Dosage Strengths of Sermorelin Acetate Injection

6 mg Lyophilized Vial9 mg Lyophilized Vial15 mg Lyophilized Vial

Sermorelin is the structurally truncated analog of Growth Hormone Releasing Hormone (GHRH). It consists of the first 29 amino acids of the naturally occurring neurohormone that is produced in the hypothalamus. Sermorelin is the most widely used member of the GHRH analogue drug class. It can significantly promote the synthesis and release of growth hormone (GH) from cells in the pituitary gland, improving the serum concentrations of GH and subsequently insulin-like growth factor 1 (IGF-1) in animals and humans. It is able to influence the concert of hormonal signals that affect GH secretion from the anterior pituitary including GHRH, somatostatin, and insulin like growth factor (IGF) and others. The positive and negative opposing regulation of growth hormone by GHRH and somatostatin, respectively, creates a rhythmic-circadian pattern of GH secretion. Thus, modification of both pulse amplitude and frequency of GH secretion results from Sermorelin administration. After sermorelin stimulates the release of GH from the pituitary gland, it increases synthesis of IGF-1 in the liver and peripheral tissues.

Sermorelin acts on the growth hormone releasing hormone receptor (GHRHr) in the pituitary to regulate cellular activities. GHRHr is the natural receptor for the endogenous hormone, GHRH, and for sermorelin. This receptor regulates growth hormone release directly by stimulation and indirectly by a feedback relationships with somatostatin.

Sermorelin is readily degraded after reaching the bloodstream, having a biological half-life of approximately 10-20 min. Due to the biological half-life and bioavailability of Sermorelin, administration for growth in childhood GHD must occur periodically several times a day as subcutaneous-injections. However, single daily dosing is sufficient to treat most cases of adult-onset GH insufficiency. Three (3) mcg/kg subcutaneous-injections of Sermorelin have been reported to simulate a naturally occurring GHRH mediated GH release responses.

In addition to increasing production and secretion GHRH also affects sleep patterns by increasing the amount of slow wave sleep (SWS) while augmenting sleep-related GH secretion and reducing cortisol secretion.

To exert all its beneficial effects, Sermorelin requires a functioning pituitary and a host of peripheral tissues. This is due to the reliance on endogenous receptors controlling hormone secreting glands and tissues. More precisely, functioning growth hormone releasing hormone receptors (GHRHr) are required on somatotrophs in a functioning anterior pituitary.

Sermorelin essentially mimics the hypothalamic peptide, GHRH. Sermorelin acts directly on the pituitary stimulating the somatotroph cells ability to produce and secrete GH. Sermorelin increases proliferation of somatotroph cells during development. With the increase of serum GH, downstream effects occur. A notable hormone that is commonly used as a surrogate for growth hormone therapy, insulin like growth factor 1 (IGF-1), is known to increase with the administration of Sermorelin. IGF-I negatively regulates GHRH-mediated GH secretion.

Sermorelin is able to influence the concert of hormonal signaling that effects the GH axis. GH secretion from the anterior pituitary is regulated by GHRH, somatostatin, and GH secretagogues. The positive and negative opposing regulation of growth hormone by GHRH and somatostatin creates a rhythmic-circadian GH secretion. GH asked by signaling target cells, most notably increasing the synthesis of IGF-1 in the liver and peripheral tissues.

Sermorelin acts on the growth GHRHr in the pituitary to regulate cellular actives. GHRHr is the natural receptor for the endogenous hormone GHRH, a signaling hormone produced by the hypothalamus. This receptor among many other functions, controls growth hormone release, mainly by inhibition of somatostatin activity.

Tell your doctor of all prescription and nonprescription medication you may use, especially: corticosteroids and thyroid medications. This drug may affect the results of certain lab tests (e.g., inorganic phosphorus, alkaline phosphatase). Make sure laboratory personnel and your doctors know you use this drug. Do not start or stop any medicine without approval from your healthcare provider. Hypothyroidism: Untreated hypothyroidism can jeopardize the response to Sermorelin. Thyroid hormone determinations should be performed before the initiation and during therapy. Thyroid hormone replacement therapy should be initiated when indicated. Intracranial lesions: Patients with GH deficiency secondary to an intracranial lesion were not studied in clinical trials; Sermorelin treatment is not recommended in such patients. Obesity, hyperglycemia or hyperlipidemia: Subnormal GH responses have been seen in obesity and hyperglycemia, and in patients with elevated plasma fatty acids.

FDA pregnancy risk category C. Exercise caution during lactation; it is not known if this drug is excreted in breast milk. Laboratory Tests: Serum levels of inorganic phosphorus, alkaline phosphatase, GH and IGF-I may increase with therapeutic use. Corticosteroids: Glucocorticoids may inhibit the response to Sermorelin. Controlled studies did not indicate an interaction of Sermorelin with drugs commonly used in the treatment of routine pediatric problems/illnesses. However, formal drug interaction studies have not been conducted

Call your doctor for medical advice if pain/swelling/redness occurs at the injection site (occurring in approximately 16% of patients). Other possible, but less common side effects of rhGH (not Sermorelin) are upper respiratory conditions, nerve sensitivity, insomnia, depression, nausea, hypothyroidism chest pain, gynecomastia, headache, flushing, dysphagia, dizziness, hyperactivity, somnolence, urticaria and sore bones. Call your health care provider immediately if you are experiencing trouble swallowing, vomiting, and tightness in the chest. Antibody formation to Sermorelin has been reported after chronic subcutaneous administration of large doses but their clinical significance is unknown. Antibodies do not appear to affect growth hormone release nor appear to be related to a specific adverse drug reaction profile. No generalized allergic reactions have been reported. A temporary allergic reaction described by severe redness, swelling and urticaria at the injection sites has been reported in one patient who developed antibodies. Additionally, its use may reduce insulin sensitivity, thereby raising blood sugar to levels which could be harmful to diabetes sufferers. It may also decrease triiodothyronine (T3) levels due to its tendency to reduce the bodily levels of sodium, potassium, and phosphorous.

Store dry powder at 68F to 77F (20C to 25C) and away from heat, moisture and light. Once reconstituted keep this medicine in a refrigerator between 36F to 46F (2C to 8C). Keep all medicine out of the reach of children. Throw away any unused medicine after the beyond use date. Do not flush unused medications or pour down a sink or drain.

See the rest here:
Sermorelin Acetate Injection | Empower Pharmacy

A study published in the BioDrugs journal supports that sermorelin is usually injected just under the skin, known as a subcutaneous injection. A Michigan University Rogel Cancer Center document states that this type of injection goes into the body fat, not the bloodstream or a muscle. Sermorelin therapy requires tiny needles.

Sermorelin injections are usually administered once a day, often before bedtime because it mimics the bodys natural cycle of growth hormone production. A doctor, however, may offer different advice. Sermorelin may interact with other hormones in the body, so it usually needs to be taken on an empty stomach.

Studies published in Pediatrics and Clinical Endocrinology in the 1980s and 1990s confirmed that subcutaneous injections are the best delivery route for sermorelin in children and adolescents who are receiving this hormone because of a problem with their pituitary gland or other growth restriction concern.

Some adults may use sermorelin injections as a part of a program to improve declining levels of human growth hormone as they age. Sermorelin usually gets injected into the stomach or thigh because a subcutaneous injection targets the fatty tissue just below the skin. Anywhere someone can pinch their skin and pull fatty tissue into a roll should work, though a doctor may recommend specific sites.

For a free consultation, call (305) 682-1818

Just like insulin-dependent diabetics who rotate the location on their body where they administer an injection, a person will want to alternate the site of sermorelin injections to avoid bruising and soreness. Some people like to keep a written record of where and when they took their injections to ensure a good rotation.

For example, a four-day rotation may include:

On the fifth day, someone would administer the injection into the abdomen again and repeat the rotation. Depending on their doctors advice, they can create this type of pattern to reduce the bruising and soreness they experience at each injection site.

Sermorelin stimulates the body to produce and secrete human growth hormone, a major hormone that continues to play a significant role in the way the body functions even after someone reaches adulthood. If a person has declining or low levels of human growth hormone, a program that includes sermorelin therapy may help them.

A study published in the journal Clinical Interventions in Aging reports that sermorelin injections for adults with declining levels of human growth hormone is an off-label use. However, people who participate in sermorelin therapy as a part of a comprehensive program report a wide range of positive effects that may include:

Sermorelin is often used in conjunction with additional hormone therapies as a key part of a larger protocol or program that can help users regain and maintain the levels of human growth hormone they previously had.

Click to contact our specialist today

Sermorelin is a medically proven, science-based therapy that addresses declining hormone levels and other concerns. Before treatment, a person must submit a blood sample for a laboratory panel. Bloodwork of this kind helps determine someones current hormone levelsthe potential cause of their decline in vitalityand the dose that may be necessary to improve their overall wellness.

If a persons bloodwork shows that they have declining or low levels of human growth hormone, they may be a good candidate for sermorelin therapy as a part of a comprehensive plan to address their lowered hormone levels. Testing is the only way to learn if sermorelin therapy might be effective for them.

Once tested, someone may receive a customized plan based on the results of a lab panel. If a persons results show decreased human growth hormone, sermorelin therapy may play a major role in their program. Because sermorelin is a prescription medication, they will not receive this type of therapy unless they have a deficiency.

Complete a Free Consultation form now

At HealthGAINS, health advisors can help people visualize their full potential and reach it through one of the optimal wellness solutions. HealthGAINS has individualized plans and bio-identical therapies designed for both men and women at every age and stage of life. These therapies are medically proven and scientifically based. HealthGAINS members also receive care in state-of-the-art facilities with the latest tech.

When patients enter a wellness clinic, they are greeted by a concierge health coach in spa-inspired surroundings. There is also no wait time when people come in for their therapy session, and HealthGAINS provides white-glove service to all members. Hotel-like amenities and plenty of attention to detail may help people feel at ease during their treatment.

To discuss individual needs and make an appointment to visit a facility, interested parties can reach out to a HealthGAINS health adviser who can explain relevant services, therapies, and programs. An adviser can help people understand their options for revitalization through human hormone growth treatments like sermorelin.

Call or text (305) 682-1818 or complete a Free Consultation Form

Link:
Where Do You Inject Sermorelin? | HealthGAINS

Anyone considering sermorelin for weight loss, also known as sermorelin acetate, should know that its a peptide that aids in boosting the bodys release of human growth hormone via the pituitary gland and should only be used under supervision of a healthcare professional.

Peptides like sermorelin are short chains of amino acids that have a hand in metabolism and appetite, but since theres not much research on their effectiveness and safety.However, theres plenty of anecdotal evidence online that suggests it may be good for weight loss but deciding if its worthwhile or if another alternative such has human growth therapy (HGT) is better and/or safer.

So take glimpse into a few peoples journeys of using sermorelin treatment, view their before and after sermorelin results, and get science backed answers to the questions of does it work and how long results can take.

The human growth hormone (HGH) found naturally in the body functions to provide muscle development and regenerates cells. Though many people now use sermorelin for weight loss, sermorelin therapy was initially used for both children and adults who had growth deficiencies or developmental delays.1

Its primarily used in young children who have poor growth rates, but when the bodys natural growth hormones start to slow down (often around age 30), people may notice:

Due to these symptoms of less natural HGH production, some adults choose to turn to sermorelin as a better approach to management of adult-onset growth hormone insufficiency and to stimulate more natural HGH production from the pituitary gland.2

Although many artificial HGH products and treatments are available, sermorelin is not one of these; rather, its a natural peptide that stimulates the body to release more of its natural growth hormone.

Sermorelin, ipamorelin, and vitamin B are all similar treatments that can elevate the body up to par when it struggles to naturally keep up.

With certain therapies including sermorelin and ipamorelin, the goal is often to reduce body fat and increase lean muscle mass, among other benefits; vitamin B treatments are administered through a similar process and are identical to many sermorelin benefits including boosting energy levels, aiding in wound healing, treating anxiety, and improving overall well-being.

Those wondering how does sermorelin work must look no further: sermorelin injections for weight loss are administered subcutaneously and are recommended to be injected into the thigh or stomach areas where the body has more fat.

However, when it comes to sermorelin, weight loss is far from the only benefitin fact, sermorelin seems to help the body defy aging.

Sermorelin peptide benefits are abundant and include the following:

As with many peptides, theres both benefits and risks so be sure to see the risks section below to understand the pros and the cons of sermorelin.

Anyone on weight loss diets is tempted to ask how much weight can be lost on the program theyre on and those considering sermorelin are likely no exception. Unfortunately there is no universal answer because weight loss can vary greatly depending on countless factors including starting weight, calories burned, activity level, genetics, eating habits, and more.

Another important factor is ones frequency of use. Some recommend taking one dose (usually 0.2-0.3 mcg) each evening for a month, while others stand by a sermorelin cycle of 3-6 months being the most effective.

Furthermore, some dont recommend taking any breaks whatsoever and adamantly argue that its safe to use year-round.

The amount of weight loss on sermorelin therapy can vary just as much as the differing views on its usage. The best advice we have to offer is to err on the side of starting slowly as ones body adjusts and consulting a doctor to ensure proper use and dosages per person.

Its imperative to see how a growth hormone, athletic performance, and aging interact with one another when trying something like sermorelin and its natural to wonder how long does it take for sermorelin to work and on sermorelin, how long to see results?3

Sermorelins effectiveness kicks in almost immediately in terms of health benefits and stimulation of the pituitary gland, but most people feel their body reacting within the first month or so, then begin seeing true results within 3-6 months.

A loose timeline follows, but keep in mind that this will always vary from person to person based on their normal hormone levels and many other factors..

For some extra motivation and insight into what sermorelin injections for weight loss can do, we have a few examples of sermorelin weight loss results to share. Here are 3 sermorelin before and after results and pictures of different people who opted for sermorelin peptides for weight loss to assist them in their health and fitness goals.

Amber decided to give sermorelin a try and hasnt looked back since; she lost over 30 lbs in under 6 months after starting sermorelin injections paired with semaglutide for weight management. Shes not only lost an impressive amount of weight, but now feels energized, has improved complexion, and is sleeping better.

Source: @feelerconsulting from Instagram

After being a former athlete and letting life get in the way of her health goals, Amber used sermorelin to support her on her health journey and improved her diet. Her goals for sermorelin were better rest and recovery and burning more fat and sermorelin has served her well.

Before starting sermorelin therapy to increase his HGH production, Derek regularly overindulged in junk food, drank alcohol, slept a lot, and noticed he easily became breathless.

Source: u/Theenhancedman from Reddit

Source: u/Theenhancedman ong Reddit

After beginning his use of sermorelin and TRT, Derek soon began to notice subtle changes that quickly became much more drastic and within 6 months his physique changed in shockingly impressive ways.

Derek said that he now has enough energy to work out for 1 hour 7 days per week and fuels his body with frequent small meals and plenty of fruit and vegetable servings each day instead of junk food and alcohol.

He watches out for hidden sugars and noted that he actually sleeps less now but much more deeply and restfullyso much so that he doesnt even use an alarm clock anymore since his body is so attuned that his body clock does the job for him.

Note: These results may not be perfectly indicative of weight loss on sermorelin alone since Derek used TRT as well; the results are impressive regardless but be sure to have appropriate expectations if trying sermorelin therapy alone.

After mentioning that she didnt realize she had gained some weight until seeing photos of herself, Regina started her own round of sermorelin treatments and decided to stick with it after both feeling better and liking how she looked more. With more energy and clearer skin, Regina said that she couldnt be happier with her results.

Source: @feelerconsulting from Instagram

Whether trying peptides on their own, with other weight loss treatments or supplements, or paired with trending diets, its important to know if there are any potential risks. Its wise to ask if any potential sermorelin long term side effects exist, but we are happy to report that any negative impacts are extremely rare.

Not only is sermorelin highly effective in comparison to other hormone replacement therapiesit also causes far fewer side effects due to it being used to boost natural HGH instead of putting synthetic HGH into the body.

Notably, most negative reactions (if any) happen right away and are due to skin irritation or allergic reactions at the injection site. These can include pain, redness, or swelling at the site or occasionally a rash or hives.

If anyone has swelling of the tongue or difficulty breathing they should seek medical help immediately.

Other side effects are rare as well but may include:

Although sermorelin for weight loss may not be a good fit for everyone, overall it is healthy, has few negative health risks, and is very effective. Generally, sermorelin may be worth considering for healthy adults, however, only under the supervision of a healthcare professional. Its always best to consult a physician before making any major adjustments to your diet, lifestyle, supplementations or adding in peptides such as sermorelin.

Between sermorelin vs tesamorelin, our preference is sermorelin for weight loss.4 Although tesamorelin injections serve a similar purpose and are used to help reduce belly fat, increase energy, and boost metabolism, our top choice is sermorelin due to having much fewer side effects and seeming to work more efficiently in most people.5

Tesamorelin not only has been shown to take up to 26 weeks to reduce body fat in any significant way, but it also has much more severe potential side effects including swelling, fluid retention, numbness, blood glucose fluctuations and increased joint pain.

Whether wanting increased strength and lean muscle mass to improve ones powerlifting routine or simply wanting to reap other benefits such as weight loss, immune support, and increased energy, a clear winner for HGH-increasing peptides is sermorelin for weight loss and for general wellbeing.

Read this article:
Sermorelin for Weight Loss: Does It Work? How Long To See Results?