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NeonMind Taking Steps to Prove Psilocybin Effective for Weight Loss – Yahoo Finance

Posted: May 22, 2020 at 6:00 am

Vancouver, British Columbia--(Newsfile Corp. - May 21, 2020) - The Yield Growth Corp. (CSE :BOSS) (OTCQB: BOSQF) (FSE: YG3) majority owned subsidiary NeonMind Biosciences Inc. ("NeonMind") has taken further steps towards commencing its clinical studies to confirm that psilocybin (a compound in psychedelic mushrooms) is an effective treatment for food cravings and weight loss. NeonMind has now identified a source of psilocybin in Canada and has identified a laboratory at a University in Canada in which to conduct the studies.

NeonMind Taking Steps to Prove Psilocybin Effective for Weight Loss

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NeonMind previously announced that it had engaged Translational Life Sciences Inc. ("TLS") to conduct the study and that TLS had completed the design of a study to confirm that psilocybin (found in psychedelic mushrooms) is an effective treatment for weight loss and food craving.

TLS has identified a source of synthetically created psilocybin, manufactured by a licensed laboratory, for use in the NeonMind studies. Also, NeonMind has identified a laboratory where the studies can be carried out (the "Lab"). Before the psilocybin can be ordered and before NeonMind can enter into an agreement with the Lab, the Lab must first obtain an exemption from the Canadian Minister of Health pursuant to Subsection 56(1) of the Controlled Drugs and Substances Act, S.C. 1996, c. 19 by the researchers at the Lab to allow them to use psilocybin, a controlled substance, in research studies. NeonMind expects the exemption to be granted within a few months. Researchers at the Lab have previously obtained other exemptions for research involving controlled substances.

"Psilocybin is known to activate serotonin receptors," says Dr. William Panenka, the Director of TLS, "As a neurotransmitter, serotonin helps to relay messages from one area of the brain to another. Serotonin is responsible for some of the drivers which govern eating. We are very interested in furthering studies to test various dosing regimens for NeonMind to see the effects that psilocybin may have on the serotonin receptors that regulate food cravings."

TLS has provided an estimate of $250,000 as a budget for the study and an estimated time frame of 6 months to complete the study, with valuable data anticipated to be available within the first few months. TLS estimates that all necessary approvals can be obtained so that the study can commence in the fall of 2020. NeonMind plans to fund the study using previous capital raised and from the proceeds of a planned initial public offering of NeonMind, for which due diligence is currently underway with a Canadian investment dealer.

According to the terms of the TLS engagement, signed on May 6, 2020, NeonMind and TLS agreed to work together to conduct the evaluation of psilocin or psilocybin on cravings, on the metabolism, on food addiction and on glucose and hormone levels. Neon authorized TLS to perform activities required to prepare for and conduct the study and the parties shall work towards entering into a clinical study agreement. NeonMind agreed to pay for all costs related to the study and TLS agreed to arrange for required regulatory exemptions and licenses, and engagement of all necessary parties to conduct the study.

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According to the World Health Organization, in 2016, more than 1.9 billion adults, 18 years and older, were overweight. The global projected market for weight loss and weight management is estimated at US$245 billion, according to marketsandmarkets. This is over 12x the size of the global anxiety disorder and depression treatment market which is forecast to reach US$18.9 billion by 2026, according to a report by Reports and Data.

About Translational Life Sciences Inc.

TLS is a contract research organization and a life sciences company focused on developing proprietary formulations that contain restricted substances such as psilocybin and cannabis for clinical applications to serve unmet medical needs in the market. The TLS team is composed of physicians and scientists who are recognized thought leaders in the fields of Neurology, Pharmacology, Diabetes, Addiction and Biochemistry and have significant experience in the clinical application of cannabinoid compounds. The founder of TLS, Dr. Panenka, is a dually boarded Neurologist and Psychiatrist and Canadian Institute of Health Research funded academic faculty member at the University of British Columbia. Dr. Panenka did a post doctoral fellowship at UBC and Harvard University, and maintains an internationally recognized research program in brain injury, mental health and addictions.

About NeonMind Biosciences Inc.

NeonMind is dedicated to the enhancement of human life and wellness through the advancement of bioscience to engage the mind to heal the body. It aims to be a leader in the fast-growing functional and adaptogenic foods market, and is engaged in research and the development of products and services using medicinal and psychedelic mushrooms to heal the body through the mind. NeonMind has filed a U.S. provisional patent application to protect the invention that the administration of psilocin and/or psilocybin results in overall weight loss in individuals by reducing food cravings, counteracting compulsive overeating, improving quality of diet, increasing metabolism, treating diabetes, regulating blood glucose and reducing susceptibility to cardiovascular disease, high blood pressure, diabetes mellitus and other illnesses associated with obesity. NeonMind owns 18% of Translational Life Sciences Inc. Yield Growth owns approximately 68% of the issued and outstanding stock of NeonMind.

About The Yield Growth Corp.

The Yield Growth Corp. (CSE: BOSS), (OTCQB: BOSQF) is a phytoceutical and consumer packaged goods company that develops and acquires intellectual property and other assets related to plant-based products and therapeutics, and develops, manufactures, markets, sells and distributes plant-based products that improve lives. It has over 200 proprietary wellness formulas at various stages of commercialization. It is currently launching several hand sanitizer products in response to COVID-19. Its products are sold through e-commerce worldwide and retail stores in 3 countries with distribution agreements in place for 12 more countries. It has 14 patent applications filed in what the Global Wellness Institute reports is a $4.2 trillion-dollar global wellness market. Its majority owned subsidiary NeonMind Biosciences Inc. is launching a line of medicinal mushroom products and is developing intellectual property in the emerging area of psychedelic medicine. The Yield Growth management team has deep experience with global brands including Johnson & Johnson, Procter & Gamble, Skechers and Aritzia.

For more information about Yield Growth, visit http://www.yieldgrowth.com or follow @yieldgrowth on Instagram.

Investor Relations Contacts:

Penny White, President & CEO

Kevan Matheson, Investor Relations

invest@yieldgrowth.com

1-833-514-BOSS 1-833-514-2677

1-833-515-BOSS 1-833-515-2677

The Canadian Securities Exchange has not reviewed, approved or disapproved the contents of this news release.

Cautionary Statement Regarding Forward-Looking Statements

This press release includes forward-looking information and statements (collectively, "forward looking statements") under applicable Canadian securities legislation. Forward-looking statements are necessarily based upon a number of estimates, forecasts, beliefs and assumptions that, while considered reasonable, are subject to known and unknown risks, uncertainties, and other factors which may cause actual results and future events to differ materially from those expressed or implied by such forward-looking statements. Such risks, uncertainties and factors include, but are not limited to: risks related to the development, testing, licensing, brand development, availability of packaging, intellectual property protection, reduced global commerce and reduced access to raw materials and other supplies do to the spread of the Coronavirus, the potential for not acquiring any rights as a result of the patent application and any products making use of the intellectual property may be ineffective or the company may be unsuccessful in commercializing them; and other approvals will be required before commercial exploitation of the intellectual property can happen. Demand for the company's products, general business, economic, competitive, political and social uncertainties, delay or failure to receive board or regulatory approvals where applicable, and the state of the capital markets. Yield Growth cautions readers not to place undue reliance on forward-looking statements provided by Yield Growth, as such forward-looking statements are not a guarantee of future results or performance and actual results may differ materially. The forward-looking statements contained in this press release are made as of the date of this press release, and Yield Growth expressly disclaims any obligation to update or alter statements containing any forward-looking information, or the factors or assumptions underlying them, whether as a result of new information, future events or otherwise, except as required by law.

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NeonMind Taking Steps to Prove Psilocybin Effective for Weight Loss - Yahoo Finance

Mike Schultz: 5 Fast Facts You Need to Know – Heavy.com

Posted: May 22, 2020 at 6:00 am

Mike Schultz pictured on his Instagram page in February 2020.

Mike Schultz is the San Francisco nurse who lost 50 pounds following a battle with coronavirus. Schultzs side-by-side photos showing the weight loss went viral in May 2020.

In his most recent Facebook post, Schultz shared the news that he had been sent home from the hospital and stopped at McDonalds along the way. Schultz was being treated at New England Sinai Hospital in Stoughton, Massachusetts. Schultz has previously said that he had no underlying health conditions.

Heres what you need to know:

Schultz, 43, posted the photo on May 11. At the time of writing, the picture has received over 18,000 likes. Schultz said in the caption of the photo that he had been sedated for six weeks. He added that due to pneumonia, his lung capacity has been reduced. Schultz spent eight weeks in the hospital, away from family and friends. Schultz concluded the post: Getting stronger everyday and working to increase my lung capacity. Ill get back to where I was in healthier ways this time.maybe even do cardio.

In the space of those six weeks, Schultzs weight went from 190 to 140 pounds, he told BuzzFeed News.

Instagram/Mike SchultzSchultz on May 6.

In a post on May 6, Schultz wrote that he was able to eat and drink what he wanted after passing a medical test. Schultz also paid tribute to his boyfriend, renowned Boston-area DJ J Warren aka Josh Hebblethwaite. Schultz said the couple hadnt seen each other since March 17.

Schultz then took the opportunity to remind everybody, This disease is no joke people. If you think youre too young to get it, think again.

Schultz told Buzzfeed News that after six weeks of being sedated and intubated, he lost his sense of time. Schultz said, I thought only a week had gone by. I was so weak. This was one of the most frustrating parts. I couldnt hold my cellphone; it was so heavy. I couldnt type, because my hands shook so much.

Pink News was the first to report in April 2020 that Schultz was one of the attendees at the Winter Party Festival in Miami Beach who had contracted coronavirus. During his time at the festival, Schultz posted several photos of himself in Miami Beach. In total, the Miami Herald reported at least 38 people contracted coronavirus at Winter Party, and three people died, according to NBC Miami.

Schultz told Buzzfeed News about the feeling around coronavirus during the festival saying, We knew it was out there. There were no real restrictions in place, though. No lockdowns. We just thought, Well, we gotta wash our hands more and be wary of touching our face. Schultz said he and his boyfriend have received negative comments on social media due to their attendance at Winter Party.

On March 10, Schultz traveled to Boston alongside Hebblethwaite following an amazing weekend in Florida, according to Pink News. Hebblethwaite had been a DJ at the event. It was in Boston that Schultz first noticed the symptoms before being hospitalized a few days later.

A GoFundMe page was set up to help Schultz to pay for the medical costs incurred from a two-month stay in the hospital. The most recent update on the page is from Schultz announcing his release from the hospital. Schultz said:

After 57 days in the hospital and rehab unable to see any visitors, Im finally going home!! I plan on continuing my recovering with my guardian angel and boyfriend, Josh, who checked in on my several times a day if not more.

Im am forever thankful for everyones donations, kind words, and prayers. I truly believe they helped me get through this horribly scary ordeal. But first I have to make a stop at McDonalds for a yummy shake.

In a Facebook post following Schultzs release from the hospital, Hebblethwaite said that his boyfriend inspires me with his strength and courage! The couple has been together since the summer of 2019.

Multiple posts on Schultzs Instagram page show him modeling in leather wear. Those posts are accompanied with the hashtag leatherdaddy.

On his Instagram bio, Schultz describes himself as being Made in Detroit. Schultz said that he is a San Francisco-based registered nurse. Schultz goes by the moniker The Bearded Nurse on his profile. He has over 30,000 followers.

READ NEXT: Teenage Porn Star Controversy Rocks California High School

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Mike Schultz: 5 Fast Facts You Need to Know - Heavy.com

Intermittent fasting: if you’re struggling to lose weight, this might be why – The Conversation UK

Posted: May 22, 2020 at 5:59 am

Intermittent fasting is a way of losing weight that favours flexibility over calorie counting. It restricts the time you are allowed to eat, which reduces calorie intake by limiting opportunities to eat. Thats the theory, at least.

A popular version of intermittent fasting is the 5:2 diet, which involves eating a very low-calorie diet (about a quarter of usual calorie intake) for two days each week and unrestricted eating on the other five days. This approach has worked well for some people, but not everyone. In our latest study, we found that people cheat on their intermittent fasting diet, without realising it.

Conducted over three days, the study aimed to find out how eating and physical activity changed around a period of calorie restriction.

A group of male participants completed two trials. On the first trial day, they were told they would have a very low-calorie diet (about 700 calories) the following day. Throughout the rest of the day, we tracked how much the participants ate and we assessed their hunger before and after each meal. Their physical activity was also monitored throughout the day.

The next day, participants ate the very low-calorie diet, and we monitored their physical activity. The morning after completing the low-calorie diet day, we measured their food intake at an unrestricted breakfast and assessed their hunger before and after the meal.

Each participant also completed a control trial that followed the same method. During the control trial, participants ate a typical diet (about 2,800 calories) instead of a very low-calorie diet.

We found that participants ate 6% more on the first day of the study and 14% more at the unrestricted breakfast on the low-calorie diet trial. This was despite hunger levels before and after each meal being similar to the control trial. This suggests participants ate more because they knew food intake would be restricted the following day, rather than because they felt hungrier.

Physical activity was also 11% lower the day before eating the low-calorie diet, and 18% lower while eating the low-calorie diet.

Interestingly, low-intensity physical activity, such as washing the dishes, which tends to be spontaneous behaviour rather than consciously planned activities, was the most affected component of physical activity. We found changes in eating and physical activity behaviour occur before, during and after a day of low-calorie dieting. These behavioural changes reduce the likelihood of intermittent fasting leading to weight loss.

For a diet to lead to weight loss, calories burned must exceed calories consumed to produce a calorie deficit. Intermittent fasting diets assume that the large calorie deficit produced by fasting or very low-calorie dieting is not recovered during the unrestricted period, so the calorie deficit is preserved. But our study shows that eating a little more and reducing spontaneous physical activity may be enough to recover almost half of this calorie deficit. The calorie deficit may also be reduced further at subsequent meals after a very low-calorie diet day.

Earlier studies support our findings. Skipping breakfast for six weeks was shown to reduce physical activity and increase calorie intake at later meals. This was enough to fully compensate for calories skipped at breakfast. This raises the question: is fasting or severe calorie restriction worth the sacrifice?

Weight loss from any diet is always likely to be lower than expected. Compensatory mechanisms defend against a calorie deficit far more strongly than a calorie surplus. In scientific studies of intermittent fasting, participants are often guided by a dietitian on how many calories they should eat on the unrestricted days. Even with this support, participants in these studies still lose less weight than would be expected if the calorie deficit had been fully preserved.

Our study highlights what and when compensatory behaviours occur. This information can be used to improve the effectiveness of intermittent fasting diets. Being more mindful when eating before and after a period of calorie restriction and incorporating exercise into diet plans, could help increase the likelihood of intermittent fasting leading to weight loss.

Intermittent fasting is not a miracle diet, but some people may benefit from its flexibility, and with a few minor adjustments, it could be even more effective.

If youd like to take part in our next study, exploring pre-lockdown and during-lockdown exercise and nutrition habits, please click on this link. You must be 18 years or older and have taken part in regular physical activity before the lockdown.

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Intermittent fasting: if you're struggling to lose weight, this might be why - The Conversation UK

Obesity and COVID-19: Americas Diet Takes Its Toll – Worth

Posted: May 22, 2020 at 5:59 am

Data unequivocally shows that being obese and/or having diet-related diseases is responsible for 90 percent of non-age-related hospitalizations from COVID-19.

Weve all read countless articles saying were pitted in a war against the coronavirus. We question the frequent use of war and battle when referring to disease mitigation, but if we accept these military terms, wed like to add collaborator to the discussion.

An example: In WWII, the German advance was aided by French collaborators who smoothed the way into their country by identifying weaknesses in French defenses.

In todays America, junk, processed and fast food, along with soda, are relentlessly hawked by corporations to an increasingly obese public. In other words, the excess calories, sugar, salt and fat that were eating and drinking are slowly killing us.

Now, theyre also lending a helping hand to COVID-19the new enemy.

The U.S. military, for whom words like war and battle are not metaphors, as they are above, is handicapped by the obesity epidemic. They have stated their current pool of potential recruits are so unhealthy, due to obesity and heart disease, that fitness standards were lowered in order to fill their ranks. A 2018 study, Unhealthy and Unprepared, concluded that overweight youth are having an impact on the militarys ability to maintain effectiveness. Currently one-third of 17- to 24-year-olds are ineligible to join because of their weight.

Data unequivocally shows that being obese and/or having diet-related diseases, such as hypertension, diabetes or heart disease, or the conditions that flow from these like kidney failure, is responsible for 90 percent of non-age-related hospitalizations from COVID-19. So, if it isnt bad enough that diabetes leads to amputations, blindness and dialysis, it also is a highly correlated factor for virus-related deaths.

Aside from the heartbreak of increased vulnerability to COVID-19, theres a crippling economic cost. In a truly scandalous situation, America now spends 21 percent of its health care dollars on obesity-related diseases.

A main one of which is the aforementioned diabetes. According to the American Diabetic Association, a third of Americans are either diabetic or prediabetic. The national cost of treatment in 2017 was more than $327 billion, up 26 percent from $245 billion in 2012.

According to the CDC, Chronic disease accounts for approximately 75 percent of the nations aggregate health care spending. In terms of public insurance, treatment ofchronic diseaseconstitutes an even larger proportion of spending96 cents per dollar for Medicare.

Even prominent bankers, not traditionally focused on issues beyond profit and loss, have raised the alarm. The May 3 Bank of America Global Research Paper on predicted post-COVID economic trends, states, [P]ublic health is the new national wealth. Stakeholders will increasingly focus on health-related ESG metrics; governments will come to appreciate health more as an economic resource.

Its not often that bankers and health care officials are on the same page, but in this case, they are. The National Association of Chronic Disease Directors has issued this statement: As the United States seeks ways to regain our economic footing and rebuild prosperity, all should be reminded of the simple but immensely important fact that the nations collective health bears both an economic and human cost. Poor health of a population can exert tremendous force on employment rates, interest costs and other tangible factors that ultimately affect the ability to maintain a strong global economic position.

Its not like we havent been warned. Medical experts have been trying to get us to wake up and smell the roasted vegetables and whole grains for years.

Sadly, however, when Michelle Obama championed her Lets Move initiative, which included a healthy diet for school children, she was ridiculed by conservatives and libertarians as pushing the nanny state. They were fine with pepperoni pizza, sloppy Joes and soda being on the menu. Recently, TVs Bizarre Foods host, Andrew Zimmern, in a video interview, decried the role the American diet is playing in COVID-19 morbidity. Too bad we didnt listen to the First Lady.

One explanation as to why we allow ourselves and our children to eat so poorly is hyperbolic discounting, our inability to see the long-term consequences of our short-term behavior. For example, if smoking caused cancer the next day, a lot less people would smoke. Its the same with food choices. The immediate pleasure of sugary sodas outweighs the possibly of dialysis a decade later.

Why would we steadfastly deny the obvious? Marion Nestle, Paulette Goddard Professor of Nutrition, Food Studies, and Public Health, Emerita, at New York University and author of Food Politics, Soda Politics, The Unsavory Truth and many other books, told Worth, The coronavirus pandemic poignantly illustrates why we need food systems devoted as much or more to public health as they are to profit. Profit-making is what drives food companies to push junk foods on us as hard as they can and to lobby government to make sure they can do so with impunitywhat happens to human health be damned. If the pandemic teaches us anything, it is that we need a government that supports public health over corporate health.

Until public policy steps in, nonprofits, such as Wholesome Wave, are helping. Through their efforts with both nonprofits and corporations, fruits and vegetables have been made available to low-income Americans.

When the current crisis moderates and we catch our collective breaths, it will be a good time to look into what food is doing to make our society so health-compromised, so susceptible to new threats. From farmer to consumer, we cannot afford to continue weaponizing our diet against ourselves. Instead, we need our food policies to keep us safe. Business as usual should no longer apply. We must clearly see that allowing agribusiness to profit as they have takes a financial and human toll on all of us.

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Obesity and COVID-19: Americas Diet Takes Its Toll - Worth

Target fiber and phytate in corn and wheat to improve pig performance – National Hog Farmer

Posted: May 22, 2020 at 5:59 am

Corn and wheat grains, and their co-products, are the most widely used sources of energy in swine diets. However, these feedstuffs contain phytate and fiber that reduce nutrient utilization. Undesirable effects of phytate and fiber can be alleviated through dietary supplementation of phytase and fiber-degrading enzymes. The most abundant types of fiber in wheat and corn are arabinoxylans that are composed of xylans (a sugar that creates the backbone of arabinoxylans) and arabinose units (the sugars that link to and create branches off the xylan backbone).

The enzymes that breakdown xylans are known as xylanases, whereas those which break down the arabinose branches are known as arabinofuranosidases (debranching enzymes). While xylanase and arabinofuranosidase act on different substrates, their combined supplementation efficiently degrades arabinoxylans, making each enzyme group more effective and valuable in simple and complex diets.

In swine production, supplementing corn- or wheat-based diets with xylanase has reported positive effects. However, there is a lack of information on the combined effects of xylanase and arabinofuranosidase on the nutrient utilization in pigs fed corn-wheat-based diets.

A study at South Dakota State University evaluated the effects of supplementing a multi-enzyme product (xylanase, glucanase, arabinofuranosidase and phytase; supplied by Adisseo France SAS) on the growth performance, bone strength and nutrient digestibility of growing pigs fed corn-wheat-wheat bran-based diets that were low in nutrient density. Criteria measured included average daily gain, average daily feed intake, gain-to-feed ratio, bone strength (femur ash) and nutrient digestibility (apparent total tract digestibility of energy and phosphorus).

A total of 276 pigs with initial body weight of 34 kilograms were housed in 45 pens of six or seven pigs, blocked by gender and weight, and fed five diets (nine pens per diet). Diets consisted of a positive control and two negative controls (NC1 and NC2) that were supplemented without or with the MEP. The MEP supplied at least 1,800, 1,244, 6,600 and 1,000 units of xylanase, -glucanase, arabinofuranosidase and phytase per kilogram of diet, respectively. The PC diet was adequate in all nutrients, and had greater digestible P content than NC1 or NC2 diet by 0.134 percentage points (Table 1).

Table 1: Ingredient and calculated chemical composition of the basal diets

Additionally, the PC diet had a higher net energy and standardized ileal digestible amino acid content than the NC1 diet (74 kilocalories per kilogram; 3% SIDAA) and NC2 diet (124 kcal/kg; 5% SIDAA). The diets were fed in four phases based on bodyweight; Phase 1: 34-50 kg, Phase 2: 50-75 kg, Phase 3: 75-100 kg, and Phase 4: 100-120 kg. Nutrient digestibility and bone mineralization were determined at the end of Phase 1.

For the overall study period (34-120 kg bodyweight), pigs fed the PC and NC1 diets did not differ in ADG and ADFI (Table 2); however, pigs fed the PC diet had greater ADG and G:F than those fed the NC2 diet. Pigs fed the PC diet had greater bone ash content and ATTD of P than those fed the NC1 diet. The ATTD of energy for the PC diet was greater than that for the NC1 or NC2 diet.

Table 2: Effect of dietary treatment on growth performance and nutrient digestibility

Supplementing the MEP did not affect ADG for pigs fed the NC1 diet, but it increased the ADG for pigs fed the NC2 diet by 5.09%. Supplementing the NC1 and the NC2 diet with the MEP increased G:F, bone ash content and ATTD of energy and P. The ADG, bone ash content and ATTD of energy and P for the MEP-supplemented diets were similar to the PC diet. Thus, net energy, SIDAA and P can be lowered by about 5% in MEP-supplemented diets without negative effects on growth performance and bone strength of pigs.

Sources: Kevin Jerez-Bogota, Maamer Jlali, Pierre Cozannet, Aurlie Preynat and Tofuko Woyengo, who are solely responsible for the information provided, and wholly own the information. Informa Business Media and all its subsidiaries are not responsible for any of the content contained in this information asset.

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Target fiber and phytate in corn and wheat to improve pig performance - National Hog Farmer

High blood pressure – the 25p fruit that could prevent deadly symptoms of hypertension – Express

Posted: May 22, 2020 at 5:59 am

High blood pressure is a common condition that affects more than a quarter of all adults in the UK. But, you could lower your risk of developing hypertension by eating an apple everyday, it's been claimed.

High blood pressure - which is also known as hypertension - puts extra stress on blood vessels and vital organs.

The condition could lead to some deadly complications, including strokes and heart attacks.

It could be caused by eating an unhealthy diet, or by not doing enough exercise.

You could lower your chances of high blood pressure by regularly eating apples, it's been revealed.

READ MORE: High blood pressure - condition raises the risk of this disorder

"Certain foods are particularly good to eat if you have hypertension and can significantly lower your risk of experiencing a heart attack or stroke, Dr Brewer told Express Health.

"When it comes to blood pressure, studies involving over 187,000 health professionals showed that those who ate four or more apples a week had significantly lower blood pressures than those who ate less than one a month, on average.

"Its important to eat the peel, as this contains antioxidants with blood-pressure lowering actions that are similar to those of ACE inhibitor drugs.

"You can grate the flesh and mix with lemon juice [to prevent browning] and add to salads, coleslaw and Bircher muesli. Dried apple rings and apple crisps also make tasty snacks."

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High blood pressure - the 25p fruit that could prevent deadly symptoms of hypertension - Express

Flat belly 45 with the training and diet of Kate Beckinsale – Play Crazy Game

Posted: May 22, 2020 at 5:59 am

His last appearance in the gala of awards of a well-known mens magazine represents the test of that Kate Beckinsale have given with the elixir of eternal youth. To its 45 years, the actress retains the same figure -if not even more toned with which it became world famous thanks to his role in the movie Pearl Harbour. This statuesque body allowed him to defend a dress from Julien Macdonald in which the multiple air -leg, neck, back it became an option only suitable for those who feel very sure of themselves and Beckinsale is. Not in vain, in their day-to-day training and healthy eating are always present as she recounts the portal Inquisitr and is that, for to maintain a flat belly year after year the british dont believe in miracles and work hard to achieve it.

I do circuit training interspersed with sessions of brutal cardio, routines, as crazy as over a treadmill without a motor. That part is a torture I love yoga and its what I used to do normally. However, the hard training has been a big difference in my life, admits Kate. The moral that is drawn from the new approach fitness of the star is to get a few measurements sculptural that challenge -and overcome the passage of time, the sweat t-shirt is not only recommended, but obligatory: I wake up, I take the breakfast and after workout.

In fact, your account of Instagram acts as a witness of the spartan training sessions to which it is subjected the interpreter, and also what it is that you enjoy yoga in your day-to-day, a discipline known for its ability to control the levels of stress that combines physical exercise with meditation: Sports is basically a natural antidepressant, ensures. Dr. Reed, a pediatrician and contributor to HELLO!, corroborated when explains to overcome episodes of stress to make physical exercise an intense, sometimes grueling, practice a sport and compete are appropriate activities.

To finish, the food plays an essential role if you want to achieve effective results. The interpreter knows that and, although in his day declared himself a vegetarian, has evolved to include chicken and fish in your diet, relying on vegetables and salads to accompany your dishes, and avoid alcohol at all costs even when she attends social events. A style of life with physical care as one of the fundamental pillars and head of the actress is kept equal to that of twenty years ago.

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Flat belly 45 with the training and diet of Kate Beckinsale - Play Crazy Game

Marius Pharmaceuticals Announces Issuance of Two Key Patents Protecting its Proprietary Oral Testosterone Therapy – GlobeNewswire

Posted: May 22, 2020 at 5:58 am

RALEIGH, N.C., May 21, 2020 (GLOBE NEWSWIRE) -- Marius Pharmaceuticals announced today that the United States Patent and Trademark Office (USPTO) has issued two key patents related to its lead asset, Kyzatrex*. Kyzatrex is an oral Testosterone Replacement Therapy (TRT) that uses an innovative formulation to improve effectiveness and safety.

These allowed claims will provide strong IP protection to December 2030, over 8 years of potential commercial runway. They supplement Marius Pharmaceuticals already robust global patent portfolio for Kyzatrex, which includes granted patents in the European Union, Canada, China, Taiwan, Japan, New Zealand and other key markets, and pending applications in India, and US. Marius Pharmaceuticals patent portfolio includes filings that extend protection to 2033, with the potential to extend protection out to 2040.

The allowed claims protect Kyzatrex, an innovative formulation designed to increase bioavailability and provide a favorable pharmacokinetic (PK) profile compared to other therapeutic alternatives. Om Dhingra, Chief Executive Officer of Marius commented This innovation is truly exceptional as we have created a formulation with a unique PK profile which we believe drives important clinical significance.

Marius Pharmaceuticals Chief Financial Officer Shalin Shah said We are very pleased to strengthen the intellectual property portfolio for Kyzatrex and excited that it has tremendous potential to be differentiated and unique option in the TRT space. We are also drawing a line in the sand between a new treatment paradigm and old testosterone therapies.

Marius Pharmaceuticals has recently completed its pivotal Phase 3 study for Kyzatrex and intends to submit its New Drug Application (NDA) to the Food & Drug Administration (FDA).

About Kyzatrex

Kyzatrex is an experimental therapy for the treatment of primary and secondary hypogonadism (congenital or acquired). Testosterone is a crucial hormone that plays key roles in human growth and development and a wide range of other functions including metabolic and cardiovascular. Sources estimate that 15 million men in the United States suffer from hypogonadism, but only approximately 10% are currently treated. The co-morbidities of men suffering from hypogonadism are also a significant burden on patients and the healthcare system, these include Type 2 Diabetes and other serious chronic conditions.

Current marketed treatments are dominated by painful injections and messy topical applications with transference risk. Kyzatrex is an orally administered therapy, which avoids those drawbacks. Market research points to 93% of patients indicating they would ask their physician about Kyzatrex and more than half would consider a switch from their current regimen.

About Marius Pharmaceuticals

Marius pharmaceuticals is a cutting-edge biopharma company focusing on treating widespread conditions that have been triggered primarily through Androgen deficiency. Our pipeline consists of assets focused on inflammation while our commercial arm is at the forefront of data science technologies core to our commercialization of our lead asset Kyzatrex.

*Kyzatrex is a tentative Tradename currently under review with the FDA

For more information, contact:Shalin Shahshalin@mariuspharma.comwww.mariuspharma.com

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Marius Pharmaceuticals Announces Issuance of Two Key Patents Protecting its Proprietary Oral Testosterone Therapy - GlobeNewswire

Welcome to the table – The Tech

Posted: May 22, 2020 at 5:58 am

By Nathan LiangMay. 21, 2020

Equali-tea Time is a platform for educational discourse surrounding various topics about the LGBTQ+ community. If you would like to contribute a guest post, have a question youd like answered, or want to send feedback or comments on subjects that have been discussed in the column, please email equalitea@tech.mit.edu.

Disclaimer: This first column discusses gender expression from a binary perspective. My story should not be used as a comparison point for all trans experiences. In the future, Equali-tea Time will more directly tackle the idea of gender as a spectrum, along with a slew of other ideas relevant to the LGBTQ+ community!

Transgender is a term that describes people whose gender identity does not agree with the sex they were assigned at birth. A persons sex is usually defined by biological markers, such as genitalia or chromosome designations, whereas gender identity is a socially understood concept of how people present themselves along the gender spectrum.

One of the clearest memories I have from when I was younger (maybe five or six years old) is asking my mother this: Is it possible that I am a boys spirit trapped inside a girls body?

Her response to this was dismissive: Youre just making yourself think that.

I remember feeling crushed. I was confused and at a loss. Was I really making myself think that? Wasnt I taught to follow the beliefs I held in my heart? And why was it that everytime I saw a shooting star in the night sky, Id close my eyes, hold my hands together, and wish with all my heart to wake up the next day in a boys body?

Gender dysphoria is often succinctly described by the saying I was born in the wrong body. This thought often persists in the minds of transgender people. Being identified as the wrong gender brings anxiety. Seeing ourselves in a body that doesnt match our gender identity may bring us extreme discomfort.

I struggled with these feelings into middle school, dreading my first period, hating how my body changed as I went through puberty. I developed crushes on female friends, but I didnt like the label lesbian. I didnt know why, but I just didnt vibe with the term. I couldnt see myself completely identifying with it.

It wouldnt be until the summer before my freshman year of high school that YouTube showed me the answer I had been looking for all these years. Trans men were using the platform to document their transitions and talk about what being transgender meant. It was the first time I really connected with a queer narrative. I finally felt like I had found the words to describe who I really was.

Generally speaking, there are two types of transition that a trans person can go through in their life: social and physical.

The social transition is, well, how one socially becomes their preferred gender. This usually means coming out to close friends and family, adopting the desired pronouns, changing ones name, changing ones wardrobe, and the list goes on and on.

When I think back on my coming out experience, Im always glad to know it ended well. My high school friends and my little sister were really accepting and loving. My mom was confused and hilariously suggested, Are you sure you dont want to be nonbinary instead? because she was afraid of the discrimination I may face by going through with such an extreme transition from one end of the spectrum to the other. Regardless, she trusted me and supported my decision.

However, the wait leading up to the coming out always makes me think. I was always too scared to come out in high school because I didnt want to be bullied. I waited until after my high school graduation to tell my family because I really believed there was a solid chance I would be disowned and kicked out of the house, despite knowing, deep down inside, that they loved me unconditionally. I was prepared to pack up my things and spend my summer couch surfing at friends places until I could escape to a new life at MIT.

Knowing I really genuinely thought that it always makes me a lil sad. Its what compels me now to be a visible example of the trans experience. I want people who are scared to come out to know that unconditional love exists in the world. I was lucky enough to have found it in my family, but its also important to note that everyones journey with this will be different. The key is finding a solid support system to help navigate the turbulence of coming out and transitioning. Chosen families also exist for a reason, and Im always grateful for the one I found at MIT because they understand me on that queer level that my blood-related family just cant.

Along this same vein, I also urge people who arent trans to work toward a more respectful and accepting world. I dont want trans youth to have to go through what I went through. To have to sit and wait for years, stewing in fear and anxiety and preemptive mourning of relationships that could be lost, just to wait to come out at a moment when theyre primed to escape if they have to. I dont want that to be a reality that persists into the future, and changing that takes work from people inside and outside of the community.

Pronouns and names are important to trans people because it is a method of affirming their identity. Especially when trans people are trying to figure out their gender identity or are just beginning to socially transition, having other people affirm them with their preferred pronouns or help them try out new names helps to validate their thoughts and feelings as they explore themselves.

When I came to MIT, I was that really obnoxious trans frosh that would go, Hi, my name is Nathan and I use he/him pronouns. It was my first time actually being out in the world as male, but since I was pre-physical transition, I was always conscious of the fact that my feminine voice, my round face, and my curvy body would give away the fact that I wasnt born male. To combat this, I reminded everyone I met that my pronouns were he/him. Looking back, I feel a bit embarrassed at how adamant I was about it, but its how I felt secure in a place as new and chaotic as MIT.

The physical transition can look very different depending on the person. The most common first step for a physical transition is starting HRT (hormone replacement therapy), which usually means taking regular doses of testosterone for trans men and regular doses of estrogen for trans women. Trans men and trans women will often also pursue cosmetic surgery to transform their bodies in ways that alleviate their gender dysphoria. Some trans people decide that physically transitioning just isnt for them, which is cool too.

I started testosterone hormone injections February of last year, right smack at the beginning of my sophomore spring. I was elated to finally start the next step in my transition and the days couldnt pass by quickly enough for me to see the changes I wanted to happen. See, my voice gave me the most dysphoria because I knew it was the one thing that really gave me away as AFAB (assigned female at birth), so when it finally started to drop with the passage of time, the relief was indescribable. Funnily enough, a lot of friends initially asked if I had caught a cold, but I assured them that No, I was just going through second puberty. This would become an ongoing joke well into my junior fall.

More recently, Ive made plans to undergo top surgery to deal with the thing that started causing me the most dysphoria after my voice dropped: my chest. Im not gonna lie, Im dreading the inevitable post-op period of recovery, but the important thing is I will no longer feel trapped in my own body. I will have removed a weight off my chest (literally and metaphorically), and those scars will mark the end of my transition. Its bittersweet to know Ill finally close off this chapter of my life, but I got through it and I made it out the other side a much happier, more complete person than I started.

To all my friends and family whove supported me as I transitioned, thank you. I love you all.

See the original post here:
Welcome to the table - The Tech

The Real-Life Diet of TimTheTatman, Who’s Intermittent Fasting and Trying to Stay Healthy – GQ

Posted: May 22, 2020 at 5:57 am

In 2015, it all came together. Tim Betar, aka TimTheTatman, was able quit his day job and transition to playing video games for a living.

To be fair, he wasnt just playing the gameshe was streaming them, usually for tens of thousands of fans, providing a running commentary of his exploits. His streams began in earnest in 2012, but those first years werent as lucrative, and they required some expert-level time management. (He estimates he was working 70-plus hour weeks between his normal job and his streaming.) After making the switch to gaming full-time, TimTheTatman amassed more and more and more followers across platforms; his meteoric rise timed out perfectly with the meteoric rise of Twitch, the go-to streaming service for gamers and, really, anyone doing anything. He now has millions of followers across platforms.

Theres no guide on how to stream video games for a living, nor is it easy to work from home every day, as many are learning during the COVID-19 crisis. Over the last handful of years, Tim has experienced his own ups and downs as hes establishedand then attempted to maintaina healthy lifestyle while also staring at a screen all day. Mostly, he makes sure to always leave the house in the morning for a Starbucks coffee run.

GQ called up TimTheTatman, whos currently streaming lots of Call of Duty: Warzone, to talk about working from home without losing your mind (relatable!), and how he feels healthier than ever after an on-again, off-again weight-loss journey.

GQ: How did you figure out a healthy structure as you progressed to streaming for hours and hours every day?

TimTheTatman: When I was working a full-time job and doing this on the side, I was basically working like 70 hours a week. I was younger and didnt have a ton of obligations, so it was doable. Once I started streaming full-time, I had to change that. Ive always been a big advocate of streamers taking a couple days off. I always make sure I can take like, two days a week to relax and reset. Not many streamers do that, surprisingly. A lot of them are younger, and play and play and playI get it to an extent, because I used to do that too.

Do you have any sort of working-at-home rituals based around your streaming schedule? I think lots of people are trying to figure out their working-at-home rituals right now.

I have a daily regimen, especially for when I wake up. Before the pandemic happened, I would go to Starbucks and grab my coffee, almost like my own little work commute, even though Im just going to get coffee and then going back home [laughs]. It is pretty easy to sit in your bed all day, but Im a new father, so thats basically impossible for me, since my son wakes me up every day. Ill get up and have my routine with him now.

So you have to force yourself into a routine a bit?

Yeah, totally. When I first started doing this, it was really easy to be like, Im just going to sleep in. Whos gonna tell me otherwise? I was and am my own boss. I really had to force myself into forming habits around my day, which made things a lot better.

Do you have anything that you do to separate your job from your daily life when youre working from home? Theres got to be some sort of mental switch that you flip when you go from streaming for lots of people to relaxing, right?

Before I had this job, I would go to work and come home to play games to relax. So sometimes Ill play games on streams for the majority of the day, and then to wind down, Ill sit back and play some more games at night [laughs]. My audience really loves first-person shooters and battle royales, games that are more fast-paced. They dont like World of Warcraft or similar games as much since theyre more low-key. Sometimes at night, Ill finish streaming for eight hours, and be like, Alright, see ya guys later! Ill put my son to bed, and then play some World of Warcraft. Its kind of hard to explain to my wife and difficult to justify in general.

See original here:
The Real-Life Diet of TimTheTatman, Who's Intermittent Fasting and Trying to Stay Healthy - GQ


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