The Global Testosterone Replacement Therapy Market Analysis To 2028 is a specialized and in-depth study of the industry with a special focus on the global market trend analysis. The Testosterone Replacement Therapy market report aims to provide an overview of the Testosterone Replacement Therapy market with detailed market segmentation by type, application, and geography. The global Testosterone Replacement Therapy market is expected to witness high growth during the forecast period. The report provides key statistics on the market status of the leading Testosterone Replacement Therapy market players and offers key trends and opportunities in the market.

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Major Key Players: AbbVie, Endo International, Eli lilly, Pfizer, Actavis (Allergan), Bayer, Novartis, Teva, Mylan, Upsher-Smith, Ferring Pharmaceuticals, Kyowa Kirin, Acerus Pharmaceuticals etc.

Furthermore, the research report includes the detailed information about major players and provides the data regarding the current market scenario as well as upcoming market opportunities or challenges. Similarly, in segment report covers the types, and applications according to the countries and key regions. The research report consists the various drivers and restraints for Testosterone Replacement Therapy market along with their effects over the forecast period. Similarly, according to the region Testosterone Replacement Therapy market research report includes the study of opportunities available in the market situation.

The Testosterone Replacement Therapy market research report provides the in-depth data analysis by using the various graphs, figures, charts, and tables. Furthermore, the report provides the different business challenges which are impacting market growth in all direction.

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Key Analytical Areas:

The report aims to offer a complete solution to various businesses operating in the Testosterone Replacement Therapy market in making strategic decisions based on credible information. Thereby, the report covers various aspects of your requirements such as industry overview, market dynamics, regional analysis and competitive landscape.

Competitive Snapshot:

In addition, to detailed information on the companies operating in the Testosterone Replacement Therapy market, the report also includes a competitive snapshot of all the companies covered in the report. Thereby, this offers a visual representation of how all the companies stand comparatively based on their competencies, geographic presence, market hold, and years of operations and financial strength, among others.

Regional Analysis of Global Testosterone Replacement Therapy Market

All the regional segmentation has been studied based on recent and future trends, and the market is forecasted throughout the prediction period. The countries covered in the regional analysis of the Global Testosterone Replacement Therapy market report are U.S., Canada, and Mexico in North America, Germany, France, U.K., Russia, Italy, Spain, Turkey, Netherlands, Switzerland, Belgium, and Rest of Europe in Europe, Singapore, Malaysia, Australia, Thailand, Indonesia, Philippines, China, Japan, India, South Korea, Rest of Asia-Pacific (APAC) in the Asia-Pacific (APAC), Saudi Arabia, U.A.E, South Africa, Egypt, Israel, Rest of Middle East and Africa (MEA) as a part of Middle East and Africa (MEA), and Argentina, Brazil, and Rest of South America as part of South America.

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Testosterone Replacement Therapy Market Segmentation, Analysis by Recent Trends, Development by Regions to 2028 AbbVie, Endo International, Eli lilly,...

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What are you willing to sacrifice for happiness? For me, it was my voice.

As a performer, my voice was one of the biggest obstacles in my coming out. In the theatres where I worked back home, I was known for my voice; specifically, how high it could go. I played Marian in The Music Man, Rosa Bud in The Mystery of Edwin Drood, and whenever I was in the ensemble, the music director would add in an extra high note at the end of songs just for me. I had put so much of my value and identity into my voice that the thought of it changing was absolutely terrifying. But I couldn't keep pretending to be someone that I wasn't. During one voice lesson, my teacher communicated to me that if I kept up my current eating habits (or lack thereof), I could do permanent damage to my voice. My eating disorder had been what I had used to cope with my body. I had been sacrificing my mental and physical health for my voice. But now, my voice was on the other side of the line, too.

I finally came out as transgender at 16 and, after a while, started testosterone. The issues that I had been having with my body dissolved, along with my disordered eating. I was so much more comfortable in my body and myself. While I was absolutely catapulting into my new life, finally able to feel the joy that was pushed down with the rest of my identity, the one thing that I mourned was my voice. I missed being able to pick up any piece of music and know that my voice could hit whatever notes were required. I now had to live with uncertainty. After about a year and a half, my voice settled comfortably in a high-tenor range. What had I been worried about? My new voice was great - I could hit all those Dear Evan Hansen notes. This was right about the time I was auditioning for colleges. I was accepted to both of my dream schools and enrolled at Baldwin Wallace University. Then, three weeks before I arrived on campus, my voice made a major shift.

The first assignment of the year was to audition for the fall show. I had chosen my songs at the beginning of the summer and could no longer hit the notes required. I was surrounded by future-Broadway-star peers and felt so lost. I had always been a 'singer first,' but no longer knew how to operate my instrument. I felt untalented. I felt like I didn't deserve to have been admitted to such a prestigious program. I was worried I might have to change the direction of my career.

It has taken a while for me to regain confidence in my voice and learn how to navigate its many new avenues. For the majority of my freshman year, I was terrified of my upper register and was afraid to practice. It was painful to not be able to hit soaring high notes that I previously had access to, and I didn't want to demonstrate to myself that I could no longer hit them.

Something I have learned as a trans performer is that time away from performing can be invaluable. Before college, I took breaks from dancing when my dysphoria got to be too much, I took a break from performing entirely for a while after I came out, and back home after my first year of college, I decided not to sing for a month. I didn't sing until I wanted to, until I wanted to start exploring my upper range. While my freshman year was extremely difficult, I can safely say that I am very excited about the direction my voice is headed. My voice seems to have settled and my upper range is opening back up. I am gaining more and more confidence in it every day. My voice suits me much more now than it did before, and I am finally starting to sing the songs that I always wanted to sing.

Singing is an important part of the musical theatre world, but many things need to be improved in order to make it accessible and enjoyable for trans students and performers. Here are a few ways to help trans and nonbinary singers feel more comfortable:

We need to get rid of the idea that certain vocal ranges denote certain genders. We can all name a cisgender singer whose vocal range sits outside of what we consider 'typical' for their gender. We need to stop using terms like 'countertenor' and 'contralto.' If you are talking about people whose voices fall in the alto range, call them an alto, regardless of gender. If you are calling for tenors and basses to sing a part, ask for 'tenors and basses,' not 'men.' People of all genders fit into every vocal distinction.

Far too many trans voices have been harmed because they are trying to fit a sound their voice is not designed to produce. Our voices are marvelous, beautiful instruments, whether or not they conform to cis-normative standards. If we are best for a role, hire us and modulate the key. It truly is that simple.

Some of our voices are shifting and changing. Have multiple keys ready for when they grow. This was something that my college voice teacher has done that has been incredibly helpful as we became acquainted with my new voice.

Often hormone therapies and certain gender-affirming surgeries can affect our singing voices. Voice teachers, directors, music directors, etc. should educate themselves on how our voices work. Even with hormone replacement therapy, trans voices often operate differently than their cis counterparts. Those who plan to work with singers should educate themselves on these differences. I recommend reading "The Singing Teacher's Guide to Transgender Voices" by Liz Jackson Hearns and Brain Kremer.

Vocal dysphoria is the discomfort that some trans people feel regarding their voice as it relates to their gender. It can come up at any time. There have been lessons where I have experienced vocal dysphoria and became overwhelmed and an instructor gotten angry or kept pushing. There may be certain parts of our voices that we are only rarely comfortable using. Please be patient with us.

Some of us are comfortable singing songs written for people with the gender we were assigned at birth. Some of us are not. Pronouns in songs can be changed, keys can be modulated. Absolutely provide suggestions for repertoire, but become comfortable with us saying no.

The journey through one's new voice can be incredibly frightening and extremely difficult, but the implementation of practices that allow space for students and performers to learn and grow will not only make them more comfortable, it will make space for trans artists in the industry going forward.

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Student Blog: My Vocal Journey Through Testosterone and 6 Things Theatre Needs to do for Trans Voices - Broadway World

PRL-02 formulation of abiraterone decanoate that was designed to be used with hormone therapy to treat prostate tumors without causing adverse liver and drug-drug interaction effects. Multiple studies have already demonstrated the potential of androgens for the treatment of this disease, according to the press release. Now, following a 3 + 3 dose-escalation design, the study of PRL-02 with evaluate its ability to suppress testosterone as a primary end point and its safety and tolerability as a secondary end point.

PRL-02 may provide improved bioavailability and convenience over the currently available therapies while also providing patients a potentially safer treatment option than the approved androgen biosynthesis inhibitors said Robert Dreicer, MD professor of medicine and urology at the University of Virginia. I am personally intrigued by the PRL-02 profile and its potential to be a clinically meaningful new option for the treatment of patients with metastatic prostate cancer.

Patients with metastatic prostate cancer included in cohort 1 of the study will receive PRL-02 at 180 mg. In cohort 2, the dosing of the agent is escalated to 360 mg, then to 720 mg in cohort 3 and 1260 mg in cohort 4. In all cohorts, PRL-02 is given as a 10 mL vial containing 990 mg of abiraterone decanoate in 5.5 mL of solution. Further, patients treated in the dose-expansion cohort will receive the recommended phase 2 dose of PRL-02 as determined in the phase 1 portion.

According to the studys protocol, those receiving treatment will remain on the study until their serum testosterone is >1 ng/dL on 2 sequential determinations starting on Day 21 through Day 77, or until they experience unacceptable toxicity, withdraw their consent, at the discretion of the investigator, or following 4 complete cycles of therapy.

The study is actively recruiting patients in treatment sites in Arizona, Indiana, Maryland, Nebraska, New Mexico, and South Carolina. Those eligible are patients with metastatic prostate cancer who have undergone orchiectomy or ongoing gonadotropin-releasing hormone agonist or antagonist therapy for at least 3 months prior to the time of screening and who have an ECOG performance status of 0 or 1, adequate bone marrow reserve, adequate renal and hepatic function, and serum albumin of 3 gm/dL and serum potassium of 3.5 mEq/L.

Metastatic castration-resistant prostate cancer patients with hepatic metastases or known central nervous system metastases are grounds for exclusion from the study. Patients are also ineligible to enroll if they present with another active neoplastic disease that requires concurrent anti-neoplastic treatment, have undergone major surgery or trauma within 4 weeks of screening for the study or present with visceral metastatic disease or impending fracture due to bone metastases.

In terms of comorbidities and medical history, patients cannot have a history of impaired pituitary or adrenal gland function, need systemic glucocorticoids greater than replacement doses, or of prior myocardial infarction, stroke or transient ischemic attack, or who have an uncontrolled inter-current illness, including but not limited to, ongoing or active infection, New York Heart Association Class 3 or 4 congestive heart failure, uncontrolled hypertension, unstable angina pectoris, uncontrolled cardiac arrhythmia, active interstitial lung disease, poorly controlled diabetes, or psychiatric illness/social situations, or substance abuse.

Reference:

Propella announces first patient dosed in phase 1/2a trial of PRL-02 for treatment of metastatic prostate cancer. News release. Propella Therapeutics, Inc. June 29, 2021. Accessed June 29, 2021. https://bit.ly/3qy4Whs

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First Patient Receives Next-Generation Androgen Biosynthesis Inhibitor for Metastatic Prostate Cancer - Targeted Oncology