A new study has linked an old school drug used to treat alcoholism with rapid weight loss and protective effects in obese mice, hinting at a potential new treatment for obesity. The research comes from the National Institutes of Healths National Institute on Aging, which found that mice given the medication disulfiram lost weight much faster than mice that only went on a diet.

Disulfiram is a drug that has been used to treat alcohol use disorder for more than five decades, according to NIH, which found that it may also be able to protect against metabolic damage associated with obesity while helping return the subject to a healthy weight. The study involved both male and female mice; it is described as a basic research finding.

When it comes to alcoholism, disulfiram works by causing the patient to feel nauseous if they consume alcohol. Researchers became interested in studying the drugs potential use in cases of metabolic disorders and obesity due to the class of drugs reputation for treating rats with type-2 diabetes.

The study involved a total of four groups of lab mice that were fattened up over the course of 12 weeks: one fed a high-fat diet, another fed a high-fat diet alongside a low dose of disulfiram, yet another given a high-fat diet alongside a high dose of disulfiram, and a group given their standard diet. The mice were fed these arrangements for an additional 12 weeks.

The results were described as dramatic. The study found that overweight mice in the disulfiram groups experienced drops in both metabolic damage and body weight despite eating a high-fat diet. The mice given a higher dose of disulfiram lost up to 40-percent of their body weight in four weeks; mice in both of the drug groups also had improvements in blood glucose akin to the mice that were put on a standard diet without the medication.

NIA scientist Michel Bernier, Ph.D., explained:

When we first went down this path, we did not know what to expect, but once we started to see data showing dramatic weight loss and leaner body mass in the mice, we turned to each other and couldnt quite believe our eyes.

The study found that the benefits likely resulted from the drug directly, not from behavioral changes caused by the medication. The mice were not made to exercise as part of the study nor did the scientist notice any increased activity from them during the study. As well, the study didnt note any harm caused by the disulfiram use. Its important to remember, of course, that these results pertain to mice, not necessarily to humans.

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Alcoholism drug linked to dramatic weight loss in obesity study - SlashGear

Global Weight Loss Drinks Industry

Market Overview

Obesity and overweight trouble people due to the excessive fat accumulation that may impair the health of an individual. The weight loss is the result of exercise and the intake of weight loss drinks. These drinks affect the health and energy levels throughout the day in a positive manner and also contribute to the weight loss at the same time. Some effective weight loss drinks are green tea, detox water, lemon water with chia seeds, protein shakes, drinks containing ginger, and carbonated water.

Try Sample of Global Weight Loss Drinks Market @https://www.wiseguyreports.com/sample-request/4504492-global-black-pepper-market-professional-survey-report-2019

COVID-19 can affect the global economy in three main ways: by directly affecting production and demand, by creating supply chain and market disruption, and by its financial impact on firms and financial markets. The outbreak of COVID-19 has brought effects on many aspects, like flight cancellations; travel bans and quarantines; restaurants closed; all indoor events restricted; over forty countries state of emergency declared; massive slowing of the supply chain; stock market volatility; falling business confidence, growing panic among the population, and uncertainty about future.

Consumers these days are becoming more aware and conscious of their dietary intake and the willingness to reduce the consumption of unhealthy food and drinks. These changes in the lifestyles of an individual are leading to the popularity of weight loss drinks. There has been an increase in physical inactivity due to the nature of any form of works, changing modes of transportation and increasing urbanization that is making people more obese and overweight. This energy imbalance among the population is increasing the consumption of weight loss drinks on a large scale.

The global weight loss drinks market report analyses the market value and volume at the regional, global and company levels. The global weight loss market is expected to rise at a faster rate in the forecast period of 2019-2025. The report also presents the market size of the weight loss drinks market based on the historical data and the upcoming future prospects. According to the WHO, in 2016, more than 1.8 billion adults aged 18 years and older were overweight and the worldwide prevalence of obesity has nearly tripled between 1975 and 2016.

The following manufacturers are covered:GNCskinnyfitLiquid I.VLadyBossRenewlifeHerbal CleanBPICellucorHUMKate Farms

Market Segmentation

The continuing rates of obesity and overweight, coupled with low unemployment and higher incomes are boosting the global weight loss drinks market. Hence, on the basis of market segmentation by type, the market can be split into Meal Replacement and Diet Management. A meal replacement is quite popular these days. It includes a drink, bar, soup, etc. that is intended as a substitute for a solid food meal, which has a controlled and balanced rate of nutrients and calories. It also includes health shakes. It is also popular among bodybuilders, not made for weight loss but to save food preparation time when eating 5 to 6 meals per day. And based on the market segmentation by application, the global market for weight loss drinks can be categorized into Online and Offline.

Regional Overview

Regions like Southeast Asia, Europe, North America, and regions like Japan, China and India are among the key players in the global weight loss drinks market. This report analyses the production, consumption, import, and export of the product and also provides an analysis of the manufacturing sites, capacity production, ex-factory price, and revenue in the global weight loss drinks market. The key companies are introducing innovative, and local flavours of weight loss drinks to attract more consumers in the regional market. The stakeholders in the product market are streamlining the market plans and strategies to improve awareness about the benefits of the consumption of weight loss drinks.

Industry News

Disruptive Enterprises LLC, a company that focuses on advancing health and wellness with its brands KetoLogic and FBOMB, has teamed up with an entrepreneur, broadcaster, philanthropist and world-class athlete, Tim Tebow, who will help make the ketogenic diet more accessible and convenient for consumers by endorsing the KETO 30 Challenge.

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Norah TrentWISEGUY RESEARCH CONSULTANTS PVT LTD08411985042

NOTE : Our team is studying Covid-19 and its impact on various industry verticals and wherever required we will be considering Covid-19 footprints for a better analysis of markets and industries. Cordially get in touch for more details.

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Impact of COVID-19 Outbreak on Weight Loss Drinks Market 2020 - stopthefud

Finding time to commit to exercise can be a real challenge, forcing many of us to squeeze in a quick run or gym session whenever there's a spare moment. But researchsuggests if you really want to make the most of your exercise, you should do it at the same time each day. It's a schedule your body will thank you for.

A 2019 study lead by researchers from Brown Alpert Medical School in the US showed it really doesn't matter if you're a dawn jogger or a twilight cyclist; it's the consistency that's key if it's weight-loss you're after.

The US Department of Health and Human Services suggests two and a half hours of moderate physical activity each week is the least we should be doing to keep healthy.

And not just a minute here or there, but at least 10 minutes of heart-pounding exercise in each session.

Needless to say, if you're fairly fit and in a good state of health, you're probably meeting this requirement. But many of those who have problems keeping their weight down often struggle to get the exercise they need.

Using survey results on the physical activity of 375 individuals exercising for weight loss, the researchers of the 2019 study identified a strong relationship between a moderate-to-vigorous level of exercise at the same time of day and the amount of time spent exercising.

Roughly half of the volunteers were morning people, which, when taken in context with a previous study by some of the same scientists, could indicate physical activity before you start your day is the way to go.

This preference for regularity might all come down to the way we think about our diary.

Activities we expect to do at set times such as picking up the kids, going to work, or attending social meetings aren't really things we give a great deal of conscious thought to.

This mindless repetition is referred to as automaticity in psychology circles, and has already been shown to be important when it comes to sticking to an exercise regime.

By actively considering how we could slot in quick walk or a treadmill session, we're more likely to cut back minutes of pulse-raising activity rather than commit to the exercise.

The secret is to therefore associate exercise with some pre-existing mental 'cue' for an appointment that you won't avoid, reducing the effort required if you had to plan an activity and then motivate yourself to see it through.

You might catch the 7:30 train, manage a short cardio workout at the gym near the office, and then be at your desk for that daily 9 am meeting. Or, if you're a night owl, going for a late run the moment you get home.

That walk to the train station might be a habit, but it doesn't count. Incidental exercise can be worked into a routine, but only if it's of a kind that makes your heart noticeably pump harder and demands effort.

"Repeatedly exercising in the presence of consistent cues, such as at the same time of day or in the same location, may help to establish cue exercise relationships," write the researchers.

On its own, a survey such as this can only go so far in demonstrating what causes something as complicated as an exercise habit. Individual motivators can't be dismissed, and more research is needed before any definitive claims can be made.

"It will also be important to determine whether there is a specific time of day that is more advantageous for individuals who have initial low physical activity levels to develop a physical activity habit," the study's first author, Leah Schumacher, said in 2019.

Around the globe, just under a third of women and nearly a quarter of all men aren't engaging in a level of physical activity that will keep them on the right side of healthy.

The reasons are no doubt complex and varied, and also seem to be linked with how much leisure time we actually have at out disposal.

It's hard, especially for busy folks, but getting your 150 minutes a week is important. Pick a time and stick to it.

This research was published in Obesity.

A version of this article was originally published in 2019.

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The Key to Weight Loss Through Exercise Could Be Picking The Right Time of Day - ScienceAlert

News Release

Thursday, May 14, 2020

Treatment with disulfiram, normally prescribed to treat alcohol use disorder, shows health benefits in animal study.

An off-label experiment in mice using disulfiram, which has been used to treat alcohol use disorder for more than 50 years, consistently normalized body weight and reversed metabolic damage in obese middle-aged mice of both sexes. The international study was led by researchers at the National Institute on Aging (NIA), part of the National Institutes of Health . The results were published online in the journal Cell Metabolism on May 14.

The scientific team studied groups of 9-month-old lab mice who had been fed a high-fat diet for 12 weeks. As expected, this diet made the mice overweight and they started to show signs of pre-diabetes-like metabolic problems, such as insulin resistance and elevated fasting blood sugar levels. Next, the scientists divided these mice into four groups to be fed four different diets for an additional 12 weeks: a standard diet alone, a high-fat diet alone, a high-fat diet with a low amount of disulfiram, or a high-fat diet with a higher amount of disulfiram. As expected, the mice who stayed on the high-fat diet alone continued to gain weight and show metabolic problems. Mice who switched to standard diet alone gradually saw their body weight, fat composition and blood sugar levels return to normal.

The mice in the remaining two groups, with either a low or high dose of disulfiram added to their still-fatty food, showed a dramatic decrease in their weight and related metabolic damage. Mice on the high disulfiram dose lost as much as 40% of their body weight in just four weeks, effectively normalizing their weight to that of obese mice who were switched back to standard diet. Mice in either disulfiram dose diet group became leaner and showed significant improvement in blood glucose levels on par with the mice who were returned to standard diet. Disulfiram treatment, which has few harmful side effects in humans, also appeared to protect the pancreas and liver from damage caused by pre-diabetic type metabolic changes and fat build up usually caused by eating a high-fat diet.

The NIA scientists, Michel Bernier, Ph.D., and Rafael de Cabo, Ph.D., collaborate frequently with researchers at NIH and beyond on studies into how changes in dietary patterns like intermittent fasting could lead to cognitive and physical health benefits. They first became interested in disulfiram after reading about the benefits this class of drug has shown in treating type 2 diabetes in rats, coupled with the growing interest in repurposing drugs that may also improve healthy aging.

When we first went down this path, we did not know what to expect, but once we started to see data showing dramatic weight loss and leaner body mass in the mice, we turned to each other and couldnt quite believe our eyes, Bernier said.

According to studys research team, the key to the positive results seem to stem from disulfirams anti-inflammatory properties, which helped the mice avoid imbalances in fasting glucose and protected them from the damage of fatty diet and weight gain while improving metabolic efficiency. Both groups of obese mice (control and disulfiram) were not subjected to any form of exercise, nor did they demonstrate noticeable spontaneous behavioral changes. Based on the evidence they observed, the researchers believe the beneficial results of disulfiram stem solely from the drug. They did not observe any negative side effects from disulfiram in the mice.

The research team stresses that these results are based on animal studies, and they cannot be extrapolated to any potential benefits for human at this point. It is recommended that disulfiram not be used off-label for weight management outside of the context of clinical trials. Still, given the findings, they are planning future steps for studying disulfirams potential, including a controlled clinical study to test if it could help individuals with morbid obesity lose weight, as well as deeper investigation into the drugs molecular mechanisms and potential for combining with other therapeutic interventions.

The research was supported by NIA through its intramural research program, NIA grants AG031782 and AG038072, in collaboration with colleagues from the National Institute of Alcohol Abuse and Alcoholism, Yale University, Albert Einstein College of Medicine, Korea Research Institute of Bioscience and Biotechnology, and University of Sydney, Australia.

This press release describes a basic research finding. Basic research increases our understanding of human behavior and biology, which is foundational to advancing new and better ways to prevent, diagnose and treat disease. Science is an unpredictable and incremental process each research advance builds on past discoveries, often in unexpected ways. Most clinical advances would not be possible without the knowledge of fundamental basic research.

About the National Institute on Aging (NIA): NIA leads the U.S. federal government effort to conduct and support research on aging and the health and well-being of older people. Learn more about age-related cognitive change and neurodegenerative diseases via NIAs Alzheimer's and related Dementias Education and Referral (ADEAR) Center website. For information about a broad range of aging topics, visit the main NIA website and stay connected.

About the National Institute on Alcohol Abuse and Alcoholism (NIAAA): The National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health, is the primary U.S. agency for conducting and supporting research on the causes, consequences, diagnosis, prevention, and treatment of alcohol use disorder. NIAAA also disseminates research findings to general, professional, and academic audiences. Additional alcohol research information and publications are available at https://www.niaaa.nih.gov/.

About the National Institutes of Health (NIH):NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIHTurning Discovery Into Health

Bernier et al. Disulfiram prevents and treats diet-induced obesity and related co-morbidities in mice.Cell Metabolism. 2020 May 14. doi:TBD

###

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Repurposed drug helps obese mice lose weight, improve metabolic function - National Institutes of Health

Action Bronson is one of the most talented rappers to have ever come out of New York. The multi-faceted artist has also established himself as an author, a chef, a television host, and more. With some extra downtime in these last two months because of the virus, Action Bronson decided that he wanted to get healthy, making active choices with his diet and exercise pattern to get to where he wants to be.

Bam Bam was on air with TMZ when he spoke about the weight he has lost since the quarantine started.

"Me, myself, I lost 50 pounds just now. I mean, Im still fat, which shows you I still need to lose another 60," laughed the rapper. "I mean, Ive been working out crazy, Ive been eating really good, Ive been juicing."

He has still been cooking three-to-four meals per day for his wife but he's making sure he's using this time to get right.

Unfortunately, Action Bronson also says that he has lost a lot of money since this began, blaming his canceled tours for much of his income loss.

Bronsolino didn't give too much of a show, but he did note that he's still got a long way to go so there's that.

Good job on starting off strong!

See the article here:
Action Bronson Reveals 50-Pound Weight Loss In Shirtless Interview - HotNewHipHop

Laura Chiatti is not there and, through a long post on instagram, she replied once and for all to the sea of criticism and negative comments that for days have been flocking to social networks for your weight loss.

The actress, in fact, who appears slimmer and in great shape in recent posts, has had to defend herself more than once from the numerous offenses received. In fact, there are those who have accused her of excessive thinness shouting at her to eat. Yet another sad testimony of how even today, the alleged epoch of acceptance and inclusion, the beauty of a person is assessed only on the basis of size, weighed in kilos and measured in centimeters.

To appease the fuss of malicious messages, only a few days before, Chiatti had published a selfie in the mirror, full-length, to explain the reason for her new physical form after the constant requests and pressures of the fans who wanted explanations about his physical change. Having many food allergies, I changed my diet from February and was followed by a very good nutritionist wrote the actress thinking of silencing the negative wave of the haters . But the effort did not help since the offenses followed one another until the post of two days ago, in which he decided to raise his tone, calling on people not to debase serious and delicate problems such as disturbances food trying to pass off a normal weight loss for anorexia.

There is no joking about these issues because there are people who are really struggling with life because of a disease called anorexia , and who thank God does not it has nothing to do with my food allergy problem. Being a public figure does not mean being slaughter and taking defamation without defending yourself, because damaging one's neighbor, whether public or private, is a serious crime that can lead to serious consequences reads the post.

This is nothing but another unhappy chapter of body shaming which opens a scenario paradoxical. On the one hand avid haters who take the liberty of saying everything, even at the limit of offenses, hidden behind a nickname. On the other, the victims of insults forced, in a blatant way, to justify themselves and give explanations regarding their bodies.

The vintage beauty of moms on Instagram

Change of look: the stars before and during the quarantine

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Laura Chiatti responds to the offenses received for her weight loss - NJ MMA News

Hair loss is rarely a cause for concern but it can foster insecurities so treating it becomes a priority for many people. Unfortunately, the market is saturated with sham products so people often turn to cosmetic options. This can be costly and invasive, however. After a spirited attempt to find a solution, many people simply give up.

In a study conducted on balding human hair at the University of Lubeck in Germany, carnitine was shown to promote hair growth, stimulate hair shaft elongation and reduce hair cell death.

According to the study, carnitine was able to produce these effects by boosting the proliferation of follicular keratinocytes the epidermal cells that produce keratin, which hair strands are made of.

It also slowed down cellular death.

The authors of this study concluded: "Our findings suggest that Carnitine stimulates human scalp hair growth by up regulation of proliferation and down regulation of apoptosis in follicular keratinocytes in vitro."

DON'T MISSHair loss treatment - the 5p drink to stimulate hair growth at home[TIPS]Parkinsons disease warning - the smelly symptom you shouldnt ignore[INSIGHT]How to live longer: The best drink for boosting your life expectancy - how much to drink[TIPS]

According to the study, prolonging the life and function of the keratinocytes within the hair follicles means you get to benefit from a healthier scalp and consequently, thicker hair.

Carnitine helps transport fatty acids that easily enter the hair follicles.

These fats are easily burned by the cells to produce energy.

The increase in energy helps the hair follicles to function better, which can result in more hair growth and reduced hair loss.

According to the NHS, finasteride and minoxidil are the main treatments for male pattern baldness.

"Minoxidil can also be used to treat female pattern baldness. Women shouldn't use finasteride," notes the health site.

There are some drawbacks to using these treatments, however.

As the NHS explains, these treatments don't work for everyone and only work for as long as they're used.

They also aren't available on the NHS and can be expensive.

Some wigs are available on the NHS, but you may have to pay unless you qualify for financial help.

It is worth noting that there are pros and cons to consider before purchasing wigs too.

As the NHS explains, synthetic wigs are easier to look after than real-hair wigs but do not last as long and can be itchy and hot.

Real-hair wigs, on the other hand, last three to four years and look more natural but cost more and can be harder to maintain.

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Hair loss treatment: The weight loss supplement shown to strengthen hair follicles - Express

OBESITY is known to double a patient's chances of being hospitalised by coronavirus.

And now Boris Johnson is planning to step up the nation's fight against obesity as part of his plans to beat the deadly disease.

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The Prime Minister, previously a critic of the "nanny state", is said to now support a "more interventionist" approach to obesity.

Boris last month spent three days in intensive care fighting off the virus after his symptoms failed to clear following a ten-day spell in self-isolation.

He is now convinced that his weight is the reason the virus, which for many people is invisible, had such a dramatic affect on him, according to The Times.

The PM has often been photographed jogging or riding a bike through London, but still weighed 17.5 stone, while only 5'9" in height, when he entered hospital.

Obesity and Covid-19

Risk of Stroke If there is a build-up of fatty tissue, which is common in overweight people, it can cause inflammation. This in turn can increase the risk of blood flow difficulties and blockages which, together with the high blood pressure seen with obesity, can lead to strokes.

Sleep Apnoea Being overweight carries a high risk factor for the development of sleep apnoea when breathing repeatedly stops for several seconds at a time during sleep. With additional soft tissue around the face and neck, airways can become blocked and breathing restricted. This then leads to a reduction in oxygen in the blood, which can cause issues with ineffective breathing during Covid-19 infection.

Risk of Heart Attack Being obese has long been linked to an increased risk of cardiovascular issues such as heart and circulatory diseases. While less oxygen in the blood can cause issues, the British Heart Foundation states that fatty material building up in your arteries can also cause problems and even lead to heart attacks.

Risk of Liver Disease Non-alcoholic fatty liver disease typically affects people who are overweight or obese, as its caused by a build-up of fat in the liver. People with more fat in their liver are also at increased risk of other health problems such as diabetes, high blood pressure and kidney disease.

Immune System in Overdrive Obesity is a pro-inflammatory condition, meaning the immune system is already in overdrive. Adding coronavirus on top of that could tip it over the edge, according to Mr Ahmed, and cause serious inflammation.

Reduced Lung Capacity The more overweight you are, the more pressure there is on your diaphragm as its pushed up towards your rib cage essentially compressing the lungs and reducing their capacity. This ultimately makes it harder to get oxygen into the blood, which can lead to heart issues too. As the coronavirus primarily attacks lung tissue, the less lung capacity you have, the greater the effect of the virus.

Type 2 Diabetes Obesity has one of the biggest risk factors for Type 2 diabetes. Previous studies have claimed abdominal fat can cause fat cells to release pro-inflammatory chemicals, which in turn can lead to insulin resistance where cells fail to respond normally to the hormone insulin.

Risk of Kidney Failure Diabetes and high blood pressure are two of the main causes of kidney disease and both of them are linked to obesity. Meanwhile, being overweight also puts extra pressure on the kidneys as they often have to work harder to filter waste.

More than 60 per cent of patients in intensive care with the viruswere overweight or classed as morbidly obese, arecent NHS survey found.

And data from the Health Survey for England (HSE) conducted in 2018 indicated that 31 per cent of adults in the UKwere recognised as clinicallyobesewith a Body Mass Index (BMI) greater than 30.

But as as Boris vows to crack down on obesity levels, we ask a top personal trainer how to lose weight safely...

Harry Thomas, owner of No1 Fitness and celebrity PT, says if you are trying to lose weight it is important to become more conscious of exactly what you're consuming.

He says: "Pay attention to your intake - knowing what you are eating for a few days, can be the game changer for achieving results.

"Many people have never realised how many calories they are overeating from snacking.

"Over the course of the week, these do add up, and could be the main factor for stalling progress."

NHS advice on calorie intake

As a guide, an average man needs around 2,500kcal (10,500kJ) a day to maintain a healthy body weight.

For an average woman, that figure is around 2,000kcal (8,400kJ) a day.

These values can vary depending on age, size and levels of physical activity, among other factors.

Our bodies need energy to keep us alive and our organs functioning normally.

When we eat and drink, we put energy into our bodies. Our bodies use up that energy through everyday movement, which includes everything from breathing to running.

To maintain a stable weight, the energy we put into our bodies must be the same as the energy we use through normal bodily functions and physical activity.

An important part of a healthy diet is balancing the energy you put into your bodies with the energy you use.

For example, the more physical activity we do, the more energy we use.

If you consume too much energy on one day, do not worry. Just try to take in less energy on the following days.

Source:NHS

One of the best ways to lose weight and burn more calories is simply by exercising more.

And Harry says that all you need is ten minutes of exercise a day to start making a difference.

"With the recent announcements last Sunday by Boris, we are now able to get outside much more to exercise," Harry says.

"Get out your diary and block out some time for exercise, stretching and yoga.

"Remember if you are tight for time, be strict with the time you do block out, set the intention that this is a no disturbance time.

"Ten minutes is all you have? Great, get a HIIT circuit in."

To get results and to stay motivated you must see changes.

Harry says: "I recommend taking photos of your progress - even if you dont like the way you look.

"Get your belly out and legs out if you want them areas to change and after a few weeks comparing you will be surprised what you can see.

"Use scales, people say these are bad and we should focus on other things, but if your goal is weight loss, this is the BEST way to see progress.

"Clothes are a great way to see changes - that dress that's sitting in your wardrobe, or your old jeans you want to get back into, the clothes dont lie and will quickly show change."

Many people are said to be struggling with getting a good night's sleep during lockdown.

However, getting too little sleep alters our metabolism so our bodies cannot process food as effectively - ultimately hindering weight loss goals.

Getting just one more hour of sleep a night can aid weight loss - as the stress hormone cortisol, which is said to increase appetite, is higher when you do not get a good sleep.

Being well-rested also means you'll have more energy and be able to put maximum effort into your workout.

Harry says: "Although sleep is not directly responsible for weight loss, it will help aid everything else that does help."

It is important to create some accountability so you stick to your weight loss plan.

"Announce what you are doing to loved ones," Harry recommends.

"Book in times that you can train with a friend virtually, or work with a trainer so that you have someone else pushing you.

"Its easier when other people are involved in the process, and their motivation will be key for getting you through the tougher days."

When it comes to losing weight, if you're consistent all the hard work and sacrifices made will be worth it.

However, it's important not to beat yourself off if you go off your weight loss plan.

Harry says: "Stay good to yourself throughout - if you have a few days off, dont stress, get back on track.

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"Keep reinforcing the positives you have achieved - training more consistently, completing more in the session, getting stronger, getting fitter etc.

"Weight goes far beyond what happens in a month, and to get the weight loss that you want, it's going to take much longer than 30 days.

"But dont worry, you will see results all the way through, you just need to look out for them that's all."

Harry is hosting virtual fitness classes during lockdown - take part in a class at 9am on Sunday here.

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As Boris Johnson vows to lose weight the 6 ways to do it safely - The Sun

Youd have to be living under a rock these past few weeks to have missed the media hype surrounding globally renowned singer Adele. Twitter, Facebook, and countless news sites have been plastered with the same image of the slimmer 32 year old each accompanied with hundreds of comments lauding her incredible transformation and supposed 7 stone weight loss.

Shes an inspiration. Shes so beautiful now.

Of course, I have no problem with Adele losing weight. I recently read an article which condemned Adele for supposedly letting down plus-size women everywhere a somewhat regressive statement which is more telling of the writers own insecurities. For me, the underlying issue is that the over-glorification of Adeles almost unrecognisable and slimmer physique is that is debases her previously larger but completely healthy body.

Praise is focused principally on how much more attractive the multi-Grammy Award winning singer has become. She is an inspiration for her physical transformation, almost nullifying her many other achievements, and, crucially, perpetuating the toxic and misguided belief that weight loss is synonymous with happiness and self-improvement.

The hype surrounding Adeles dramatic weight loss parallels another destructive modern trend and one which has always made me uncomfortable on Instagram the toxic culture of the before and after transformation post. This has arguably become even more prominent in the recent months since this lockdown and the ensuing productivity contest that is perpetuated on social media.

In such posts, the bodies depicted pre-transformation portray the supposedly undesirable body types. For women this tends to be an undefined waist, the love handles, the touching thighs, the muffin top, whilst for men its any physique which doesnt resemble a Marvel movie superhero.

Obviously, there is nothing objectively flawed about these bodies. They are perfectly healthy and normal, but the negative implication is there when it is displayed as a beforephoto.

Why would anyone want the before body? Who would ever want to look like that? This new, skinnier body is so much better.

Perhaps youve never had body hang-ups before. Perhaps your lack of visible abs has never really crossed your mind. But the criticism implied by these comparisons can lead people to question the desirability of your body type.

Is there something wrong with the body in the first image? Should I, like these people, be doing something to change it? Would I be more desirable if I did?

In addition to their denunciation of perfectly normal body types, the vast majority of the post-transformation images are grossly misleading. In many cases, our exposure to before and after comparison comes from social media influencers who share posts to sell more of their fitness and diet plans.

Thus, body transformation images become just another marketing tool, a means of persuading the consumers mostly impressionable young men and women on Instagram into spending money and buying into this ideal.

More than that, theyre also used by young people to market themselves to carefully construct an idealistic profile in the ongoing, seemingly endless battle for social media clout.

No one ever said marketing has to be transparent. Angles. Lighting. Pose. Posture. Body makeup. Time of day. Clothing. Photoshop. All powerful deceivers, all extensively used to manipulate the after image to give the illusion of a quicker, more dramatic, more incredible transformation. Can anyone realistically (and safely) achieve such dramatic weight loss in a matter of weeks? Almost definitely not. Seeing is not necessarily believing.

Of course, some of these young people are simply proud of the progress they have made, eager to share with others the rewards of their determination and hard work. While I am happy for them, I would urge them to reconsider so publicly portraying their pre-transformation body as undesirable it is somewhat dismissive to their previous selves and damaging to others.

It may be extremely clich, but it really does ring true: try to be sensitive and mindful with how you post and interact online. Denouncing and comparing body types can provoke very real and harmful issues.

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Cruel comparisons: The toxic culture of the 'Before and After' photos - The Mancunion