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CAP Beauty’s Kerrilynn Pamer Makes Coconut Ceviche and Endless Matcha – Grub Street

Posted: July 30, 2017 at 11:43 pm

At Soeun. Photo: Melissa Hom

Almost any discussion of what wellness means in 2017 includes a nod to CAP Beauty: first a web store, and now a brick-and-mortar New York shop and spa that takes an inside-out approach to natural beauty. In addition to cosmetics, CAP has helped popularize exotic superfoods, tonics, and teas, earning founders Kerrilynn Pamer and Cindy DiPrima a cult following. Not surprisingly, Pamers diet involves all kinds of herbs and potions and raw foods which she recognizes that many will find polarizing and inaccessible. I didnt always have this diet, she says. I found out I had celiac eight years ago, and that was a big wake-up call for me. She calls her new way of eating transformational, but also admits, Im the first one to say that this is not an inexpensive way to eat, at all. Read all about it in this weeks Grub Street Diet.

Thursday, July 20My mornings look pretty much the same every day. I start my day with 20 minutes of Transcendental Meditation, drink a big glass of water with the Beauty Chef Glow (my probiotic) and Genesis Gold mixed in, and then make my matcha and herbs to jump-start my morning. The herbs change from time to time, but today its a big batch of Rhodiola for focus; tocotrienols for a little creaminess; pine pollen to get my creative juices flowing; astragalus for immune support; he shou wu for hair, skin, and nail health; and the CAP Beauty coconut butter, because it tastes so good. My version of Bulletproof! I crawl back into bed with my husband and doggies, Beba and Ricardo, and we check in with each other, share our dreams, and talk about whats on the agenda for today.

I then prep some stuff for dinner and snacks for the week. Ive been really into making farinata, a chickpea-flour pancake thats also called socca, this summer. Its my answer to having a frittata around. It works as a canvas for flavor. I allow the batter to ferment overnight, drop it in coconut oil, and then pop it into the oven, and it cooks in 10 to 15 minutes. Whatever Im craving, I add it to the batter. Today, its paprika from Ray at the Grand Army Plaza farmers market, berbere, pink salt, and parsley. Then, I toss some soaked lentils into a pot; cook those up; and add preserved lemon, mint, capers, sherry vinegar, Wonder Valley olive oil (the best!), and salt. Happy to have both of these on hand for the full week ahead.

I have a meeting in midtown and its a scorcher today, so I bring a green juice, some cut watermelon, and an avocado to get me through the morning. I pretty much always have snacks on me; lately, thats been primarily fruit since its so hot outside.

I head back to the office and make a Gynostemma tea to warm me up, given the arctic conditions inside. The contrast is so intense in New York in the summer, I cant decide if I want hot soup, an ice-cold salad, or a huge bowl of fruit, which is what I end up going with for lunch. Watermelon and pineapple. Im having a serious love affair with fruit this summer.

Afternoon meetings take me to the kitchen for another matcha. This time neat and straight up. And an Ommm! from Juice Press, my pick-me-up for the second half of the day.

Im heading to an old friends house for dinner and am very excited about it. She makes a gorgeous spread. Leave it to her to work all day, raise an amazing child that we shared dinner with, and get a meal like this on the table. Tonight, we feast on zucchini noodles with pumpkin-seed pesto; roast carrots with zaatar and parsley over chickpeas with raisins; shredded romaine with yellow tomatoes and peppers; and sliced avocados. Another old friend comes over and we end up getting kicked out around 1:30. Its amazing how time slips away when seeing the people you love. I head home and John is still up, so we have herbs together. Our tea-and-herb ritual is one of my favorite parts of my day.

I had always been sick as a kid and had digestive and skin problems. I had never really considered how impactful a diet could be, and my body responded fast and furiously to this change. Ive taken down my inflammation a lot. Ive gotten much deeper into this way of eating lately, but it doesnt feel super rigid, and also this season lends itself to what Im doing right now. This isnt the way Id eat in the winter Id add a lot more cooked foods, a little more grains.

Friday, July 21Up early. TM, Glow powder, and another round of matcha and herbs. Astragalus, he shou wu, pine pollen, coconut butter, and Rhodiola. I drink this, have a bowl of cherries, pack up an avocado (I like to be prepared!), throw a bag of Gynostemma tea into my bag, and Im off. I head to an appointment in Chelsea, and on my way back to the office, I stop at Foragers. I grab a LuliTonix Kick Blend thats spinach, mango, fig, and mint. Its another hot day, and I dont have too much of an appetite because of the heat, so Im hitting the beverage train hard. I grab some watermelon when Im back in the office, make a matcha, and get to work.

Another night out. This time with my business partner, Cindy, and my old friend Kimille. We plan on meeting at Dimes at 7:30. We start with a bowl of grilled shishito peppers, one of my favorites. Then I order the big salad with beets, carrots, a side of avocado, hold the dukkah. Cindy and I share the quinoa plate with steamed kale, sweet potatoes, and sesame otsu. The sweet staff sends Champagne over post-dinner. I love it here.

Socially, keeping this diet is actually pretty easy. I dont talk about it, which is kind of funny. At a restaurant, Ill barely mention it. I dont want to be the person who says, Im not eating this or that. Thats a fucking bore. But Id say almost all of my friends and family are curious because theyve seen me transition into feeling better. I dont preach about it, but my family probably still thinks all I eat are sticks and twigs.

Back at it with the tea and herbs. Another round of meditation, some time spent with John, some snuggles with Beba and Ricky, and Im out for the night. Im thrilled to have tomorrow off. Especially because its a beach day.

Saturday, July 22Our Saturdays are pretty routine. They begin with TM, then we suit up the dogs, gather the weeks worth of compost from the freezer, and head to the farmers market. After we drop off the compost, we make our way down to Juice Press and Blue Bottle. I grab a couple juices for our beach day at Fort Tilden, and John gets an iced Americano. I dont really drink coffee it tweaks me out but I am known to have sips off of Johns or Cindys. My version of party smoking.

Then its back to the market to stock up for the week. We pick up collard greens, sunflower sprouts, and some beyond-delicious cucumbers, mushrooms, carrots, radishes, lettuce, and peaches. Once we get home, I prep the food for the week, snack on some pineapple, and get ready for our beach day. I always want snacks at the beach, so I cut up a bunch of watermelon, pineapple, and cucumbers. The beach has some good food options these days; theres a stand that I always hit that sells Thai coconuts, and another stand on the boardwalk called TropPops. They make the most delicious Popsicles just out of fruit and today its mango, and one side is covered with dark chocolate.

Back at home, we start preparing a huge post-beach salad. Tonight, its a lot of the stuff from todays market: greens from Evolutionary Organics; beets; the lentil salad I made this week; my husbands sauerkraut; micro watercress; lettuce mix from Evolutionary Organics (the best!); carrots from Willow Wisp Farms (another favorite at the farmers market); avocado and my new favorite salad dressing, which is a combination of Basbaas cilantro coconut (this stuff makes everything better); sauce with some Wonder Valley olive oil; and pink salt. I add a side of Vegan Marios bread (this is one of the best breads Ive ever had we order it from California; its that good!) and some coconut oil on top. Dinner is served.

Theres validity to people saying this kind of diet is prohibitively expensive. I dont really go out for big dinners. I eat in a lot. We have a juicer at home, so I make a lot of my juices myself. I also dont drink. People will say, Your juice is $12, and Ill say, Your cocktail is $16. And thats okay! Its expensive, but I am committed to this. I havent always been in a position for that to be the case, but its an important decision to me. Im the first one to say that this is not an inexpensive way to eat, at all. And all the adaptogens that I take, would I be taking those if I didnt own CAP? Probably not. Im super lucky in that sense. If I was just walking in, hell no. Crazy. I wouldnt be able to buy all of those! But the initial investment is definitely valid.

After dinner, its back to the kitchen for tea and herbs, some Kundalini, and lights out.

Sunday, July 23I have a lot to do at the office lately, so I prep some herbs and matcha, and head in on this rainy Sunday morning. Im feeling super focused with the herbs and matcha on my side, and I plow through my stack of papers and lingering items. I drink a Greens + Earth, have a rose Tulsi tea, and snack on some pineapple and watermelon. Now that my work life is feeling more in order, I head home and have a Juice Press Lucky Seven, and an avocado with pink salt and some sunflower seeds. Im obsessed with these sunflower seeds from Joshua Tree that this woman hand-roasts at her home. It seems absurd to like sunflower seeds this much, but theyre that good.

Dinner tonight is quick, as we are going to a friends house for Game of Thrones, and I know there will be good snacks on hand. Maya Kaimal sweet-chili lentil chips, carrots, radishes and green hummus, tortilla chips and salsa, and Go Raw carrot-cake cookies. Dinner before the big event is a big bowl with quinoa, that lentil salad again, sauted greens from the market, Seed + Mill green-herb tahini, sauerkraut, cucumbers, grated carrots, more microgreens, and a delicious sesame-seed shake that is a collaboration between Seed + Mill and La Bote. The farinata makes an appearance.

Some more herbs, sleepy-time tea, and Im out.

Monday, July 24I wake up and have more herbs (astragalus and he shou wu) with matcha, and head uptown to see a possible fulfillment center. Its pouring out and I grab a Juice Press Ommm! juice, a beautiful shiro plum that I snagged at the farmers market, and one of my favorite snacks, Splitz, which are these delicious split-pea crackers made in New York. They dont sound exciting, but our whole office is obsessed with them.

After our visit uptown, we head downtown, swing by Ninth Street Espresso for an espresso pick-me-up, and head into the office. Today, I get a big container of salad-bar stuff from Life Thyme. They have tons of options. I go with a cabbage salad; roast sweet potatoes; grated carrots with pumpkin seeds; celery with olive oil; beets with sesame seeds; and raw broccoli salad. The list goes on. I add some sauerkraut, Cindys husbands homemade hot sauce, avocado, and a side of Moon Juices green fermented crackers, and call it lunch.

My day at the office is coming to a close, so I start thinking about dinner. I swing by Integral Yoga and pick up a bunch of tomatoes, botija olives, basil, onions, garlic, and zucchini. When I get home, I start a tomato sauce with my grocery haul and let that simmer while I soak more chickpea flour for another farinata. Im big on having snacks around, so theres always something soaking in the kitchen. While Im waiting on dinner, I have some pickled summer squash from the farmers market, olives, cucumbers, and fennel. I also start the zucchini noodles for the sauce. I cant bring myself to call them zoodles. I add some nutritional yeast at the end of the pasta sauce, toss it with the noodles, add some basil on top, hit it with olive oil, and dinner is served.

After dinner, its chocolate. Im in love with Honey Mamas peppermint bar. I found it on my last trip to Oregon and have been stockpiling. Another round of herbs, some time on the couch, reading (I recently got into the Ocean Greens cookbook that is all seaweed recipes and am really enjoying it), and its time for bed.

Tuesday, July 25I start the morning with herbs and matcha (clearly a theme here). While Im making that, I start prepping dinner for tonight. Its from Meredith Bairds cookbook, Coconut Kitchen, and its a ceviche made from (you guessed it!) coconut. I thawed it out the night before, and now all I do is cut it up and add tons of lime juice, tomatillos, tomatoes, cilantro, jalapeos, radishes, and salt. That will spend the day in the fridge, waiting for me when I get home. I make a green smoothie thats banana, kale, spinach, fig, mint, lime, and coconut water, and drink that while sitting down to answer emails.

I head into the office and have a Chaga tea, drink a green juice from Juice Press, and snack on some cherries. Lunch today is from Souen, one of my favorite old-school downtown restaurants. The chef salad is a favorite; its loaded with seaweed, avocado, lettuce, carrots, steamed cauliflower, broccoli, daikon, and tahini dressing. I find it hard to find a really big salad in the city and this is a great option.

I grab some more tomatoes and peppers on the way home, and make a big batch of gazpacho for tonight. Mine includes tomatoes, apple-cider vinegar, shallots, red peppers, olive oil, cucumbers, pimentos, and salt. Soup and ceviche are ready to go, and dinner is served.

Im still hungry after dinner, so I make a huge bowl of popcorn. I pop it in coconut oil, and then melt some more for the topping and add in tamari, berbere, and nutritional yeast. We catch up on the latest Game of Thrones and turn in for the night.

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CAP Beauty's Kerrilynn Pamer Makes Coconut Ceviche and Endless Matcha - Grub Street

Floyd Mayweather’s diet: How to eat like a boxer – Telegraph.co.uk

Posted: July 30, 2017 at 11:43 pm

Competing in the lowest possible weight class can give boxers a significant strength advantage, so their diets are tailored to keep their weight down while maintaining lean muscle mass.So, what does a boxers diet look like?

Consistency is key, says MattSmith, who trains current southern super featherweight titleholder Craig Poxton. Firstly, opt for small but regular meals four to five a day. Secondly, choose foods of high nutritional value, cutting out the empty calories you get from sweets and crisps. The diets similar to the Paleo or low glycaemic diet. Look to eat quality protein in every meal. This can be red meat, eggs, poultry or oily fish. Healthy fats are in too such as avocado and nuts.

And, just as Mayweathers former chef disclosed, fibrous fruit and vegetables should make up a large portion of each meal. Fresh fruit and vegetables contain vitamins, minerals and antioxidants that help with repair and recovery. Root vegetables in particular provide slow release energy that will keep the boxers brain alert and aid performance.

Blood sugar levels need to be kept consistent, too. Especially in the lead up to a fight when boxers are trying to make weight to qualify for certain categories. When blood glucose is spiked, it can inhibit the breakdown of fat, says Smith a process that could stop boxers losing the weight they need to qualify. A Paleo style diet is beneficial because it cuts out processed foods with hidden sugars.

As well as the Paleo style diet that Smith discusses, slow release carbohydrates - such as whole grains and oats -are essential saysperformance nutritionist Mark Ellison, who works with GB Boxing."They provide accessible energy that the body needs duringhigh intensity exercise. Without it, boxerscanfatigue quicker."

From one athlete to the next, diets vary hugely depending on the energy demands of training. Sports nutritionists will spend months analysing their performance in the run up to the fight, testing certain foods to ensure theyre performing at their best. Anyone looking to enhance their boxing performance with their diet should start with cutting out empty calories and following a consistently nutrient-rich diet, says Smith.

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Weight loss: THESE three moves will help you shed pounds fast – Express.co.uk

Posted: July 30, 2017 at 11:43 pm

While getting in shape doesnt take place overnight there is a quick way to slim down.

For those wanting to look and feel good in a short space of time this summer, Chris Wharton, Co-owner and Director at Better Body Group, has revealed how.

He said: The people you see looking ripped on their holidays get that way by carefully structuring their training plans, being mindful of what they eat and, most importantly, for fat loss, create a consistent calorie deficit.

That being said, the quickest way to get in shape is by including big,compound strength exercises, that recruit lots of muscle mass and subsequently raise the number of calories you burn throughout the day post workout.

Chris has three exercises for those looking to get in shape on a tight schedule.

Push press

The push press is a relatively easy exercise to learn, but packs a lot of bang for its buck. Not only does it target the arms, shoulders and trunk, but also the whole of the lower body. Its also a great exercise for adding practical strength for everyday life.

How to do it:

Perform the push press with either a barbell or pair of dumbbells. Start with the weights rested on shoulders (dumbbells) or collar (barbell)

Note - unless you are experienced in compound lifts like this, be sure to start light and perfect the technique before adding weight.

Deadlift

The deadlift should be included in pretty much every plan that aims to improve physique. The move targets many muscle groups in one single movement - the quads, calves, hamstrings, gluten, trunk, arms and upper and lower back. Its also great for improving posture and total body strength.

How to do it:

Note - this is a tricky move to perform correctly. Be sure to start light and ask for help if you need it. There is no quicker way to injure your lower back than by doing a dodgy deadlift.

Spiderman press up

Any press up variation is a valuable addition to your training regime. As another great compound exercise, the Spiderman press up not only targets your chest, shoulders and arms but also adds an extra challenge to your abs and obliques.

How to do it:

Note - for beginners, its essential to master the standard press up first, as the Spiderman press up is far more challenging on hip and core stability.

While these three gym exercises are great to add to your summer training plan, Chris urges people to remember no single exercise alone will help you shape up for summer.

He said: Be consistent and focus on creating a calorie deficit in combination with plenty of activity.

Chris Wharton is the Co-owner and Director of the Better Body Group, a chain of gyms in the South East that specialises in body transformation, injury rehabilitation and improving fitness performance, all delivered by graduate-level personal trainers. Find out more on the website http://www.betterbodygroup.co.uk/

Another tip to lose weight is not eating at THIS time of day.

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Weight loss: THESE three moves will help you shed pounds fast - Express.co.uk

SUTHERLAND: Not so fast! Get the skinny on fasting to lose weight – Alaska Highway News

Posted: July 30, 2017 at 11:43 pm

Intermittent fasting has recently become more popular within the fitness community. Athletes are using a variety of different fasting methods to cut body fat and lose weight. But what exactly is fasting, and what are the pros and cons to this weight loss method?

The definition of fasting is the abstinence of food and drink (except water) for any length of time after the complete absorption of a meal. Food is usually absorbed within three to five hours after eating, and that is when the body begins metabolic changes. Prolonged fasting is a fast that lasts anywhere between eight and 72 hours.

Fasting can have a lot of benefitsif it is done safely. According to the U.S. National Academy of Sciences, tests using fasting have shown positive effects such as stress resistance, increased insulin sensitivity, reduced morbidity, and an increased life span. Fasting gives the body a chance to rest and cleanse. Energy that is normally directed at the digestive system can be used elsewhere throughout the body to repair and detox other systems. Intermittent fasting has been shown to improve cholesterol and reduce inflammation. Fasting can also improve mental clarity, focus, and increase energy levels. After your body uses up all the available energy from the food you have recently eaten, it will begin to use the fat stores within your body. That is when you will start to see weight loss, and possibly fat loss depending on the length of the fast and how often you fast.

Although there are many positives to fasting, there are also negatives. The body needs more than carbohydrates to run efficiently; it also needs protein, vitamins, and minerals. Those are not stored in fat, unlike carbs, so your body does not have access to them and cannot perform a variety of jobs throughout the body. Even though increases in energy levels are in the positives, fasting can also make your body feel lethargic and tired due to a drop in blood sugar levels. Also, without food, stomach acids are more likely to burn through the lining in your stomach.

There are people who should not attempt fasting: pregnant and breastfeeding women (this is a time to nourish your body and your baby), children and young teenagers who are growing and active, those with adrenal fatigue, or low thyroid function. Also, if you have had eating disorders in the past, fasting may cause those issues to resurface. Lastly, if you are on medication it is important to consult with a doctor before fasting. Fasting on certain medications may cause complications. Extended or prolonged fasting can lead to thinning hair, electrolyte imbalances, downy hair, cardiac arrhythmia, renal failure, and even starvation leading to death.

I wouldnt recommend fasting for longer than 48 hours at a time, and make sure to drink plenty of water during your fast to maintain hydration. Drinking lots of water will also help to lessen the feeling of hunger you will experience during your fast. Every person is different. For some, fasting will be a walk in the park, but for others it may not be so easy. Listen to your body; if you dont feel well it is OK to break the fast.

I have done 24-hour fasts before, and I dont mind them. They can be tough at different points in the day, and exercising can be a little bit more draining, but I do experience a lot of the benefits. Weigh the pros and cons, and give fasting a try if you it is safe for you to do so. If you dont like it, hopefully you wont ever have to do it again. If you do like it then you can begin to make it apart of your routine.

Stephenie Sutherland is a Fort St. John student studying nutrition and food sciences. She can found at the gym, hiking local trails, and serving up a hot cuppa joe at Whole Wheat and Honey. Have a question? Email her at stephenie.sutherland13@gmail.com.

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SUTHERLAND: Not so fast! Get the skinny on fasting to lose weight - Alaska Highway News

Calorie tracking app aims to whet investors’ appetites – The National

Posted: July 30, 2017 at 11:43 pm

The Weightmonitor app provides calorie counts along with paid nutritionist advice. Chris Whiteoak for The National

Dev Khosla is a healthy weight now, but back in college he was obese.For a while, he had no interest in losing weight. But when he saw his new friends get into fitness, he decided to try.I told my mum, who is a well established nutritionist, that I wanted to start losing weight and we started a phone and Skype diet plan, which worked really well for me, says Mr Khosla, from New Delhi in India.So I thought I could create a programme, professionalise it and customise it and offer it at compelling prices, I am sure we could benefit other people.And he did. He developed Weightmonitor, an app which offers nutritional advice and helps you track calories. The app was a success in India, and soon people were also signing up in the UAE.As you already know, there are a lot of Indians in the UAE so we were seeing a lot of organic demand from one friend to the other friend, like a friend reference, he says. People are losing weight. People have been using the scoring programme which we launched, which is basically the main selling point of the programme. What it does is once you have a target to reach every day it keeps you motivated to achieve a higher score, independent of your food habits. That has been a great validator for us.Mr Khosla moved to the UAE just over a year ago to launch Weightmonitor UAE, which has two elements a free calorie-counting service and paid nutritionist advice. For Dh499 per quarter, users receive access to a personal nutritionist who puts together a personalised diet plan.However, when the app was launched in Dubai based on the same paid for model as in India, the company did not see a lot of success initially.We had to change it to a model where people come in and feel the product, see the product, without having to pay for it immediately. You can lose weight by using the free [calorie-counting] service and go on to use it for the rest of your life or pay for the premium element [which also gives you access to a nutritionist].The app now has 1,500 users and Mr Khosla is on the verge of raising a Series A round of funding.We have been able to demonstrate a proof of concept to a suitable investor, says Mr Khosla. We have already been talking to a few venture capital funds, so we are in the process of engagement on that side.They may not need much persuasion.Anything that has a proof of concept, anything that is scalable and anything which has a barrier to entry is something that excites a VC, he says.VentureSouq, an angel investing platform, says there has been increased interest from investors in health and fitness tech start-ups as the size of financings and valuations in both the Middle East and the US have increased significantly over the last five or six years.This is not surprising given that people generally are starting to take better care of themselves through healthier eating and exercise, and technology is starting to increasingly intersect into peoples lives including health and wellness, says Suneel Gokhale, a partner at VentureSouq.The global mobile health, or mHealth market, which includes the fitness tracking sector, is expected to reach US$102.43 billion by 2022, according to Zion Market Research. Weightmonitor UAE is a very good example of this fast developing start-up space and is an ideal fit for the emerging UAE entrepreneurial ecosystem, says Ramesh Jagannathan, the managing director of the innovation and entrepreneurship platform StartAD.

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Calorie tracking app aims to whet investors' appetites - The National

Propecia works great – Will propecia make my hair grow back – Hayati Magazine (blog)

Posted: July 30, 2017 at 11:43 pm

Propecia works great - Will propecia make my hair grow back
Hayati Magazine (blog)
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Propecia works great - Will propecia make my hair grow back - Hayati Magazine (blog)

How to Safely Use Weight Loss Shakes – wikiHow

Posted: July 12, 2017 at 7:52 pm

Steps

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Resist regaining weight. Once you stop using shakes for weight loss, there is a risk that you will regain the weight you lost. It is more important than ever that you are careful about what you eat when you cease replacing meals with shakes. Continue to calculate how many calories you need daily and stick to that number. Try not to go back to eating just as you were before using the shakes, as this will lead to weight gain.

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Gelesis Announces Last Patient Out in the Pivotal Gelesis100 Weight-Loss Study – Business Wire (press release)

Posted: July 12, 2017 at 7:52 pm

BOSTON--(BUSINESS WIRE)--Gelesis, Inc., a biotechnology company developing a novel category of therapies to safely induce weight loss, improve glycemic control, and treat other chronic diseases related to the gastrointestinal (GI) pathway, is pleased to report today that the last patient has completed treatment in the pivotal GLOW (Gelesis Loss Of Weight) Study. The GLOW study was designed to assess the long-term efficacy and safety of lead product candidate Gelesis100 over a six-month period across a broad patient population. The company has also enrolled its first European patient in the ongoing LIGHT-UP study with its second product candidate, Gelesis200, for weight loss and glycemic control. The study will enroll individuals who are overweight or have obesity and also have prediabetes or metformin-treated type 2 diabetes at more than 30 sites across the United States, Canada, and Europe.

Were pleased to have reached these two milestones for Gelesis as we continue to progress our platform technology and expand our pipeline, said Hassan Heshmati MD, Chief Medical Officer of Gelesis. Were also continuing to establish a body of data around our platform technology, as we explore additional GI-related conditions such as nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and inflammatory bowel disease (IBD).

Further investigation of the Gelesis mechanism has led to an international collaboration with leading obesity and nutrition experts and new insights about how people with prediabetes respond to different types of diets, published in the American Journal of Clinical Nutrition. We are learning a remarkable amount about the potential positive impact on local inflammation and glycemic parameters through our unique hydrogel system that is at the forefront of mechanobiology, added Elaine Chiquette, Pharm.D., EVP Head of Science, Gelesis. This emerging field at the interface of biology and engineering focuses on how cells sense and respond to mechanical stimuli and is helping us to unlock insights into the gut-brain-inflammation axis.

About Gelesis100 and Gelesis200Gelesis100 is a pivotal-stage product candidate for weight loss and glycemic control, which has demonstrated statistically significant weight loss, reduced hunger, increased satiety and strong safety in previous clinical studies. Gelesis200 is a second product candidate that has been engineered for rapid hydration with significantly higher elasticity to enhance glycemic control and weight loss for patients who have pre-diabetes or type 2 diabetes. A proof-of-concept clinical study with Gelesis200 (LIGHT-UP) has been initiated for weight loss and glycemic control in people with prediabetes or type 2 diabetes. The results from this study are expected mid-2018.

Both Gelesis100 and Gelesis200 are orally administered capsules containing small hydrogel particles made by cross-linking two naturally occurring food ingredients to generate novel compositions that are expected to be safe and well tolerated. Gelesis product candidates are designed to employ multiple mechanisms of action that leverage mechanotransduction along the gastrointestinal (GI) tract to induce weight loss and improve glycemic control. The hydrogel particles swell and shrink in different parts of the GI system, mix homogeneously with food, travel through the GI tract, and once in the large intestines release most of the water, which is reabsorbed by the body. The small hydrogel particles are then safely eliminated by the body in the same manner as food.

To our knowledge, Gelesis novel hydrogels are the only super absorbents made from materials which are considered Generally Recognized As Safe (GRAS) by the U.S. Food and Drug Administration (FDA) and commonly used in foods. Gelesis also received positive confirmation from the FDA that GLOW is a nonsignificant risk (NSR) device study. Gelesis holds 11 families of patents, several of which have already been allowed or issued in major markets. Most recently, Gelesis received a Notice of Allowance from Japan Patent Office (JPO) on Patent No. 2014-514632 covering composition of matter for Gelesis100.

About GelesisGelesis is developing a novel hydrogel platform to treat obesity and other chronic diseases related to the gastrointestinal (GI) pathway. Gelesis proprietary approach acts mechanically in the GI system to potentially alter the course of chronic diseases safely and effectively. Gelesis is currently evaluating its lead product candidate, Gelesis100, in a pivotal trial for weight loss, which is expected to read out in Q3 2017. Additionally, Gelesis recently initiated a proof-of-concept study for its second candidate, Gelesis200, which is optimized for weight loss and glycemic control in patients with type 2 diabetes and pre-diabetes. New hydrogel compositions based on the Gelesis platform are also being explored in preclinical and pilot studies in other GI-related conditions such as nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and inflammatory bowel disease (IBD).

The Gelesis executive and advisory team includes some of the worlds leading experts in obesity research and clinical development, innovators in material science, and entrepreneurs. Gelesis was co-founded byPureTech Health (PRTC.L), an advanced, clinical-stage biopharmaceutical company (www.puretechhealth.com).

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Gelesis Announces Last Patient Out in the Pivotal Gelesis100 Weight-Loss Study - Business Wire (press release)

5 Important Hydration Tips to Stay Safe in the Heat – KDRV

Posted: July 12, 2017 at 7:52 pm


KDRV
5 Important Hydration Tips to Stay Safe in the Heat
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Summer has just begun, and already places across the country have seen temperatures in the mid- to high-90s and low 100s. Don't let these hot temperatures hold you back from enjoying all your favorite outdoor summer activities. Here's how you can ...

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How to Ramp Up Training and Stay HealthyNo Matter Your Diet – Outside Magazine

Posted: July 12, 2017 at 7:50 pm

Ask an elite athlete how nutrition factors into her performance, and shell likely tell you that its just as important as her training plan. In many cases, she may even call it the most important factor. But the increased effort levels during training can make sticking to your diet tough since even healthy regimens often include eliminating classic performance foodslike lean proteins if youre vegetarianor carbs if youre paleo. If you fall into one of these camps, rest easy. A few small tweaks will give your body what it needs to crank at its full potential. We spoke with two sports dietitians who work with high-performing endurance athletesHeather Mangieri, spokesperson for the Academy of Nutrition and Dietetics, and Barbara Lewin, sports dietitian for the U.S. Olympic Registryfor the details.

Keto dieters get about 75 to 85 percent of their calories from fat and eat very few carbohydrates (generally fewer than 50 grams a day). Although revered by many endurance athletes, the keto approach to healthful eating can backfire if you arent deliberate about finding your fuel elsewhere, getting adequately diverse nutrient intake, and tracking whether your body is adapting to fat burning.

Emphasize Diversity: You need a lot of vitamins, minerals, and natural antioxidants when youre training. Without a careful approach to keto, you risk micronutrient deficiency, Mangieri says. Make sure youre not eating the same rotation of foods. Instead, rely on easy swaps to ensure youre putting a variety of vitamins and minerals into your body without having to take a supplement.

Monitor Your Performance: Its been the silver bullet for many athletes, but the keto program doesnt have the same impact on every individual, so it remains debated. Many people can run a marathon or do a tri while following the keto rules of thumb, but science shows that increasing intensity typically requires carbohydrates, Lewin says. She recommends keeping a journal to monitor what youre eating and how youre performing in your training. Its key to see if youre falling off pace or exerting more effort to clock in at slower times without necessarily noticing it.

Gluten-free athletes avoid foods that most others consider essential to their training. Thankfully, eating gluten-free is a breeze these days with so many healthy choices, Lewin says. But there are still a few pitfalls to watch for.

Skip the Packaged Foods: A diet packed with gluten-free bread, crackers, and pastas isnt inherently healthy or useful for fueling hard training, since those foods often have added sugar or fat to make them more palatable. Instead, eat naturally gluten-free foods like quinoa and starchy vegetables like sweet potatoes or corn, Mangieri says.

Go for Variety: Gluten-free dieters often eat a lot of rice productsrice bread, rice crackers, rice pastaso they get a limited nutritional panel on repeat. Instead, switch up your alternative-carb products so you get a longer list of macros (and prevent stale taste buds). Try bean-based pastas, buckwheat pancake mixes, or corn tortillas instead of flour.

Plant-based diets have become the darlings of the health world and the hallmark of many exemplary endurance athletes, but its surprisingly easy to eat a very unhealthy diet even when cutting out animal products. Its less about what you arent eating and more about what you are eating, Mangieri says. To really perform your best, you need to be a well-rounded vegan or vegetarian. That means your pantry cant be filled solely with energy bars and protein powder.

Pay Attention to Protein: Get your protein from real plants. There is a lot of amino-rich produce out thereyou just have to be a little more conscious of making sure youre getting enough. It may be worth using a food-tracking app at the start to guarantee that youre getting the recommended 90 grams a day. Besides beans and legumeslauded as plant-based protein sourceschia seeds, wild rice, oatmeal, and even potatoes contain significant amounts of plant protein that can be easily incorporated into your meals throughout the day

Be Mindful of B12: Strict vegans need to be sure theyre getting enough vitamin B12, which is naturally found only in meat and is essential for red blood cell production. Try incorporating fortified cereals or alternative milks a few times a day. If youre really struggling to hit the mark, pop a B12 vitamin daily.

Time Your Fiber Wisely: I recommend that triathletes and runners reduce their fiber for two days prior to their race, eating fewer big salads and the like. This may actually reduce their weight by a few pounds and will reduce GI issues and the chance they have to find a restroom along the way, Lewin says. Thats tough for anyone who abstains from meat, but its important for being race-ready.

Athletes who fuel themselves on this ancestral diet eschew agricultural-era foods such as grains, legumes, dairy, and refined foods while focusing on meat, fish, fruits, and veggies. Its pretty easy to be a paleo athlete as long as you time the carbs you do eat for adequate fueling and recovery.

Enjoy Those Well-Timed Potatoes: The Paleo Diet for Athletes allows high-glycemic carbs like potatoes around your training and racing times to ensure you have adequate glycogen stores for high-intensity efforts and recovery.

Make Your Own Sports Drinks: Commercial sports drinks will be off-limits, but you can make your own from raw honey, sea salt, lemon juice, and water.

Some athletes believe this approach helps them stay lean and fast. There is good research that this pattern of eating can be beneficial. You just need to practice it wisely, Lewin says.

Eat Enough: For athletes, the goal of intermittent fasting isnt to go into starvation mode or to shed pounds quickly. Instead, its meant to increase your strength-to-weight ratio by triggering your body to burn fat stores. When you do eat, you want to make sure you consume enough to maintain muscle mass, restock your glycogen store, and stay fueled.

Time It Right: Schedule your high-intensity sessions close to your last meal so you have fuel on board. Avoid prolonged fasts of more than two to three days just before races so you dont go in with depleted glycogen stores.

Raw-food practitioners, notably professional triathlete Brendan Brazier, fill themselves with foods that havent been cooked, believing that modern cooking deleteriously alters foods nutritional content. The foods you choose and how you prepare them can have a major impact on how well (or not) you do as you train.

Prioritize Protein: Its easy to feel satisfied on uncooked foods yet miss out on getting the protein you need. Raw, less-processed food fills your stomach faster even if it doesnt give you lasting energy. To combat this effect, eat a large variety of nuts, seeds, legumes, and vegetables, rather than just munching on raw crudits and trail mix, to get all your essential amino acids without filling up first.

Think About Fiber: Fiber hits harder with a raw-food diet because your body has to do all the work of digesting it without the help of cooking, which might ordinarily kick-start the breakdown process. A high fiber pre-workout or pre-race meal doesnt sit very well and usually doesnt provide adequate calories, Lewin says. The same is true for recovery. Eating a high-fiber recovery meal means that you miss the window of 20 to 30 minutes after your workout where the body is able to most efficiently restore muscle glycogen levels and rebuild muscle. Juicing some of your foods will help eliminate some of the fiber while still providing nutrition.

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How to Ramp Up Training and Stay HealthyNo Matter Your Diet - Outside Magazine


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