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Category Archives: Testosterone
Kathy Lettes new book Husband Replacement Therapy has an empowering message for women over 50 – 7NEWS.com.au
Posted: April 27, 2020 at 9:49 am
Kathy Lette has spent 40 years making us laugh out loud with her side-splitting stories.
The Aussie author has now penned 19 books, including the controversial teen classic Puberty Blues - which was turned into a feature film and TV show.
Watch the full story above
Now, the author has released a saucy new novel about breaking free at 50, the power of female friendship, and proving that women only get better with age.
This is a book about women ageing disgracefully, Lette said.
Its saying to women its okay for once in your life to have some fun - because so many women are tethered to the kitchens by our aprons and heartstrings.
But when the kids start to leave home, women can finally put themselves first for a change.
I thought at my age, Id be sitting at home knitting my own bus pass - but I dont feel like that at all. I feel like swinging off a chandelier with a toyboy between my teeth.
So this is a book thats all about that, and saying to women, have fun and be frivolous. Enjoy yourself. Its a comedy with a lot of girl talk.
The novel, titled HRT, Husband Replacement Therapy, also touches on divorce.
The majority of divorces in Australia now are actually initiated by women, Lette said.
The two chief times are when the last kid finishes school or when the husband retires.
More on 7NEWS.com.au
As a woman ages, her estrogen drops and her testosterone comes up - so she gets a little bit more selfish and more like a bloke.
For men, its the opposite - they want to stay at home and nest, but the womans like, Ive nested. Theres a real difference between what older men and women they want, so I thought it would be an interesting area to explore.
I dont see divorce as a failure - I just see it as a change. It is okay to have a second act.
Kathy Lettes new book is out now - find out more here.
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Kathy Lettes new book Husband Replacement Therapy has an empowering message for women over 50 - 7NEWS.com.au
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Global Human Immunoglobulin (pH4) for Intravenous Injection (COVID-19) Market to Surpass US$ 99,772.2 Million by 2027 – CMI – GlobeNewswire
Posted: April 24, 2020 at 3:47 am
SEATTLE, April 23, 2020 (GLOBE NEWSWIRE) -- According to Coherent Market Insights, the global human immunoglobulin (pH4) for intravenous injection (COVID-19) market is estimated to be valued at US$ 43,205.8 million in 2020, and is expected to exhibit a CAGR of 12.7% during the forecast period (2020-2027).
Key Trends:
Key trends in the market include viral disease outbreaks, the increasing prevalence of chronic lymphocytic leukemia, and demand for immune globulin products in the market.
According to the American Cancer Society around 60,530 new cases of leukemia will be diagnosed in the U.S in 2020 out of which 21,040 new cases will be of chronic lymphocytic leukemia (CLL).
Similarly, according to the Cancer Research UK, around 3,500 new cases of chronic lymphocytic leukemia (CLL) were diagnosed in the U.K in 2017.
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Moreover, the growing demand for immune globulin (IG) products is expected to drive the human immunoglobulin (ph4) for intravenous injection (COVID-19) market growth. For instance, on August 12, 2019, the U.S. Food and Drug Administration (FDA) confirmed that demand for immune globulin products has increased in recent years and there is a shortage of Immune Globulin (Subcutaneous) (IGSC) and Immune Globulin (Intravenous) (IGIV) products in the U.S. The U.S. Food and Drug Administration is working closely with manufacturers such as Asceniv, Bivigam, Octagam, Panzyga, Privigen and others of various immune globulin (intravenous) (IGIV) products to help mitigate the supply situation for IG products.
Key Market Takeaways:
Key players operating in market are
Takeda Pharmaceutical Company Limited, Baxter International Inc., CSL Behring, Bayer AG, Grifols, S.A., Octapharma AG, Shanghai RAAS Blood Products Co., Ltd., Hualan Biological Engineering Inc., China Biologic Products, Inc., Sichuan Yuanda Shuyang Pharmaceutical Co., Ltd., Boya Bio-Pharmaceutical Group Co., Ltd., ADMA Biologics, Inc., and Sinopharm Group Co., Ltd.
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Market Segmentation:
Related Topics:
HEALTHCARE CONTRACT RESEARCH OUTSOURCING MARKET
Healthcare Contract Research Outsourcing is conducted by pharmaceutical and medical device sectors for development of new drugs and medical devices. Clinical trials form the key part of pharmaceutical drug and medical device development and in the current scenario clinical trials are conducted across multiple locations in various geographies. Increasing cost and time required for drug development is expected to propel growth of the global healthcare contract research outsourcing market over the forecast period.
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ANDROGEN REPLACEMENT THERAPY MARKET
Androgen replacement therapy (ART), often referred to as testosterone replacement therapy (TRT), is a form of hormone therapy, in which androgens, often testosterone, are replaced. ART is often prescribed to counter the effects of male hypogonadism. It typically involves the administration of testosterone through injections, skin creams, patches, gels, or subcutaneous pellets. Testosterone replacement therapy is a promising technology for improving symptoms of hypogonadism and to raise the testosterone level.
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Global Human Immunoglobulin (pH4) for Intravenous Injection (COVID-19) Market to Surpass US$ 99,772.2 Million by 2027 - CMI - GlobeNewswire
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Testosterone Replacement Therapy Market Analysis by Size, Share, Top Key Manufacturers, Demand Overview, Regional Outlook And Growth Forecast to 2026…
Posted: April 22, 2020 at 8:47 pm
Acerus Pharmaceuticals
Global Testosterone Replacement Therapy Market Segmentation
This market was divided into types, applications and regions. The growth of each segment provides an accurate calculation and forecast of sales by type and application in terms of volume and value for the period between 2020 and 2026. This analysis can help you develop your business by targeting niche markets. Market share data are available at global and regional levels. The regions covered by the report are North America, Europe, the Asia-Pacific region, the Middle East, and Africa and Latin America. Research analysts understand the competitive forces and provide competitive analysis for each competitor separately.
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Global Testosterone Replacement Therapy Market Regions and Countries Level Analysis
The regional analysis is a very complete part of this report. This segmentation highlights Testosterone Replacement Therapy sales at regional and national levels. This data provides a detailed and accurate analysis of volume by country and an analysis of market size by region of the world market.
The report provides an in-depth assessment of growth and other aspects of the market in key countries such as the United States, Canada, Mexico, Germany, France, the United Kingdom, Russia and the United States Italy, China, Japan, South Korea, India, Australia, Brazil and Saudi Arabia. The chapter on the competitive landscape of the global market report contains important information on market participants such as business overview, total sales (financial data), market potential, global presence, Testosterone Replacement Therapy sales and earnings, market share, prices, production locations and facilities, products offered and applied strategies. This study provides Testosterone Replacement Therapy sales, revenue, and market share for each player covered in this report for a period between 2016 and 2020.
Why choose us:
We offer state of the art critical reports with accurate information about the future of the market.
Our reports have been evaluated by some industry experts in the market, which makes them beneficial for the company to maximize their return on investment.
We provide a full graphical representation of information, strategic recommendations and analysis tool results to provide a sophisticated landscape and highlight key market players. This detailed market assessment will help the company increase its efficiency.
The dynamics of supply and demand shown in the report offer a 360-degree view of the market.
Our report helps readers decipher the current and future constraints of the Testosterone Replacement Therapy market and formulate optimal business strategies to maximize market growth.
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Table of Contents:
Study Coverage: It includes study objectives, years considered for the research study, growth rate and Testosterone Replacement Therapy market size of type and application segments, key manufacturers covered, product scope, and highlights of segmental analysis.
Executive Summary: In this section, the report focuses on analysis of macroscopic indicators, market issues, drivers, and trends, competitive landscape, CAGR of the global Testosterone Replacement Therapy market, and global production. Under the global production chapter, the authors of the report have included market pricing and trends, global capacity, global production, and global revenue forecasts.
Testosterone Replacement Therapy Market Size by Manufacturer: Here, the report concentrates on revenue and production shares of manufacturers for all the years of the forecast period. It also focuses on price by manufacturer and expansion plans and mergers and acquisitions of companies.
Production by Region: It shows how the revenue and production in the global market are distributed among different regions. Each regional market is extensively studied here on the basis of import and export, key players, revenue, and production.
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Market Research Intellect provides syndicated and customized research reports to clients from various industries and organizations with the aim of delivering functional expertise. We provide reports for all industries including Energy, Technology, Manufacturing and Construction, Chemicals and Materials, Food and Beverage and more. These reports deliver an in-depth study of the market with industry analysis, market value for regions and countries and trends that are pertinent to the industry.
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Tags: Testosterone Replacement Therapy Market Size, Testosterone Replacement Therapy Market Growth, Testosterone Replacement Therapy Market Forecast, Testosterone Replacement Therapy Market Analysis
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Testosterone Replacement Therapy Market Analysis by Size, Share, Top Key Manufacturers, Demand Overview, Regional Outlook And Growth Forecast to 2026...
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Given Alex Rodriguez’s history with doping scandals, should he be allowed to own New York Mets? – MEAWW
Posted: April 22, 2020 at 8:46 pm
This week, reports emerged that former baseball player Alex Rodriguez and his fiance Jennifer Lopez are eyeing a bid to buy the Major Leagues Baseball (MLB) team, New York Mets. However, with Rodriguez's extensive history with using performance-enhancing drugs, should such a sale be allowed?
In an earlier report, we had written that Rodriguez had opened up to 'The Tonight Show' host Jimmy Fallon about his inclination towards launching a future bid for the Mets and also confessed how he grew up a Mets fan before winning a world series with the Yankees. "I will say this, if the opportunity came up (to buy the Mets), I would certainly look at it," he told Fallon. He also went on to say how the 1986 championship-clinching game was one the best nights of his life after the birth of his daughters.
While Rodriguez now has a thriving career as a baseball analyst, commentator and host and enjoys the limelight coming from being engaged to actor, dancer and singer Jennifer Lopez it is difficult to erase his baseball career. Even though he was once dubbed the greatest baseball player of his generation, his achievements were marred by cheating scandals.
His playing career had resulted in one World Series title, three MVP awards, 14 All-Star appearances, 696 home runs and earnings of $452M the most in the history of Major League Baseball.
The Biogenesis scandal, which resulted in Rodriguez's suspension, broke out in 2013 and was the biggest baseball performance-enhancing drugs (PED) scandal, but Rodriguez had been caught using performance-enhancing drugs much before that.
In July 2007, former outfielder and steroid-user Jose Canseco called Rodriguez a "hypocrite" and alleged that the latter was using steroids something Rodriguez vehemently denied.
In 2009, Sports Illustrated reported that Rodriguez had tested positive for two anabolic steroids, testosterone and Primobolan, during his 2003 season playing for the Texas Rangers. This was the same season in which he captured his first American League Most Valuable Player award, broke 300 career home runs (hitting 47 that year) and earned one of his 10 Silver Slugger Awards.
The same year, Rodriguez told ESPN that he had used PEDs when he first started out, stating, "When I arrived in Texas in 2001, I felt an enormous amount of pressure. I felt like I had all the weight of the world on top of me and I needed to perform, and perform at a high level every day."
In 2003, as the result of a collectively bargained union agreement, there was no penalty or punishment for a positive test during an anonymous drug survey and mandatory drug testing only began in 2004 after more than 5% of the samples taken from players in 2003 came back positive. In 2013, the New York Times alleged that Rodriguez tested positive for a banned stimulant in 2006.
It was the Biogenesis scandal that broke out the same year that catapulted the MLB, Rodriguez and other players of note to infamy. A disgruntled former employee of Biogenesis in America a health clinic briefly operating in Coral Gables, Florida, specializing in weight loss and hormone replacement therapy released records of the clinic's real business. These records showed that players such as Rodriguez, Melky Cabrera, Bartolo Coln, Ryan Braun and Nelson Cruz were getting access to PEDs, thanks to an unlicensed doctor.
Over the next two months, MLB suspended 14 players. Meanwhile, penalties for getting caught increased. First-time offenses went from 50 to 80 games, while second-time offenses went from 100 games to an entire season. Any offender caught doping is now ineligible for that year's playoffs, no matter when the infraction occurs.
For a long time, Rodriguez insisted he was innocent and even alleged that the MLB engaged in a "witch hunt" to get him out of baseball when he sued the league in 2013. Rodriguez and his team voluntarily dropped the suit in February 2014.
In 2019, Billy Corben's documentary on the scandal titled 'Screwball' released and oddly, news of Rodriguez's engagement to Lopez broke a day after the trailer for the documentary released. In an interview with Rolling Stone, Corben described the scandal as Florida f**kery distilled like freebasing Florida f**kery and crony capitalism".
Although Rodriguez has since apologized for his role in the Biogenesis scandal, Corben was suspicious of Rodriguez's image rehab. Corben told Rolling Stone, "This is the guy who was never beloved. He was booed by his own fans, for crying out loud. Without so much as a mea culpa tour, he hasnt rehabilitated his image, hes created an entirely new one that never existed before."
In August 2013, Rodriguez was suspended through the 2014 season (211 games at the time of the decision), but was allowed to play in 2013 pending his appeal of that decision. His suspension was upheld in January 2014 after being allowed to play in the 49 games between the decision and the hearing, technically reducing the suspension to 162 games. In July 2014, Rodriguez was sued by his lawyers for $380,000 in unpaid legal fees.
In November that year, it was revealed that Rodriguez had admitted to the Drug Enforcement Administration that he had used performance-enhancing drugs as early as January of the same year and Rodriguez got immunity from prosecution.
Many have also called into question MLB's handling of the Biogenesis scandal, suggesting that the MLB's actions were motivated to save face rather than to take serious action on the use of PEDs among players.
Given Rodriguez's lengthy history of association with PEDs, it stands to question whether the one-time-great baseball player ought to be given the power of owning an entire baseball team and whether the MLB would even allow it.
However, with Rodriguez's new image and with Lopez's name included in the deal, it stands to reason that the MLB would be okay with Rodriguez being one of the owners of the New York Mets, even if that may leave baseball lovers with a sour taste in their mouths.
As 'Screwball' filmmaker Corben said on the Biogenesis scandal, "When Alex was useful as a heel, he was the villain. When Bud Selig needed to salvage his own reputation as the steroid commissioner and was trying some kind of redemption and legacy-saving measures, Alex was the villain. And now that Bud Seligs gone, (current commissioner) Rob Manfred, who was responsible for this entirely botched, potentially illegal investigation of Biogenesis, ascends (within MLB) into a position of power and decides, "Oh, Alex is an ally." They let bygones be bygones now? Like after the s**tshow that they put each other through? It certainly goes to show how not legitimate MLBs concerns are about steroids and shooting up in baseball, because its obviously good for business."
Continued here:
Given Alex Rodriguez's history with doping scandals, should he be allowed to own New York Mets? - MEAWW
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Options to Increase Your Testosterone
Posted: April 21, 2020 at 9:48 pm
In the last 100 years, life expectancy for men has increased by 65 percent, according to the Centers for Disease Control and Prevention (CDC).
In 1900, men lived until about age 46. By 2014, that age jumped to 76. Theres no question that men are redefining what it means to be 50, 60, and 70 years old or older.
Regular exercise, a healthy diet, and adequate rest all help maintain energy and vitality in men over 50. But men are also turning to one of the most advanced aging solutions available. Over the last decade, testosterone use among middle-aged and senior men has become popular.
Testosterone is the hormone responsible for the development of male external genitalia and secondary sexual characteristics. Its produced by the testicles. Testosterone is important for maintaining:
Testosterone also contributes to vitality and well-being.
As men age, their bodies gradually produce less testosterone. This natural decline starts around age 30 and continues throughout the rest of a mans life.
Some men have a testosterone deficiency called male hypogonadism. This is a condition in which the body doesn't produce enough testosterone. It may be caused by problems in the:
Men at risk for this condition include those who have had an injury to the testicles or have HIV/AIDS. If youve gone through chemotherapy or radiation therapy, or had undescended testicles as an infant you are also considered at risk for hypogonadism.
Symptoms of male hypogonadism in adulthood include:
Doctors can determine if you have male hypogonadism through physical exams and blood tests. If your doctor detects low testosterone they may perform additional tests to determine the cause.
Treatment typically includes testosterone replacement therapy (TRT) in the form of:
TRT reportedly helps to:
However, scientists caution there isnt enough information to determine the safety of regular testosterone supplementation.
Many men experience changes as they age similar to the symptoms of hypogonadism. But their symptoms may not be related to any disease or injury. Some are considered a normal part of aging, such as:
The Mayo Clinic reports that TRT can help men with hypogonadism. The results are not as clear with men who have normal levels of testosterone or older men with decreasing testosterone levels. More rigorous studies are needed, according to the Mayo Clinic.
Studies are mixed on whether TRT is beneficial for normal men as they age. Some research has brought up serious risks with the therapy, particularly when taken long term. This has led doctors to be cautious about recommending it.
A large, 2010 meta-analysis of 51 studies looked at the safety of TRT. The report concluded that safety analysis of TRT is of low quality and fails to inform the public about potential long-term effects.
The Mayo Clinic cautions that TRT also may:
There are also risks involved in having low testosterone levels, such as:
Previously, there were concerns that TRT raised the risk of developing prostate cancer.
Most current data, including two reports in 2015, no longer supports a link between testosterone replacement and the development of 1) prostate cancer, 2) more aggressive prostate cancer, or 3) prostate cancer that returns after treatment.
If you have male hypogonadism or low testosterone, talk with your doctor about whether TRT may be a good option for you. Discuss the risks and benefits of TRT.
If you dont have hypogonadism, but youre interested in feeling more energetic and youthful. The following alternative methods may help increase your testosterone level without the use of hormone therapy.
One way to increase your testosterone levels is through TRT. Its especially effective if you have hypogonadism. Studies have not yet demonstrated the effectiveness of TRT in helping men with normal levels of testosterone or older men with decreasing testosterone levels due to aging.
Men who take TRT usually experience increased energy, a higher sex drive, and overall well-being. But its long-term safety hasnt been established.
There are a variety of lifestyle treatments involving exercise, diet, and sleep that have been shown to increase testosterone levels. Talk to your doctor about what may be best for you.
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Testosterone Replacement Therapy Studies 2019
Posted: April 21, 2020 at 9:48 pm
2018 saw a plethora of reports on testosterone replacement therapy, health risks, studies, trials, and types of TRT. Here at HGH doctor, our hormone replacement physicians keep up on the latest research to ensure we provide the best quality care to our clients. Part of our focus is passing new information and studies forward to you here on our website.
The results of one study on middle-aged and older men focused on the best type of treatment for fat-free mass (FFM) and muscle strength response. Men participating in the study received either intramuscular testosterone injections, transdermal TRT, or a placebo.
Although all forms of testosterone therapy showed positive improvements in FFM, total body strength, and lower and upper extremity strength, the changes seen were 3 to 5 times greater in the men who received testosterone injections rather than transdermal TRT. [1]
Testosterone therapy studies such as this one help our doctors choose the appropriate treatment for each person.
The Testosterone Therapy Trials in elderly men consisted of seven coordinated trials looking at the following areas:
We will report on these, as well as other trials and studies in this article.
Testosterone studies shed light on the benefits and safety of using testosterone replacement therapy.
For years, doctors steered men with or at greater risk of developing prostate cancer away from TRT. Even if a male had all the signs of low testosterone, many doctors believed that treatment with testosterone therapy would increase prostate cancer dangers. Luckily, there has been much research done in this area, showing the safety and benefits of TRT following prostate cancer treatment. Also, men who suffer from prostate enlargement or prostate cancer risks can also safely use testosterone therapy.
In the most recent testosterone replacement therapy studies, mounting evidence points to the safety of testosterone without reducing the risk of prostate cancer.
In a pooled analysis of 18 testosterone replacement therapy recent studies on 3,886 men diagnosed with prostate cancer, and 6,439 in the control group, there was no association between testosterone levels, DHT, and prostate cancer. [2, 3]
In a 2017 report, the Registry of Hypogonadism in Men reported that there was no increase in the odds of developing prostate cancer with the use of TRT. [4]
A 2013 study of men who underwent prostatectomy for prostate cancer found no increased risk of prostate cancer following testosterone therapy. [5]
In 2015, a study of men who underwent radiation therapy for prostate cancer followed up by testosterone therapy showed only a minor increase in serum PSA and a low rate of biochemical recurrence. [6]
Based on the current research, testosterone replacement therapy shows positive benefits for improving quality of life and well-being in men treated for prostate cancer.
With a multitude of testosterone replacement therapy studies reversing the prior concerns about cardiovascular risk, many men can improve their quality of life with TRT to treat the symptoms of hypogonadism.
Testosterone supports heart health through the production of red blood cells needed for circulation. Additionally, testosterone improves nitric oxide production crucial for proper insulin function and blood flow.
Nitric oxide is crucial to heart health and is made by the endothelium the lining of the blood vessels. Testosterone helps to lower LDL cholesterol to reduce the plaque clogging the arteries.
In 2017, a look at testosterone and the heart showed that low levels of testosterone might increase risk factors for metabolic syndrome, coronary artery disease (CAD), and type 2 diabetes. Testosterone replacement therapy helps to improve myocardial ischemia in males diagnosed with CAD. TRT also increases exercise capacity in men with congestive heart failure (CHF). Testosterone aids in weight loss and improving serum glucose levels and insulin resistance. This study reports that TRT reduces the risk of mortality in testosterone deficient men. [8]
Testosterone has many benefits for heart health, improving circulation, and reducing the risk of cardiovascular disease.
The study duration of one year consisted of receiving either testosterone gel or a placebo. Three different questionnaires every three months assessed sexual function. Results of the study showed that TRT had significant improvements for 10 out of 12 measures of sexual activity. [9, 10]
Testosterone replacement therapy studies for men with urinary symptoms such as urinary frequency, weak stream, urgency, straining to void, and other issues have found that benign prostatic hyperplasia (BPH) can impact urinary health. Prostate enlargement often occurs as men age, along with a decline in testosterone levels. Urinary issues can impact not only quality of life, but also overall health. Treatment with testosterone therapy has been shown to decrease nocturia (nighttime voiding) and improve urinary symptoms. [11]
A 2017 study of more than 650 men showed that testosterone therapy reduces weak urinary stream, nighttime waking to urinate, incomplete emptying of the bladder, and frequent urination. Additional benefits were found in erectile functions and quality of life. [12]
Testosterone has benefits for improved sexual functions as well as urinary health.
Reviewing testosterone replacement therapy studies allows our doctors to incorporate the latest research into patient treatment protocols. Low testosterone is frequently associated with the following medical conditions:
In the Physical Function Trial for men with hypogonadism, the focus was on walking distance as a measurement of testosterone benefits. TRT increased the fraction of distance walked, and the absolute increase in distance walked in 6 minutes.[13]
The Vitality Trial measured only the Functional Assessment of Chronic Illness Therapy fatigue scale, and while the results were not significant, the overall findings from the entire testosterone trials whose positive improvements on vitality, mood, and depression symptoms. However, a 2018 report found that testosterone replacement therapy reduces depressive symptoms except in individuals with major depressive disorder.[14]
The results of the Anemia Trials from these studies on testosterone therapy were extremely positive. In both men with explained and unexplained anemia, there was a considerable increase in hemoglobin concentration. The increase was associated with a significant change in the impression of vitality and general health in these men.
The Bone Trial purpose was to determine if TRT in older men could increase volumetric bone mineral density (vBMD) and bone strength. The outcome showed a total increase in vBMD of the trabecular bone in the spine as well as the whole bone vBMD. Hip strength also improved with TRT. Treatment with testosterone therapy could result in reduced risk of bone fractures for older men.
A surprising outcome of the Testosterone Therapy Trials is that there was not much in the way of cognitive benefits. However, other studies offer different findings. A double-blind, placebo-controlled study found modest improvement in global cognition.[15]
Testosterone replacement therapy can benefit physical ability, red blood cell production, and bone density.
Based on the many testosterone replacement therapy studies available for review today, we believe that the safe and supervised use of TRT can offer many benefits for middle-aged and older men. The key factor here is the need to engage in proper diagnostic testing for low testosterone and remain under doctor-supervision while receiving testosterone therapy.
To date, there is less research on testosterone therapy for women with Low T. A 2014 review of 20 randomized, placebo-controlled trials shows positive benefits for sexual response, sexual desire, frequency of activity, and overall satisfaction and orgasm. The majority of research does not show a connection between testosterone and breast cancer, making TRT a possible menopausal treatment for women who cannot use estrogen therapy. [16]
A 2015 report discusses the possible cardiovascular effects of testosterone for women, as well as enhancements for cognitive performance and musculoskeletal health in postmenopausal women. [17]
Regarding future testosterone therapy studies, 2019 should also be a promising year. HGH Doctor looks forward to keeping you informed of the latest research. At this time, we believe testosterone therapy to be extremely safe for men and women following proper diagnostic procedures.
For more information on testosterone replacement therapy, please contact our hormone clinic for a free and confidential consultation.
Research has shown testosterone replacement therapy to be extremely safe and highly effective for treating symptoms of Low T.
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Testosterone Replacement Therapy Studies 2019
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Testosterone Replacement Therapy: Get Facts on Side Effects
Posted: April 21, 2020 at 9:48 pm
Testosterone deficiency introduction
Testosterone is a hormone produced by the testicles and is responsible for the proper development of male sexual characteristics. Testosterone is also important for maintaining muscle bulk, adequate levels of red blood cells, memory, bone growth, sense of well-being and sexual function.
Inadequate production of testosterone is not a common cause of erectile dysfunction; however, when ED does occur due to decreased testosterone production, testosterone replacement therapy may improve the problem.
What causes testosterone deficiency?
As a man ages, the amount of testosterone in his body gradually declines. This natural decline starts after age 30 and continues throughout life. Other causes of lowered testosterone levels include:
The significance of age-related testosterone decline is controversial and poorly understood.
What changes occur in the body due to testosterone deficiency?
How do I find out if I have a testosterone deficiency?
The only accurate way to detect the condition is to have your doctor measure the amount of testosterone in your blood. Because testosterone levels fluctuate throughout the day, several measurements will need to be taken to detect a deficiency. Doctors prefer, if possible, to test levels early in the morning since this is when testosterone levels are at their highest.
How is testosterone deficiency treated?
Testosterone deficiency can be treated by:
Each of these options provides adequate levels of hormone replacement; however, they all have different advantages and disadvantages. Talk to your doctor to see which approach may be right for you.
Who shouldn't take testosterone replacement therapy?
Men who have prostate cancer or breast cancer should not take testosterone replacement therapy. All men considering testosterone replacement therapy should undergo a thorough prostate cancer screening prior to starting this therapy with a rectal exam and PSA test.
What are the side effects of testosterone replacement therapy?
In general, hormone replacement therapy is safe. Possible side effects include:
Laboratory abnormalities that can occur with hormone replacement include:
If you are taking hormone replacement therapy, regular follow-up appointments with your doctor are important.
Like any other medication, directions for administering testosterone should be followed exactly as your doctor orders. If you are unsure or have any questions about testosterone replacement therapy, ask your doctor.
Latest Sexual Health News
References
Get-Back-On-Track.com.
The Hormone Foundation.
Edited by John M. Baird, MD, FACS on January 01, 2007
'Portions of this page The Cleveland Clinic 2000-2004
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Testosterone Replacement Therapy: Get Facts on Side Effects
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Testosterone Therapy Effects: What to Expect After …
Posted: April 21, 2020 at 9:48 pm
Testosterone replacement therapy can sound a little like the fountain of youth. Replace lost levels of the hormone, travel back in time to your younger years?
As guys age, their levels of testosterone tend to decline. And thats a big problem: Testosterone binds to proteins throughout your body and brain called androgen receptors, which help control and regulate a whole range of different bodily functions, explains Ronald Tamler, M.D., Ph.D., associate professor of medicine at the Icahn School of Medicine at Mount Sinai.
If theres not enough testosterone to go around, those androgen receptors all over your body and brain stay silent, leading to symptoms like low libido, weak erections and orgasms, inability to build muscle mass, low energy, or just feeling a little blue. A condition called hypogonadism low testosteronedevelops when your body cant produce enough of it.
Related: 8 Sneaky Signs Your Testosterone Is Too Low
Thats where testosterone replacement therapya treatment that raises your low testosterone levelscomes in. Testosterone can be supplemented in the form of an injection, a gel, a suction cup on your gums, and even a deodorant. It comes down to personal preference and what your insurance covers, says Dr. Tamler.
Now, testosterone therapy is just for guys whose levels are actually low, usually under 300 nanograms per deciliter (ng/dl) on a blood test. If youre in the normal range, T-therapy isnt on the tableand wouldnt do you good anyway, he says.
If you are prescribed testosterone therapy, youll likely start to see some changes, big and small, pleasant and not-so-pleasant. You may not see them all, and they may not all appear right away, but here are 9 benefits and drawbacks of testosterone therapy you should watch for.
When youre low on testosterone, you might notice your sex drive begin to dip. Androgen receptors are located in the parts of your brain that influence sexual desire, so if you dont have enough T to activate them, you may notice a drop in wanting to get it on, says Abraham Morgentaler, M.D., the director of Men's Health Boston and author of Why Men Fake It: The Truth About Men and Sexand Testosterone for Life.
When you replace your lost testosterone, that can activate those androgen receptors in the part of your brain that controls desire. In fact, regaining a healthy sex drive is one of the biggest benefits of testosterone replacement therapy, says Dr. Morgentaler.
In addition to upping libido, T-therapy can possibly make your erections more satisfying, too. You need to have testosterone to work on the receptors in the penis to help it trap blood to keep it [erect], says Dr. Tamler. Receptors help steer that process, and if you dont have enough T then the process is impaired.
This isnt the only piece of the puzzle, thougherections also rely on healthy nerves and blood flow. So that means that testosterone therapy by itself isnt a cure for erectile dysfunction itself.
Related: 5 Ways Happy Couples Deal When Their Sex Drives Diverge
"Muscles are extremely responsive to testosteroneone of the most reliable things we see [when someone starts testosterone replacement therapy] is an increase in muscle mass," says Dr. Morgentaler.
This is because androgen receptors are found in muscle tissue, so testosterone activates them to stimulate growth. Of course, to make the most of this benefit, youll need to be doing your part by strength training as well.
In addition to an increase in lean muscle mass, some men report fat loss as well. While testosterone doesnt directly incite fat loss itself, part of it may be thanks to the uptick in muscle massthe more muscle you have, the higher your basal metabolic rate (or BMR) will be, which means your body will burn more calories at rest. (Want to max out the process even more? Try The 21-Day Metashred from Men's Health, the at-home workout plan that will help you build lean muscle and burn fat at the same time.)
Jed Kaminetsky, M.D., a clinical assistant professor in the department of urology at NYU Langone Medical Center also notes that this may be partially because testosterone improves overall motivation to get up and sweat it out, so if you're motivated to put in the work again, you'll see results.
Related: 7 Reasons You're Not Building As Much Muscle As You Could
"It's very common for men to come in with low T and one of their primary symptoms is fatigue," says Dr. Morgentaler. "And when we treat them, a lot of men will say that their energy has improved." Many men also report an improvement in the "brain fog" that can come along with low testosterone, adds Dr. Tamler.
While researchers aren't exactly sure how exactly testosterone plays a role in energy yet, Dr. Morgentaler says one of the thoughts is that it has an effect on your mitochondria, which produce energy within cells. This case isnt closed on this yet, but the theory is that "testosterone turns them on so they're more productive in terms of creating the energy that the cells need."
Dr. Tamler also notes that it may be tied back to androgen receptors as well. "If they don't get sufficient input, that can cause fatigue," he says. So bringing testosterone levels back up can help reverse this.
Related: The 8 Best Foods to Keep You Energized All Day Long
Similar to its effects on energy, experts don't have a definitive answer to why testosterone impacts mood so deeplyafter all, "the brain is a complicated thing," says Dr. Tamlerbut they do see it as a potential life-changing benefit.
"In some ways, the impact on mood is one of the most profound benefits of T that we see," says Dr. Morgentaler. "Not everybody has that, but when we see it, it's remarkable. In my practice, patients will say, 'Oh, my mood's OK, maybe I just feel a little bit tired or blah.' And they come back and they say things like, 'I wake up in the morning and I'm optimistic about my day. I haven't felt that way in years.'"
In fact, a 2012 study published in The Aging Male found that after 12 months of testosterone therapy, the percentages of guys with moderately severe to severe depression symptoms decreased from 17 percent to 2 percent.
And more recent research also backs that up: "The largest randomized control trial for T was just completed a year ago, called the T Trials, and it showed that men who received T had a greater improvement in mood than men who received placebo," notes Dr. Morgentaler.
Related: 7 Surprising Symptoms Of Depression In Men That Prove It's Not All About Sadness
This is one of the most common side effects of testosterone replacement theory.
Normally, when your pituitary gland senses that there's not enough testosterone in the bloodstream, it sends down a hormone called luteinizing hormone (LH) to signal your testicles to start producing more testosterone, and a hormone called follicle stimulating hormone (FSH) to signal sperm production.
Related: Why Your Balls Might Feel Like a Bag Of Worms
When you take outside testosterone, the pituitary gland gets the memo that there's enough T in your bloodstream, so it stops sending these signals. This essentially puts the testicles to sleep (read: little or no sperm and testosterone production), says Dr. Kaminetsky.
"Most of the size of the testicle is dedicated to making sperm, so when you're making less sperm, the testicles get smaller," says Dr. Morgentaler. This also means it can hamper fertility, acting like birth control, so if you're planning on having kids, testosterone replacement therapy isn't an option.
6 Things Every Man Should Know About His Penis:
And production doesn't always go back to normal afterwards, either says Dr. Kaminetsky. A 2017 study in Fertility & Sterility found that increasing age and longer length of T-therapy was linked to less chances of normal sperm recovery. (Here are 7things you do every day that might be messing with your sperm.)
Some people notice a little swelling in their feet and ankles because testosterone can encourages your body to hold onto excess fluid, says Dr. Morgentaler.
This isn't a big deal for most people, he says, and its more common to see it if you're taking a non-daily treatment like an injection, where you're getting a higher dose of T in one sitting. You may notice a pound or two of difference on the scale, but it should melt away after a few days.
Related: Tom Brady Drinks 25 Glasses Of Water a Day. Should You Drink That Much, Too?
Going on testosterone replacement therapy may change your skin typefor better or for worse, says Dr. Morgentaler.
Like other hormones, testosterone can increase oil production, which isn't necessarily a bad thing. It's important for healthy skin, so you may actually end up with a better complexion. However, too much oily buildup can lead to breakouts.
Thankfully, this isn't that common, says Dr. Morgentaler, and it's typically seen in men who have a history of acne. (If you shudder at the reminder of your teenage skin, this might be a more likely side effect.)
Similar to the fluid retention, this is mainly seen with treatments like injections, when you're getting a higher dose all at once.
Related: 5 Reasons You Still Get Acne As a Grown-Ass Man
In all menwhether youre taking T or notsome testosterone is converted into the hormone estradiol, a form of estrogen. And in men who have more breast tissue by nature, the T they're taking that's naturally converted into estradiol could stimulate this breast tissue to grow.
This is called gynecomastia, says Dr. Morgentaler, and it's relatively uncommonhe says he doesn't even see one case a year.
If this does happen, though, your doctor will likely stop treatment for a month or two to allow your breast tissue to go back to normal, and then start you back up with T along with a drug that blocks the conversion of testosterone to estradiol.
Related: How to Get Rid Of Man Boobs
Testosterone replacement therapy has traditionally come along with serious warning labels that your risk for heart attack, stroke, and prostate cancer could rise, but this is still very controversialand recent evidence has begun to debunk some of these fears.
In the case of heart attacks and strokes, the concern is that testosterone thickens blood because it binds to androgen receptors that stimulate bone marrow to produce more red blood cells. Thicker blood is linked to a greater risk of heart attack and stroke.
But there isn't strong evidence to connect these cardiac events to testosterone itself, and some more recent studies actually suggest that normal testosterone levels might actually protect against these risks, says Dr. Morgentaler.
One mechanism at play here could be that reduced body fat is linked to overall better health, and testosterone replacement therapy can encourage this, says Dr. Morgentaler. More research is needed, he says, and to be safe your doctor will monitor your red blood cell count throughout your treatment.
As far as prostate cancer goes, this is fuzzy, too. Because there are androgen receptors in the prostate, testosterone can make it grow. So if you already have an enlarged prostate that makes it difficult to urinate, testosterone could exacerbate the issue, says Dr. Tamler.
Related: Should You Get the PSA Test to Screen For Prostate Cancer?
If you have existing prostate cancer, theoretically, testosterone could make it grow in the same way, says Dr. Kaminetsky. However, there isn't evidence to suggest that T actually causes prostate cancer.
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Benefits of Testosterone Replacement Therapy or TRT …
Posted: April 21, 2020 at 9:48 pm
the numbers of people suffering from testosterone deficiency are on a constant rise. also, testosterone deficiency is at an all-time high, the cause of the problem is unavoidable a modern lifestyle. there are several causes of testosterone deficiency, but all of them manifest in form of hypogonadism or reduced performance of the testes. the most commonly prescribed treatment for people who have no hopes of recovering from the condition is testosterone replacement therapy or hormone replacement therapy.
often, the patients find it stressful to decide whether to go for the testosterone replacement therapy or not. the main reason for this is that testosterone replacement therapy is a lifetime treatment. once started the patient has to continue it for rest of their life. also, the administration of exogenous testosterone further suppresses the natural production of testosterone. also, there are chances of fertility being diminished, this is a major concern for patients who wish to have children.
but, often the benefits of the testosterone replacement therapy outweigh the discomforts it causes.
testosterone replacement therapy does not aim to cure the problem of reduced testicular function. instead it aims to solve the symptoms by administration of synthetic testosterone.
testosterone is the male sex hormone, testosterone is what defines secondary sexual characteristics in men, in short testosterone makes us men.testosterone deficiency in males negatively affects all aspects of life, the quality of life is greatly reduced due to low testosterone levels. testosterone is a very active hormone in all parts of the human body, thus testosterone deficiency has a devastating effect on our body. testosterone deficiency also creates further conditions and complications that make the life miserable. let us understand what happens when the body is not producing enough testosterone.
secondary hypogonadism is generally treated by addressing the root cause of the problem, for example, many times hypogonadism is caused due to estrogen dominance due to high aromatase activity in the fat tissue. in such case, losing the fat mass, especially the abdominal fat will help resolve the problem and bring testosterone production back to normal. but this does not always happen, once the HPGA is disturbed, seldom does it fully recover. the testosterone production never comes back to the original high level. in such cases, hormone replacement therapy or testosterone replacement therapy is prescribed by the physicians.
primary hypogonadism currently has no cure and the only treatment available is testosterone replacement therapy or hormone replacement therapy.
there are various causes of low testosterone, and there are various treatments to address those root causes of low testosterone. but unfortunately, the testosterone deficiency problem is not resolved even after such treatments. the reason is that the system that produces testosterone is very delicate, and our physical capacity to produce testosterone falls with every year of our age.
doctors do recommend other forms of therapies that aim to jump-start the testosterone production by restoring the HPGA, there are various therapies, but the results of these therapies vary a lot from case to case and there are very less long-term success stories resulting from these therapies, the reason is that everyones body responds differently to these therapies. following are alternative therapies recommended by doctors as they find fit based on patients analysis
these therapies are not the standard protocol for treatment of low testosterone. they are a hit or miss in most cases. doctors do recommend these therapies because, even when they are a hit or miss they have some potential to mostly cure the problems that cause testosterone deficiency, the success rates increase if the patient puts in dedication and supplements these therapies with major lifestyle changes. but, unfortunately, most people do not respond successfully to these therapies. this brings us to the testosterone replacement therapy, yes it has its own sets of drawbacks, but testosterone replacement therapy is a standard therapy to treat low testosterone across the world because the benefits outweigh the drawbacks of the testosterone therapy.
this is the single most noticed benefit experienced by people undergoing testosterone replacement therapy. good and positive mood, clarity in thinking, and overall improved cognition are experienced by patients undergoing testosterone replacement therapy. concentration is also improved, this results in better focus and increased productivity at work. TRT also improves verbal memory means you can speak more fluidly as words line up in your brain for the thoughts you need to communicate. this effect has a profound effect upon confidence. better speech abilities translate indirectly to higher self-confidence.
testosterone has a direct effect on both muscle and fat, optimal testosterone results in increased muscle mass and decreased fat. this result is not only aesthetically pleasing but it also has long-term health benefits. the increase in muscle mass means you become stronger, also a higher amount of muscle mass means a higher metabolic rate. this increased metabolic rate means your body is spending more calories for the maintenance, because of this your body gets to store less fat, or even if it stores the fat it is quickly used up.
a healthy level of testosterone is required to maintain healthy bones. TRT helps bones absorb more minerals making them strong. on testosterone replacement therapy you are less likely to get avoidable fractures.
testosterone replacement therapy results in increased response to sexual arousal and sexual activities. testosterone is also responsible for increase performance and certain physiological sexual capabilities. it should also be noted that there is only a limit to performance improvement from testosterone. a healthy person will have no positive benefit from testosterone administration. low libido is often the cause of depression in many men suffering from sexual dysfunction due to low testosterone or secondary hypogonadism, Testosterone replacement therapy resolves this problem.
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Benefits of Testosterone Replacement Therapy or TRT ...
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8 Effective Alternatives To Testosterone Replacement Therapy
Posted: April 21, 2020 at 9:48 pm
The Alternatives To Testosterone Replacement Therapy, What Are They?Discover What They Are Here; And Why You May Want To Consider Them
With average male testosterone levels decreasing, a number of men are looking at testosterone replacement therapy as a way to address this.
While there are benefits, there are also negatives that come with TRT therapy & that is why Ive created this article looking at the alternatives to testosterone replacement therapy.
So as stated there are some negatives that come with testosterone replacement therapy.
Hence why people should consider looking at alternatives, so lets take a look at what some of the draw backs are:
The following conditions can also potentially be made worse with TRT therapy:
As you can see there are a number of potential negative TRT Therapy side effects.
Not everyone will suffer from all the above or even any of it; but the potential side effects combined with the high costs mean you should probably be considering alternatives first.
Check out this article on TRT Therapy Side Effects to get a full picture of the potential issues.
So weve spoken about why you may want to look at alternatives to testosterone replacement therapy.
Lets take a look at what other options there are to increase your T levels:
Now Im not saying that each of the above is a direct replacement for testosterone replacement therapy.
Combined they will definitely help you boost testosterone production, Im going to cover each of the above in a bit more detail now.
Your diet is one of the major contributors to your testosterone production.
There are plenty of foods promoted as healthy which lower testosterone production.
There are also a wide number of foods that have been demonized over the past couple of decades, which have since been proven to be healthy and be foods that boost testosterone production.
As we all need to eat, your diet is one of the easiest ways to boost testosterone levels.
I advise to check out the following two articles so you know what to remove & what to consider adding to your diet to boost testosterone levels:
Fasting is a great way to boost testosterone production, one study showed that intermittent fasting can boost testosterone by as much as 180%!
It takes a lot of energy for your body to process food/ calories, when this isnt happening your body is able to regenerate itself.
This is a process call autophagy, autophagy taking place is great for your wider health including being a natural testosterone booster.
Eating frequently or grazing on the other hand has the opposite effect.
As your body is using a lot of energy to process foods, it isnt able to carry out autophagy.
A direct result of this is, your testosterone production and wider health to suffering.
Ill be creating a post in the near future in regard to fasting and testosterone production.
Keep an eye out for that, in the short term I suggest you have a quick read of this study.
It looked at the effects that fasting had on the testosterone levels of obese & non obese men.
Being over weight is another cause of reduced testosterone production, having higher body fat leads to reduced testosterone production.
What makes it even more interesting is the more T you produce the leaner your body will be, so it is an unusual loop.
I will be creating a more in depth article looking at the relationship between testosterone & body fat so keep an eye out for that.
For now, keep it in the back of your head that losing excess body fat is a natural testosterone booster.
There are a number of key vitamins & minerals that control testosterone production & will help you increase production.
The key ones are as follows:
All of these can be gained through diet and in some cases you will need to gain them through supplementation.
If you suspect you may be low on any key vitamins or minerals, that impact testosterone or your health as a whole.
I suggest you check out check out my article below on a service from Medichecks UK, where they test vitamin levels for you.
In broad speaking terms exercise can be split in to two different categories, weight lifting & cardio.
Weight lifting as a whole helps to increase testosterone production, there are certain things you can do for a greater T increase.
These include lifting heavier weights & increasing your rest period between sets but this is covered in greater in this article below:
Cardio is where it gets slightly more interesting. Stereotypical steady state cardio, like jogging, cycling, aerobics etc. can lower T production.
As you are constantly moving, the body is under constant stress, this leads to cortisol release which inhibits testosterone production.
The best type of cardio for testosterone production is HIIT (high intensity interval training).
This involves working at the maximum for a short period, followed by a period of rest (ideally 3* the exercise period).
For example sprinting on the spot for 10 seconds, followed by 30 seconds of rest.
This type of cardio doesnt lower T as the rest periods mean your body isnt put under stress.
So no cortisol is released & no inhibiting of testosterone production takes place.
Getting 7 9 hours of quality sleep per night is an easy to achieve natural testosterone booster.
Once your sleep volume dips below 5 hours your testosterone production is severely lowered.
Getting suitable rest doesnt just mean getting enough sleep though, check out this article to find out more about ensuring you get enough rest to boost testosterone production.
The body being stressed leads to cortisol release & cortisol restricts testosterone production.
So keeping your stress levels down is a great natural testosterone booster, there are multiple ways this can be achieved.
Ive published a couple of different articles on how reducing stress is one of the best ways to increase testosterone naturally
If you are looking for in depth methods of stress reduction though, Id suggest you check out this site on ways to reduce your stress & remember with less stress comes a natural testosterone booster!
Plastics & a number of products you use daily contain chemicals that disrupt hormone balance including lowering testosterone production.
A number of these chemicals cause other health issues, there are too many products to name that cause issues.
This article on Chemicals That Lower Testosterone Where Are They Found is a starting point, for you to learn what to avoid and substitute.
In regard to plastics I suggest you take look at another article I wrote looking at alternative products to plastics that wont lower testosterone.
Check it out below!
In regard to other products that contain these chemicals, they include things like non-stick cooking items, air fresheners, commercial cleaning products & weed killer to name a few.
Ive created some articles looking at under thisThings That Lower Testosterone Category, so check them out.
I hope you have found this article on alternatives to testosterone replacement therapy useful.
There is no denying that TRT is a highly effective way to boost testosterone production.
However the cost and the side effects in my opinion make it the very last thing that you should try.
While the above methods, may not be a like for like comparison with TRT in terms of how much they boost testosterone production.
They certainly can increase your levels enough that you no longer suffer from low T.
In most scenarios, they should lead to you having high enough testosterone to see the health benefits associated with higher T.
I would advise to use as many of these alternatives to testosterone replacement therapy in unison as you can.
The more you use, the greater the natural testosterone booster you will see!
If you decide that TRT is the route you need to go down, you will need a reputable organisation. In the UK I can recommend an organisation called Optimale.
They offer testosterone testing and replacement therapies and have plenty of happy customers who have seen fantastic results.
You can get a 10% discount on all product orders using my of discount code of War10 at the checkout.
If you do decide that you are going to go ahead with TRT Therapy or are already taking part in TRT or anabolic steroids course.
Then the testosterone testing and blood testing company that I use, Medichecks provide a TRT health check test.
This is an in depth health check for men on testosterone replacement therapy.
It includes a measure of your full blood count, kidney, liver, thyroid function, cholesterol, hormones and PSA numbers, functioning and levels.
This is everything you need to know to make sure that your TRT is working efficiently and safely!
Keep an eye out for my future articles where I will be covering each of the above in far greater detail.
If you have any questions in regards to alternatives to testosterone replacement therapy just drop me a comment and Ill get back to you!
Please share this article with anyone you think may find it interesting.
You can also follow me on my social media for more tips on alternatives to testosterone replacement therapy & all thing testosterone related.
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8 Effective Alternatives To Testosterone Replacement Therapy
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