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The role of hepatic lipoprotein metabolism in diet-induced remission of type 2 diabetes is currently unclear. Type 2 diabetes can be reversed back to normal glucose control by controlling weight as was shown in DiRECT trial. A small group of patients, however, regains the weight and re-developed Type 2 diabetes. When a person accumulates too much fat, after storage under the skin, it goes to liver and over-spills to the rest of the body including the pancreas. This overspill of fat to pancreas has been shown to cause Type 2 Diabetes, according to the researchers.

Researchers at Newcastle University have found that fat over-spills from the liver into the pancreas may trigger Type 2 diabetes.The research, led by Professor Roy Taylor at Newcastle University, UK, is published in the academic journal, Cell Metabolism.

The study involved a group of people from Tyneside who previously had Type 2 diabetes but had lost weight and successfully reversed the condition as part of the DiRECT trial, which was funded by Diabetes UK and led by Professors Roy Taylor and Mike Lean (Glasgow University).

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The majority remained non-diabetic for the rest of the two-year study, however, a small group went on to re-gain the weight and re-developed Type 2 diabetes.

Professor Roy Taylor, from the Newcastle University Institute of Translational and Clinical Research, explained what the advanced scanning techniques and blood monitoring revealed.

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He said: We saw that when a person accumulates too much fat, which should be stored under the skin, then it has to go elsewhere in the body. The amount that can be stored under the skin varies from person to person, indicating a personal fat threshold above which fat can cause mischief.

When fat cannot be safely stored under the skin, it is then stored inside the liver and over-spills to the rest of the body including the pancreas. This clogs up the pancreas, switching off the genes which direct how insulin should effectively be produced, and this causes Type 2 diabetes.

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This research by Professor Taylor confirms his Twin Cycle Hypothesis that Type 2 diabetes is caused by excess fat actually within both the liver and pancreas and especially that this process is reversible.

Body of research

This latest paper builds on previous Newcastle studies supported by Diabetes UK showing exactly why Type 2 diabetes can be reversed back to normal glucose control. Those studies led to the large DiRECT trial which showed that Primary Care staff can achieve remission of Type 2 diabetes by using a low-calorie diet with support to maintain the weight loss.

A quarter of participants achieved a staggering 15 kg or more weight loss, and of these, almost nine out of 10 people put their Type 2 diabetes into remission. After two years, more than one-third of the group had been free of diabetes and off all diabetes medication for at least two years.

In 2020, this approach to the management of short-duration Type 2 diabetes is to be piloted in the NHS in up to 5,000 people across England, and a similar programme is being rolled out in Scotland.

Professor Taylor adds: This means we can now see Type 2 diabetes as a simple condition where the individual has accumulated more fat than they can cope with.

Importantly this means that through diet and persistence, patients are able to lose the fat and potentially reverse their diabetes. The sooner this is done after diagnosis, the more likely it is that remission can be achieved.

The team are continuing work to establish what may affect an individuals personal threshold and are supporting the roll-out of the NHS Initiatives in both England and Scotland. Life Without Diabetes The definitive guide to understanding and reversing your Type 2 diabetes by Professor Roy Taylor will be published by Short Books on 26th December 2019.

For more details click on the link: http://dx.doi.org/10.1016/j.cmet.2019.11.018

Hina Zahid Joined Medical Dialogue in 2017 with a passion to work as a Reporter. She coordinates with various national and international journals and association and covers all the stories related to Medical guidelines, Medical Journals, rare medical surgeries as well as all the updates in the medical field. Email:hina@medicaldialogues.in. Contact no. 011-43720751

To know about our editorial teamclick here

Source: Cell Metabolism

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Overspill of fat to pancreas shown to cause Type 2 Diabetes - Specialty Medical Dialogues

Its that time of year again. Youve reveled your way through December and now youre feeling guilty about your excesses and upset that your jeans feel too snug. Its January 2020, a new day, a new year, a new you, and this timeno more junk food! Or so you promise yourself.

According to a digital poll conducted by the Insider at the end of 2018[1],nearly 50% of New Years resolutions are about dieting or healthier eating, yet the evidence shows that by the secondweek of February 80-90%[2], of these resolutions have failed.Why do we keep making well-intentioned resolutions about restricting our intake of fatty, sugary foods, and then consistently relapse?Are we stupid to continuously make such futile promises?

Sisyphean attempts to change our eating behaviors suggests that were not very good at learning. But that nod to our foolishness would be to gloss over the problems underlying why we push that rock up the dieting hill eating every January only to have it roll down on our thighs by Valentines Day. There are three main reasons for our repeated dieting failures: 1) habits, 2) the food environment, 3) our biology, and theyre all extremely hard to alter.

Firstour well-learned habits.Do you make a daily stop for a pastry or milk-shake latt on your way to work?Do you mindlessly snack at your desk?Do you automatically say yes to fries with that sandwich? In order to change our eating behavior, we first have to figure out what our bad eating habits are, which is not so easy. Then we have to break the mold on all those automatic routines.This means crushing habits from breakfast to our midnight snack, at home, work, and play. Put this in the face of the fact that a central reason why changing behaviors so often fails is that people try to change too much at once.For best success, we need to make a list and slowly tackle one bad habit at a time. This itself is a tedious task, which only adds to the burden of restricting our eating. Eating is among the greatest pleasures of existence and we have to do it fairly constantly.This means that if we make eating unpleasant we wont give up eating, well give up making it unpleasant.

Next, is our perilous food environment. Even if you dont have much money (in fact its worse if you dont have much money), unhealthy food is more accessible than fresh fruit, vegetables, and fish.Our Western eating environment offers a plethora of relatively inexpensive, high calorie, delicious options with very minimal effort involved in getting any of it.You dont even need to leave your couch except to answer the doorbell for that UberEats delivery.There is a large scholarly literature on everything from portion size, to fast food availability, to how we eat (constant snacking, eating on the run or in your car), and how much we eat (a lot), and you will find many studies demonstrating the ways in which the modern eating environment undermines our health and waistlines.But you already know that. The point is that the new normal food environment makes changing our eating patterns, portions, and passions very difficult to thwart.

Finally, there is our innate biology.We did not evolve in a landscape of Starbucks and MacDonalds.Rather, until relatively recently having enough food to eat was a rare luxury, and there are still societies where famine is a real and present danger.Because we may have to go for days, or more, without sufficient sustenance, when we encounter calorie-dense foodsthe best kinds are fatty, and carbohydrates-- the best form of easy energy, our biology dictates that we eat as much as we can so that we can survive to find the next meal.We are programmed to love fatty, high carbohydrate foods. To counteract these impulses is to work against millions of years of evolution.

Our food habits rewire our neural circuits for pleasure and reward, our food environment reinforces our food habits, and our innate biological motivations shape our enabling food environments. So, yes, we are stupid to think that intoning a promise to eat less rich, alluring food when faced with such huge obstacles will be successful.But we are not stupid to keep on trying, because each attempt teaches us about ourselves and potentially one step closer to a better relationship with food.The key is to realize that atthe heart of both our good and bad eating behaviors is the motivation to survive and experience pleasure, which is smart indeed.

Originally posted here:
Are We Stupid to Make Dieting a New Years Resolution? - Psychology Today

Image Courtesy-crazy-nana-Unsplash

So the New Year is upon uswell almost, and as wemove into the beginning of a new decade its perhaps best to bid goodbye tothings that didnt work out for us.

Goodbyeto hunting for the perfect diet and Hi to our new bodyThe decade promised us the perfect body just by following The Atkins Diet, TheGrapefruit Diet, The Caveman Diet, The Ayurveda diet and so many more, yet allof them worked for some time, only to be replaced by the newer one .When welooked at the weighing scales and realized that the pounds came back faster than we dropped themand our perfect body was nowhere in sight, its perhaps time to drop thesediets forever and change our mindset about the perfect body and embrace ourselvesas we are-fat,thin,slim legs, chunky thighs, pear shaped bodies, tiny waists,big-boned and focus on just eating healthy and eating right. Eating healthypretty much is quite dependent on common sense dont eat French fries as a snackbut reach out for that apple-and just stop comparing yourself to anyone elsebecause you are perfect in your own way.

Goodbyeto others expectations and Hi to the actual youWhen was the last time you actually spoke your heart out to your near and dearones without sugar coating it? When was the last time you instagrammed apicture without photo shopping it?Isnt it high time we start living our lifeon our terms rather than according to what someone else wants us to be. As MarkTwain said, You wouldnt worry so much about what people think of you,if you knew how seldom they do. Its fine to be tired and not be a supermom/amazingcareer woman all the time and if you want to quit a boring 9 to 5 job and followa dream of being an entrepreneur go ahead and do it and while youre at it goahead and rewrite your life as you want it to be. Youll be amazed by so manypeople who will accept and love you for what you are the real you.

Goodbyeto Toxicity and Hi to Positivity-I keep reiterating theimportance of positivity because its something we tend to overlook. The toxicpeople in our life only corrode our happiness. Try spending some time with themand you feel deflated as though someone punctured the joy out of your life.Ive stopped buying their excuses for their grim worldview and have only onemantra for them.

Eliminatethem by the truckloads!

Goodbye to all Unhappiness and Hi to Happiness-Happiness is a state of mind and to achieve that there are so many tools like Meditation, Introspection and mindfulness. These help us to be on the path of long lasting happiness rather than a momentary joy. So use these powerful tools effectively to say hi to happiness and goodbye to unhappiness. That is exactly what the HAPPY in NEW YEAR stands for

Till next year-

HAPPY NEW YEAR and live life EmpressSize.

Link:
Hi to 2020 and New Dreams - Thrive Global

LOMA LINDA, Calif. Six mornings a week, youll find Heinz Lindsor in the gym.

I do aerobics. I exercise with a ball, he says.

Whats more impressive than his workout routine is his age.

I am 80 plus, he says.

And hes not the only octogenarian in this gym located inside Loma Linda Universitys Drayson Center.

My diet is an all plant-based diet, Dr. Benjamin Lau says.

Benjamin Lau and his wife Esther walk a mile to the gym every day for their half-hour workout. They are both in their 80s.

I put a lot of emphasis on food, Esther Lau says. That's probably the most crucial, what we eat and also how active we are.

In Loma Linda, California, being able to do a one-hour aerobics class later in life isn't uncommon. Much of the fuel to stay active and healthy for the people in this city is religion.

Started to work out I got really excited, oh this is great because I feel really vibrant, I feel 40 again. Is this possible, God? Marijke Sawyer says.

Loma Linda is home to one of the largest concentrations of Seventh-day Adventists. The Christian denomination puts an emphasis on a healthy diet and exercise.

Most Adventists, like 72-year old Sawyer, dont smoke or drink alcohol.

"My body is actually the temple of God, she says. So, therefore, whatever I put in I want to keep it whole. Clearer minds, better body, better performing in my life.

Many also follow a vegetarian diet.

Lots of fruits and lots of vegetables, and we grow a lot of our vegetables, so mostly unprocessed, Esther Lau says. "I cook very simply. Basically, I dont use any oil to cook but I do eat food that's naturally high in oils, like avocados, nuts and seeds.

Jackie Tucker, 71, is a lifelong vegetarian.

My grandfather died at 60 of a heart attack, Tucker says. My father died at 73 with blood-related heart disease so I know that the exercise and a diet have made a difference.

National Geographics Dan Buettner named this community one of his five original Blue Zones," places across the globe where people are living longer and healthier lives.

Loma Linda was the only Blue Zone listed in North America.

"It becomes normal, it becomes a way of life, Sawyer says. For me not to come out and not exercise, I would be frazzled because I just feel so much better. And my age I dont feel like Im 72. I love it.

But in Loma Linda, there is no fountain of youth or magic spell to be able to work out like Lindsor later in life.

A person who is motivated, he says, he or she can do a lot of good things to maintain a good level of health.

Excerpt from:
A senior community in Loma Linda, California is thriving when it comes to health. These are their secrets - KSBY San Luis Obispo News

Lose weight, eat less junk food, and stick to a diet top plenty of New Years resolution lists, but many experts say that these goals may set unrealistic expectations and set you up for failure before February even hits. Instead, doctors and registered dietician say that a more sustainable approach to managing weight, feeling good, and changing eating habits is to focus on identifying which foods nourish your body and give you the proper fuel you need to live a great life. So to jumpstart 2020, we rounded up some of the best products to help you eat well and feel your very best.

[Photo: courtesy of EverlyWell]Find your food sensitivitiesSome foods that are generally considered nutritious may not be good for you specifically, thanks to food sensitivities that can cause headaches, joint pain, fatigue, and digestive issues. To identify which foods might be the culprits, you can start elimination diet test from scratch, which can take months or years to execute properly. You can also jumpstart that process withEverlyWells mail-in food sensitivity test($159), which requires just a small sample of blood. The tests, which are reviewed and approved by independent board-certified physicians, measure IgG antibodies in your bloodstream when exposed to certain foods and ingredients. (Its important to note that this test is merely for food sensitivities, not more serious food allergies, nor can it identify is someone is lactose intolerant.) You can then use your test results to start a guided elimination diet.

[Photo: courtesy of Peter Pauper Press]Keep a food journalResearch shows that for people interested in learning more about healthy eating habits, keeping a journal is very effective tool. During onestudyof nearly 1,700 participants, those who kept daily food records lost twice as much weight as those who kept no records. Additionally, a food loglike this handy, self-guidedDaily Food Journal ($8)is crucial in helping to identify eating patterns and certain foods that dont make you feel good or cause bloating, digestive issues, headaches, and the like. If youre going to try an elimination diet, a food journal is key. The only time we wouldnt recommend using a food log is if you aresusceptible to obsessive eating patterns or food phobias; have a history of an eating disorder; or, if for any reason, a food log makes you feel guilt, shame, or fear. If thats the case, skip this step. Because keeping track of what you eat should make you feel mindfulnot bad about yourself.

[Photo: courtesy of Seedlip]Skip the boozeRegardless of how much (or little) you drink, anyone can all benefit from cutting back on alcohol, since consumption is linked to increased risk of cancer, heart disease, immunity issues, weight gain, muscle loss, and a slew of other not-so-fun side effects. But that doesnt mean your dry January needs to be joyless. The botanical spirits of nonalcoholic distillery Seedlip has become a hit with high-end mixologists. Now you can try them at home with theSeedlip Distilled Non-Alcoholic Spirits Sampler ($107.50, set of 3). With only three ingredients (water, natural botanical distillates, and citric acid), these spirits are good for your health and surprisingly enjoyable for the palate. Beer lovers also have more alcohol-free options available to them, such asWellbeing Brew Cosnon-alcoholic craft beer($12), which only has 68 calories and contains zero grams of sugar. You can also try the award-winningnonalcoholic brews($12) of the breakout Athletic Brewing Company.

[Photo: courtesy of Sun Basket]But dont skip mealsSkipping meals is a bad ideathat can spike your blood sugars and lead to overeating laterand wreak havoc on your metabolism and immune system. If you find youre simply too busy to shop for and cook your own meals and you want to avoid eating unhealthily on the run, consider a subscriptions service like the Sun Basket meal kit($11.99 per serving for 2 people, $10.99 per serving for 4 people, regardless of frequency), which brings you a weekly box of organic and non-GMO ingredients to prepare your own meat-free or vegan meals. For people who are even more pressed for time,Sakara(starting at $239/week) delivers fresh meals, teas, and supplements that are completely organic, plant-based, gluten-free, dairy-free, non-GMO, and contain no refined sugar. No prep or cooking required.

Looking for more goodies and gadgets? Check out our handpicked suggestions.

Fast Companymay receive revenue for some links to products on our site.

Read the rest here:
2020 New Year's resolution: How to eat better and master your nutrition - Fast Company

Real Health NZ is helping hundreds of Kiwi women achieve their health, fitness and wellness goals from the comfort of their living room, and is owned by Renee Norman and Jenna Smith who both hold qualifications in sports science, personal training and health coaching.

When you start up a business, you've got to have passion.

Renee and Jenna say they are lucky to love what they do and the women they work with.

"Days often merge together and weekends sometimes don't feel like weekends you can't just walk out the door and forget it so you have to have a huge passion for what you are working towards. In saying that, passion will only get you so far in business; you also need to have a bloody good work ethic."

Launched in October 2016, the business came about for two reasons: the first being the duo's passion for fitness, all things wellness and helping women make lifestyle choices to feel their best selves.

"The second was frustration with the fitness and diet industry," Jenna explains.

"Something we both found when working in gyms was that many women felt threatened about walking into a gym. While they can be a really great empowering place for some, for many of the women we came across the thought of the gym was pretty scary! Loads of equipment, long mirrors and the feeling of 'am I doing it right?'"

Renee and Jenna say that they saw the same with nutrition.

"Many of our clients told us they also felt overwhelmed when it came to food with so many diets, trends, fads and unsustainable quick fixes out there. We had seen many women spend hundreds of dollars and repeat the vicious cycle of starting a diet, falling off the wagon and starting again.

"We wanted to create something simple that reminded women to get back to basics in the kitchen and encouraged fun ways to get active."

"For too long we tried to make everything perfect. Now with two toddlers, two babies and a growing business, we don't have the time to check everything 10 times. We trust that each other will do our jobs 100 per cent.

"Another lesson is you can't do it all yourself! Initially, to keep our costs down, we literally did everything ourselves, but now we are in a position to outsource some of our behind-the-scenes work and we are proud to have a small team that makes life so much easier."

"We move daily we always say to our clients 'something is always better than nothing' when it comes to exercise and we truly live by that! Some days it's a walk with the stroller, other days it's a sweat-dripping workout.

"We've grown the business by realising each other's strengths," they say.

"After spending three years working in each other's pockets we know each other very well. We both have very different strengths we know who is good at what, and we capitalise on each other's 'genius' zones."

"When you want a business to work you do need to spend hours behind the computer, but our family and our friendship is absolutely number one.

We do have a few tricks up our sleeve to manage it all, such as no emails or client contact after 5pm."

The biggest challenge the pair have faced in business is becoming new mums.

"While we knew we wanted to have families, we didn't think or plan to have our children at exactly the same time both times round!

While we would be lying if we said it hasn't been a challenge, it has worked out rather well. It takes a village and we are each other's. We both understand that some days we will be productive and some days we won't," says Jenna.

"The greatest thing about running our own business is flexibility not having to fit into the traditional 9-5 is awesome," tells Renee.

"It's also great to have your own business with a young family. Yes, it's hard but it means we get to keep learning and developing our skill-sets."

Continued here:
The two Kiwi mums who are helping other women achieve their health and fitness goals - Now To Love