Weight loss at the time of diagnosisappears common among people with amyotrophic lateral sclerosis (ALS),regardless of whether they have dysphagiaor other bulbar-onset symptoms, a study looking at more than 2,400 patients found.

A severe degree of weight loss is associated with a higher risk of death, its researchers reported, indicating that body weight may be an important prognostic factor of survival. Care to avoid a sudden drop in weight may need to be tailored to the individual.

The study, Prognostic value of weight loss in patients with amyotrophic lateral sclerosis: a population-based study, published in the Journal of Neurology, Neurosurgery & Psychiatry.

With an estimated prevalence of 56%62% in ALS patients, weight loss is a key clinical feature of the disease. It appears to have numerous causes, although patients with dysphagia (difficulty swallowing), and subsequent feeding problems are thought to be the main triggers.

Several studies have reported poorer disease courses (prognosis) in that patients who drop weight quickly or have a low body mass index (BMI) at the time they are diagnosed

Despite the value of these studies, they vary significantly in definition, methodology and/or results. Consequently, the direct associations between survival, WL [weight loss] or BMI loss remain dubious, the researchers wrote.

To investigate the potential prognostic value of BMI and weight loss in ALS, researchers carried out a large population-based study, using patient information stored at the national database of The Netherlands ALS Centre in Utrecht.

Their study included data on 2,420 people diagnosed with ALS between 2010 and 2018. When possible, investigators gathered detailed patient information, including disease features, ALS-related genetic profile, and cognitive abilities at diagnosis or within three months of that diagnosis.

Statistical analyses were used to identify possible relationships between weight loss and patients risk of death during follow-up.

During the studys eight years, 1,836 (75.9%) of these 2,420 people died. More than half (67.5%) had reported weight loss at the time of their diagnosis.

A higher percentage of patients with thoracic/respiratory disease-onset claimed to have lost weight (86.6%), followed by those with bulbar-onset (71.8%), and those with spinal-onset (64.2%).

Of note, bulbar-onset ALS is marked by initial symptoms of weakness or wasting of muscles involving the head and neck, whilethoracic/respiratory onsetaffects muscles that move the chest and lungs and are essential for breathing; sometimes lumped with bulbar-onset, it was a separate category in this study. Spinal-onset disease is first felt in the muscles of the arms and legs.

Patients with thoracic/respiratory-onset had the most severe drop in weight, losing an average of 11.0% of their body weight at time of diagnosis. This was followed by those with bulbar-onset (6.9%), and spinal-onset ALS (5.5%).

At diagnosis, weight loss was observed in 73.5% of those with dysphagia, and in 62.8% of those who did not have swallowing difficulties, suggesting that WL is not solely related to dysphagia, the researchers wrote.

Analyses also found that weight loss was a strong independent predictor of patients survival. According to statistical models, each time patients lost 10% of their body weight, their risk of death rose by 23%.

This population-based study shows that two-thirds of the patients with ALS have WL at diagnosis, which also occurs independent of dysphagia, and is related to survival, the researchers wrote.

Potential factors influencing weight loss range from muscle weakness due to motor neuron damage to loss of appetite reported in 29%to 47% of all ALS patients to loss of autonomy dueto disease progression or side effects of medication, they added.

Preventing severe weight loss will likely require care tailored to those factors that most affect a given patient.

Multifactorial causes are involved in the genesis of WL, and sorting out these causes in every individual patient with ALS might result in well-tailored care, and improved therapeutic strategies, the researchers concluded.

Joana holds a BSc in Biology, a MSc in Evolutionary and Developmental Biology and a PhD in Biomedical Sciences from Universidade de Lisboa, Portugal. Her work has been focused on the impact of non-canonical Wnt signaling in the collective behavior of endothelial cells cells that made up the lining of blood vessels found in the umbilical cord of newborns.

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Ana holds a PhD in Immunology from the University of Lisbon and worked as a postdoctoral researcher at Instituto de Medicina Molecular (iMM) in Lisbon, Portugal. She graduated with a BSc in Genetics from the University of Newcastle and received a Masters in Biomolecular Archaeology from the University of Manchester, England. After leaving the lab to pursue a career in Science Communication, she served as the Director of Science Communication at iMM.

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Severe Weight Loss Linked to Higher Risk of Death in Study of Patients - ALS News Today

Libby recommended making sure youre prioritising your emotional wellness at the same time as focusing on your physique, in order to better achieve your weight loss goals.

Finding a way to switch off and relax, as well as working through any problems is important, Libby advised

Everything from regular walks to gardening or being in nature, yoga, exercise and meditation to reading are good for this.

However, while managing your stress levels by taking time out is key to keeping those hormones in check, you may also want to look at the very foods you are eating.

While you may be trying to cut down on calories, its important to remember that theyre not all created equal.

From a dietary perspective if you are trying to lose weight, be mindful of not just how many calories you consume but also what those calories are made up of, warned Libby.

The very foods you eat could affect your cortisol levels - so your stress can affect your diet and vice versa.

High sugar foods can spike blood sugar; this causes the release of insulin, another hormone which also drives weight gain, explained Libby.

Often the body can then also rebound with low blood sugar, that drives cravings and cortisol production.

Having balanced meals which contain adequate protein (at least 20g) and abundant vegetables that give complex carbs and fibres, will help balance blood sugar, manage cortisol and energy levels, Libby added.

This approach will mean you feel fuller for longer, as you work with your bodys hormones rather than battling against them.

Whats more, if you are dealing with raised stress levels, you can change certain elements to your diet to make you feel calmer.

Even what you drink can affect your state of mind - and reaching for a mug of coffee for an energy boost could be doing more harm than good.

High doses of caffeine can make the body create even more stress hormones, which is why you may feel jittery after a few too many cappuccinos.

Switching to matcha green tea could help, however, as it contains a substance which has a relaxing effect.

Green tea does contain some caffeine, but less than coffee, revealed Dr Naomi Newman-Beinart, medical nutritionist.

But the primary reason that tea is a better choice when were stressed is thanks to its content of a natural substance called L-theanine, which is virtually unique to the tea plant. L-theanine has been found to have a relaxing effect on the mind, reduce anxiety, and help with focus and concentration. Its thought to do this by increasing alpha waves in the brain, which are associated with being calm but alert i.e. increasing relaxation without causing drowsiness.

Matcha green tea has a particularly high percentage of the wonder ingredient, so switching your morning caffeine fix to the herbal alternative such as Pukkas Supreme Matcha Green Teawill help you feel alert, but calm. For tea lovers looking for a more soothing brew, try the brands Relax Tea fusion for a dose of relaxation.

Other herbal remedies can also help; Libby recommended a natural supplement such as Link Nutrition Relax capsules to balance out your stress hormones and your mood.

It contains chromium, which is key for blood sugar balance, as well as cortisol-balancing herbs, ashwagandha and ginseng, Libby revealed.

Several studies have proven that ashwagandha can significantly reduce and regulate your bodys cortisol levels.

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Weight loss: Why reducing lockdown stress is the key to getting rid of belly fat - Express

New Jersey, United States,- The latest research study on Weight Loss and Weight Management Market Added by Verified Market Research, offers details on current and future growth trends pertaining to the business besides information on myriad regions across the geographical landscape of the Weight Loss and Weight Management market. The report also expands on comprehensive details regarding the supply and demand analysis, participation by major industry players and market share growth statistics of the business sphere.

Global Weight Loss and Weight Management Market was valued at USD 254.11 billion in 2016 and is projected to reach USD 432.97 billion by 2025, growing at a CAGR of 6.1% from 2017 to 2025.

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Rebel Wilson is an Australian-born comedian, best known for her roles in raucous comedies like Pitch Perfect. Wilson is popular with fans for her brash, unfiltered attitude and outspoken personality. Still, Wilson is making headlines for a whole new reason these days her devotion to a healthy lifestyle. Recently, a well-known doctor opened about the plan that Wilson has been following and why it can seriously help to improve digestive health.

RELATED: How Rebel Wilson Hallucinated Herself Into Her Acting Career

Rebel Wilson was born in Australia in 1980. Raised by a mother who worked as a professional dog handler, Wilson has three siblings, with whom she has worked on occasional projects.

Wilson was very academically-inclined and did well in school. She even briefly considered pursuing a career in mathematics. As a young woman, Wilson went on a school trip to South Africa, where she contracted malaria.

While in the grips of the disease, Wilson got hallucinations. In one of her vivid hallucinations, Wilson saw herself becoming a successful actress and receiving an award.

Following this event, Wilson began studying theater. However, her natural affinity for comedy led her to pursue comedy, and she developed quite a name for herself in local clubs in Australia.

Eventually, Wilson made the move to Hollywood, where she began acting in movies such as What to Expect When Youre Expecting and Bachelorette. She is perhaps best known for the role of Fat Amy in the Pitch Perfect film series however, in real life, Wilson has undergone a drastic slim down.

In early 2020, Wilson shocked fans when she posted a series of photos to her Instagram, debuting a trim figure and a happy smile. Fans were quick to notice the change in Wilson.

Still, as the actress revealed, her new look can be attributed to a new devotion to a healthy lifestyle, rather than a fad diet. Wilson claimed that, for her, 2020 was going to be the Year of Health. She stated that she has been working out hard in the gym, hydrating, and actively avoiding junk food and excessive sugar.

The actress revealed that she initially lost a great deal of weight while filming the musical Cats, but was so inspired by the positive changes that she saw, that she wanted to keep the ball rolling.

For months, fans have been wondering how exactly Wilson has been managing to maintain her healthy lifestyle and how she got started on that track in the first place. According to sources, Wilson first got inspired to get healthy when she visited a luxury medical detox and wellness center called VivaMayr. While there, Wilson was introduced to the Mayr Method, a specialized diet plan that allowed Wilson to see some truly incredible results.

The Mayr Method, according to the assistant medical director of VivaMayr, Dr. Christine Stossier, completely revamps peoples diets in order to eliminate snacking, reduce gluten and dairy intake and change how people chew their food. Whole foods are the central focus of the diet, with devotees consuming foods like fresh fish, lots of vegetables, and yogurt.

It isnt just the food that matters, either on the Mayr Method, people are instructed to chew very slowly, often counting chews. This approach is said to aid digestion and reduce inflammation.

While this specialized diet might not work for everyone, it certainly has worked for Rebel Wilson. The comedian is looking happier and healthier than ever on her social media pages, and her career is on fire.

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Rebel Wilson Weight Loss Secret Is the Mayr Method, But What Is It? - Showbiz Cheat Sheet

Lots of people shun carbs in a bid to lose weight. The idea that carbohydrates are calorific is widespread and has left people avoiding the whole food group. But should we really be switching to brown bread instead?Express.co.ukreveals how bread affects weight loss.

Carbohydrates are a wide category, including bread, pasta, beans and potatoes.

They are one of three macronutrients found in food, the others are fat and protein.

Obviously you cant eat bread all day every day, but many have taken to cutting the foodstuff out of their diet entirely.

So what is the difference between white and brown bread?Express.co.uktakes a look.

READ MORE- Veganism benefits: Should I go vegan? Will I lose weight?

No, carbohydrates will not make you put on weight if you eat them in the right quantities.

Hardly any foods contain only one nutrient and most are a combination of carbohydrates, fats and proteins in varying amounts.

They are important to your health because they give you energy and reduce risk of some diseases.

Carbs are not going to make you gain weight, unless you add butter and creamy sauces to them.

Carbohydrates actually contain fewer calories gram for gram than fat, making them a useful part of maintaining a healthy weight.

There are three different types of carbohydrates in food: sugar, starch and fibre.

The type of sugars that we tend to eat too much of is called free sugars.

They are often added to food or drinks such as biscuits, chocolate, and breakfast cereals.

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You are better off sticking to naturally occurring sugars, such as those found in honey, syrups, and smoothies.

Starch is found in foods that come from plants, such as bread, rice, potatoes and pasta.

Starch is good for you because it provides a slow and steady release of energy to keep you going all day.

Fibre is another important carbohydrate, and good sources include fruit and vegetables, wholegrain bread, and wholewheat pasta.

Significantly reducing carbohydrates from your diet could potentially lead to health problems.

Carbohydrates are the bodys main source of energy, and if you dont eat them your body will use protein and fat for energy instead.

It may be hard to get enough fibre without carbs, and fibre is crucial for digestion.

However, you should opt for healthier sources of carbohydrates such as wholegrain, potatoes, vegetables, fruit and legumes.

Brown bread is a healthier choice than white bread, according to a number of studies.

The NHS website says that wholegrain, wholemeal and brown breads give us energy.

They also contain B vitamins, vitamin E, fibre, and a range of minerals.

White bread gives you some of this too, but not as much.

Brown bread, wholegrain and wholemeal are also lower in fat.

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Weight loss: Is brown bread good for weight loss? - Express

Quarantine has Yo Gotti looking chiseled.

If you follow Gotti on Instagram, you've probably seen his recent post, where the Memphis rapper's newly-toned figure is front and center as he works out in his driveway. "40lbs down 40M's Up," he captioned the post, which was shared on Tuesday (June 30). In an earlier post, he made it clear that his transformation took plenty of hard work as he shared another glimpse of his fitness plan, which includes boxing. "Do the work, the results will do itself," he captioned one pic, while adding the hashtag #NoDaysOff.

Earlier this year, Yo Gotti spoke about incorporating his experience and accomplishments into his music. "I think a lot of the things Ive accomplished in the last year, year-and-a-half, and a lot of the experiences, the things Ive been dealing with, those are the messages on this album," he explained of his latest album, Untrapped, which boasts collaborations with Lil Baby, Megan Thee Stallion and Lil Uzi Vert.

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Yo Gotti Shows Off 40 Pound Weight Loss: See His Transformation - iHeartRadio

Are you on a Ketogenic diet and experiencing a strange breath of late? Then read on to know about Keto Breath.

If you are reading this then I am assuming that you are already on Keto diet or planning to follow one. Still, those who are curious and want to know about Keto Diet, it is a low-carb high-fat diet. And one of the big benefits of it is major weight loss. When you start following the Keto diet your body burns fats instead of glucose as the main source of energy. After some days, the body switches over from using glucose as a fuel source and instead breaks down of fat stores starts. The fat gets converted into energy in the form of ketones.In a super low carb ketogenic diet, 75 percent of your daily calories are from fat, 20 percent from protein, and just five percent from carbohydrates.

There are certain side effects of it such as Keto Flu and Keto Breath and today we are talking about the latter one which is a quite unpleasant but reversible side effect. If you have or know someone who follows the Keto diet must have noticed a weird odor/breath. The same is due to the buildup of ketones and it is also an indication that your body is in ketosis. So, don't worry if you have keto breath as it is a good sign. The excess ketones are released from our body through urination and respiration and lead to keto breath.

The ketones which are generated include beta-hydroxybutyrate, acetoacetate, and acetone and that's why Keto Breath some times smell like nail polish remover. Many people describe keto breaths as fruity smelling or metallic. Another reason for the Keto breath is protein intake. When our body breaks down protein, it produces amino acids, one of which is ammonia. And ammonia smells like urine and chemicals. And it could also contribute to unpleasant breath.

How to deal with it?

Fortunately, the keto breath is mostly temporary, just like the keto flu. After a few weeks, your body will get adjusted to your way of eating and soon you should get your normal breath back.

In the meantime, you can do few things neutralize keto breath.

- Drink more keto-approved fluids, especially water.

Aside from exhalation, your body flushes acetone and ketones through urination. Stay hydrated to increase urination. As soon as excess ketones get removed your breath will also become better.

- Control protein intake

Are you eating too much protein? Then you should keep a check on protein intake as it can worsen bad breath. As mentioned, after the breakdown of protein, there is a production of ammonia.

- Mints and Gum can help

You can chew gum and mints to keep bad breath away. But make sure you choose sugar-free mints and gum.

- Slightly increase your carbohydrate intake

This is another simple way to eliminate keto breath. Make sure to not increase the carb intake too much. For instance, if you are eating 15 grams of carbohydrates per day then try increasing your intake to 20 grams per day and see if your bad breath improves.

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Weight Loss: What is Keto Breath and how to deal with it? - PINKVILLA

Think about it: For some people, they gain or lose first in the belly, hips, or thighs; for others, that weight might go straight to or from the boobs. Or, you may notice the weight leave your face immediately, for instance.

The truth is, as much as you think you might be targeting certain areas for weight loss with so-called belly fat-busting or butt and thigh workouts,studieshave found that you can't necessarily control where fat loss occurs. But do some body parts naturally slim down at a faster rate? Experts explain what areas of the body tend to trim down firstand why.

RELATED:Why Crash Diets Can Majorly Backfire When It Comes To Quick Weight Loss

First of all, weight loss is going to be a different scenario between men and women. "Men and women tend to lose weight differently based on the types of fat they contain and childbearing factors," says Romy Block, MD, an endocrinologist and co-founder ofVous Vitamin.

For example,researchhas shown that women have more subcutaneous fat, a type of fat that deposits right underneath the skin and is partially responsible for women's curves, than men. The first place men typically lose weight is the belly, while women tend to lose weight all over, but hold onto weight in their thighs and hips, Dr. Block explains.

When it comes to weight loss, though, it's less about your natural body shape and more about genetics,how your hormones work, andyour metabolism, says Dr. Block. Regardless, she adds, you can't choose a specific area of focus for weight loss.

Janet Brill, PhD, RD, a Philadelphia-based nutritionist, theorises that where fat melts off on your body first is totally different for everyone, and you might lose weight from wherever you last gained it. "If you tend to gain weight around your waist, you'll likely lose weight from your midsection first as well," says Brill. Meanwhile, if weight goes straight to your boobsas it does for many womenyou'll probably notice it leave your chest first, too.

In some cases, you might lose weight from around your internal organs as well. Dr. Block notes that this is the case specifically in people who have NASH, or non-alcoholic fatty liver disease. Even losing 5 percent of your body weight can boost the function of organs like the liver.

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The other factor at play when it comes to where you shed weight is Mother Nature's plan for your body to be always be ready to get pregnant. For that reason, many women say that the fat around their hips, butts, and thighs stays put for the first several weeks of a weight-loss regimenwhile their backs, calves, and even their faces begin to thin out much sooner.

"The fat on these body parts [the hips, butt, and thighs] is crucial for childbearing," says Brill, "which is why most women notice that their body naturally hangs onto it as long as possible." The increased fat in these areas is related to the higher levels of estrogen necessarily for fertility, Dr. Block adds.

As people near menopause, weight gain may shift to the belly. Because you have lower estrogen levels duringmenopause, more fat might distribute to the abdominal area, says Dr. Block.

In a perfect world, you could switch things up so you lose weight from where you want to first. But the fact is,you don't really have much control over where the pounds peel off firstwith one caveat: "When you work out, your metabolism increases, and that helps get rid of some of the visceral fat that goes to your stomach and abs area," Brill says. It's just a modest difference and doesn't count as spot reducingbut it's something to keep in mind if your body hangs onto belly fat forever and you want the waistband of your jeans to feel roomier faster.

Other than potentially speeding up your metabolism, focused exercise is not going to shed weight in any one specific area. Your body has a mind of its own in terms of deciding where to lose weight and when, the experts say.

However, the healthiest way to lose weight is a combination of diet and exercise. That's really keyone without the other won't have as much of a long-term impact. "Diet will directly impact stored energy, while exercise will increase your metabolism and help you keep the weight off," Dr. Block says.

Don't think of weight loss as a sprintreally, it's a marathon. "Small changes[to your diet and exercise plans] can make big differences over time and impact your health and energy in a significant way," Dr. Block says.

Even cutting out high-calorie drinks, including your favorite flavoured latte and mixed drinks, is a good place to start. Of course, leveling up your exercise routine also can positively impact your metabolism (HIIT workoutscan help you blast fat and increase your endurance, too).

Adding more movement to your life, Dr. Block says, like walking around the block an extra time and adding more stairs as opposed to elevators to your routine, can also contribute.

This article originally appeared on Women's Health US.

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This Is Likely The First Place You'll Notice Weight Loss - Women's Health