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This Guy Explains How Beating Addiction Helped Him Lose 210 Pounds and Get Jacked – Men’s Health

Posted: August 24, 2020 at 2:59 pm

For Tony Sander, a packed and intense working schedule meant that he relied on an unhealthy diet to keep himself going. Over time, food, along with drinking, became a source of relief from that stress. "The food was as much of an addiction as alcohol ever was," he says in a recent episode of Brand New Me.

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Then in 2016, Tony's car came off the road while he was driving home drunk. He shattered his knee in the accident, and doctors told him that at his current weight of 429 pounds, it wasn't safe to operate on him. This, he recalls, was the wake-up call he needed, and he started to make some serious lifestyle changes, starting with cutting out alcohol and changing his diet.

"My goal from the beginning was to save my life," he says. "My health was beyond a mess, so that was just self-preservation at the beginning, and then self-preservation turned into 'my health is getting better, let's get physically fit.'"

Working with his trainer Keith, Tony has now lost a staggering 210 pounds through working out and a strict diet plan, and has also found that exercise provides a healthier, more sustainable way to handle his stress and anxiety than food or alcohol.

"It's now my stress relief, going to the gym is my 90 minutes of my solace, it's my office, it's my time," he says. "The mental transformation that I've had, to be able to make the physical changes, I've had to come to terms with who I was, what my addictions were, and how I was going to fix them. The mental changes have been bigger than the physical."

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The best advice he can offer to anybody who wants to start making changes to their lifestyle and lose weight: "Just start today. You don't have to wait for tomorrow, you don't have to have a great plan, there is a community out there that wants to help, there's people who have done it, and all they want to do is help other people do it."

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This Guy Explains How Beating Addiction Helped Him Lose 210 Pounds and Get Jacked - Men's Health

Kelly Osbourne’s Gastric Surgery Was a Push in Right Direction" – The Beet

Posted: August 24, 2020 at 2:59 pm

Kelly Osbournes secret to weight loss success was a vegan diet and intermittent fasting but it turns out there is more to the story, as Osbourne revealed on a podcast. The 35-year-old entertainment personality said that she kickstarted her weight loss journey with gastric sleeve surgery two years ago.

Osbourne appeared on Dax Holts podcast, Hollywood Raw, alongside comedian Adam Glyn, where she opened up about her weight loss surgery which is less drastic than gastric bypass but is used by doctors to help patients lose stubborn weight. Osbourne said:

I dont give a f**k what anyone has to say. I did it, Im proud of it, they can suck s**t. [I did] gastric sleeve," she continues: "All it does is change the shape of your stomach. I got that almost two years ago. I will never, ever, ever lie about it ever. It is the best thing I have ever done.

Gastric sleeve surgeries are less invasive than gastric bypass procedures. Gastric sleeve surgery helps weight loss by reducing the size of the stomach, according to the Mayo Clinic, and that in turn decreases appetite and helps you feel fuller for longer. It also reduces the amount of "hunger hormone" produced by the stomach, which may contribute to weight loss after this procedure.

Osbourne doesnt regret the choice to have surgery and encourages people to think it through and make sure its right for you since after surgery you need to be committed to healthier habits to see results. Osbourne admits she had to do a total overhaul of her eating habits and workout routine. If you dont work out and you dont eat right, you gain weight, Osbourne explained. All it does is move you in the right direction. So, anyone whos thinking of doing something like this, really think about that, since the surgery is no substitute for eating healthier and working out.

Before she could even fully commit to surgery, Osbourne said that she went through therapy to ensure it wouldnt derail her sobriety. I had to do a year of stand-alone therapy to prepare myself for the surgery before I even had it, she explained. What people dont realize is it cuts out this hormone that if you have addiction issues, it stops your craving, and it makes you not emotionally eat, which is a huge problem for me."

All the work she did on herself pre and post-surgery only helped her get the weight off, 85 pounds in all, and shut down her cravings. "I was sober before, [and] it did help, I dont crave alcohol at all anymore. All [the surgery] is is a push in the right direction. It doesnt solve all your problems. Its not a quick fix.

To Kellys surprise, people started to speculate that she had used surgery to help her with her weight loss journey. In fact, the thing they remarked on was her jawline, but that was related to having another condition, called TMJ, or Temporomandibular joint dysfunction.

I had a really bad TMJ (pain and lack of movement in the jaw) ... One of the things they did to stop it was they gave me injections in my jaw. It kinda made my jaw look skinnier. Thats when people started to notice that I had really lost weight because it changed the shape of everything, Osbourne explained. ... I found out Its called buckle fat. It changed everything on my face! Why the f--k didn't I know about this sooner?"

Osbourne couldnt believe the attention she received after one Instagram that showed off her weight loss. I woke up one day and I was all over the newspapers and sites. I had literally hundreds of text messages. I got asked out seven times in one day. I said no thanks to every single one of them, she explained.

Osbournes surgery isnt the only thing that helped her get the weight off. Years of hard work and eating healthy also play a huge role, including her vegan and her daily workout routines. Osbourne says that her vegan diet has helped her remain sober and stay the course on her weight loss journey. She also uses intermittent fasting to lose weight and keep it off. Kellys newfound passion for fitness and her daily workout routine is also what helped keep her on track throughout quarantine. Osbourne says she is the healthiest and happiest shes been in a long time and her gastric surgery helped kickstart that journey

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Kelly Osbourne's Gastric Surgery Was a Push in Right Direction" - The Beet

The Miracle Tree: Cacao Moringas Nutritional Facts and Recipes – SWAAY

Posted: August 24, 2020 at 2:59 pm

Moringa oleifera, also called a miracle tree, or a ben oil tree is a plant native to subtropical places, such as India, Asia, or Africa.

Since time immemorial, people have used moringa due to its medical characteristics. Moringa is known to have antifungal, anti-inflammatory, antiviral, and antidepressant properties. It helps significantly in curing diseases, such as diabetes, eds disease, and even cancer. Moringa can also do wonders when it comes to all types of infections and inflammations.

The mystery behind moringa's health benefits lies in its components. The plant is full of valuable minerals, and vitamins like bone-building potassium and immune-system boosting vitamin C. Other compounds include calcium, protein, and various antioxidants.

Some of those antioxidants can lower blood pressure and help reduce fat in the body.

Due to the latter one, lots of people have lately started to include moringa in their daily diets. Over the last couple of years, numerous cookbooks, cooking blogs, and articles on moringa recipes have been written.

Some of them have come up with a solution called a cocoringa. Cocoringa is a hot chocolate made of mixed unprocessed cacao and moringa. It is sweetened with natural probiotics, and it includes coconut and tapioca-based plant creamer.

Cocoringa is believed to be the healthiest cocoa drink in the world. If you want to know all the interesting nutritional facts and recipes with cocoringa, keep on reading.

When it comes to more cocoringa ingredients, they resemble the ones in moringa plants much, and they all contribute to the overall condition of your health.

The potassium in cocoringa is almost 15 times the potassium in bananas, which are known to be among the richest sources of this mineral. The high amounts of potassium help reduce a high-fat diet and induce obesity.

Moringa itself has as much as 17 times more calcium than milk, so imagine how much calcium does cocoa, and moringa powder have since you usually drink it with milk! This property keeps the blood circulation healthy and functioning correctly.

A lot of people use moringa when on a diet because of the various vitamin compounds. They are known for reducing cravings and excessive hunger, boosting the immune system, improving the condition of our skin and hair, and more.

Cocoa powder mixed with moringa powder has almost 25 times more iron than the spinach. Regular iron intake improves mood, so if you feel a little grumpy, make yourself a cup of cocoringa, and you will feel much better!

The cocoa and moringa drink is also famous for the protein amounts it includes; a single cup can have nine times the protein of yogurt. It is beneficial for muscle mass growth, brain functioning, and regulating blood circulation.

Now that you know all about the cocoringa's healthy and beneficial ingredients, it is time to get to know some of the best, easy to make, and yummy moringa and cocoa powder recipes.

All you need to prepare for the perfect moringa smoothie are four ingredients:

Fruits

Greens

Liquid aka the base

Nutrient-dense powder

Fruits add sweetness to the smoothie. It is best to freeze them before preparing the drink. Fruits you might consider suitable for a moringa smoothie are:

Blueberries

Banana

Strawberries

Peaches

Acai

Cherries

Raspberries

Choose only two or three of the fruits listed above, and add it to the smoothie.

The greens will balance the sweetness of fruits. Moreover, they are extra nutritious.

Greens that are perfect for moringa smoothie:

Kale

Spinach

Chard

Collard greens

One of the best liquid bases for a smoothie is milk. Depending on your preferences, you can go for the regular cow milk, almond milk, or soy milk. If you are not a great fan of milk, juice, or even water will work.

To make it a cocoringa smoothie, you will need to use a moringa powder and a cocoa powder. Choose your preferred ones, select the proportions, and start mixing it all with the other ingredients.

There are other meals, such as various baked foods, that don't originally include moringa but are edible with it as an additional ingredient.

A baked casserole dish is one of the salty examples. Moringa blends perfectly into marinara sauce. It is an excellent way of adding some veggies into the lasagne.

The sweet option for having moringa in the dish is any baked goods, such as vegan brownies.

Moringa is one of the healthiest plants in the world. It is full of nutritious ingredients and contributes positively to overall health.

Moreover, moringa can be added to various drinks and meals, including smoothies and lasagne.

One typical recipe is a cocoringa - hot chocolate with cocoa and moringa powder. The drink is healthy, nutritious, and easy to make. If you haven't tried it yet, it is about time!

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The Miracle Tree: Cacao Moringas Nutritional Facts and Recipes - SWAAY

Here’s What Biking 100 Miles in Ketosis Did to This Cyclist’s Body – Men’s Health

Posted: August 24, 2020 at 2:59 pm

Global Cycling NetworkYouTube

The low-carb, high-fat ketogenic diet is a controversial one, but many athletes and fitness enthusiasts swear by it and claim that it has had a positive impact on their performance. Curious about the kind of results he might be able to get from achieving ketosis, former professional cyclist Jeremy Powers recently embarked on a 5-hour, 100-mile bike ride while on the keto diet.

He starts out with a breakfast of eggs, bacon, spinach and cheese, then hits the road, maintaining an average speed of 20 miles per hour and keeping a close eye on his heart rate and ketone levels.

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"They say when you're working out and you're doing ketosis your ketone levels start to drop, so 0.7 is what I would expect," he says. "I haven't eaten anything yet, I may have a snack.. So far I feel fine, I'm averaging 212 watts, average heart rate of 126."

While on the road Powers eats peanut butter and bacon sandwiches (on keto-friendly bread of course) with salted cashews, as well as using salt capsules to keep up with his body's electrolyte demands considering the day's intense heat.

"I feel a little crampy, I'm not gonna lie, but given the heat and stuff, it's hard to get the electrolytes in," he says. "I feel good overall though, my power output is going up, my ketone level is continuing to rise. So far, so good... I haven't eaten nearly enough calories to justify this type of energy expenditure, but the ketones are protecting me and continuing to churn out, and I'm continuing to be able to do the work, which is so surprising. This is definitely one of the weirdest things I've ever done in my entire life, I can say that factually."

In order to stay safe in the heat, Powers' ride ends up being closer to 90 miles than 100. "I predicted things were going to go a certain way, and the outcomes just didn't come true," he says. "I was certain that I was going to bonk catastrophically and need to be driven home... But literally nothing went wrong. I was able to churn out the watts, my heart rate didn't go crazy, I didn't get heatstroke. I did do the ride at a low intensity, so I didn't give it 100 percent up every climb, but I did have periods where my heart rate went up to 170 and I went super hard."

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Powers explains that he has always had a problem with burning out on long races due to his blood sugar, and that this challenge was a way for him to push himself in that regard. "I wanted to see if I could be more metabolically flexible, as a test for myself," he says. "And honestly, this was not easy for me... Diet is so personal. What works for me will not necessarily work for you."

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Here's What Biking 100 Miles in Ketosis Did to This Cyclist's Body - Men's Health

The Sleep Diet: What to eat to help you sleep – Telegraph.co.uk

Posted: August 24, 2020 at 2:59 pm

Kalinik advocates a stress-relieving practice before you even tackle your diet, as the burden of chronic stress has a profound effect on your adrenal glands. When your adrenal glands are working overtime, health problems from poor sleep to long term gut issues can begin. While you cannot always control the stress youre exposed to, Kalinik says you can control your response to it.

Take the hour before bed to remove stress and that includes anxiety around getting to sleep. That might mean writing down any concerns and brain dumping from the day, so this stress isnt swirling around your mind. Take a warm bath, read a book or do some meditation or deep breathing exercises.

In the current working-from-home climate, our continuous use of devices is another cause of underlying stress that affects sleep. Blue-light exposure in the evening is particularly disruptive. Frankly, the bedroom should only be used for two things and neither of them is internet shopping or checking social media.

Kalinik advises against using our mobiles as alarm clocks and instead suggests getting an old-fashioned clock, switching off your phone and putting it in another room when you go to bed.

Now youve set yourself a relaxing bedtime routine, follow Eves 5 easy ways to eat your way to better sleep

Restrict your intake of caffeine (from tea, coffee and energy drinks) to no later than midday, and stick to no more than two to three cups per day on average. If you are particularly sensitive to caffeine then reduce further. Caffeine can stay in your system for 10-12 hours so that 3pm latte could be why youre lying awake at 1am.

Natural sources of GABA (a calming neurotransmitter) can help to promote better sleep, such as green, black and oolong tea, milk kefir, live yogurt and tempeh. Foods that can boost our own production include lentils, walnuts, oats, almonds, fish, berries, spinach, broccoli, potatoes and cocoa. And ensure that your meals include a diversity of fibre and fermented foods to support the health of your gut microbiota.

Another common sleep saboteur is consuming lots of high-energy food and drinks, such as sugary snacks, junk food and soft drinks. Its easy to get into a negative feedback loop with these kinds of food and the associated cravings. When we feel tired it makes sense to seek an immediate fix. However, these foods and drinks can mask fatigue, so we get less rest and end up more sleep deprived. We then compensate by eating more of these foods to get energy, further disrupting sleep.

Avoid skipping meals as that may have you reaching for a sugary snack. Include plenty of complex carbohydrates in these meals, such as whole grains, oats, quinoa, buckwheat, spelt, wild rice or sourdough, along with some kind of protein to keep you better satiated. If you need a snack in the afternoon, plan it so you dont go for whatever is hanging around the kitchen. Try half an avocado sprinkled with seeds or an oatcake with some cheese.

Alcohol is another sleep disruptor. It is a diuretic so it makes us want to pee more, which causes us to wake in the night. It also disrupts the hormones that govern the sleepwake cycle by producing a chemical called adenosine. This hormone makes us feel sleepy, so we go to sleep, but then wake before were fully rested. While a glass of wine with dinner for those who enjoy it is generally fine, too much isnt and using wine or beer to help us get to sleep is not a good idea. Instead, try sipping a cup of chamomile tea or my Sweet Dreams Milk instead.

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The Sleep Diet: What to eat to help you sleep - Telegraph.co.uk

Foods To Eat And Avoid While Treating Malaria – NDTV Food

Posted: August 24, 2020 at 2:59 pm

Malaria is one of the most common vector-borne diseases which can prove to be fatal.

Highlights

It is that time of the year again. The monsoon showers are here to take all our summer woes away. The arrival of the much-awaited rains has also triggered a bevy of infections and diseases. Malaria is one of the most common vector-borne diseases which can prove to be fatal, if not taken care of in time. It is associated with high grade fever and is transmitted by the bite of an Anopheles mosquito. This mosquito transports the parasites from one infected person to another. They eventually enter the blood stream infecting the red blood cells.

Headache, fever, fatigue, muscle pain, back pain, chills, sweating, dry cough, enlargement of the liver, and vomiting.

In some cases of a more severe kind, other organs get involved and there could be sever blood loss, hypoglycaemia, kidney failure, respiratory involvement, cerebral malaria, jaundice, loss of consciousness and even death.

(Also Read:Kadha For Monsoon: Fight Infections With Natural Ingredients This Rainy Season)

Treatment includes various drugs recommended by the World Health Organization (WHO), and the severity of the ongoing infection. However, there is no vaccination for prevention of Malaria and preventive therapy is dictated by the place of origin and by your doctor's advice.

If you are infected by the malarial parasite, eating a healthy diet becomes the cornerstone for fast and healthy recovery and to fight the infection. Food keeps the body fuelled to fight of the parasite attack, our immune system must be fed well to fight well. Good nutrition is an established prerequisite for quick and safe recovery. The medications may boost our internal system to fight back but fuelling our body with healthy foods will make our system work more efficiently. We really don't feel like eating when we are unwell; therefore, to make it easy for you, here are a few pointers to keep in mind when you have suffering from Malaria.

- Energy Giving Foods

Simple sources of carbohydrates that do not need much digestion and provide instant energy are at the top of the list. With low appetite and bouts of fever, you need to refuel the body fast. Glucose water, electoral, sugarcane juice, coconut water, sherbets of rose or khus, orange squash are instant energy drinks that replenish fluids and provide energy. Toffees, chocolates, ice creams are other items that can be added to the list. Chilled foods also help reduce nausea.

- Load-Up On Proteins

Proteins are a must have as our immune system feeds on proteins, and foods like dals, chicken and eggs are some of the right options to add to your diet. Dals can be made into a soup and flavoured with lemon; cakes are a good way to consume eggs when appetite is low and taste buds need to be cajoled. Milk, chaas, lassi and yogurt add not just proteins but valuable minerals. Yogurt also adds probiotics, which help overcome gastric symptoms and improve taste and digestion.

(Also Read:Here's Why You Should Not Eat Raw Foods During Monsoon)

- Include Vitamins In Your Diet

Vitamins from fruits, fresh fruit juices help not just the immune system but also are good sources of energy and electrolytes. Citrus fruits help fight the infection with Vitamin C; red and yellow fruits help add Vitamin A, which is a crucial nutrient for our immune system and a potent antioxidant. Fruits like guava add both Vitamin C and Iron to help build up RBC'S

- Have Nuts And Seeds

Nuts and seeds are small powerhouses of several healthy nutrients along with healthy fats and proteins. Soaked almonds, or crushed almond in milk, give a lot in small amounts. They are also rich in phytonutrients, which help fight the antioxidant stress caused by the infection

- Herbs And Spices

Ajwain-infused water will help keep the digestion healthy. Ajwain being a strong carminative, it well prevents bloating and gas. Saunf is another digestion booster.

Turmeric, as we all know, has anti-inflammatory and antioxidant abilities. It also enhances the immune system.

- Keep Yourself Hydrated

Clean drinking water up to 3-3.5 litres a day to keep yourself hydrated even if you have a fever. Dehydration can put you at risk of further deterioration of your condition. So, stay hydrated!

- High Fibre Food

Very high fibre foods may not sit well in your tummy, so give it a break. Whole grains, whole dals and vegetables with tough fibres may cause gas and indigestion.

- Spicy Food And Sauces

Avoid very spicy and rich sauces. The chatpata food may sound good but it could trigger of a reaction because of the medication you are taking.

- Junk Food

This one is a no brainer! Junk food is a big no when you are suffering from Malaria. Having junk food may even worsen your condition. Junk food is not healthy for a normal body, and during illness, it may wreak havoc.

- Avoid Caffeine

Excessive intake of coffee, tea, or any strong caffeine drink may disturb your digestive system.

Early Morning: Ajwain water + 5 Raisins and 5 soaked almonds

. Tea: 1 cup with sweet Biscuits

. 9am: 2 Toasts with butter and scrambled egg/ paneer bhujia + fresh coconut water

. 11am: Fruit + Dahi 1 big bowl or thick lassi 1 glass

. 1pm: Rice + Dal + Cucumber Raita

. 4pm: Tea+ Paneer aloo chat/ Bread with nut butter/ Cake piece/ Besan Ladoo

. 6 pm: Fruit + 5 Almonds+ 1 tsp pumpkin seeds

. 8pm: 1 Bowl Rice Kheer/ Sooji kheer with stir-fried veggies like zucchini, carrots, peas, broccoli

. 10pm: 1 glass milk + a pinch of haldi and cinnamon

In any infection, we may not feel like eating but one must remember that our body needs maximum nutrition to fight at that time. Taking small frequent meals helps; it also keeps the digestive system in check. Having strong medicines may disturb our digestive system. Ideally, if you eat well daily and keep your body healthy, recovery from infectious diseases is faster. So, eat well and stay healthy!

Disclaimer:

The opinions expressed within this article are the personal opinions of the author. NDTV is not responsible for the accuracy, completeness, suitability, or validity of any information on this article. All information is provided on an as-is basis. The information, facts or opinions appearing in the article do not reflect the views of NDTV and NDTV does not assume any responsibility or liability for the same

About Rupali DattaRupali Datta is a Clinical Nutritionist and has worked in leading corporate hospitals. She has created and lead teams of professionals to deliver clinical solutions for patients across all medical specialties including critical care. She is a member of the Indian Dietetic Association and Indian Association of Parenteral and Enteral Nutrition.

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Foods To Eat And Avoid While Treating Malaria - NDTV Food

Which is Better for Weight Loss and Immunity: Juicing or Blending – The Beet

Posted: August 24, 2020 at 2:59 pm

There is an on-going debate about which is better for you if you're looking for Immunity, energy, fordetoxing after binging and to jumpstart your healthy weight loss: Juicing or blending. Here, Nadja Pinnavaia, founder of Plantable plant-basedmeal delivery, explains how to make the perfect green juice, and why she believes the benefits of juicing outweighblendingto deliver healthy nutrients and detoxifying benefits to your body. Pinnavaia, who has a Ph.D. in quantum chemistry, started Plantable to give people control over their well-being. "It all starts with how we eat," she says.

The dilemma about juicing versus blending has been around for a while. Both juicing and blending are potent systems that give the digestive system a break and enhance the battle against inflammation and other chronic diseases. Also, both are perfect ways to pack vitamins, minerals, and antioxidants in a single glass [perfect for immunity]. But what are really the benefits of juicing, and what is behind the famous celery juice?

Juicers extract the pulp from the fruit and vegetables, leaving only the liquid.

As a result, thanks to the absence of these fibers, [the nutrients] will be more easily digested, allowing the digestive system to rest and focus its energy on getting rid of toxins.

Lately, celery juice has become controversial, because some people claim that it can cure conditions like cancer, obesity, thyroid issues, and acne. Although none of these benefits have been proved, celery juice may provide several benefits when consumed as part of a healthy diet.

Therefore, although juicing and specificallycelery juice has its benefits, nothing is a magic fix. Juicing can contribute amazing beneficial properties as part of a plant-based whole food diet rich in fibers and nutrients.

For a simple and effective Celery Juice recipe, Try this one from The Beet.

Add to it anything plant-based and green, or low in sugar such as: Spinach, Kale, Apple, Cucumber, or a squeeze of lime juice for a kick of tart taste and a boost of Vitamin C.

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Which is Better for Weight Loss and Immunity: Juicing or Blending - The Beet

Work-style reform needed at the government’s center – The Japan Times

Posted: August 24, 2020 at 2:59 pm

Earlier this month, a shocking survey result was announced. The survey, conducted by work-style consultancy Work Life Balance Co. on 480 public servants between March and May, revealed that a distressing number of bureaucrats in government ministries have been logging overtime at a level that could cause death from overwork.

Due particularly to the spread of COVID-19, some 40 percent of the officials surveyed who work in the bureaucratic ground zero of Tokyos Kasumigaseki district have been putting in a whopping 100 hours of overtime or more per month.

Many workers at Japanese firms were once considered corporate warriors who spent more time in the office than at home. But now, the concept of work-life balance has gradually penetrated the private sector, and the recent pandemic has also forced businesses across a wide spectrum to accept telework and other flexible work styles. It is now time to review the work style of government employees to improve efficiency.

Environment Minister Shinjiro Koizumi, who announced the surveys results with Work Life Balances president, Yoshie Komuro, relayed one of the responses written by a health ministry official in his 30s: My son told me that it was the first time for me to sit down with him and have dinner (on a weekday). I cried because I felt very sorry for my son that I hadnt done things that an ordinary parent would do. I realized the work style of Kasumigaseki is based on such sacrifice of those bureaucrats.

Because of the pandemic, the workload at government ministries and agencies has piled up, but because of the stay-home period it is also true that some bureaucrats have been able to spend more time with their families.

A major reason why government officials cant change their work style is that politicians refuse to adapt themselves to the digital age and continue to ask bureaucrats to give various briefings in person, even late at night or early in the morning. Fax messages and telephone calls continue to be their regular communication methods. Bureaucrats always have to promptly respond to requests from those lawmakers in such archaic ways.

According to the survey, 80 percent of the respondents said briefings for politicians are conducted in person and not online, while 90 percent noted that they feel politicians dont have consideration for bureaucrats and their work environment.

Even though they should be urgently adopting a paperless system, 86 percent of the bureaucrats said they have to use faxes to send messages to politicians.

While many politicians favor face-to-face communication, traditional methods of doing business are also deeply rooted in every sector of the government. For example, using documents and hanko seals are a main means for policy approval, while the use of online conference tools is limited, with some bureaucrats commenting that they cant use videoconferencing apps except Skype.

To change the government, digitalization of the Diet is also key.

In mid-March, Hayato Suzuki, a Lower House member of the ruling Liberal Democratic Party, launched a project team with other young lawmakers. They are proposing that the Diet adopt online conference tools and enable lawmakers to vote remotely if they are unable to go to the Diet due to official duties, pregnancy or illness.

After state minister of health Gaku Hashimoto and parliamentary vice minister Hanako Jimi went onboard the coronavirus-stricken cruise ship Diamond Princess in the port of Yokohama in February to inspect the ship, they were unable to go to the Diet for the quarantine period of two weeks. During this time there were deliberations on the national budget, but they were unable to participate.

Japan needs to create new rules and a system that fit the new age. In the future, an increase in female politicians would mean more will be giving birth when the Diet is in session, while more people with disabilities may also become Diet members. Ministers meanwhile may have to go overseas to conduct important official duties. Article 56 of the Constitution requires both houses of the Diet to have one-third or more members in attendance to hold a plenary session and vote, but if online voting without physically being present in the Diet can be done, this requirement can be met in the virtual realm.

Replacing old rules and practices with new ones will not only help improve the working environment of bureaucrats, it will surely save time and expenses for many people, which will ultimately mean saving taxpayer money.

The world is facing tremendous challenges due to the pandemic and Japan needs to prepare for a possible twin outbreak of COVID-19 and influenza this fall and winter. Unless the current inefficiency in the government is addressed, it will be extremely difficult for Japans policy-making center to deal swiftly and effectively with future crises.

The Japan Times Editorial Board

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Work-style reform needed at the government's center - The Japan Times

Is Keto a fad? And is it safe? – NewmarketToday.ca

Posted: August 24, 2020 at 2:59 pm

Don't confuse ketoacidosis with ketosis using fats for energy which is our natural state of being, nutritionist Nonie De Long says

Dear Nutritionist, Ive been trying to lose weight. Im a middle-aged female (54) and have done Weight Watchers, but didnt keep the weight off. Im interested in giving Keto a try. so I would like to know if you think its a fad and also is it safe? Betty

Dear Betty,

I get asked this question a lot actually. I will go into my reasons below, but the short answer is no, its not a fad and yes, keto is safe for almost all people.

There are some medical conditions that make keto problematic, but that is not the vast majority of folks. Lets unpack the keto diet a bit to understand why its not a fad.

We have all seen diets come and go. Across the board its safe to say they would be unnecessary if we ate only natural food that we are biologically adapted to eat, in the right proportions, with some moderate movement in our daily lives.

Its a myth that dieting is natural. If we look at the vast majority of our history as a species, its food scarcity and not overeating that impacted mortality. In the developed countries to varying degrees we have now gone in the other direction.

Its also a myth that we need to be gym rats to be fit. Just look at 80-year-old farmers around the globe. Staying fit has to do with staying active and that can be any activity from work to house keeping to gardening to walking the dog to my personal favourite dancing around the living room. Movement keeps us fit. But diet keeps us slim.

Please read that again if you are interested in losing weight. Body composition is determined by your diet. You can not exercise off a bad diet. And trying to will leave you frustrated and often injured.

Consuming a healthy, biologically appropriate diet will get you to a good body composition meaning the fat to lean tissue ratio, which is what we are talking about when we talk about weight loss. If you are short and stout by nature, with a lot of muscle, you are never going to diet yourself twiggy. But you can be lean, with a nice shape and healthy fat distribution.

What does that mean?

Well, a healthy person has a little fat just under their skin all over their body. An unhealthy body holds fat in the middle. That is the primary indicator of longevity, heart disease, diabetes, and a whole host of other disease states.

If you want to know your risk, look at your waist to hip ratio. If the waist is bigger or even close to your hips, youre in trouble. If you have a muffin top over your jeans or look pregnant when youre not, you can stand to lose fat, no matter how thin your overall frame is. This will reduce your disease risk more than anything you can do.

This is where keto comes in.

Historically, our ancestors had periods of plenty and periods of scarcity. They would migrate to follow food. They never got to choose a diet, as we do today. They never had processed foods.

Even growing crops and using grains is relatively new in terms of our development! For the vast majority of our development as a species, we existed on what we could pick or dig and what we could hunt and catch in terms of animals.

Its also noteworthy that we used the entire animal in times of scarcity and in times of plenty there is evidence that dogs (which co-evolved with humans) ate the muscle meat while we ate the organ meat and bones. The organs were often consumed raw after a kill. Today (when dogs and humans eat natural food) that trend is reversed.

In this respect, our paleolithic ancestors would have naturally had cycles of ketosis because ketosis is what happens when the body runs on fats for fuel rather than carbohydrates or protein.

When game is the primary source of sustenance, fat becomes the natural fuel source for the body. Healthy human bodies dont use protein for energy in the presence of fat. And they dont burn fat in the presence of carbs. In a time when carbs were scarce (fruit in season, which was far less sweet than it is now, and a few tribes that used tubers more often) the body would naturally default to using fats for energy. This is ketosis. It is our natural state of being.

And its why the body stores energy as fat (the primary human fuel source) for times of scarcity. If we look at this even a century ago, we can see that even agricultural societies before the advent of modern food production and storage technology would lend itself to ketosis because carb-rich foods are ready in the autumn and would be consumed to pad the body for the famine of winter. Then, when winter scarcity set in, the body was using its own fat to survive. This is ketosis.

With a keto diet, the body becomes more efficient at using fat for energy because during that time it burns its own fat stores, which many people now want to take advantage of. It also decreases the strain on the digestive organs and decreases inflammation (as insulin and adenosine are both highly inflammatory and both are down-regulated with this diet).

A keto diet is also very low in allergens and does not contain anti-nutrients that vegetarian proteins contain. Its easier to digest. And it contains bones, the perfect source of minerals. No other mineral source is as healthy or as sustainable. And no other nutrient group is as essential for human health and longevity.

Werent there carbs historically speaking?

For the most recent agrarian part of our development there have been carbohydrate-rich foods but there were ways of consuming the carbs that made them healthier for us than what we do today.

First of all, there were no factories and processing them was lengthy so they were less plentiful. Bread was not the sticky, glutenous gooey nonsense we have today. The crop was different and the processing was different. Access was minimal due to the work to process it.

Maize (corn) was not the sweet crop we know today and it was always processed with lime or ash. This process is called nixtamalization. You can read more about it here. When this was not done there was an upsurge in pellagra, which causes psychosis, thinking problems, skin rashes, photosensitivity, and aggression.

Is it a coincidence we now have improperly processed corn in so many of our processed foods and are experiencing so many mental health conditions with these features today? Hmmmm...

Thus, returning to a diet that mimics the natural, evolutionary state of being adapted to using fat for energy (ketosis) is natural and healthy. Its often dismissed as a fad by people who say its not balanced enough or simply because its popular.

But thats what people thought about the automobile when it first came out. A fad. And dangerous. Totally impractical technology. But just because something becomes popular does not make it transitory in nature. Look at televisions. Look at industrialization. There are many many more examples.

The idea that ketosis is dangerous is fuelled by people who dont understand metabolism. They confuse it with ketoacidosis, which is very dangerous. But its an entirely different thing. The truth about the keto diet is that it can reverse a host of health conditions that other diets cant. Diabetes and metabolic syndrome alone are good enough reason to hail this diet, as it does more to reverse them than any other.

The only time a keto diet is unhealthy or dangerous is when its composed of processed fatty foods like processed meats and bars and keto snacks. You will still lose weight on them, but they are not natural foods.

In the industry we call this dirty keto. Its far superior to return to a minimally processed animal based diet with natural animal fats and healthy veggies and occasional fruit.

This naturally puts us in and out of ketosis cyclically, with ample nutrients. This is the diet I advocate in my practice, not because it helps with weight loss (although it does) but because it reverses many disease states even serious mental health conditions like psychosis and seizures. Weight loss is actually just a side effect of eating for health. Its really not the goal.

Thank you, Betty, for the great question. I hope you have a better understanding of it now. As always, if readers have a health or nutrition related question, I welcome you to write to me at nonienutritionista@gmail.com. And if youre looking for more specific health information, check out my website at nonienutritionista.com, where I provide 1:1 health coaching for those who need it.

Namaste!

Nonie Nutritionista

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Is Keto a fad? And is it safe? - NewmarketToday.ca

Auxolytic’s Nutrient-Based Shut-Off Switch Boosts Cell Therapy Safety Without Transgenes – BioSpace

Posted: August 24, 2020 at 2:59 pm

Auxolytic has developed a nutrient-based safety-switch for cell therapies that doesnt rely on introducing transgenes. The process, auxotrophy, uses the engineered inability of an organism to synthesize a compound required for its survival to allow physicians to turn off a gene therapy if serious side effects develop.

The work currently is in preclinical phases, in humanized cells in mice, and appears promising. When it advances to clinical applications, patients receiving cell therapies (such as CAR T, stem cell, and TCR therapies) containing this safety switch would be given supplements of a particular nutrient uridine, in this case. If the cell therapy went awry, patients could simply stop taking the uridine supplement and the cellular therapy would cease to function.

A paper published in Nature Biotechnology describes how the off switch could be engineered into cell therapies. Basically, it says, the approach knocks out the gene that disrupt(s) uridine monophosphate synthetase (UMPS) in the pyrimidine de novo synthesis pathway in cell lines, pluripotent cells, and primary human T cells.

This knockout makes proliferation of the cell therapy dependent on the external supply of uridine. Therefore, researchers can control cell growth by modulating the uridine supply in vitro and, importantly, in vivo after transplantation.

In the movie Jurassic Park, the dinosaurs were engineered to need lysine. If they escaped, there was no lysine to keep them alive. This therapy is very similar, founder and CEO James Patterson, M.D., Ph.D., told BioSpace.

Rather than lysine, Auxolytic uses uridine as the controlling nutrient. Uridine is important in carbohydrate metabolism and is found in yeast, tomatoes, broccoli, sugarcane and other foods, and also can be produced by the body when inadequate amounts are consumed in the diet.

The quantities available through the diet or produced by the body, however, arent high enough to sustain the engineered cells, Patterson said. Evidence comes from a rare genetic disease, orotic aciduria. Patients with that condition have a mutation in the UMPS gene that causes them to produce insufficient levels of the enzyme that breaks down orotic acid. They often die at very young ages if not supplied with quantities of pure uridine. This shows that a normal diet wont compensate.

Patients of cell therapies that incorporate Auxolytics nutrient-based safety switch likely would be able to eat their usual foods, but with nuridine added as a supplement. The approach Dr. Patterson developed hasnt been tested in patients yet.

This is the same nutrient I worked with in yeast, but now in human cells, Patterson said. Early work shows that only the engineered cell therapy would be affected by uridine modulation. Within one week of withdrawing the uridine, the engineered cells were inactive and unable to proliferate. Normal cells continued to function as usual.

At age 27, Patterson already has worked with many of the thought leaders in medicine and biomedical research while pursuing his M.D. and Ph.D. degrees at the University of Cambridge and the Francis Crick Institute. Beginning early during his university days, he performed research placements at the University of Zurich, The Gurdon Institute, The Whitehead Institute and The Cambridge Stem Cell Initiative.

This nutrient-based approach to controlling cell therapy is the direct result of that body of experience.

During my M.D./Ph.D. training, I became interested in cell therapy and its potential for curing patients, but there were safety risks. My Ph.D. work focused on yeast biology, studying how cells control their size. There, the idea of nutrient-based cell control was commonplace, but no one was working on this in human cells, he said. I became interested in science when I was very young, so during my undergraduate work I made sure I was thinking about the science being done in the labs in addition to what I was learning in lectures. Theres a difference.

Lectures lay the scientific foundation, but lab work is cutting-edge and forward-thinking.

I started working in labs when I was 19 in Zurich. I spent all my summers working in labs, asking a range of questions and working in lots of different systems, Patterson said.

Such broad exposure proved foundational for Auxolytic.

As you can see, this is a yeast technology. Thats not where you usually go to look for cell therapy ideas, he added.

He advises students early on to get into exciting labs that are doing interesting, fundamental science. Ask basic questions of how cells work, for example. You never know what youll find that could be applicable to the clinic. Jumping to clinical research (too early) causes you to lose the blue sky thinking.

Auxotyic, based in Cambridge, UK, is, for now, a virtual company of onebut with ample advisors.

Theyve helped along the way in the academic sector and also in the management of business, Patterson said. Those mentors include seasoned industry veterans who know what it takes to take a drug from bench to bedside, and who understand patenting and licensing.

The next step for Auxolytic, scientifically, is to identify potential applications around selecting for differentiated cells from induced pluripotent stem cells (iPSCs). Much of the scientific work is being done in collaboration with the Matthew H. Porteus lab at Stanford University.

On the business side, he continued, Were excited to get this into the hands of big cell therapy companies that currently are making cell therapies without a safety switch. Were looking to partner with them to get this to patients.

Auxolytic is talking with several interested companies. People recognize the need for a safety switch and are very excited, Patterson said. Discussions are going well.

Continued here:
Auxolytic's Nutrient-Based Shut-Off Switch Boosts Cell Therapy Safety Without Transgenes - BioSpace


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