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Karyopharm Announces Dosing of First Patient in a Phase 1/2 Study of Selinexor in Combination with Standard of Care Therapy for Patients with Newly…

Posted: June 9, 2020 at 5:44 pm

NEWTON, Mass., June 09, 2020 (GLOBE NEWSWIRE) -- Karyopharm Therapeutics Inc. (Nasdaq:KPTI), an innovation-driven pharmaceutical company, today announced dosing of the first patient in a Phase 1/2 clinical study evaluating oral selinexor in combination with standard of care therapy in patients with newly diagnosed or recurrent glioblastoma (GBM). This global study is expected to enroll approximately 400 patients at clinical sites in the U.S., Europe, and Israel.

Selinexor is an oral selective inhibitor of nuclear export (SINE) compound which blocks the cellular protein XPO1, whose function includes playing a key role in regulating the activity of tumor suppressor proteins and other oncoproteins relevant in cancer cell biology. XPO1 may be an important, novel target in the treatment of patients with GBM as it is frequently overexpressed in both GBM and in high-grade gliomas, and the degree of XPO1 over-expression correlates with higher tumor grade and poor overall patient survival. Nonclinical studies indicate that selinexor has potent anti-GBM activity as monotherapy and is synergistic when combining with radiation, temozolomide and lomustine. Additionally, in previous clinical studies (KING study/NCT01986348), selinexor has demonstrated that it crosses the blood-brain barrier with adequate intra-tumoral penetration and single-agent efficacy with durable response and disease stabilization in heavily pretreated GBM patients further supporting the rationale for clinical development of selinexor to treat patients with brain cancers.

The randomized, multi-center, Phase 1/2 study (XPORT-GBM-029/NCT04421378) will be conducted in two phases: a Phase 1 dose finding study followed by a Phase 2 randomized efficacy exploration study, designed to independently evaluate three different combination regimens in three treatment arms in patients with newly diagnosed GBM (Arms A and B) or with recurrent GBM (Arm C). Arms A and B will investigate selinexor in combination with radiation therapy with or without the addition of temozolomide, while Arm C will evaluate the combination of selinexor and lomustine. The primary endpoints in the study are progression-free survival in patients with newly diagnosed GBM and overall survival (OS) in patients with recurrent GBM.

Yazmn Odia, M.D., Chief of Neuro-Oncology at Miami Cancer Institute, Baptist Health South Florida (BHSF), and investigator in the study, stated, We are very excited about the launch of this innovative clinical trial on behalf of our patients who desperately need new treatment options for what is typically an incurable disease and given the few meaningful therapeutic advances in recent years.

We are hopeful that this study evaluating the activity of selinexor in combination with currently used standard treatments will help us further identify promising novel approaches for the treatment of patients with both newly diagnosed and recurrent GBM, commented Minesh Mehta, M.D., Chief of Radiation Oncology at Miami Cancer Institute, BHSF, and investigator in the study.

While selinexor has been most extensively studied in patients with hematologic malignancies, there is increasing evidence that selinexor may also play an important role in the treatment of a variety of solid tumors, including patients with GBM, said Sharon Shacham, PhD, MBA, President and Chief Scientific Officer of Karyopharm. We were highly encouraged by the results from our previous Phase 2 KING study, which evaluated selinexor as a single agent in patients with recurrent GBM and demonstrated clear anti-cancer activity. We now look forward to assessing selinexors activity in combination with currently used standard of care treatments where we hope it will prove to be synergistic and even more effective.

Selinexor, marketed as XPOVIO, is currently approved by the U.S. Food and Drug Administration (FDA) as a treatment for patients with relapsed or refractory multiple myeloma. Selinexor is currently the only XPO1 inhibitor approved by the FDA and has been extensively tested in clinical trials across numerous cancer indications worldwide since 2012. Karyopharm has also submitted two additional supplemental New Drug Applications for XPOVIO which are currently under review by the FDA; one is for an expansion of XPOVIOs label to include XPOVIO as a treatment for patients with multiple myeloma after at least one prior line of therapy and the other for the treatment of patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL).

About GBM

Glioblastoma Multiforme (GBM) is one of the most common and particularly aggressive forms of brain tumors of primarily glial cell origin. GBM is diagnosed in patients at a median age of 64 years but can occur at any age, including in childhood. GBM is an incurable disease and the prognosis for patients is typically poor due in part to its aggressive and extensive infiltration of surrounding central nervous system tissue and its frequent inaccessibility for surgical resection within the brain. In addition, the blood-brain barrier presents an obstacle for many chemotherapeutic agents, with only small, lipophilic molecules able to reach the tumor. Median survival in patients with newly diagnosed GBM is approximately 15 months and approximately five to seven months in patients with recurrent disease.

About XPOVIO (selinexor)

XPOVIO is a first-in-class, oral Selective Inhibitor of Nuclear Export (SINE) compound. XPOVIO functions by selectively binding to and inhibiting the nuclear export protein exportin 1 (XPO1, also called CRM1). XPOVIO blocks the nuclear export of tumor suppressor, growth regulatory and anti-inflammatory proteins, leading to accumulation of these proteins in the nucleus and enhancing their anti-cancer activity in the cell. The forced nuclear retention of these proteins can counteract a multitude of the oncogenic pathways that, unchecked, allow cancer cells with severe DNA damage to continue to grow and divide in an unrestrained fashion. Karyopharm received accelerated U.S. Food and Drug Administration (FDA) approval of XPOVIO in July 2019 in combination with dexamethasone for the treatment of adult patients with relapsed refractory multiple myeloma (RRMM) who have received at least four prior therapies and whose disease is refractory to at least two proteasome inhibitors, at least two immunomodulatory agents, and an anti-CD38 monoclonal antibody. Karyopharm has also submitted a Marketing Authorization Application (MAA) to the European Medicines Agency (EMA) with a request for conditional approval of selinexor. A supplemental New Drug Application was accepted by the FDA seeking accelerated approval for selinexor as a new treatment for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), and selinexor has received Fast Track and Orphan designation and Priority Review from the FDA with a scheduled PDUFA date of June 23, 2020 for this patient population. Selinexor is also being evaluated in several other mid-and later-phase clinical trials across multiple cancer indications, including in multiple myeloma in a pivotal, randomized Phase 3 study in combination with Velcade (bortezomib) and low-dose dexamethasone (BOSTON), for which Karyopharm announced positive top-line results in March 2020. In May 2020, Karyopharm submitted a supplemental New Drug Application based on data from the Phase 3 BOSTON study. Additional, ongoing trials for selinexor include as a potential backbone therapy in combination with approved myeloma therapies (STOMP), in liposarcoma (SEAL) and in endometrial cancer (SIENDO), among others. Additional Phase 1, Phase 2 and Phase 3 studies are ongoing or currently planned, including multiple studies in combination with approved therapies in a variety of tumor types to further inform Karyopharms clinical development priorities for selinexor. Additional clinical trial information for selinexor is available at http://www.clinicaltrials.gov.

For more information about Karyopharms products or clinical trials, please contact the Medical Information department at:

Tel: +1 (888) 209-9326Email: medicalinformation@karyopharm.com

IMPORTANT SAFETY INFORMATION

Thrombocytopenia

XPOVIO can cause thrombocytopenia, leading to potentially fatal hemorrhage. Thrombocytopenia was reported as an adverse reaction in 74% of patients, and severe (Grade 3-4) thrombocytopenia occurred in 61% of patients treated with XPOVIO. The median time to onset of the first event was 22 days. Bleeding occurred in 23% of patients with thrombocytopenia, clinically significant bleeding occurred in 5% of patients with thrombocytopenia and fatal hemorrhage occurred in <1% of patients.

Monitor platelet counts at baseline, during treatment, and as clinically indicated. Monitor more frequently during the first two months of treatment. Institute platelet transfusion and/or other treatments as clinically indicated. Monitor patients for signs and symptoms of bleeding and evaluate promptly. Interrupt and/or reduce dose, or permanently discontinue based on severity of adverse reaction.

Neutropenia

XPOVIO can cause neutropenia, potentially increasing the risk of infection. Neutropenia was reported as an adverse reaction in 34% of patients, and severe (Grade 3-4) neutropenia occurred in 21% of patients treated with XPOVIO. The median time to onset of the first event was 25 days. Febrile neutropenia was reported in 3% of patients.

Obtain neutrophil counts at baseline, during treatment, and as clinically indicated. Monitor more frequently during the first two months of treatment. Monitor patients for signs and symptoms of concomitant infection and evaluate promptly. Consider supportive measures including antimicrobials for signs of infection and use of growth factors (e.g., G-CSF). Interrupt and/or reduce dose, or permanently discontinue based on severity of adverse reaction.

Gastrointestinal Toxicity

Gastrointestinal toxicities occurred in patients treated with XPOVIO.

Nausea/Vomiting

Nausea was reported as an adverse reaction in 72% of patients, and Grade 3 nausea occurred in 9% of patients treated with XPOVIO. The median time to onset of the first nausea event was 3 days.

Vomiting was reported in 41% of patients, and Grade 3 vomiting occurred in 4% of patients treated with XPOVIO. The median time to onset of the first vomiting event was 5 days.

Provide prophylactic 5-HT3 antagonists and/or other anti-nausea agents, prior to and during treatment with XPOVIO. Manage nausea/vomiting by dose interruption, reduction, and/or discontinuation. Administer intravenous fluids and replace electrolytes to prevent dehydration in patients at risk. Use additional anti-nausea medications as clinically indicated.

Diarrhea

Diarrhea was reported as an adverse reaction in 44% of patients, and Grade 3 diarrhea occurred in 6% of patients treated with XPOVIO. The median time to onset of diarrhea was 15 days.

Manage diarrhea by dose modifications and/or standard anti-diarrheal agents; administer intravenous fluids to prevent dehydration in patients at risk.

Anorexia/Weight Loss

Anorexia was reported as an adverse reaction in 53% of patients, and Grade 3 anorexia occurred in 5% of patients treated with XPOVIO. The median time to onset of anorexia was 8 days.

Weight loss was reported as an adverse reaction in 47% of patients, and Grade 3 weight loss occurred in 1% of patients treated with XPOVIO. The median time to onset of weight loss was 15 days.

Monitor patient weight at baseline, during treatment, and as clinically indicated. Monitor more frequently during the first two months of treatment. Manage anorexia and weight loss with dose modifications, appetite stimulants, and nutritional support.

Hyponatremia

XPOVIO can cause hyponatremia; 39% of patients treated with XPOVIO experienced hyponatremia, 22% of patients experienced Grade 3 or 4 hyponatremia. The median time to onset of the first event was 8 days.

Monitor sodium level at baseline, during treatment, and as clinically indicated. Monitor more frequently during the first two months of treatment. Correct sodium levels for concurrent hyperglycemia (serum glucose >150 mg/dL) and high serum paraprotein levels. Treat hyponatremia per clinical guidelines (intravenous saline and/or salt tablets), including dietary review. Interrupt and/or reduce dose, or permanently discontinue based on severity of adverse reaction.

Infections

In patients receiving XPOVIO, 52% of patients experienced any grade of infection. Upper respiratory tract infection of any grade occurred in 21%, pneumonia in 13%, and sepsis in 6% of patients. Grade 3 infections were reported in 25% of patients, and deaths resulting from an infection occurred in 4% of patients. The most commonly reported Grade 3 infections were pneumonia in 9% of patients, followed by sepsis in 6%. The median time to onset was 54 days for pneumonia and 42 days for sepsis. Most infections were not associated with neutropenia and were caused by non-opportunistic organisms.

Neurological Toxicity

Neurological toxicities occurred in patients treated with XPOVIO.

Neurological adverse reactions including dizziness, syncope, depressed level of consciousness, and mental status changes (including delirium and confusional state) occurred in 30% of patients, and severe events (Grade 3-4) occurred in 9% of patients treated with XPOVIO. Median time to the first event was 15 days.

Optimize hydration status, hemoglobin level, and concomitant medications to avoid exacerbating dizziness or mental status changes.

Embryo-Fetal Toxicity

Based on data from animal studies and its mechanism of action, XPOVIO can cause fetal harm when administered to a pregnant woman. Selinexor administration to pregnant animals during organogenesis resulted in structural abnormalities and alterations to growth at exposures below those occurring clinically at the recommended dose.

Advise pregnant women of the potential risk to a fetus. Advise females of reproductive potential and males with a female partner of reproductive potential to use effective contraception during treatment with XPOVIO and for 1 week after the last dose.

ADVERSE REACTIONSThe most common adverse reactions (incidence 20%) are thrombocytopenia, fatigue, nausea, anemia, decreased appetite, decreased weight, diarrhea, vomiting, hyponatremia, neutropenia, leukopenia, constipation, dyspnea, and upper respiratory tract infection.

The treatment discontinuation rate due to adverse reactions was 27%; 53% of patients had a reduction in the XPOVIO dose, and 65.3% had the dose of XPOVIO interrupted. The most frequent adverse reactions requiring permanent discontinuation in 4% or greater of patients who received XPOVIO included fatigue, nausea, and thrombocytopenia. The rate of fatal adverse reactions was 8.9%.

Please see XPOVIO Full Prescribing Information available atwww.XPOVIO.com.

About Karyopharm Therapeutics

Karyopharm Therapeutics Inc. (Nasdaq: KPTI) is an innovation-driven pharmaceutical company dedicated to the discovery, development, and commercialization of novel first-in-class drugs directed against nuclear export and related targets for the treatment of cancer and other major diseases. Karyopharm's Selective Inhibitor of Nuclear Export (SINE) compounds function by binding with and inhibiting the nuclear export protein XPO1 (or CRM1). Karyopharms lead compound, XPOVIO (selinexor), received accelerated approval from the U.S. Food and Drug Administration (FDA) in July 2019 in combination with dexamethasone as a treatment for patients with heavily pretreated multiple myeloma. In May 2020, Karyopharm submitted a supplemental New Drug Application requesting approval for XPOVIO as a new treatment for patients with multiple myeloma after at least one prior line of therapy based on the data from the Phase 3 BOSTON study. A Marketing Authorization Application for selinexor is also currently under review by the European Medicines Agency. A supplemental New Drug Application was also accepted by the FDA seeking accelerated approval for selinexor as a new treatment for adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). In addition to single-agent and combination activity against a variety of human cancers, SINE compounds have also shown biological activity in models of neurodegeneration, inflammation, autoimmune disease, certain viruses and wound-healing. Karyopharm has several investigational programs in clinical or preclinical development. For more information, please visit http://www.karyopharm.com.

Forward-Looking Statements

This press release contains forward-looking statements within the meaning of The Private Securities Litigation Reform Act of 1995. Such forward-looking statements include those regarding Karyopharms expectations and plans relating to selinexor as a potential treatment for patients with GBM; the design and execution of a global randomized clinical trial to study this potential application of selinexor and the therapeutic potential of and potential clinical development plans for Karyopharms drug candidates. Such statements are subject to numerous important factors, risks and uncertainties, many of which are beyond Karyopharm's control, that may cause actual events or results to differ materially from Karyopharm's current expectations. For example, there can be no guarantee that Karyopharm will successfully complete necessary clinical development phases of selinexor in this indication; that data from a clinical trial of selinexor would support its use in treatment of patients with GBM; or that regulators will approve the use of selinexor in patients with GBM. Further, there can be no guarantee that any positive developments in the development or commercialization of Karyopharms drug candidate portfolio will result in stock price appreciation. Managements expectations and, therefore, any forward-looking statements in this press release could also be affected by risks and uncertainties relating to a number of other factors, including the following: the risk that the COVID-19 pandemic could disrupt Karyopharms business more severely than it currently anticipates, including by reducing sales of XPOVIO, interrupting or delaying research and development efforts, impacting the ability to procure sufficient supply for the development and commercialization of selinexor or other product candidates, delaying ongoing or planned clinical trials, impeding the execution of business plans, planned regulatory milestones and timelines, or inconveniencing patients; the adoption of selinexor for treatment of GBM in the commercial marketplace, the timing and costs involved in commercializing selinexor for such indication or any of Karyopharms drug candidates that receive regulatory approval; the ability to retain regulatory approval of selinexor for such indication or any of Karyopharms drug candidates that receive regulatory approval; Karyopharm's results of clinical trials and preclinical studies, including subsequent analysis of existing data and new data received from ongoing and future studies; the content and timing of decisions made by the U.S. Food and Drug Administration and other regulatory authorities, investigational review boards at clinical trial sites and publication review bodies, including with respect to the need for additional clinical studies; the ability of Karyopharm or its third party collaborators or successors in interest to fully perform their respective obligations under the applicable agreement and the potential future financial implications of such agreement; Karyopharm's ability to obtain and maintain requisite regulatory approvals and to enroll patients in its clinical trials; unplanned cash requirements and expenditures; development of drug candidates by Karyopharms competitors for indications in which Karyopharm is currently developing its drug candidates; and Karyopharms ability to obtain, maintain and enforce patent and other intellectual property protection for any drug candidates it is developing. These and other risks are described under the caption "Risk Factors" in Karyopharms Quarterly Report on Form 10-Q for the quarter ended March 31, 20, which was filed with the Securities and Exchange Commission (SEC) on May 5, 2020, and in other filings that Karyopharm may make with the SEC in the future. Any forward-looking statements contained in this press release speak only as of the date hereof, and, except as required by law, Karyopharm expressly disclaims any obligation to update any forward-looking statements, whether as a result of new information, future events or otherwise.

Contacts:

Investors: Karyopharm Therapeutics Inc. Ian Karp, Vice President, Investor and Public Relations857-297-2241 | ikarp@karyopharm.com

Media:

FTI ConsultingSimona Kormanikova or Robert Stanislaro212-850-5600 |Simona.Kormanikova@fticonsulting.com or robert.stanislaro@fticonsulting.com

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Karyopharm Announces Dosing of First Patient in a Phase 1/2 Study of Selinexor in Combination with Standard of Care Therapy for Patients with Newly...

Soup Diet Review: Do They Work for Weight Loss? – Healthline

Posted: June 9, 2020 at 5:43 pm

A soup diet is generally a short-term eating plan thats designed to help individuals lose weight quickly.

Instead of one official soup diet, there are several soup-based diets. While some involve only eating soup for the duration of the diet, others also include a limited list of allowable foods.

As the idea is to lose weight quickly, most of these diets are only meant to last for 510 days.

This article reviews different types of soup diets, pros and cons of these diets, and whether a soup diet is effective for weight loss.

There are many types of soup diets, with some of the more popular ones listed below. Just keep in mind that theres currently no research on the effectiveness of these specific diets.

Broth-based soup diets generally last for 7 days. However, some can last as long as 1014 days. Over that time, proponents of a broth-based diet claim you can lose up to 10 or even 20 pounds (4.5 to 9 kg).

On a broth-based soup diet, cream-based soups are restricted, as theyre higher in calories and fat. Instead, youre encouraged to consume homemade or canned broth-based soups that include vegetables and protein.

While some programs recommend only consuming broth-based soups, others may allow for small amounts of low calorie options like lean proteins, non-starchy vegetables, and nonfat dairy.

One of the more popular bean soup diets is from Michael Greger, MD, author of How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease.

The diet encourages eating Dr. Gregers Champion Vegetable Bean Soup up to twice a day. In addition to the soup, youre allowed to consume any oil-free, plant-based foods, like whole grains, fruits, and vegetables.

While theres no calorie restriction, the diet recommends limiting intake of calorie-dense foods like dried fruits and nuts for optimal weight loss results.

Unlike other soup diets, Gregers is meant to be a lifelong shift to a plant-based diet.

Proponents of this diet claim you can lose 916 pounds (47 kg) in just the first week.

Theres currently no research on Gregers bean soup diet. However, plant-based diets have been linked to benefits for weight loss and heart health (1, 2).

One of the most popular soup diets, the cabbage soup diet is a 7-day eating plan that involves eating a chicken- or vegetable-broth-based soup that contains cabbage and other low carb vegetables.

In addition to cabbage soup, you can also have one or two other low calorie foods, such as skim milk or leafy greens.

If following the meal plan closely, the diet claims you can lose up to 10 pounds (4.5 kg) over the 7 days.

The chicken soup diet is a 7-day weight loss diet that involves eating chicken soup for every meal except breakfast.

For your morning meal, you can pick from five low calorie options, which include foods like nonfat milk and yogurt, fat-free cheese, whole-grain cereal or bread, and fresh fruit.

For the rest of the day, the diet recommends consuming frequent small portions of homemade chicken soup throughout the day. By eating small, frequent portions of soup, the diet claims it will help reduce cravings and encourage feelings of fullness.

The soup itself is low in calories and carbs, as its made with broth, cooked chicken, aromatics like garlic and onion, and plenty of non-starchy vegetables, including carrots, turnips, broccoli, and collard greens.

Designed for those following the ketogenic (keto), paleo, Whole30, or another low carb diet, the keto soup diet claims it can help individuals lose up to 10 pounds (4.5 kg) in just 5 days.

As with the general keto diet, the soup version is a low carb, high fat, moderate protein eating plan. The program provides 1,2001,400 calories per day, limits carbs to 20 grams per day, and restricts nuts, dairy, and artificial sweeteners.

The plan recommends eating the same breakfast each day, which consists of eggs, butter, bacon, avocado, and unsweetened bulletproof coffee. One low carb, high fat snack is also allowed, such as celery with keto-friendly tuna salad.

The rest of the day, you eat four cups of the keto soup, split between lunch and dinner. The soup recipe includes ingredients like chicken, bacon, olive oil, chicken stalk, sun-dried tomatoes, mushrooms, and other low carb vegetables and herbs.

Similar to the cabbage soup diet, the Sacred Heart soup diet is a 7-day eating plan that consists almost entirely of a broth-based soup with non-starchy vegetables.

While other low calorie foods are allowed, the diet is very specific as to which foods can be included each day.

When followed closely, the Sacred Heart soup diet claims to help you lose 1017 pounds (4.58 kg) in 1 week.

There are several types of soup diets. While some are more restrictive in what you can eat, like the cabbage soup diet, others allow for more flexibility, like the bean soup diet.

Observational studies have found individuals who regularly consume soup tend to have a lower body mass index (BMI) and are less likely to have obesity, compared with those who dont eat soup at all (3, 4, 5).

The reason why soup is linked to lower body weight is unknown. Some studies suggest that soup may help increase feelings of fullness. Thus, regularly eating soup may help reduce the number of calories you eat per day (5, 6).

Its also important to consider other factors that could explain this relationship, such as cultural or genetic differences between individuals who regularly eat soup and those who dont (7).

Overall, more rigorous and long-term studies are needed to confirm the potential weight loss benefits of eating soup.

One other thing to note is that soup consumption hasnt been shown to reduce the risk of metabolic syndrome, a group of conditions that increase your risk for developing heart disease and type 2 diabetes (3, 8).

As for specific soup diets, theres currently no scientific evidence on their effectiveness for weight loss.

Yet, as most soup diets result in a significant reduction in calories, following them will likely help you lose weight (9, 10).

And the fewer calories you eat on a soup diet, generally the more weight youll lose.

Just keep in mind that as with other low calorie diets, most of the weight lost over the 510 days is likely due to water rather than fat loss (11).

Furthermore, as the diets are generally for only a week or less, youll likely regain the weight you lost unless youre able to transition into a more sustainable weight loss eating plan (12).

As the bean soup diet recommends transitioning into a plant-based eating pattern, it may have better long-term success than the others.

Regularly consuming soup has been linked to a lower body weight. However, theres insufficient research on the benefits of soup diets for weight loss. Still, due to the low calorie nature of these eating plans, youll likely lose some weight in the short term.

In addition to helping you lose weight quickly, soup diets may offer additional benefits, including:

However, keep in mind that just 1 or 2 weeks of increased vegetable, fiber, and water intake is unlikely to have any meaningful benefits for long-term weight and health, unless following the diet helps you make lasting lifestyle changes.

Soup diets are generally easy to follow and can help increase your intake of water, fiber, and vegetables. While these changes can be beneficial, you would need to maintain these increases to reap the long-term effects.

With the exception of Gregers bean soup diet, one of the biggest downsides to soup diets is that most of them arent meant to be followed for more than 510 days.

Therefore, unless you have a more sustainable diet to transition to, youll likely regain any weight you lose on the diet.

Furthermore, studies suggest that when you greatly restrict calorie intake or lose a sustainable amount of weight quickly, theres a reduction in your metabolic rate. This means that your body begins to burn fewer calories per day than it did before (11, 19, 20).

As a result, after going off the diet, your lowered metabolism may make it harder to maintain your weight loss.

Additionally, as soup diets like the cabbage soup diet and Sacred Heart diet are quite restrictive in the types and amounts of foods allowed, theres a concern for nutrient deficiencies.

While eating a restricted diet for just 5 to 10 days is unlikely to result in serious nutrient deficiencies, especially if taking a multivitamin, significantly reducing calorie intake can lead to side effects, such as dizziness, weakness, or fatigue (21).

As most soup diets are only designed to last for 5 to 10 days, they arent sustainable weight loss solutions. Furthermore, the severe and rapid reduction in calories and weight can slow your metabolism, making it even harder to maintain your weight loss.

Soup diets have become popular for their ability to help you shed a significant amount of weight in just 5 to 10 days.

However, most of the weight lost on these diets is largely due to a loss of water rather than fat.

Furthermore, as these diets are only designed to be followed for a short period, youll likely regain any weight you were able to lose.

Instead, as eating soup may help curb your appetite and reduce calorie intake over the day, youre likely better off simply incorporating soups into a balanced, less restrictive weight loss eating plan for long-term success.

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Soup Diet Review: Do They Work for Weight Loss? - Healthline

It’s time to rethink the disrupted US food system from the ground up | The Conversation – The Morning Journal

Posted: June 9, 2020 at 5:43 pm

The COVID-19 pandemic and resulting economic shutdowns have severely disrupted and spotlighted weaknesses in the U.S. food system. Farmers, food distributors and government agencies are working to reconfigure supply chains so that food can get to where its needed. But there is a hidden, long-neglected dimension that should also be addressed as the nation rebuilds from the current crisis.

As scholars who study different aspects of soil, nutrition and food systems, were concerned about a key vulnerability at the very foundation of the food system: soil. On farms and ranches across the U.S., the health of soil is seriously compromised today. Conventional farming practices have degraded it, and erosion has shorn away much of it.

Iowa has lost about half the topsoil it had in 1850. Since they were first plowed, Americas farmland soils have lost about half of their organic matter the dark, spongy decomposed plant and animal tissue that helps make them fertile.

The soil that produces our nations food supply is a weakened link slowly failing under ongoing strain. This breakdown isnt as dramatic as what happened in the 1930s during the Dust Bowl, but it is just as worrying. Human history holds many examples of once-thriving agricultural regions around the world where failure to maintain soil health degraded entire regions far below their potential agricultural productivity, impoverishing the descendants of those who wrecked their land.

We believe there is an urgent need to rebuild soil health across the U.S. This can help maintain harvests over the long run and lay a solid foundation for a more resilient food system. Investing in soil health will benefit environmental and human health in ways that are becoming increasingly apparent and important.

Soil is the foundation of the U.S. food system. Fruits, vegetables, nuts and oils come directly from plants grown in soil. Meat, poultry, dairy products and many farmed fish come from animals that feed on plants. Wild-caught fish and shellfish, which provide a tiny fraction of the typical American diet, are virtually the only exception.

As populations around the globe ballooned over recent centuries, so did pressure to force more productivity out of every available acre. In many parts of the world, this led to farming practices that degraded soil far beyond its natural fertility.

In the Southeastern U.S., for example, agricultural erosion stripped soil from hillsides a hundred times faster than the natural rate of soil formation. Today farmers in the Piedmont, from Virginia to Alabama between the Atlantic coast and the Appalachian mountains, coax crops from poor subsoil rather than the rich topsoil that early European settlers praised.

Researchers, government agencies and nonprofit groups recognize soil degradation as a national problem and have started to focus on rebuilding soil health. The U.S. Department of Agricultures Natural Resource Conservation Service helps farmers improve the health and function of their soils. Nongovernment organizations are recognizing the need to restore soil health on agricultural lands. And the 2018 farm bill directed new attention and funding to soil health programs.

Beyond growing food, soils support human, public and planetary health. Well before the current pandemic, experts in public health and nutrition recognized that modern agriculture was failing to sustain consumers, the land and rural communities. This insight helped spur the emergence of a new multidisciplinary field, known as food systems, that analyzes how food is produced and distributed.

But work in this field tends to focus on the environmental impacts of food production, with less attention to economic and social implications, or to links between farming practices, soil health and the nutritional quality of food. Many studies narrowly focus on greenhouse gas emissions from agriculture when addressing soils and sustainability, without including the many ecological benefits that healthy soils provide.

To be sure, man-made climate change is a major long-term threat to human and planetary health. But soil health is just as critical in its own right. Human actions have already harmed agricultural productivity in areas around the world. And when soil is degraded, food production systems are less able to weather future challenges that we can expect in a changing climate.

The study of soil health can also have its own blind spots. Often agricultural research focuses solely on crop yields or the impact of individual conservation practices, such as adopting no-till planting or planting cover crops to protect soil from erosion. Such analyses rarely consider linkages driven by dietary demand for specific foods and crops, or the effects of farming practices on the nutrient content of forage and crops that sustain livestock and humans.

Food systems experts have called for transforming food production to improve human health and make agriculture more sustainable. Some researchers have proposed specific diets that they argue would accomplish both goals. But fully understanding connections between soil health and public health will require greater collaboration between those studying food systems, nutrition and how we treat the soil.

Now that COVID-19 has deconstructed much of the national food supply network, it would be a mistake to pour efforts into simply rebuilding a flawed system. Instead, we believe it is time to redesign the U.S. food system from the ground up, so that it can deliver both soil health and human health and be more resilient to future challenges.

What would it take to do this? The foundation of a revised system would be adopting regenerative farming methods that integrate multiple soil-building practices, such as no-till, cover crops and diverse crop rotations to restore health to land. It would also take creating and expanding markets for more diverse crops, as well as expanding regenerative grazing and promoting reintegration of animal husbandry and crop production. And it would require investing in research into the linkages between farming practices, soil health and the nutritional quality of foods and what that all could mean for human health.

Laura Lewis, Associate Professor of Community and Economic Development at Washington State University, and Dave Gustafson, project director at the Agriculture & Food Systems Institute, contributed to this article.

The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.

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It's time to rethink the disrupted US food system from the ground up | The Conversation - The Morning Journal

Do you really need meat to build muscle? – New Food

Posted: June 9, 2020 at 5:43 pm

Vivo Lifes nutritionist, Charlotte Cliffe, explains the science behind building muscle on an entirely vegan diet.

One of the key factors in building muscle is your diet. The amount of protein you consume, for instance, is crucial. Many people think this equates to how much meat you eat, as meat and fish are a great source of protein. However, they are not the only source. With a solid understanding of the science behind how you build muscle, you can easily bulk up even on an entirely vegan bodybuilding diet!

Firstly, its important to understand how you build muscle. Muscle growth or hypertrophy, to give it its technical name comes from an increase in a certain type of long protein (myofibrils). This increase can be stimulated through working out. Weightlifting, for example, can stimulate this increase by damaging the muscle tissue on a small scale. It is not the damage that causes hypertrophy, but rather, the recovery process.

Our body goes through several changes during exercise; minute muscle damage is just one of them. It can also lead to an increase in temperature, dehydration, and a disruption to the nervous and cardiovascular system. This is because exercise puts the body under stress. Having the right diet ensures that you recover from these things efficiently. You should also take other steps to encourage recovery, such as stretching, drinking lots of fluids, and getting sufficient rest.

As mentioned, protein is key. But protein is a complex term that encompasses many different amino acids. Some of these amino acids are essential meaning your body cannot produce them itself. Others are non-essential meaning your body can produce them. It is important that your diet includes the essential amino acids your body cannot synthesise itself. These essential amino acids are:

One reason meat is often considered essential for muscle growth is that it contains all of these essential amino acids. Many plant based protein sources, such as nuts and beans, do not. However, by carefully researching vegan bodybuilding recipes, you can ensure you do get the amounts you need. Soy, buckwheat, and quinoa all contain these amino acids with soy being the most efficient per portion size.1 You can also eat a mix of incomplete sources, as long as, between them, they provide all the essential amino acids.

Soybeans contain essential amino acids

Protein alone is not enough to ensure muscle growth. As with many biological processes, it is a complex balance. Other important nutrients include:

Most people think of calcium as being related to strong bones and teeth (which it is), but it is also important for building muscle. This is because it contains actin and myosin which can stimulate muscle growth. A lack of calcium can cause your body to store more fat than it should. Dark, leafy greens are a good source of calcium in plant-based diets particularly spinach.

Iron helps ensure your body can maintain energy levels during exercise. It helps get oxygen to your muscles, as well as assisting in the repair process. Like protein, most people think of meat as the best source, but it is possible to have a sufficient iron intake on a plant-based diet. Again, dark leafy greens like kale or spinach are good sources, along with lentils, nuts, and seeds.

Vitamin C helps the body absorb iron more effectively. If you are getting your iron from plant sources, then this is even more important. You want to be absorbing the iron you are getting as efficiently as possible! Luckily, plant-based diets excel at containing vitamin C fruit and vegetables are key here.

Vitamin D is not as directly impactful as the above three, nonetheless, it still has a role to play in muscle growth and many people are deficient without realising. The best source of Vitamin D is sunlight, but in some areas of the world this can be hard to obtain. There are not many foods containing high amounts of vitamin D, and most of them are meat-based oily fish, liver and red meat. However, its very easy to add a supplement to your diet for this. Many vegan supplements will contain Vitamin D sourced from lichen.

B12 is often overlooked, but it helps your body produce red blood cells. These, in turn, help bring oxygen to your muscles. This is one nutrient that is not usually found in plant-based foods, but that does not mean you need to add meat to your diet. Instead, fortified yeast or breakfast cereals have high levels of B12 and are easy to incorporate into your diet.

It is possible to build muscle on a plant-based diet it just requires a little more research and careful meal planning, but there is plenty of help available!

It is important to make sure your nutrition is spread regularly throughout the day, so eating five or six meals instead of the usual three can help with this. Switching to snacks with high levels of protein or other vital nutrients can ensure your intake is high. Pumpkin seeds, pistachios, and other nuts and seeds are good for this.

Whilst eating meat does have health benefits eating fish and poultry can be associated with a lower risk of heart disease and strokes, for example so too, does a plant-based diet. In fact, it can help you achieve improvements in cholesterol and blood pressure.

The most important thing is to eat a healthy, balanced diet with all the essential nutrients, regardless of whether it is meat or not! But those looking to investigate plant-based diets can certainly still work on building muscle.

References

Charlotte Cliffe

Charlotte Cliffe is the marketing manager and in-house nutritionist at the leading plant-based protein and vegan supplement brand, Vivo Life. The company was voted as the UKs best vegan superfood and supplement brand in the VegFest awards.

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Do you really need meat to build muscle? - New Food

What Should I Watch After Ive Binged Dead to Me? – The New York Times

Posted: June 9, 2020 at 5:43 pm

Because you like Fauda and False Flag, your first stop should be Hulus Prisoners of War (Hatufim), the Israeli series on which Homeland was loosely based. Two soldiers return to Israel after 17 years as hostages, but what should be a joyous reunion is also tainted by suspicion and violence.

For something with more visual flair, there are two recent mini-series adapted from novels by John le Carr that fit the bill: The Night Manager, starring Tom Hiddleston and Hugh Laurie, and Little Drummer Girl, starring Florence Pugh and Michael Shannon. Each follows a new recruit a former soldier, a young actress who gets sucked in to a world of international espionage, and glamorous, dangerous globe-trotting ensues. (Both shows aired on AMC; Night is streaming on Amazon, and Drummer is on Sundance Now.)

Theres The Heavy Water War, a Norwegian series set during World War II and based on real events (available on Amazon Prime). Its a little less of the heart-pounding tension and little more of the search for morality.

After all that, you might want a foreign spy comedy, in which case, try Netflixs A Very Secret Service, a French series set in the 1960s that has a sort of Archer-y vibe.

I am intrigued by survival content. I loved All is Lost the first time I saw it years ago and recently watched it twice. Life of Pi and Arctic were also hits. I devoured all the seasons of Alone, and I am even willing to go a bit off course, and let a few interlopers in, as when I enjoyed The Terror mini-series, and Shackleton documentaries. So what could be next? Abby

One of my favorites, and among my most-recommended shows, is The Last Alaskans, a documentary series on the Discovery Channel about the few people still allowed to live in the Arctic National Wildlife Refuge. While its not strict solo survivalism, its close, and the stunning cinematography is unmatched in unscripted television.

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What Should I Watch After Ive Binged Dead to Me? - The New York Times

Weight Loss: 5 Effective Spoonful Ingredients That Can Help You Shed Those Extra Kilos – India.com

Posted: June 9, 2020 at 5:43 pm

Losing weight is not an easy process. It requires discipline, exercise, and change in diet. For getting the body of your dreams, a lot of work is needed to be done. Fat burning doesnt not happen overnight. It takes hell lot of time. The only thing you can do about it is to speed up the process through certain hacks and diet. There are a few kitchen ingredients that are associated with effective weight loss. These home remedies work wonder when it comes to losing weight. Lets know about them. Also Read - Weight Loss: Eat at These Specific Times of The Day to Get The Body of Your Dreams

Mixing a tablespoon of apple cider vinegar in a glass of water and sip it daily in the morning. Doing this can help you lose weight effectively. This drink is low in calories and effective in fat burning. Having it daily can detoxify your body by flushing out all the toxins that are associated with weight gain. Apple cider vinegar is rich in acetic acid and it has anti-inflammatory properties. Notably, inflammation is linked to obesity. Also Read - Weight Loss: Roti vs. Rice, What's Healthier to Eat When You Are Trying to Shed Those Extra Kilos?

Using a tablespoon of coconut oil daily to cook food is a healthy way to lose weight. This oil is thermogenic in nature. This means, it can speed up the fat-burning process and help in effective weight loss. Also Read - Weight Loss: Consume Jaggery With Warm Water to Detoxify Your Body And Shed Those Extra Kilos

Ginger is a kitchen staple that is known to have an array of health benefits. It does not only neutralises free radicals in the body but also helps in improving digestion by speeding up your bodys metabolism. For effective weight loss, you can prepare a cumin-ginger drink and have it every morning empty stomach. It is a detox tea thats quite helpful.

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Weight Loss: 5 Effective Spoonful Ingredients That Can Help You Shed Those Extra Kilos - India.com

"With the challenges of lockdown, it is more important than ever that we try to eat a healthy balanced diet" – Evening Standard

Posted: June 9, 2020 at 5:43 pm

The necessary closure of much of the UKs food and hospitality industry has left large quantities of fresh produce at risk of going to waste. Vegetables that would usually be bought by pubs and restaurants remain unsold, while ongoing travel restrictions have meant there is an excess of seasonal produce that needs picking.

The UK fishing industry, which usually exports much of its catch overseas, has also been dramatically affected. But, despite these obstacles, there are still key ways we can come together to help support the local food industry right now

Theres plenty of vegetables that are being harvested in the UK right now from aubergine and broad beans to beetroot, spinach and summer squash that could go to waste without the right demand.

Seasonal veg such asparagus, cucumbers, courgette and tomatoes are ready now (Alamy)

Scott Watson (pictured above), a radish grower at Gs Growers in Feltwell, Norfolk is encouraging the public to eat more of this healthy vegetable.

"With the challenges of lockdown, it is more important than ever that we try to eat a healthy balanced diet and ensure we are at least trying to get our five portions of fruit and veg per day. Snacking on radishes is a healthy choice as they are a source of Vitamin C, and if you eat a third of a standard 240g pack it counts as one of your five a day," Watson says.

The majority of our sales go through major UK supermarkets, where you can typically buy our radishes in 240g bags at circa 55p a bag. This works out at 18p per portion great value. We also supply radishes to the box schemes for inclusion in stir-fry recipes and expect to see more of our radishes on fruit and veg markets as they reopen.

If youre needing a little inspiration, youll find lots of delicious ideas from the likes of Hugh Fearnley-Whittingstall and Amanda Grant at vegpower.org.uk plus, why not share your favourite recipes using #SeasonalVeg on social media

Robyn Philip has swapped London for Essex to workon New Moor Farm

The Pick For Britain initiative which encourages fit and healthy people looking for job opportunities to work on fruit and veg farms across the the country has been launched by the Government to help keep the industry moving.

Whether youre a furloughed employee whose contract allows you to take on additional work, or a student on summer holidays, there are plenty of vacancies nationwide from forklift and tractor drivers and plant husbandry, to pickers and packers.

Robyn Philip, a stylist from London, has been living and working on New Moor Farm in Southminster, Essex. Right now, I live on site on the farm, in one of the caravans in the orchard its nice, she says. The community is amazing. There are many different characters on the farm. Everyone is really friendly and were all here for the same reasons to help and to work.

Madeline Owen lives locally and works atNew Moor Farm

Madeline Owen, an A Level student, lives locally, so is able to get her mum to drop her off at New Moor Farm at six each morning.

Definitely do it; 100% definitely do it, urges Owen. Its a great way to get out. Ive met so many people that have all got stories and different things to tell me that Ive learnt from, and its definitely worth it. Its good fun.

The growing season is only just getting started, so from now until September, bringing in the harvest will require an extraordinary effort. If youd like to help out, visit pickforbritain.org.uk to find out more

Due to different international tastes, much of the Fish caught in UK waters is exported to Europe, but the pandemic has all but stopped this trade. Also, higher-end produce is no longer being bought by restaurants because of necessary closures.

Getty images

One way to help the UKs vital fishing industry an integral part of our economy is to try new things. There is a host of different fish and seafood from UK waters that much of the country dont often cook. Some fisherman now offer home deliveries, while great produce can be found at retailers and fishmongers across the country.

Supporting a local supplier is a good place to start, find one near you at fishisthedish.co.uk. And, if youre looking to brush up your fish know-how, youll discover how to buy, store and cook seafood, together with plenty of tasty recipes from spiced coconut mussels to crab and trout risotto

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"With the challenges of lockdown, it is more important than ever that we try to eat a healthy balanced diet" - Evening Standard

In Wake of Pandemic, Jersey City Set to Launch 1st in the Nation Comprehensive Inner City Vertical Farming Program – InsiderNJ

Posted: June 9, 2020 at 5:43 pm

In Wake of Pandemic, Jersey City Set to Launch 1st in the Nation Comprehensive Inner City Vertical Farming Program

Initiative to Focus on Food Deserts, Inequity with Food Access, and Education on Healthy Eating; Program is a Partnership with AeroFarms & World Economic Forum

Jersey City Mayor Steven M. Fulop announced this week that the City of Jersey City will be moving forward with the 1st in the nation municipal vertical farming program. The program will be in conjunction with AeroFarms, the world leader in vertical farming, and the World Economic Forum (WEF) who recently selected Jersey City as their first partner in the Healthy Cities and Communities 2030 Initiatives.

As we work through our municipal budget that has been decimated due to the Coronavirus pandemic, we are making choices on what programs to keep. said Mayor Fulop. It is clear that the virus has had a disproportionate impact on people with pre-existing heart conditions, high blood pressure, obesity and diabetes which is directly linked to a persons diet, and as a result we feel it is more important than ever to focus on food access and education.

The Vertical Farming Program is moving forward as the city rebounds from the impact of COVID-19. The virus has impacted Jersey City at a scale larger than many states across the country as the city has experienced to date more than 6,000 COVID-19 cases and more than 400 COVID-19 fatalities, with a disproportionate amount impacting more economically challenged areas of the city.

We know diet is a key predictor of life expectancy and the Coronavirus has made clear the huge inequities on food access and food education that exists in different communities said Stacey Flanagan the Director of Health and Human Service for Jersey City.

The Vertical Farming Program will consist of 10 vertical farms throughout Jersey City located in senior centers, schools, public housing complexes, and municipal buildings. The 10 sites will grow 19,000 pounds of vegetables annually using water mist and minimal electricity. The food will be free to the public, the only requirement being that residents participate in healthy eating workshops and agree to quarterly health screenings.

The citys Health and Human Service Department will run the program with a health-monitoring component to track participants progress under a greener diet in the areas of blood pressure, cholesterol, diabetes and obesity. Crops will be integrated with other Healthy Food Access initiatives including senior meal programs.

The program is part of the broader initiative from the World Economic Forum towards partnerships with cities. Earlier this year the World Economic Forum selected 4 cities (Moscow, Mumbai, Austin, Jersey City) to launch the Healthy City 2030 initiative, which will target measurable changes to the health of each community.

The Healthy Cities and Communities initiative is a flagship effort of the World Economic Forum. In collaboration with both private-public sector stakeholders, the initiative aims to catalyze new ecosystems that will enable socially vibrant and health and well-being centric cities and communities, said Mayuri Ghosh, Head of the Healthy Cities and Communities initiative at the World Economic Forum. Establishing a secure supply of nutritious food via locally sourced vertically farmed greens in collaboration with Aerofarms has been a key accomplishment of the Forums partnership with Jersey City. The shared insights will be incorporated into efforts underway in other global cities.

The vertical farming program with AeroFarms and the World Economic Forum is the latest and broadest initiative Jersey City has launched around food access including more than 5,000 food market tours for seniors to educate on healthy eating, and the grant program on the Healthy Corner Store initiative.

The Mayor and I were both selected as Young Global Leaders by the World Economic Forum and while we have known each other for years Im excited to work with Jersey City in this formal capacity, said David Rosenberg CEO of AeroFarms. Societies structural food problems have become more clear with COVID-19. The world needs more distributed, localized food production systems. We also need new ways to get healthy food to our most disadvantaged members of society. I am honored to work to work with Mayor Fulop and the people of Jersey City to find better solutions.

This partnership will allow us to provide thousands of pounds of locally-grown, nutritious foods that will help close the hunger gap and have an immeasurable impact on the overall health of our community, Mayor Fulop said.

About the World Economic Forum

The World Economic Forum is the International Organization for Public-Private Cooperation. The Forum engages the foremost political, business, cultural and other leaders of society to shape global, regional and industry agendas. It was established in 1971 as a not-for-profit foundation and is headquartered in Geneva, Switzerland. It is independent, impartial and not tied to any special interests.

About AeroFarms

AeroFarms is widely considered the world leader in Vertical Farming. Headquartered in New Jersey, the companys mission is to grow plants for the betterment of humanity. AeroFarms enables local food production and therefore makes it possible for people to enjoy freshly harvested food. AeroFarms grows without pesticides, not organic pesticides, but zero pesticides so food is healthier to eat.

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In Wake of Pandemic, Jersey City Set to Launch 1st in the Nation Comprehensive Inner City Vertical Farming Program - InsiderNJ

Want to lose weight quickly? These seeds will make it easy – Times of India

Posted: June 9, 2020 at 5:43 pm

You must have come across little round seeds floating on the drinks and smoothies, which must have really grabbed your attention, but did you know these seeds were silently helping you shed some weight! Yes, those little seeds with transparent membranes were sabja seeds, which can effortlessly help you lose weight. They are packed with nutrients like proteins, carbs, fibre, essential fats and omega 3 fatty acids. These seeds are rich in alpha-linolenic acid (ALA), which are present in omega 3 fatty acids that help in accelerating the fat burning hormones. Moreover, the high fiber content keeps you satiated for a long time and helps in curbing odd hunger pangs.

There are several ways you can add sabja seeds to your diet, but the best way to lose weight would be by making a simple detox water with sabja seeds, lemon juice and mint leaves, keep it overnight and sip it throughout the day. You can also add soaked sabja seeds to your puddings, yoghurts, salads, shakes, lassi to name a few.

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Want to lose weight quickly? These seeds will make it easy - Times of India

Snacking on Almonds Could Improve Heart Health – runnersworld.com

Posted: June 9, 2020 at 5:43 pm

Michelle Arnold / EyeEmGetty Images

If youre looking to improve your heart health, it may be worth adding almonds to your snack mix, according to a recent study in the American Journal of Clinical Nutrition.

Researchers found that replacing typical snacks like chips and cookies with almonds lowered LDL (bad) cholesterol levels and improved endothelial function (which involves the membrane inside the heart and blood vessels thats responsible for clotting, relaxation, and contraction).

Looking at a four-day food diary from 6,802 adults, researchers found that those who ate almondsthe median amount of almonds eaten was five grams, or about four almonds, dailyhad fewer markers for cardiovascular disease risk and a healthier diet overall, including higher intakes of protein, vitamin C, and fiber, according to lead study author Wendy Hall, Ph.D., head of the Nutrition Metabolic Research Unit at Kings College London.

The takeaway is that this is a very simple dietary strategy, involving replacing typical snacksother than fruitwith whole almonds, she told Runners World. It improves that capacity of arteries to relax in response to increased blood flow, an independent predictor of cardiovascular disease.

In terms of why, she added that there isnt one sole reason, but likely a combination of two major effects. One is that replacing those other snack foods would lower your consumption of salt, sugar, and saturated fat, she said. The other is that almonds are nutritionally dense foods that are high in fiber, good-for-you plant compounds (like polyphenols, which are packed with antioxidants), and full of micronutrients like magnesium, vitamin E, and riboflavin, which have all been shown to improve vascular function, Hall said.

A caveat here is that the trial was funded by the Almond Board of Californiawhich doesn't automatically throw the findings into question, but as a 2018 research review in the American Journal of Public Health suggests, corporate interests and industry involvement are important to highlight.

That said, the study does seem to rigorously avoid the correlation doesnt equal causation trap. Observational nutritional studies can be notoriously tricky in this regard because its challenging to prove causation when so many other factors are at play. For example, if a group of runners all get faster eating a certain food during training, that doesnt necessarily mean that specific food causes an increase in speed; it may be that being timed and observed is what motivates them to run faster, and what they eat is simply correlated with those performance improvements.

[Run faster, stronger, and longer with this 360-degree training program.]

But this studys use of a randomized, controlled trial does demonstrate causation, Hall said, because almond intake was tracked over the four-day period, as well as nutrient levels and cardiovascular disease risk indicators. When it came to body fat, though, there was some correlation involved there.

Those who consumed the whole almonds during the four-day period were more likely to have lower body fat, Hall said. This does not show that almonds caused lower body fat, but instead, that health-conscious individuals are more likely to eat whole almonds.

It should be noted, though, that consuming more than 42.5 grams of almonds, or about 35 almonds, is not effective for weight loss, per a 2018 meta-analysis.

Previous research on the impact of almonds on heart health has yielded similar results. For instance, a 2014 study published in Free Radical Research found that eating almonds can reduce the risk of heart disease by keeping your blood vessels in top shape. (The antioxidants in almonds help reduce blood pressure and improve blood flow.)

That association, along with this recent 2020 study, suggests that consuming almonds, particularly when theyre bumping less-healthy options from your diet, can be part of other healthy strategieslike exerciseto reduce the risk of heart disease.

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