market size regarding the ongoing COVID-19 pandemic. The report looks at the growth outlook as well as current and futuristic earnings expectations in a post-COVID scenario. The report also covers changing market trends and dynamics as a result of the pandemic and provides an accurate analysis of the impact of the crisis on the market as a whole.
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Industry Testosterone Replacement Therapy Study provides an in-depth analysis of key market drivers, opportunities, challenges and their impact on market performance. The report also highlights technological advancements and product developments that drive market needs.
The report contains a detailed analysis of the major players in the market, as well as their business overview, expansion plans and strategies. Key players explored in the report include:
The report provides comprehensive analysis in an organized manner in the form of tables, graphs, charts, pictures and diagrams. Organized data paves the way for research and exploration of current and future market outlooks.
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The report provides comprehensive data on the Testosterone Replacement Therapy market and its trends to help the reader formulate solutions to accelerate business growth. The report provides a comprehensive overview of the economic scenario of the market, as well as its benefits and limitations.
The Testosterone Replacement Therapy Market Report includes production chain analysis and value chain analysis to provide a comprehensive picture of the Testosterone Replacement Therapy market. The research consists of market analysis and detailed analysis of application segments, product types, market size, growth rates, and current and emerging industry trends.
Testosterone Replacement Therapy Market Segmentation, By Type
Testosterone Replacement Therapy Market Segmentation, By Applications
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The market is geographically spread across several key geographic regions and the report includes regional analysis as well as production, consumption, revenue and market share in these regions for the 2020-2027 forecast period. Regions include North America, Latin America, Europe, Asia Pacific, the Middle East, and Africa.
Radical Coverage of the Testosterone Replacement Therapy Market:
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Sperm Take Up to 3 Years to Recover After Anabolic Steroids – Medscape
Posted: October 4, 2020 at 11:48 pm
Contrary to prior understanding, many hormones related to spermatogenesis take longer to recover than previously thought, and up to 3 years in some cases after anabolic steroid misuse, according to a fertility expert speaking at the Royal Society of Medicine webinar series.
Dr Channa Jayasena, consultant in reproductive endocrinology and andrology at Imperial College and Hammersmith Hospital, London, gave a talk on male hypogonadism that he admitted might seem provocative to some people but addresses issues that extend current knowledge. The three key issues discussed were: how quickly can men recover fertility after androgen use; how to assist azoospermic men with Klinefelter syndrome (or XXY) father children; and whether testosterone therapy affects progression to diabetes in obese men.
Dr Jayasena spoke at last weeks 3-day webinar held by the Royal Society of Medicine, Endocrinology and Diabetes section, entitled, EDN50:What's new in endocrinology and diabetes 2020?
He began by asking how quicky do men who take anabolic steroids recover fertility? "This has never been studied to much extent."
Self-confessed steroid user and reality television star, Spencer Matthews, said in a tabloid newspaper article that the UK is in the grips of an epidemic of anabolic steroid use, Dr Jayasena remarked. "I see men who take anabolic steroids but then they want a baby and want to know whats next?"
The nearest data to understanding recovery from anabolic steroids comes from studies of the male pill, said the andrologist. This involves giving a high level of progesterone to suppress luteinising hormone and follicle stimulating hormone (in effect the male pill), and then giving the men testosterone replacement. A Lancet paper (Liu at al 2006) involving this regimen looked at the time from stopping the male pill to recovery of sperm. It shows that, by 12 months, all participants had recovered some sperm function, with 80% recovering to the pre-treatment semen level, explained Dr Jayasena. "This has long been presumed to be the measure of recovery. However, this does not resonate with reality and the observation that actually there are many people who dont recover within this time frame and take a lot longer, some with azoospermia[semen containing no sperm]," he pointed out.
Another cross-sectional observational study looked at 41 current users of anabolic steroids, 31 recent ( 3 months since last use), and 21 healthy eugonadal men. All were 18-55 years, exercising at least three times a week. "The critical strength of this study is that these men were all clinically indistinct," Dr Jayasena remarked. "This matching of baseline characteristics is critical for interpretation of the data. Due to recruitment issues, weve never had such a good look at recovery in this way before."
The study looked at the reproductive endocrine profiles including the levels of luteinising hormone, follicle stimulating hormone, and testosterone. In current users, the former two were suppressed and the testosterone level was high, as expected, displaying a hypogonadatropic profile. "Past users and non-users have very similar profiles, suggesting reversible luteinising hormone and follicle stimulating hormone suppression," said Dr Jayasena, adding, "this is really interesting and looking at acne, gynaecomastia, hair loss and smaller testicles all classical features of androgen abuse - appear to persist in many of the men who are past users. Its important we counsel these men that we, the clinicians, are not really clear about how long these side effects will persist."
Results also showed low HDL cholesterol and high triglycerides in users, but not in non-users or past users, and cardiac hypertrophy in users but not past users. "The latter finding is encouraging," Dr Jayasena pointed out.
Regarding fertility, the study by Shankara-Naranya found that when comparing non-users to users of anabolic steroids, it took a mean of 10.7 months for users to recover their luteinising hormone levels to the mean luteinising hormone of a non-user. "But recovery time is highly variable. Luteinising hormone (and testosterone by inference), and sperm concentration seem to recover within a year, with a mean of 10 months, but all the other hormones that are important for spermatogenesis take much longer to recover so follicle stimulating hormone was 20 months, inhibin B was 32 months, sperm motility was 38 months, up to 3 years to recover. This is critical and we didnt know this," reported Dr Jaysena.
"In answer to what is the prognosis for recovery in men after androgen misuse? The endocrine system mostly recovers in the first year but sperm take much longer to recover," he concluded.
Along with Downs syndrome, Klinefelter is the most common chromosomal disorder in men, affecting 1 in 500 men. A total of 90% of those with Klinefelter syndrome are azoospermic, and it has long been assumed to be incompatible with fatherhood.
"Things have changed, and Id like to ask what is the chance of fatherhood for a man with XXY undergoing microdissection testicular sperm extraction (mTESE)?" said Dr Jayasena. "This can be done by dissecting open a testicle and looking for an engorged seminiferous tubule that is likely to be full of sperm," he explained. "If this is confirmed, after some processing, the sperm can be used in intracytoplasmicsperm injection (ICSI)."
It has been known that it was possible for patients with Klinefelter syndrome to father children for the past 20 years, but, asked Dr Jayasena, how successful is it? "Its still an embryonic field," he noted. Referring to a meta-analysis of 37 studies, Dr Jayasena said 40% of men with Klinefelters syndrome had sperm retrieved, and of these 40%, an average of nearly 50% of men had live births after ICSI. But some studies reported 10% and others 90%.
In conclusion, the chances of fatherhood in XXY men undergoing mTESE, is around 20% but a large randomised controlled trial (RCT) is needed to confirm this, said Dr Jayasena.
Finally, the researcher moved on to the third topic of whether testosterone therapy improves the effectiveness of weight loss in men over 50 years with type 2 diabetes. Referring to outcomes of the largest, as yet unpublished, testosterone trial ever, in more than 1000 men by Dr Gary Wittert, from the University of Adelaide, Dr Jayasena described the study.
Most importantly, they did not select men with hypogonadism these results are not valid for hypogonadism because not all men had hypogonadism, explained Dr Jayasena. Two-hour plasma glucose was 7.8 to 15 mmol/l. The men were randomised to Weight Watchers weight loss programme plus placebo versus the same weight loss programme plus testosterone. They also excluded men with high cardiovascular risk, due to a Food and Drug Administration [FDA] unproven concern about cardiovascular risk. "Testosterone may be dangerous in some of these men (59-75 years and obese) in real life," he pointed out.
The paper is currently in review but some preliminary findings were presented at a conference earlier this year. Dr Jayasena says: "If testosterone improves the prevention of type 2 diabetes during weight loss in men without hypogonadism, then that would challenge our understanding of how it works. However, testosterone is still not a treatment to prevent type 2 diabetes,"
To answer the question definitively, said Dr Jayasena, confirmatory data, mechanistic data, and safety data are needed.
COI: Dr Jayasena received an honorarium for speaking during a debate organised by the Society for Endocrinology and sponsored by Besins Healthcare. He has an investigator-led grant by Logixx Pharma Ltd.
Presented at the Royal Society of Medicine, Endocrinology and Diabetes section, entitled, EDN50: What's new in endocrinology and diabetes 2020? , Day 3. September 23, 2020
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Sperm Take Up to 3 Years to Recover After Anabolic Steroids - Medscape
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