Washington, Mar 8 (ANI): Researchers have shed light on the effects of catch up growth (CUG) with different diets on bone status and the role of resveratrol in CUG models.
Although many current studies focused on catch up growth (CUG) have described its high susceptibility to insulin resistance-related diseases very few have focused on the effect of CUG on bone metabolism, especially in adulthood.
As diet is a controllable factor, the influence of re-feeding with different dietary patterns on bone parameters is important to study.
Resveratrol has been attributed a number of beneficial effects in mammals including osteotrophic properties. Wang and colleagues have described the first study to describe the effects of CUG, with various diets and resveratrol intervention on bone status.
CUG can lead to insulin resistance and low-grade systemic inflammation occurs in insulin resistance syndrome.
Tumour necrosis factor (TNF)-a is an important inflammatory cytokine, and Lange and Seriolo et al. indicated that anti-TNF alpha therapy may exert beneficial effects on bone metabolism, prevent structural bone damage and increase bone mineral density.
"Our results showed that food restriction induced a significant decrease in bone parameters. Eight-week CUG by normal chow demonstrated a greater degree of improvement in mineral density than a high-fat diet, and even returned to normal level," Dr. Wang said.
"In contrast, Mika C found that re-feeding for two years normalized bone formation activity in adolescent anorexia nervosa patients, but bone mineral density was still significantly lower than that of controls."
"Compared with neural anorexia, we found in this study the degree of impairment by four-week diet restriction on bone metabolism was relatively weaker, so that bone mineral density returned to normal level after re-feeding."
To better distinguish the effects of CUG by high-fat diet on bone status, these investigators set up a high-fat diet group.
Read more:
How diet affects bone status during catch-up growth