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George Clooney Was Hospitalized With Pancreatitis After Losing 30 Pounds for Midnight Sky – Prevention.com

Posted: December 13, 2020 at 10:55 am

George Clooney may have gotten a little too into character for his latest film role. In The Midnight Sky he plays Augustine, a gout astronomer with cancer who, as the sole survivor of an apocalyptic event, braces for the Earthbound return of astronauts who have no clue their planet is inhabitable. According to the U.K.s Mirror, the Oscar-winning actor lost 30 pounds to achieve Augustines emaciated state, which hospitalized him with pancreatitis four days before filming began.

According to Mayo Clinic, pancreatitis is caused by inflammation of the pancreas. Symptoms include abdominal pain, fever, nausea, and vomiting. It occurs when digestive enzymes become activated while still in the pancreas, irritating the cells of your pancreas and causing inflammation, per the clinic.

I think I was trying too hard to lose the weight quickly and probably wasnt taking care of myself, Clooney told Mirror. The 59-year-old also directed the film, and his diagnosis took a toll on early production.

It took a few weeks to get better and as a director its not so easy because you need energy, he explained. On the upside, the condition played right into Augustine. We were out on this glacier in Finland, which made it a lot harder work. But it certainly helped with the character, Clooney said. This is bigger than anything Ive done before and it was like herding cats to get it done. But, you know, it was fun.

As Augustine, Clooney is nearly unrecognizable. Hes obviously thinner and sports a shaved head and gray, scraggly beard. He told Mirror that his wife Amal and 3-year-old daughter, Ella were not the biggest fans of the facial hair.

[They] were really happy when it came off because it was very hard to find a face underneath all that mess, he said. But Ellas twin brother Alexander loved it because hed hide things in it, which I wouldnt know about until I got to work and Id be like, Oh, theres a popsicle stuck in my beard, he quipped.

According to Clooneys recent interview on Jimmy Kimmel Live!, the film wrapped in February, just before coronavirus lockdowns ravaged the globe. The Midnight Sky premieres on Netflix on Dec. 23.

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George Clooney Was Hospitalized With Pancreatitis After Losing 30 Pounds for Midnight Sky - Prevention.com

Is slow the best speed for fatty liver weight loss? – Marshall News Messenger

Posted: December 13, 2020 at 10:55 am

DEAR DR. ROACH: I have had fatty liver for the past 10 years. To reverse it, I am trying to lose weight. Now I am 116 kilograms. I have heard that if someone has fatty liver and wants to lose weight, they should not lose more than 1.5 kg per week. This week, I lost 3 kg. What is your advice? A.A.

ANSWER: The advice against too much weight loss too quickly was based on an observation that some people rebounded their weight after losing it. Newer studies have not confirmed that. In fact, people with large amounts of weight loss (more than 2 kg in the first four weeks) have been shown to have a better chance of keeping the weight off. If you are losing weight due to healthier diet and exercise, I would advise continuing those behaviors and not worrying about losing too much too quickly.

Any kind of weight loss can temporarily increase the risk of gallstones. Having some sources of healthy fat in the diet (such as nuts or avocados) will decrease this risk.

Early on in the first few weeks of weight loss, especially in people using a higher fat diet, much of the apparent weight loss is by loss of water associated with glycogen stores.

DEAR DR. ROACH: What is an epiretinal membrane? My doctor says I have this but it is not bad enough to be treated. I am 86 years old, and my vision is blurry. How would this be treated? T.V.

ANSWER: An epiretinal membrane, also called a macular pucker, is a thin layer that forms over the retina at the back of the eye. It is semi-translucent, and as such can cause loss of vision or visual distortion. They are common and occur more frequently in older individuals. Most of the time, they do not require treatment. They can form for no particular reason, and these are usually asymptomatic. However, an epiretinal membrane can form after certain eye conditions, especially retinal detachment. Its possible for it to attach to and pull the retina, causing distortions in the vision. It may also decrease vision when it is thicker and interfering with the function of the retina.

The only treatment is surgery. The decision to perform surgery is made by how much the vision is affected. Although surgery is relatively safe and usually effective, there are possible complications. Most eye doctors do not rush to surgery, except in less-common cases where there is swelling in the most critical part of the retina (called the macula) for central vision. People whose epiretinal membrane gets worse, or who have the kind that can pull the retina out of shape, may also require surgery.

DR. ROACH WRITES: A recent column on pneumonia vaccines contained an error: I said that the 13-valent conjugate vaccine, Prevnar, was a 2-dose series. It is a single dose. Many people get both the 23-valent polysaccharide vaccine, Pneumovax, as well as the 13-valent Prevnar, but my column misstated this. I appreciate my sharp-eyed colleagues who wrote in to correct this.

Dr. Roach regrets that he is unable to answer individual letters, but will incorporate them in the column whenever possible. Readers may email questions to ToYourGoodHealth@med.cornell.edu or send mail to 628 Virginia Dr., Orlando, FL 32803.

2020 North America Syndicate Inc.

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Is slow the best speed for fatty liver weight loss? - Marshall News Messenger

4 Reasons why Black Coffee is ideal for weight loss – PINKVILLA

Posted: December 13, 2020 at 10:55 am

Black Coffee has numerous health benefits, one of them being weight loss. Here are some ways in which this beverage can help you lose weight quickly in no time.

Black Coffee is the ultimate beverage for coffee lovers. Apart from being addictive and delicious, it is also beneficial for health and is rich in nutrients and antioxidants. It is an instant energy booster and is said to prevent various diseases like cancer, cardiovascular diseases, diabetes etc.

Other than these, it is also extremely effective in aiding weight loss. It boosts metabolism and helps in burning the fat. For reaping weight loss benefits, it is suggested to consume black coffee without any additives like sugar, milk, cream etc. Here are some more reasons why black coffee is the perfect beverage for weight loss.

Presence of chlorogenic acid

Black coffee consists of chlorogenic acid which speeds up the weight loss process. It significantly slows down glucose production in the body. It also contains various antioxidants that help in weight loss.

Caffeine

The presence of caffeine in black coffee acts as an energy booster and improves metabolism. It makes you feel active and energetic which aids in burning more calories. By increasing energy levels, black coffee also keeps the blood cholesterol levels in check.

Controls hunger pangs

Black coffee improves and speeds up the metabolic processes which result in suppressing hunger pangs and lesser energy intake. It acts on the hunger hormone known as Peptide YY which suppresses the appetite.

Reduces water content

Some people gain weight because of the high water content in their body. Consuming black coffee leads to increased urination which in turn, results in a significant decrease in water content by

Also Read:Weight loss: Do these 5 EASY exercises to get rid of the excess belly fat

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Libby Lost 38 Lb. On Weight Watchers After Years Of Yo-Yo DietingHeres How She Made It Work! – SheFinds

Posted: December 13, 2020 at 10:55 am

Libby Woockstruggled with her weight for years before finding a system that worked for her.She tells SheFinds, Growing up, I was never skinny, and I was always the bigger girl compared to my friends.

Now, at 35 years old, Libby has committed to a lifestyle that works for her bodybut that doesnt mean there wasnt plenty of trial and error before finding what actually worked. It wasnt until three years ago that Libby joined WW.

Before that, she tried out plenty of other quick fixes that never did the trick.She explains, Of course I tried other dietslike Southbeach, as well as body wraps that claimed would jumpstart a healthier lifestyle (it did not!).

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Courtesy Libby Woock

She didn't feel the push to join Weight Watchers until October 2017 when she reached her heaviest weight.

"I remember feeling disgusted and frustrated--not just with how my clothes fit but also with the person I was seeing in the mirror," Libby explained. "I've always been 110% dedicated to my family and my full-time job, and decided it was finally time to put that same effort into myself."

When she joined WW, Libby said she started to notice tangible, sustainable changes--mostly because it wasn't just a diet, but a lifestyle change.

"When I joined WW, I started participating in meetings and looked forward to the weekly weigh-ins. I realized pretty quickly that it was not a diet, but a lifestyle change you need to commit to," Libby explained.

Courtesy Libby Woock

These lifestyle changes first had more to do with smarter food choices, starting at the grocery store.

"I made sure to start creating lists before grocery shopping and made a point to steer clear of junk food like ice cream (my weakness) and chips, that I knew I would most likely finish within a day or two. To this day, more than half of my list is fresh fruits and vegetables that I incorporate into my daily meals and snacks," Libby said.

Courtesy Libby Woock

She didn't start adding exercise to her routine until later.

"At first, there were no workouts involved although I did slowly turn my basement into a small DIY gym and spent hours outdoors walking my neighborhood and riding my bicycle. I eventually hopped on the FitBit train and enjoyed using it to track my steps and workouts, which also connected to the WW app, allowing me to connect with fellow members and become bigger part of the community," she explains.

Sarah Bridgeman Photography

After committing to WW, Libby was able to reach her goal weight, losing 38 lbs. total. But the lower weight is only one of the changes she's noticed; her improved confidence is another.

"Even now, it's wild for me to look back on old photos or even shop for new clothes (which I had to do after the weight came off)! But I finally feel comfortable in my own skin, and I've gained confidence I never had before," she says.

She adds, "I even became a COVID-bride in October and bought my wedding dress online--something I would have never done for any article of clothing before WW."

And the dress fit perfectly.

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Libby Lost 38 Lb. On Weight Watchers After Years Of Yo-Yo DietingHeres How She Made It Work! - SheFinds

Looking for an effective weight loss diet? Try the low-calorie, high-protein Atkins diet – Times Now

Posted: December 11, 2020 at 8:52 pm

Looking for an effective weight loss diet? Try the low-calorie, high-protein Atkins diet  |  Photo Credit: iStock Images

New Delhi: The Atkins diet is popular among people who enjoy eating different types of food. The basic idea behind the Atkins diet is to impose restrictions on the intake of certain kinds of carbohydrates to aid the process and maintenance of weight loss.

It also helps in improving one's eating habits. This diet promotes the intake of healthy fats that can help improve levels of 'good' HDL cholesterol in the blood. Furthermore, it encourages protein intake, which would mean the consumption of fewer calories as protein induces a feeling of being full. The Atkins diet has four phases to it.

The foods allowed include eggs, sardines, salmon, coconut oil, avocado oil, chicken, pork, bacon, spinach, asparagus, kale, sunflower seeds, almonds, walnuts, dark chocolate,green tea and coffee. Limited amounts of alcohol are also allowed.

The food to be avoided are candy, soft drinks, canola oil, soybean oil, wheat, rice, potatoes, bananas, grapes, apples, turnips, carrots, lentils, chickpeas and beans.

Bottom line: If you are looking for a healthy and easy to follow a diet to start your weight loss plan, the Atkins diet would be an effective choice to go with.

Disclaimer: Tips and suggestions mentioned in the article are for general information purpose only and should not be construed as professional medical advice. Always consult your doctor or a dietician before starting any fitness programme or making any changes to your diet.

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Looking for an effective weight loss diet? Try the low-calorie, high-protein Atkins diet - Times Now

Keep Your Colon Healthy with a Diet Full of Fiber – RADIO.COM

Posted: December 11, 2020 at 8:52 pm

Maintaining a healthy diet full of fiber will go a long way to keep your colon healthy, according to Dr. Esther Cha, a colorectal surgeon at St. Mary Medical Center in Langhorne. She suggests patients eat25 grams of fiber a day by adding a variety of fruits, vegetables, cereals and breakfast bars to the menu. She also urges people to drink plenty of water to maintain good bowel health.

She suggests people begin getting colonoscopies around the age of 45. 50 used to be the suggested age, but she says doctors are seeing colon polyps and cancers in younger patients, perhaps because of changes in diet andlifestyle coupled withgenetics. Anyone with a family history of colon cancer should consider getting a colonoscopy at a younger age. Dr. Cha says problems found early are more easily treated.

She adds that changes in surgical procedures, such asminimally invasive and robotic operations are making procedures easier for patients.Incisions are smaller, there is less reliance on narcotics for pain management andrecovery time is faster. She adds that changes in post surgical care and protocols have also improved the time it takes for bowel function to return and for a patient to return to normal activity.

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Keep Your Colon Healthy with a Diet Full of Fiber - RADIO.COM

JYP Entertainment psychiatrist reveals the intense pressures on female idols to diet – PINKVILLA

Posted: December 11, 2020 at 8:52 pm

JYP Entertainment's resident psychiatrist gets candid about the pressure on female idols to diet and its detrimental effects.

On a special episode of You Can Talk To My Sister, a confessional type reality talk show under SBS Plus, a psychiatrist from JYP Entertainment got candid about the stresses that female idols face when they are told by the company to diet. The episode was broadcasted on December 10, 2020 and featured a woman who had decided to undergo gastrointestinal surgery to lose weight. She had gained the weight in the first place, from her first pregnancy, after which she could not get back to her original figure. After she shared her story of humiliation, feeling inadequate and unwanted from having gained so much weight and the lengths to which she was willing to go to lose the weight, the shows host arranged a video call with JYP Entertainments resident psychiatrist Yoo Eun Jung.

Dr Yoo revealed that whenever she speaks to idols under the company, they share their troubles and stresses regarding dieting and maintaining an ideal weight. She continued by saying that, There is so much pressure to be slim that many female idols go on extreme diets. Even IU and Jang Nara had bulimia. If you are stressed out, your stress hormones can go up and it can affect your body. It will turn your body into one that has difficulty losing weight." With this, she emphasized how stressing over losing weight can have adverse effects and in turn make it harder to lose weight.

JYP Entertainment is notorious for putting a particular focus on idols appearances. Previously, during SIXTEEN, Jihyo revealed the problems and humiliation she faced for not fitting the Korean beauty standard when it came to weight. In a past V-Live, Momo from TWICE also revealed that the one strict condition for her to be able to perform in her debut showcase was that she would have to lose 15 pounds in one week. For that week, Momo did not eat anything solid, spit all the time to remove water from her body and spent all her time in the gym. All she ate for that time was one single ice cube a day and when she went to sleep every night, she would fear for her life. Despite all that, she did not lose the assigned amount of weight in the stipulated time frame. Eventually, she was given more time and she could lose the weight. However, the question still remains at what cost?

IU has also admitted to suffering from eating disorders in the past. During an interview in 2014, she confessed that she would stress eat and sleep all the time but instead of feeling energetic and happy, she would be lethargic and plagued with anxiety. IU has since been receiving treatment to prevent relapsing into a similar situation.

It is clear to see, therefore, that idols have immense pressures of dieting which affect their mental health and overall happiness. As such, critics and haters should think a hundred times before commenting on someones appearance because we never know what they might be going through. This problem of body image within idols still persists and it is something that will take decades to change. However, no step is too small. As long as fans continue to show unwavering support towards idols, regardless of whether they're their favourites or otherwise, female celebrities will face considerably less pressure to conform to the beauty standards that society puts on them. With everyone doing their part, maybe the world will be a slightly better place eventually.

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Prebiotics vs. probiotics: Differences and health benefits – Insider – INSIDER

Posted: December 11, 2020 at 8:52 pm

While probiotics and prebiotics are just a small slice of our incredibly complex gastrointestinal system, they are very important for our health. Here's what you need to know about prebiotics and probiotics and how they benefit our body.

Trillions of little bacteria, along with viruses, fungi, and yeast, line every corner of our body and make up a miniature ecosystem, known as our microbiome. In our gastrointestinal system alone, there are around 1,000 species of bacteria, all of which can affect our health.

Prebiotics and probiotics are both important to the health of our gut microbiome, which helps digest certain nutrients and protect you from infection.

On the other hand, imbalances in gut bacteria known as gut dysbiosis can increase your risk of diseases like diabetes, inflammatory bowel disease (IBD), and cancer. Gut dysbiosis can occur due to:

"If you have any kind of chronic health problem, symptoms could be slightly reduced if we could add to your gut health and shift your gut microbiome to a more health-promoting microbiome," says Terry Wahls, MD, a clinical professor of medicine at the University of Iowa Carver College of Medicine.

To do so, it's important to understand the difference between prebiotics and probiotics, and how to get both into a healthy diet.

Prebiotics are specialized plant fibers that the human body cannot digest, but can become food for the good bacteria in your gut. These fibers aid in the healthy growth of gut bacteria, and can be found in the food we eat such as raw vegetables, beans, and bananas especially when they aren't ripe.

There can be many benefits to consuming prebiotics, like:

Increasing calcium absorption. Ingesting prebiotics may increase calcium absorption in the lower intestines. Calcium is important for bone health and building bone density, especially for those at risk for osteoporosis, says Gail Cresci, PhD, RD, a doctor of pediatric gastroenterology, hepatology, and nutrition at the Cleveland Clinic.

Processing food quickly. The fiber found in prebiotics is important for normal bowel movements. A 2013 review found fiber's bulk and water retaining abilities can decrease the time it takes to digest in the digestive tract.

Controlling blood sugar levels. Numerous studies have found fiber from prebiotics can reduce your glucose absorption rate, which can prevent spikes in blood sugar, prevent weight gain, and decrease the risk of diabetes.

A large 2010 study in Caucasians, Japanese Americans, and Native Hawaiians between the ages of 45 and 75 found high intakes of fiber significantly reduced the risk of developing type 2 diabetes.

Most people should eat between 25 to 38 grams of fiber per day. Foods high in prebiotic fibers include:

You can also take prebiotic supplements such as psyllium or methylcellulose, but Wahls says it's important to eat more vegetables and other fibrous foods first. That's because supplements won't provide important vitamins and minerals found in fiber-rich food.

"Everyone's needs are going to be unique, depending on your microbes living in your gut," says Wahl. "For example if you have more blue stools, perhaps because of inflammatory bowel disease, that's going to be a lower fiber intake. But if you're constipated, you'll have a much higher fiber need."

A doctor might recommend a low-fiber diet or one with less prebiotics due to Crohn's disease, ulcerative colitis, or if you've recently had bowel surgery or a bowel-related problem.

Probiotics contain living strains of beneficial gut bacteria and yeasts. They maintain a healthy balance in your gut by boosting the number of good bacteria in the body and fighting off bad bacteria.

There are many kinds of probiotics, and each benefits the body in different ways. The most common species are lactobacillus and bifidobacterium, both of which break down food and fight harmful bacteria.

The health benefits of probiotics include:

Strengthening digestive health. Probiotics may benefit people with digestive issues, such as diarrhea, irritable bowel syndrome, and ulcers.

A large 2019 review assessed children aged 18 and under who took antibiotics. It found those who took probiotics alongside antibiotics were less likely to experience diarrhea.

Meanwhile, a 2014 review of probiotics and irritable bowel disease (IBD), found probiotics can aid in the remission of ulcerative colitis a form of IBD and pouchitis an inflammation after IBD surgery. But, there is little evidence that probiotics can aid in treating Crohn's Disease.

Improving mental health. Research has found that the gastrointestinal tract and the central nervous system communicate, most commonly referred to as the "brain-gut axis." A 2016 review found supplementing probiotics for four weeks was efficient in improving psychiatric disorder-related behaviors like anxiety and depression.

Similarly, a 2017 review found positive results when treating depressive symptoms with probiotics, but the probiotic strains and dosing varied, and further research is needed. It's always smart to talk to your doctor about improving mental health before attempting to treat it on your own.

You can get probiotics by eating fermented foods such as:

While some people may prefer a supplement, according to Cresci, it's better to consume probiotics through food.

"The yogurt has your probiotic in it, but then you have these beneficial metabolites that you'll also be consuming at the same time," says Cresci.

The number of probiotics you should consume daily varies greatly. Since there is such a diversity in probiotics, the amount is not set, and often it can depend on daily changes in your gut condition and your body's needs.

According to Cresci, people who should not take probiotics without a doctor's approval include:

That's because these individuals should not be introducing new microbes into their diet, says Cresci. But everyone should consult with their doctor or a dietitian before beginning new supplements or considering different strains of probiotics.

What we eat is incredibly important, both for our body and for our body's microbiome. Prebiotics and probiotics are both important for keeping our gut balanced and healthy. The difference between the two is prebiotics feed live bacteria in the gut whereas probiotics are the live bacteria in the gut.

"We want to be good stewards to our microbiome," says Wahls. "And that's having enough vegetables, having enough fermented foods so we're getting enough prebiotics and probiotics and then when necessary taking supplements to further support restoration."

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Greater Adherence to a Diet for Diabetes Reduction May Improve Survival for Breast Cancer – OncLive

Posted: December 11, 2020 at 8:52 pm

Women with stage 1 to 3 breast cancer who adhered to a diabetes risk reduction diet had improved survival versus those who did not follow this specific diet, according to findings presented during the 2020 San Antonio Breast Cancer Symposium.

Diabetes may be common in women with breast cancer, especially since 75%, or more than 2.6 million women, are at least 60 years or older, which means breast cancer survivorship must be managed in consideration with aging-related comorbidity such as diabetes, said Tengteng Wang, PhD, a research fellow at Harvard T.H. Chan School of Public Health during the virtual presentation of the study.

Type 2 diabetes, in particular, is a risk factor for breast cancer incidence and may be a predictive factor for breast cancer mortality. In addition, breast cancer increases the likelihood of developing type 2 diabetes.

Identifying modifiable strategies to prevent type 2 diabetes among breast cancer survivors may be very important to improve their survival outcomes, said Wang.

Researchers analyzed data from 8,320 women with stage 1 to 3 breast cancer from 2 large cohort studies: the Nurses Health Study (1980-2014) and the Nurses Health Study II (1991-2015). Validated questionnaires were completed every 2 to 4 years to collect information on diet among other factors.

This study focused on a diabetes risk reduction diet with 9 dietary components including higher intakes of nuts, cereal fiber, coffee, polyunsaturated-saturated fat ratio and whole fruits, in addition to a lower glycemic index of diet and lower intakes of sugar-sweetened beverages/fruit juices, trans fat and red meat.

The [diabetes risk reduction diet] has been associated with 14% lower type 2 diabetes risk in [a] previous publication of the Nurses Health Study, said Wang.

Researchers calculated an average score of adherence to this diabetes risk reduction diet through repeated measures of diet after a diagnosis of breast cancer. Follow-up was conducted for a median of 16 years after cancer diagnosis.

During follow-up, 2,146 deaths occurred, of which 948 were related to breast cancer. Women with higher diet adherence scores after diagnosis had a 33% lower risk for all-cause mortality (HR = 0.67; 95% CI, 0.58-0.78; P for trend < .0001) and a 17% lower risk for mortality related to breast cancer (HR = 0.83; 95% CI, 0.67-1.02; P for trend = .03) compared with women with lower diet adherence scores.

Our results did not differ by breast tumor ER status or stage, said Wang.

During the discussion portion of the presentation, Wang said that she and her colleagues analyzed what may be the potential mechanism for this association. She said, We looked at how [diabetes risk reduction diet][ influenced gene expression in [the] breast tumor for [a] subgroup of our breast cancer patients, and according to our pathway analysis, the [diabetes risk reduction diet] is more associated with the pathway related to immune regulation and also cell proliferation, so this is, I think, an interesting finding.

When further adjusting for neighborhood socioeconomic status, the association between diet adherence and mortality risk was slightly attenuated, with patients with greater adherence having a 31% lower risk for all-cause mortality (HR = 0.69; 95% CI, 0.6-0.8; P for trend < .0001) and a 14% lower risk for mortality from breast cancer (HR = 0.86; 95% CI, 0.7-1.07; P for trend = .06).

Women who improved their adherence to a diabetes risk reduction diet after breast cancer diagnosis had a lower risk for breast cancer mortality compared with those with consistently low adherence to this diet (HR = 0.81; 95% CI, 0.65-1).

In conclusion, we felt that a greater adherence to the [diabetes risk reduction diet] after breast cancer diagnosis was associated with better survival outcomes, which means promoting dietary changes consistent with prevention of type 2 diabetes may be very important for breast cancer survivors, said Wang.

A version of this story appeared on CURE as Dietary Changes to Reduce Diabetes Risk May Also Increase Survival for Breast Cancer.

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Greater Adherence to a Diet for Diabetes Reduction May Improve Survival for Breast Cancer - OncLive

Fatty Diets Feed Cancer and Starve Immune Cells – Science Times

Posted: December 11, 2020 at 8:52 pm

Obesity has been associated with cancer for quite some time now, although the complete scenario still eludes researchers.

Now, anew Harvard studyunderscores some missing parts of this important information, discovering that cancer cells the higher availability of fat to starve immune cells of fuel and hinder them from targeting tumors.

High-fat diets are recognized for increasing the danger of many cancer types and reducing therapeutic outcomes, not to mention survival rates.

For example, aNew Atlas reportindicates, previous research has found that obesity may activate metastasis in "otherwise benign cancers," and fatty tissues can offer "hideouts" for cancer stem cells, enabling them to "come roaring back" following chemotherapy.

However, it is not that simple either; the said report specifies, inconsistently, obesity seems to enhance results for some types of treatments for cancer.

(Photo : Dan Kitwood/Getty Images/Cancer Research UK)A scientist cuts thin sections from a tissue biopsy that has been preserved in wax, to be then placed on microscope slides for analysis, at the Cancer Research UK Cambridge Institute.

In this new research, scientists at Harvard found that high-fat diets appear to lessen the amount ofCD8+ T cells, including their abilities to fight cancer. Accordingly, when fat becomes more readily available, tumors will renew their metabolism to eat up.

Meanwhile, the high-energy content fast-tracks their growth while simultaneously depriving T cells of fuel that could be otherwise used to combat cancer.

According to the study's co-senior author,Arlene Sharpe, "We know there is a metabolic tug-of-war between tumor cells and T cells that changes with obesity."

In connection to this, the co-senior author added, their study offers a road to discover this link, which can help them to start thinking about cancer immunotherapies and combination treatments in new ways.

The research team investigated this multifaceted relationship in mice that had different cancer types by providing some groups with high-fat diets and comparing the microenvironments around their tumors to mice that ate normal diets.

As a result, the study authors found that tumors developed more rapidly in obese mice, although interestingly, it was only applicable for mice that had immunogenic cancers, those that the immune system reacts to more readily.

Furthermore, the scientists noticed, too, that the tumor found in the microenvironment contained lesser free fatty acids, even though their quantities were quite high throughout the rest of the body.

This then prompted the researchers to search to discover that the cancer cells were This led the team to discover that the cancer cells were increasing their uptake of fat, leaving nothing for the CD8+ T cells.

In other assessments, when the researchers removed CD8+ T cells from mice, their diet did not affect the rate of growth of tumors anymore.

Through further research, the scientists zeroed-in onPHD3, a protein which, in normal cells, is slowing down fat metabolism.

Levels of PHD3 were found to be substantially lower in cancer cells in environments with obesity compared to the opposite. When researchers overexposed this said protein, they became more slowly and could not eat up much fat.

The researchers said the new findings could help in the improvement of cancer immunotherapy. After all, they said, "the CC8+ T cells are usedin CAR-T cell therapy," where samples of immune cells of a patient are taken out, modified against cancer, and introduced again to the body.

On the other hand, PHD3, or any other related protein, could turn into a new treatment target. The research finding could help customize too, other cancer treatments for obese individuals.

ALSO READ: Emergency Use of Pfizer COVID-19 Vaccine Recommended by FDA Advisory Committee

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Fatty Diets Feed Cancer and Starve Immune Cells - Science Times


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