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BYND Stock Could Fall Further as Competition Heats Up – Investorplace.com

Posted: December 10, 2019 at 2:41 pm

After jumping nearly 10-fold from its IPO price, Beyond Meat (NASDAQ:BYND) cratered 68%. Going forward, its going to be tough sledding for BYND stock.

Source: Shutterstock

It is easy to focus too much on the merits of fake meat in a culture that yo-yos between plant based Vegan diets and low-carb diets like Paleo and Keto. The science is far from settled on the perfect diet for health and longevity. But the question isnt whether meat alternatives are the cure-all for heart disease and other preventable diseases. Its whether Beyond Meat has a clear path to success.

Taking a look at the competitive environment, I wouldnt bet on it. Beyond Meat may secure some status as a niche purveyor of plant-based meat products, but if this trend reaches critical mass, behemoths in the food products business will go big, impacting BYNDs competitive advantage.

Does that make BYND stock a hard sell? At the current valuation, investors may be getting ahead of themselves with this plant-based story stock.

When it comes to plant-based diets, obviously health is top-of-mind. The work of health experts like Ancel Keys gave credence to the theory that high-saturated fat consumption (red meat, eggs) causes heart disease.

By the 1980s, the science was settled. It even made for a Time Magazine cover that todays keto crowd would find laughable. In the decades that followed, chicken sales skyrocketed.

The animal fat-friendly Paleo and Keto diets are not the first to tout the benefits of red meat and eggs. But unlike the eat-a-packet-of-hot-dogs Atkins diet of yesteryear, these diets focused more on consuming unprocessed foods. Paleo and Keto also emphasize the importance of lower-glycemic vegetables like spinach and kale.

By 2014, even Time magazine was telling you to eat butter again. But what does this have to do with BYND stock? Experts on the other side make valid points, calling the whole plant-based is better, case closed thesis into question. Yet, with the meme of red meat clogs your arteries still in the public consciousness, Beyond Meat stock may still benefit.

Even in a highly processed form, the general public may regard fake meat versions of burgers and steak as healthier. With regards to BYND stock, whether this is scientific fact or fake news is not important. Public perception, not settled science, has the last word.

All bets are off whether plant-based diets will reign supreme in the 21st century, but Beyond Meat doesnt hold the franchise on alternative protein products. As InvestorPlaces Will Healy discussed, Kellogg (NYSE:K) and Hormel (NYSE:HRL) are throwing their hats into the ring. Tyson Foods (NYSE:TSN) is also heavily invested in plant-based alternatives.

Beyond Meats total share of the plant-based meat market is only 2.1%. Even if bullish sales projections pan out, the companys 2025 market share will only be 13%. But speculation, not fundamentals, drive Beyond Meat stock. Given that competitors like Impossible Foods remain privately-held, BYND is your vehicle to make a bet on the future of fake meat.

Hence, despite recent declines, BYND stock trades at a high valuation. Shares trade at 223 times their projected 2020 earnings. Even if the companys explosive growth projections become reality, this valuation remains far from rational.

It also sets the bar very high for Beyond Meat stock. In order to justify its valuation, the company does not only have to win over a large segment of the meat-free population. Beyond Meat must win over meat-eaters, with a compelling alternative.

If purported health benefits do not do the trick, price may be the key to win the hearts and stomachs of the general public. But unless Beyond Meat scales up significantly, legacy food producers like Tyson could have the upper hand once plant-based meat is cheaper to produce.

Despite my own admitted bias, plant-based protein may prevail. But that doesnt mean BYND stock will be a winner in the meat wars. Once we embark on a brave new world of plant-based protein, big food companies like Tyson and Hormel have a clear edge.

Beyond Meat stock tumbled 22.2% this Octiober when 80% of outstanding shares became free to trade. But shares could fall further, as the smart money cashes in their chips. Now that theres more available float, theres less risk of a short-squeeze.

But tread carefully before making a bearish bet. While BYND stock remains frothy, that doesnt mean the party is over just yet.

As of this writing, Thomas Niel did not hold a position in any of the aforementioned companies.

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BYND Stock Could Fall Further as Competition Heats Up - Investorplace.com

Gal Gadot Looks Stronger Than Ever in the First Trailer for Wonder Woman 1984 – Prevention.com

Posted: December 10, 2019 at 2:41 pm

Mike MarslandGetty Images

In the new trailer for Wonder Woman 1984, you can watch Gal Gadot swing massive distances from Wonder Womans lasso of truth, repel bullets with her forearms, and send a fully-loaded Humvee somersaulting into the air. It might be easy to assume the action-packed clip was pulled off by stunt masters and special effects, but Gadot trained like a real-life superhero to make it all happen.

After the release of the first movie, the actress discussed her training in multiple interviews, and will likely do the same when 1984 premieres in June 2020. We can safely assume that if her second round of training differed at all from the first, it wouldve grown even more intenseif thats humanly possible.

According to her interview on Live with Kelly and Ryan, training for the first film was a lot more intensive than her time in the Israeli army, which is kind of a big deal. She told the co-hosts that she trained six hours a day for six months prior to shooting. I did two hours [of] gym work, two hours [of] fight choreography and one and a half hourstwo hours horseback riding, which is super hard! she said. When people used to tell me, Yeah, I do sport, I ride horses, I was like, Thats not sport, the horse does everything. But no! Youll be surprised, its so painful.

When shes not training specifically for her superhero side, she works out regularly to stay in shape. I cant say too much about my training regime but we do work out a lotwe do a lot of different martial arts, she told Harpers Bazaar. In my ordinary life when I dont work, I like to paddle board and do TRX. On her Instagram, she can also be spotted boxing and rock climbing.

And its not always easy, because Gadot is a self-proclaimed foodie. So during crunch time, one of her trainers, Hayley Bradley, has a basic rule that applies to every meal. Balance each meal with equal amounts of protein and greens, and to be wary of seemingly healthy choices like green juice, which can be highly caloric thanks to the large amounts of natural sugars in some fruits and veggies, she told InStyle.

Gadot told Bazaar that her regular diet is all about moderation. I love to experience food, but at the same time I look at food as fuel and I want to give the best to my body, she said. So of course I have my bad things that I eat like burgers or ice cream with chocolate. I dont restrict myself, I can eat everything Its all a matter of measurements and quantity of the food.

To face the Soviet Union and her arch nemesis Cheetah in WW 1984, she may have made a few tweaks, but sometimes, thats what it takes to save the world from evil.

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Olympic gymnast Gabby Douglas said eating 3 types of foods helped lead her to victory – INSIDER

Posted: December 10, 2019 at 2:41 pm

American gymnast Gabby Douglas is a three-time Olympic gold medalist with even more accolades on national and international stages.

But she couldn't have done it without the right nutrition plan, she told Insider during an interview Sunday to promote her partnership with Marriott Bonvoy, Marriott International's travel program.

Growing up, Douglas said she relied too much on "junk food," high in refined carbs and low in nutrients. Over time, though, she started picking up better healthy habits less fast food on the road, more healthy snacks like Greek yogurt, fruits, and veggies since she said she noticed her muscles didn't recover as well if she ate too much sugar, she said.

Then, when Douglas started a serious healthy eating regimen in preparation for 2016 Summer Olympics, she "noticed a huge difference" in her performance, she said.

Here's more about how she's changed her diet, and why those foods can improve athletic performance.

Salmon and asparagus are often on Gabby Douglas's plate. Shutterstock/Jacek Chabraszewski

Douglas said that she's been fortunate to have avoided the diet cycles that plague many young female athletes."I always had a body that was fit, lean, and picked up muscle fast, so I never struggled with diets or body image," she said.

Still, learning to eat right for her activity level took time.

Douglas's grandmother, for one, helped her get there, often helping prepare healthy meals structured around lean meat, vegetables, and complex carbohydrates, previously reported,

Specifically, Douglas turned to lean meats like grilled chicken and salmon. These are high in protein and healthy fats, both of which are crucial for muscle recovery and growth. They're also high in micronutrients like B vitamins and choline, which are important for energy.

Douglas also added in veggies like asparagus and green beans, an important source of not only vitamins but also antioxidants and polyphenols. These compounds, found in plant-based foods, help reduce inflammation, which can speed muscle recovery in addition to keeping your digestion and immune system strong, according to LiveScience.

Finally, to help fuel her hours of working out every day in preparation for the 2016 Olympics, Douglas added in complex carbohydrates like sweet potatoes or pasta, and oatmeal. Carbs are the body's preferred source of quick energy, but complex carbohydrates like whole grains and starchy vegetables provide added benefits of fiber, starch and micronutrients.

Sweet potatoes, for instance, are high in vitamin A, which is crucial for a healthy immune systems and metabolism, according to the National Institutes of Health. Another complex carb, oatmeal, is a good source of protein but also minerals like manganese, important for growth and development, and phosphorus, which is crucial for healthy bones, according to the NIH.

Read more:

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Division 1 female athletes are among those plagued by eating disorders, missing periods, and broken bones

A teenager went blind after eating nothing but fries, white bread, chips, and processed meats

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Olympic gymnast Gabby Douglas said eating 3 types of foods helped lead her to victory - INSIDER

Eggs and peanuts may prevent your high risk infants from allergies – Times of India

Posted: December 10, 2019 at 2:41 pm

As a parent, you always try and give your baby the best of everything! In fact, this often puts you in a dilemma to select the best foods for your infant. However, as per new study it has been observed that adding peanuts and eggs to high-risk babies as early as three months can help in preventing them from developing allergies caused by these foods later in life.According to UK current guidelines, babies should be fed nothing but breastmilk until six months - and only then should solid foods be introduced.Published in the Journal of Allergy and Clinical Immunology, the study found that despite low adherence, early introduction to allergenic foods (those that may cause an allergic reaction), including egg and peanut, was found to be effective in preventing the development of food allergies in specific groups of infants."These results have significant implications and are informative when it comes to infant feeding recommendations concerning allergies and the development of new guidelines," said study researcher Gideon Lack, Professor at King's College London.

"If early introduction to certain allergenic foods became a part of these recommendations, we also have data that tells us what populations may need extra support when it comes to implementing the recommendations," Lack added.

The research is a continuation from The Enquiring About Tolerance (EAT) study where over 1300 three-month old infants were recruited in England and Wales and placed into one of two groups.

One group was introduced to six allergenic foods (including peanut and egg) from three months of age alongside breastfeeding and was called the Early Introduction Group (EIG).

The other group was exclusively breastfed for six months and was termed the Standard Introduction Group (SIG).

The results showed that 34.2 per cent of children in the SIG developed food allergy in comparison to 19.2 per cent, of children in the EIG.

Among babies sensitised to peanuts at enrolment, 33.3 per cent of those in the SIG went on to develop a peanut allergy compared with 14.3 per cent of the infants in the EIG.

And among those sensitised to egg at the beginning of the study, 48.7 per cent of the infants in the SIG developed an egg allergy compared with 20 per cent in the EIG.

The early introduction of allergenic foods to infants who were not at a high risk of developing food allergies was not associated with an increased risk of developing food allergy, the study said.

There were no significant differences in food allergy rates between the two groups of infants with no sensitisation to any food at the time of enrollment.

The results were still evident despite only 42 per cent of the EIG group achieving the per-protocol adherence of sustained, high dose consumption of five or more early introduction foods.

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Eggs and peanuts may prevent your high risk infants from allergies - Times of India

The 1 Thing Beyonce Tells Herself to Combat the Haters – Showbiz Cheat Sheet

Posted: December 10, 2019 at 2:41 pm

The queen has spoken. And no we arent talking about Queen Elizabeth II. We mean the queen of all things, Beyonce. Throughout the years, Bey has become so private, only allowing her fans to know what she wants them to about her life. So anytime she gives an interview, people are waiting with baited breath and hanging on every word.

Well, Beyonce finally let a little bit of her wall down in her newest interview with Elle. Heres what we learned:

In Beyonces Netflix documentary, Homecoming, we learned about the stars very strict dieting habbits, but when answering a question about the last time that she went to a grocrey store, she revealed that she snacks just like the rest of us.

The last time I went to a supermarket, it was more like a bodega before a Madonna concert, she said. Jayand I snuck into one in Crenshaw and bought some Cuervo and Funyuns chips. Andyall know you see me at Target and I see yall trying to sneak pics.

Beyonces body has been through a lot of changes throughout her time in the spotlight. From having kids to dieting and training for huge shows, her weight is often going up and down.

If someone told me 15 years ago that my body would go through so many changes and fluctuations, and that I would feel more womanly and secure withmy curves, I would not have believed them, she told the outlet. But children and maturity have taught me to value myself beyond my physical appearance and really understand that I am more than enough no matter what stage Im at in life. Giving zero fs is the most liberating place to be.

Though the star makes it look easy, Beyonce still struggles to balance her career with being available to her kids.

I think the most stressful thing for me is balancing work and life, she said. Making sure I am present for my kidsdropping Blue off at school, taking Rumi and Sir to their activities, making time fordate nights with my husband, and being home in time to have dinner with my family. Juggling all of those roles can be stressful, but I think thats life for any working mom.

Before Beyonce became a mom, she was focused on being the best. Now, her priorities have shifted.

Success looks different to me now, she said. Havingmiscarriagestaught me that I had to mother myself before I could be a mother to someone else. Then I had Blue, and the quest for my purpose became so much deeper. I died and was reborn inmy relationship, and the quest for self became even stronger.

Being number one was no longer my priority. My true win is creating art and a legacy that will live far beyond me. Thats fulfilling.

When youre famous, you constantly have to deal with other peoples opinions about every move that you make. The negative comments do get to the music mogul every now and then, but she has a way to combat all that.

I try to remind myself that Im strong and Im built for this, she said. Thank God most of the noise bounces off of me after all of these years.

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The 1 Thing Beyonce Tells Herself to Combat the Haters - Showbiz Cheat Sheet

Getting Help, and Giving Back – The New York Times

Posted: December 10, 2019 at 2:41 pm

He wasnt getting fed the quality of food he really needed for his day-to-day survival, Ms. Lee said. Then one night were sitting on the porch and I hear preaching. Dacian and I walked seven blocks until we stumbled into a huge community dinner.

Pushing her sons stroller, Ms. Lee had happened upon the Freedom Gathering, a church-affiliated dinner that serves as many as 200 people every Thursday in a small vacant lot. Clothing and free to-go lunches are offered there as well.

Seven blocks is a long way to hear someone preaching, Ms. Lee said. And I never really heard it again. It led us to that dinner, which saved us in so many ways.

From the Freedom Gathering, Ms. Lee was referred to a pair of nearby food pantries: Hungers End, which provides groceries, clothing and hygiene products to more than 500 families a month, and Our Daily Bread, which serves meals to about 250 people a day, seven days a week. They are among the 200 food banks affiliated with Feeding America, a beneficiary agency of The New York Times Neediest Cases Fund.

Our Daily Breads self-serve pantry has provided Ms. Lee with essentials like diapers as well as coffee, canned soup and peanut butter. When fresh produce or organic macaroni and cheese comes through, Ms. Lee said, volunteers often set it aside for her. In 2018, Feeding Tampa Bay, part of Feeding Americas national network, began delivering organic food to Hungers End and other pantries in the Bradenton area. Twice a month, an outdoor pantry is assembled and opened to anyone in need. Ms. Lee returned from her most recent visit to the Hungers End fresh market with organic butter, coconut milk, mangoes, brussels sprouts and raspberries.

Because she cares for Dacian full time, money is tight. The $146 she receives in food stamps each month covers just one weeks groceries; she pays for another week out of her $700 monthly Social Security check. Utilities run about $300, leaving little for Ms. Lee to save or spend on herself.

Ms. Lee knew it was imperative to remove processed foods and refined sugars from her sons diet. Once his diet improved, Dacians symptoms subsided significantly and he started sleeping through the night for the first time in his life.

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Getting Help, and Giving Back - The New York Times

The extent of Ross Moriarty’s worrying health issue revealed as Wales and Dragons star loses stone in weight – Wales Online

Posted: December 9, 2019 at 3:46 pm

Ross Moriarty is striving to be fit for the Dragons festive derbies after the virus he picked up at the World Cup caused him to drop around a stone in weight.

The Dragons are unable to give a return-to-play date for their 41-cap back rower, who played in all seven of Wales World Cup matches in Japan but has suffered badly with illness since.

He contracted a viral infection after grazing his forehead during a training session in the Far East and subsequently suffered a chest infection, a cold, loss of appetite and significant weight loss.

So serious was the hard-hitting No. 8 or blindside flankers condition that he had to see a specialist to find out what was going on.

Whether he returns over Christmas will depend on how quickly he is restored to good health and fitness and puts weight back on.

That is his aim and it is understood he is heading in the right direction.

But the Dragons won't use him until he's 100 percent right.

Director of rugby Dean Ryan told the RugbyPass website: Ross has had a viral infection and we are not going to rush him back or give a date when he is going to play, because we want to make sure Ross has got over this infection.

He lost weight during this period and its important to ensure that he is fully recovered before we think about getting him back.

Wayne Pivac will doubtless stay in touch, with fitness issues starting to pile up for Wales in the back row ahead of the Six Nations. Taulupe Faletau still hasnt returned from the collarbone injury that ruled him out of the World Cup, nor has Ellis Jenkins from his long-term knee problem.

Josh Navidi remains off limits from the hamstring problem he suffered in the World Cup quarter-final against France, while Scarlets James Davies has a back issue and Aaron Shingler is recovering from a damaged knee.

Throw in Moriartys health problems and the picture becomes concerning for Pivac.

The 25-year-old former Gloucester player is an asset because of his versatility and physicality, allied to his competitive spirit.

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The extent of Ross Moriarty's worrying health issue revealed as Wales and Dragons star loses stone in weight - Wales Online

Anthony Joshua, Andy Ruiz and the Jab of Emotions – Sports Illustrated

Posted: December 9, 2019 at 3:46 pm

Mark Robinson/Matchroom Boxing

DIRIYAH, Saudi Arabia Depending on who you wereAnthony Joshua or Andy Ruiz, Eddie Hearn or Manny Roblesinside the ring on Saturday night, with specially made placards commemorating the Ruiz-Joshua rematch raining down like confetti, your emotions ran the gamut.

For Joshua, ecstasy. Last June, Joshua lost. He was humiliated, knocked down four times in what was supposed to be a showcase fight against Ruiz in his U.S. debut. He was publicly humiliated, with social media tattooing him as a quitter and peers dissecting his performance. He was encouraged to fire his trainer, change his camp, even pass on an immediate rematch in favor of a few softer touches to rebuild his confidence.

He didnt do any of it. His chief strategist, Rob McCracken, whose history with Joshua dates back to his amateur days. McCracken served up a perfect game plan, a jab-filled strategy that saw Joshua hammer Ruiz from the outside while never giving Ruiz a stationary target to load up on. His camp was flawless. Joshua dropped nearly 11 pounds since the last fight, allowing him to be a more mobile, agile fighter. And against a fighter some believed had his number, Joshua put on a boxing clinic.

I can knock people out when I want to and I can box when I want to, Joshua said. Tonight was just about winning and trusting my process. I know maybe I could have done more at times. But sometimes simplicity is genius. And that was the motto. Keep it simple because it is going to lead to a genius performance. Every time I step in the ring if Im prepared, no one can beat me.

For Ruiz, disappointment. For months, we wondered: Was Ruiz Buster Douglas 2.0? The signs were there. In 1990, Douglas, in his first fight since upsetting Mike Tyson, tipped the scales 15 pounds heavier for a title defense against Evander Holyfield. On Friday, Ruiz weighed in 15.7 pounds thicker than he did in June. The weight clearly saddled Ruiz, never the most mobile big man, who was unable to deal with Joshuas movement. In the final 30 seconds, Ruiz stood in the center of the ring, waving Joshua in, daring him to trade. Joshua, knowing he was up on the scorecards, could only laugh.

I should have trained harder, Ruiz said. I should have listened to my coaches more. Maybe I shouldnt have put on all this weight. I would have been faster and I would have thrown more. I had him hurt a few times and I let him survive. I should have pressured him more. Its not an excuse, but the weight. I weighed in too heavy. Theres no excuse besides me not training hard.

Inside Ruizs locker room after, Robles and Ruizs father, Andy Sr., admonished Ruiz. You should have listened, they said. You shouldnt have put on all this weight. I kind of tried to do the training on my own, Ruiz said. At the postfight press conference, Ruiz draped an arm around Robles and apologized. Robles, visibly frustrated, looked like he wanted to be anywhere else.

As a coach, you have to be with your fighter 100%, Robles said. Im not the first coach and Andys not the first fighter where situations happen in camp. Im there for him, through good and bad, thick and thin. I have to apologize to him too, because this is a team effort Im right here, sitting next to him so he knows I have his back. Im with my fighters 100%.

Long after the final bell, Joshua remained in the ring, shaking hands, taking pictures, soaking in the moment. Hearn was with him. As much as Joshua had at stake, Hearn did, too. Joshua is Matchrooms tentpole fighter. A loss would have put him on a long path to rebuild, or even retirement. A win restores Joshua to the ranks of the heavyweight elite and reignites talk of Joshua facing the winner of the rematch between Deontay Wilder and Tyson Fury, slated for early next year.

Hearn, though, says Joshua wont be chasing them anymore.

Hes been chasing them for years, Hearn said. It will happen. Maybe [Wilder] was right to walk away from the fight. Its worth a lot more now than it was back then. But [Joshua] just wants the legacy. He created a legacy here in Saudi Arabia. This isnt a guy that goes in selling seven or eight thousand tickets. This is a guy that is selling football stadiums, 80 or 90 thousand tickets. Madison Square Garden, completely sold out. Saudi Arabia, completely sold out. This is a guy that is transforming boxing. These other guys cant lace his boots like that. And hes going to get better and better. Hes 24 fights inthe best is yet to come.

Whats unlikely to come is a third fight with Ruiz, at least not in the near future. Ruiz clamored for it repeatedly after the fight, but his performance in the rematch will close that door quickly. With his belts back, Joshua must now deal with the mandatory challenges. The IBF, which has installed Top Rank promoted Kubrat Pulev as its top contender, says Joshua must face Pulev by next May while the WBO announced that Joshua has 180 days to face its mandatory challenger, former cruiserweight kingpin Oleksandyr Usyk. Hearn wouldnt commit to any course of action, though a likely scenario is for Joshua to accept the IBF challenge and seek a waiver from the WBO. Even if Joshua is forced to drop the WBO belt, Usyk is promoted by Hearnmaking it easy to create an opportunity to get it back.

And Wilder? Fury? Standing in the ring, Joshua appeared resigned to the reality a unification fight was a long way off.

What can I say? Joshua said. Ive been speaking about these guys for a long time. You can see this time, when I had this opportunity to focus on Andy, my head was in the right place. So when Wilder and Fury are really, really ready, they will make the call. But until then, I respect what they are doing and I am not going to continue to call these guys out. Im making my own history in my own lane. If they want to come and be part of thatlook at what happened to Andy when he beat me the first time. He created his own legacy. If these guys want to create a legacy, Im here, Im ready to fight anyone.

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Anthony Joshua, Andy Ruiz and the Jab of Emotions - Sports Illustrated

Magenta Therapeutics Demonstrates First-ever Successful Gene Therapy Transplant Without Chemotherapy in Primates Using a Single Dose of Antibody-drug…

Posted: December 9, 2019 at 3:46 pm

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Magenta Therapeutics (NASDAQ: MGTA), a clinical-stage biotechnology company developing novel medicines to bring the curative power of immune reset to more patients, today announced that new results from its CD117-ADC patient preparation program were presented at the 61st Annual Meeting of the American Society of Hematology (ASH). These results, which were highlighted in an oral presentation at ASH by John Tisdale, M.D., Director, Molecular and Clinical Hematology Section, National Institutes of Health, showed the first-ever successful transplant of gene-modified cells in non-human primates using a targeted, single-agent antibody-drug conjugate (ADC), without the use of chemotherapy or radiation.

Todays conditioning regimens involve high doses of chemotherapy, often paired with radiation, to remove the disease-causing cells. As a result, patients undergoing gene therapy or stem cell transplant are all faced with a difficult choice: whether to endure severe toxicity and risk infertility and cancer for the chance for a cure. Magentas portfolio of targeted ADCs represents an extremely promising new option to prepare patients for gene therapy or transplant with no need for toxic chemotherapy or radiation, said Dr. Tisdale. The results presented today show that a single dose of single agent CD117-ADC achieves the same level of depletion as four doses of busulfan chemotherapy to enable successful engraftment and persistence of stem cells modified with the -globin gene, the gene that causes sickle cell disease and -thalassemia when mutated. Importantly, the animals undergoing preparation with CD117-ADC showed none of the damaging toxicities associated with busulfan conditioning.

Magenta is the only company with the people, platforms and a product engine committed to comprehensively transforming immune and blood system reset, which includes revolutionizing the toxic methods that are used to prepare patients for gene therapy and transplant today. said Jason Gardner, D.Phil., Chief Executive Officer and President, Magenta Therapeutics. The gene therapy field has learned that higher levels of stem cell depletion, which meant higher doses of busulfan, were needed to ensure long-term engraftment of the gene-modified cells and persistence of gene therapy. Across all the modalities we have tested, we have seen that ADCs are most effective at achieving these high levels of stem cell depletion without chemotherapy to enable engraftment and long-term durability of the transplant. Todays impressive results provide important validation of the ADC approach as well as the CD117 target for patient preparation and underscore Magentas leadership in the field of conditioning.

Results from the CD117-ADC Patient Preparation Program

Title: A Single Dose of CD117 Antibody Drug Conjugate Enables Autologous Gene-Modified Hematopoietic Stem Cell Transplant (Gene Therapy) in Nonhuman Primates (Abstract #610)Presenter: John Tisdale, M.D., Director, Molecular and Clinical Hematology Section, National Institutes of Health, Bethesda, Md.

Magentas most advanced patient preparation program, CD117-ADC, targets CD117, a protein expressed on hematopoietic stem cells. CD117-ADC is designed to remove the genetically mutated cells in the bone marrow that cause certain genetic diseases, such as sickle cell disease, enabling curative stem cell transplant or gene therapy.

Results presented by Dr. Tisdale showed:

About Magenta Therapeutics

Magenta Therapeutics is a clinical-stage biotechnology company developing medicines to bring the curative power of immune system reset through stem cell transplant to more patients with autoimmune diseases, genetic diseases and blood cancers. Magenta is combining leadership in stem cell biology and biotherapeutics development with clinical and regulatory expertise, a unique business model and broad networks in the stem cell transplant world to revolutionize immune reset for more patients.

Magenta is based in Cambridge, Mass. For more information, please visit http://www.magentatx.com.

Follow Magenta on Twitter: @magentatx.

Forward-Looking Statement

This press release may contain forward-looking statements and information within the meaning of The Private Securities Litigation Reform Act of 1995 and other federal securities laws. The use of words such as may, will, could, should, expects, intends, plans, anticipates, believes, estimates, predicts, projects, seeks, endeavor, potential, continue or the negative of such words or other similar expressions can be used to identify forward-looking statements. The express or implied forward-looking statements included in this press release are only predictions and are subject to a number of risks, uncertainties and assumptions, including, without limitation risks set forth under the caption Risk Factors in Magentas Registration Statement on Form S-1, as updated by Magentas most recent Quarterly Report on Form 10-Q and its other filings with the Securities and Exchange Commission. In light of these risks, uncertainties and assumptions, the forward-looking events and circumstances discussed in this press release may not occur and actual results could differ materially and adversely from those anticipated or implied in the forward-looking statements. You should not rely upon forward-looking statements as predictions of future events. Although Magenta believes that the expectations reflected in the forward-looking statements are reasonable, it cannot guarantee that the future results, levels of activity, performance or events and circumstances reflected in the forward-looking statements will be achieved or occur. Moreover, except as required by law, neither Magenta nor any other person assumes responsibility for the accuracy and completeness of the forward-looking statements included in this press release. Any forward-looking statement included in this press release speaks only as of the date on which it was made. We undertake no obligation to publicly update or revise any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.

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How Much Weight Is Safe to Lose in a Month? | Weight Loss …

Posted: December 9, 2019 at 3:45 pm

Whether you want to slim down for a big event (hello, wedding) or to quickly fit into your old jeans, the desire forfast weight lossis understandable. Whilefad dietscan be tempting with wild promises (like, lose 20 pounds in one month!), they also tend to backfire and can wreak havoc on yourmetabolism. Most dieters who follow strict diets rebound andregain the weight.

Safe andsustainable weight loss, on the other hand, involves a lifestyle change and takes time: Most of the research supports losing weight at a slow-and-steady pace to maintain the weight loss in the long-term, confirms Ryan Maciel, RD, a certified strength and conditioning specialist based in Cambridge, Massachusetts.

Still, if youre wonderingexactlyhow much weight you can safely lose in one month, heres your guide, according to weight-loss experts:

Weight loss depends on a myriad of factors, likeage,gender,physical activity leveland theeffects of certain medications, so everyone goes at their own pace. A good rule of thumb is to aim to lose 12 pounds per week or 48 pounds per month, says Dr. Elizabeth Lowden, a bariatric endocrinologist at Northwestern Medicine Metabolic Health and Surgical Weight Loss Center at Delnor Hospital in Chicago. In other words, thats about 510% of your body weight.

If you want to lose a pound a week,youll need a calorie deficit(aka less calories in comparison to those you need to maintain your current weight) of about 3,500 calories, or 500 calories per day, explains Lowden. Because it can be difficult to decrease your intake by that much,upping your physical activitycan help burn more calories.

Keep in mind, though, week 1 of yourweight-loss planmay be misleading. It wouldnt be uncommon to lose 5 pounds your first week, maybe even up to 10, but this isnt a rate you can expect to continue and you may even notice no weight loss the next couple of weeks, says Lowden. Thats because as you lower your caloric intake and beginmaking healthier eating choices, your glycogen stores (aka molecules made from thecarbsyou eat) drop, and since theyre attached to water molecules,you lose water weight with them, explains Lowden. So dont feel discouraged if you initially burn pounds fast thenfall into a weight-loss slow down this is normal.

Unless youre enrolled in a medically-supervised weight-loss program or youve just had bariatric surgery, its very uncommon to lose more than 10 pounds per month, says Lowden. Remember, if you lose weight too quickly, your body fights back. Your metabolism slows down, yourhormones shifttoincrease your cravingsand appetite, and you even burn less fat, according toa reviewin the International Journal of Obesity.These changes could lead todisordered eating habits, warns Lowden.

Whats more, no matter how quickly youre losing weight, you also lose a certain amount oflean muscle massin the process (especially if youre not working out to build muscle), and losing too much could deeply damage your metabolism. Thats whystrength training when trying to lose weightis important. Plus, a diettoo low in caloriescould result in nutritional deficiencies, and rapid weight loss could lead to gallstones from improper gallbladder functioning, adds Maciel.

In short, a speedy weight-loss regimen to drop a dress or pants size is generally not worth it. As frustrating as it may be, try to be patient so you are successful long-term.

Here, a few ways you can lose weight safely:

Its essential tohave realistic goalsand expectations before setting out on your weight-loss journey, says Maciel.Tracking your weight-loss goalswith an app likeMyFitnessPalcan be very helpful, he adds. Then, carve out time each week toplan your mealsandworkouts. After youve built up your confidence by reaching a few small goals, you can begin toaim higher with bigger challenges. For example, start by getting into aregular walking habitbeforetraining for your first 5K.

Of course,progress is anything but linear there will be times whenyoull hit a weight-loss plateauor evengain a few pounds back,despite your best efforts. But knowing and accepting this is part of the journey helps you stay on track, says Maciel. While thenumber on the scalemight take time to change, remember to acknowledge and celebrate how your clothes fit differently and how youre able to lift heavier weights or jog longer, suggests Lowden. These are all signs youre on the right track.

Dont give up on the fundamentals of weight loss in search of the magic bullet, says Maciel. Its important to keep in mind that eating morenutrient-dense whole foods, exercising regularly,getting quality sleepandmaking time for self-careare all essential parts of the weight-loss equation. If youre not losing weight on your current plan, take a hard look at youreating, exercise and lifestyle habitsand consider reaching out for help from a support group or nutritionist, he suggests.

When youre working oneating and lifestyle changes, theres a normal amount of hunger that comes with reducing your intake, but you should never feel obsessively hungry, says Lowden. Honor yourhunger cueswith healthier choices. To avoid overeating,mindful eating techniquescan also help.

While healthy weight loss requires a lot of perseverance and dedication, theslow-and-steady routeis your best bet. So many people stop what theyre doing because theyre not seeing immediate changes, butconsistency is key. You will note weight changes over time, but you have to stick with it, says Lowden.

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How Much Weight Is Safe to Lose in a Month? | Weight Loss ...


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